发布求助
文献互助 智能选刊 最新文献

Current Opinion in Cell Biology最新文献

筛选
英文 中文
Biogenesis of extracellular vesicles from the pathogen perspective: Transkingdom strategies for delivering messages 从病原体角度看细胞外囊泡的生物生成：传递信息的跨王国战略
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-05-04 DOI: 10.1016/j.ceb.2024.102366
Alicia Rojas , Neta Regev-Rudzki
{"title":"Biogenesis of extracellular vesicles from the pathogen perspective: Transkingdom strategies for delivering messages","authors":"Alicia Rojas ,&nbsp;Neta Regev-Rudzki","doi":"10.1016/j.ceb.2024.102366","DOIUrl":"https://doi.org/10.1016/j.ceb.2024.102366","url":null,"abstract":"<div><p>EVs are nanoparticles enclosing proteins, nucleic acids and lipids released by cells and are essential for their metabolism and useful for intercellular communication. The importance of EVs has been highlighted by their use as biomarkers or as vaccine antigens. The release of vesicles is exploited by a wide range of organisms: from unicellular bacteria or protozoa to multicellular prokaryotes like fungi, helminths and arthropods. The mechanisms elucidated to date in each biological group are presented, as well as a discussion of interesting directions for future EV studies.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"88 ","pages":"Article 102366"},"PeriodicalIF":7.5,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140822913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tubulin posttranslational modifications through the lens of new technologies 通过新技术透视管蛋白翻译后修饰
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-05-02 DOI: 10.1016/j.ceb.2024.102362
Gonzalo Alvarez Viar, Gaia Pigino
{"title":"Tubulin posttranslational modifications through the lens of new technologies","authors":"Gonzalo Alvarez Viar,&nbsp;Gaia Pigino","doi":"10.1016/j.ceb.2024.102362","DOIUrl":"https://doi.org/10.1016/j.ceb.2024.102362","url":null,"abstract":"<div><p>The Tubulin Code revolutionizes our understanding of microtubule dynamics and functions, proposing a nuanced system governed by tubulin isotypes, posttranslational modifications (PTMs) and microtubule-associated proteins (MAPs). Tubulin isotypes, diverse across species, contribute structural complexity, and are thought to influence microtubule functions. PTMs encode dynamic information on microtubules, which are read by several microtubule interacting proteins and impact on cellular processes. Here we discuss recent technological and methodological advances, such as in genome engineering, live cell imaging, expansion microscopy, and cryo-electron microscopy that reveal new elements and levels of complexity of the tubulin code, including new modifying enzymes and nanopatterns of PTMs on individual microtubules. The Tubulin Code's exploration holds transformative potential, guiding therapeutic strategies and illuminating connections to diseases like cancer and neurodegenerative disorders, underscoring its relevance in decoding fundamental cellular language.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"88 ","pages":"Article 102362"},"PeriodicalIF":7.5,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067424000413/pdfft?md5=8b5932a6190c03ceff9ef8eb416a10e3&pid=1-s2.0-S0955067424000413-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140822912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrially-associated actin waves maintain organelle homeostasis and equitable inheritance 线粒体相关肌动蛋白波维持细胞器平衡和公平遗传
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-04-30 DOI: 10.1016/j.ceb.2024.102364
Stephen M. Coscia , Andrew S. Moore , Yvette C. Wong , Erika L.F. Holzbaur
{"title":"Mitochondrially-associated actin waves maintain organelle homeostasis and equitable inheritance","authors":"Stephen M. Coscia ,&nbsp;Andrew S. Moore ,&nbsp;Yvette C. Wong ,&nbsp;Erika L.F. Holzbaur","doi":"10.1016/j.ceb.2024.102364","DOIUrl":"https://doi.org/10.1016/j.ceb.2024.102364","url":null,"abstract":"<div><p>First identified in dividing cells as revolving clusters of actin filaments, these are now understood as mitochondrially-associated actin waves that are active throughout the cell cycle. These waves are formed from the polymerization of actin onto a subset of mitochondria. Within minutes, this F-actin depolymerizes while newly formed actin filaments assemble onto neighboring mitochondria. In interphase, actin waves locally fragment the mitochondrial network, enhancing mitochondrial content mixing to maintain organelle homeostasis. In dividing cells actin waves spatially mix mitochondria in the mother cell to ensure equitable partitioning of these organelles between daughter cells. Progress has been made in understanding the consequences of actin cycling as well as the underlying molecular mechanisms, but many questions remain, and here we review these elements. Also, we draw parallels between mitochondrially-associated actin cycling and cortical actin waves. These dynamic systems highlight the remarkable plasticity of the actin cytoskeleton.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"88 ","pages":"Article 102364"},"PeriodicalIF":7.5,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140813733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In situ studies of membrane biology by cryo-electron tomography 利用低温电子断层扫描技术进行膜生物学原位研究
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-04-26 DOI: 10.1016/j.ceb.2024.102363
Jenny Keller , Rubén Fernández-Busnadiego
{"title":"In situ studies of membrane biology by cryo-electron tomography","authors":"Jenny Keller ,&nbsp;Rubén Fernández-Busnadiego","doi":"10.1016/j.ceb.2024.102363","DOIUrl":"https://doi.org/10.1016/j.ceb.2024.102363","url":null,"abstract":"<div><p>Cryo-electron tomography (cryo-ET) allows high resolution 3D imaging of biological samples in near-native environments. Thus, cryo-ET has become the method of choice to analyze the unperturbed organization of cellular membranes. Here, we briefly discuss current cryo-ET workflows and their application to study membrane biology <em>in situ</em>, under basal and pathological conditions.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"88 ","pages":"Article 102363"},"PeriodicalIF":7.5,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067424000425/pdfft?md5=6cd061af1f2f41caa4ae48498c3e6627&pid=1-s2.0-S0955067424000425-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140650058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The molecular architecture of the ciliary transition zones 睫状过渡区的分子结构
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-04-21 DOI: 10.1016/j.ceb.2024.102361
Olivier Mercey , Souradip Mukherjee , Paul Guichard, Virginie Hamel
{"title":"The molecular architecture of the ciliary transition zones","authors":"Olivier Mercey ,&nbsp;Souradip Mukherjee ,&nbsp;Paul Guichard,&nbsp;Virginie Hamel","doi":"10.1016/j.ceb.2024.102361","DOIUrl":"https://doi.org/10.1016/j.ceb.2024.102361","url":null,"abstract":"<div><p>Cilia and flagella are specialized eukaryotic organelles projecting from the surface of eukaryotic cells that play a central role in various physiological processes, including cell motility, sensory perception, and signal transduction. At the base of these structures lies the ciliary transition zone, a pivotal region that functions as a gatekeeper and communication hub for ciliary activities. Despite its crucial role, the intricacies of its architecture remain poorly understood, especially given the variations in its organization across different cell types and species. In this review, we explore the molecular architecture of the ciliary transition zone, with a particular focus on recent findings obtained using cryotomography and super-resolution imaging techniques.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"88 ","pages":"Article 102361"},"PeriodicalIF":7.5,"publicationDate":"2024-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067424000401/pdfft?md5=cdd1200bd7a6c8e5461a56ebeb982c82&pid=1-s2.0-S0955067424000401-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140621934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The emerging tools for precisely manipulating microtubules 精确操控微管的新兴工具
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-04-18 DOI: 10.1016/j.ceb.2024.102360
Yen-Ling Lian , Yu-Chun Lin
{"title":"The emerging tools for precisely manipulating microtubules","authors":"Yen-Ling Lian ,&nbsp;Yu-Chun Lin","doi":"10.1016/j.ceb.2024.102360","DOIUrl":"https://doi.org/10.1016/j.ceb.2024.102360","url":null,"abstract":"<div><p>Cells generate a highly diverse microtubule network to carry out different activities. This network is comprised of distinct tubulin isotypes, tubulins with different post-translational modifications, and many microtubule-based structures. Defects in this complex system cause numerous human disorders. However, how different microtubule subtypes in this network regulate cellular architectures and activities remains largely unexplored. Emerging tools such as photosensitive pharmaceuticals, chemogenetics, and optogenetics enable the spatiotemporal manipulation of structures, dynamics, post-translational modifications, and cross-linking with actin filaments in target microtubule subtypes. This review summarizes the design rationale and applications of these new approaches and aims to provide a roadmap for researchers navigating the intricacies of microtubule dynamics and their post-translational modifications in cellular contexts, thereby opening new avenues for therapeutic interventions.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"88 ","pages":"Article 102360"},"PeriodicalIF":7.5,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067424000395/pdfft?md5=3d62439f454368aa36856730bee51ca9&pid=1-s2.0-S0955067424000395-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140618249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel tools to study cell-ECM interactions, cell adhesion dynamics and migration 研究细胞-ECM 相互作用、细胞粘附动力学和迁移的新工具
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-04-16 DOI: 10.1016/j.ceb.2024.102355
Michal Dibus , Omkar Joshi , Johanna Ivaska
{"title":"Novel tools to study cell-ECM interactions, cell adhesion dynamics and migration","authors":"Michal Dibus ,&nbsp;Omkar Joshi ,&nbsp;Johanna Ivaska","doi":"10.1016/j.ceb.2024.102355","DOIUrl":"https://doi.org/10.1016/j.ceb.2024.102355","url":null,"abstract":"<div><p>Integrin-mediated cell adhesion is essential for cell migration, mechanotransduction and tissue integrity. <em>In vivo</em>, these processes are regulated by complex physicochemical signals from the extracellular matrix (ECM). These nuanced cues, including molecular composition, rigidity and topology, call for sophisticated systems to faithfully explore cell behaviour. Here, we discuss recent methodological advances in cell-ECM adhesion research and compile a toolbox of techniques that we expect to shape this field in future. We outline methodological breakthroughs facilitating the transition from rigid 2D substrates to more complex and dynamic 3D systems, as well as advances in super-resolution imaging for an in-depth understanding of adhesion nanostructure. Selected methods are exemplified with relevant biological findings to underscore their applicability in cell adhesion research. We expect this new “toolbox” of methods will allow for a closer approximation of <em>in vitro</em> experimental setups to <em>in vivo</em> conditions, providing deeper insights into physiological and pathophysiological processes associated with cell-ECM adhesion.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"88 ","pages":"Article 102355"},"PeriodicalIF":7.5,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067424000346/pdfft?md5=37f432a7ed686d2bd28a85c47d5c9d11&pid=1-s2.0-S0955067424000346-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140554224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoplasmic reticulum – condensate interactions in protein synthesis and secretion 蛋白质合成和分泌过程中内质网与凝结物的相互作用
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-04-15 DOI: 10.1016/j.ceb.2024.102357
Dan T.M. Nguyen , Max Koppers , Ginny G. Farías
{"title":"Endoplasmic reticulum – condensate interactions in protein synthesis and secretion","authors":"Dan T.M. Nguyen ,&nbsp;Max Koppers ,&nbsp;Ginny G. Farías","doi":"10.1016/j.ceb.2024.102357","DOIUrl":"https://doi.org/10.1016/j.ceb.2024.102357","url":null,"abstract":"<div><p>In the past decade, a growing amount of evidence has demonstrated that organelles do not act autonomously and independently but rather communicate with each other to coordinate different processes for proper cellular function. With a highly extended network throughout the cell, the endoplasmic reticulum (ER) plays a central role in interorganelle communication through membrane contact sites. Here, we highlight recent evidence indicating that the ER also forms contacts with membrane-less organelles. These interactions contribute to the dynamic assembly and disassembly of condensates and controlled protein secretion. Additionally, emerging evidence suggests their involvement in mRNA localization and localized translation. We further explore exciting future directions of this emerging theme in the organelle contact site field.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"88 ","pages":"Article 102357"},"PeriodicalIF":7.5,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S095506742400036X/pdfft?md5=c828e3c6bed7a83c52706a036385b4ee&pid=1-s2.0-S095506742400036X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140552472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macropinocytosis at the crossroad between nutrient scavenging and metabolism in cancer 癌症中营养物质清除与新陈代谢交叉路口的巨核细胞增多症
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-04-15 DOI: 10.1016/j.ceb.2024.102359
Elena Rainero
{"title":"Macropinocytosis at the crossroad between nutrient scavenging and metabolism in cancer","authors":"Elena Rainero","doi":"10.1016/j.ceb.2024.102359","DOIUrl":"https://doi.org/10.1016/j.ceb.2024.102359","url":null,"abstract":"<div><p>Macropinocytosis (MP), the actin-dependent bulk uptake of extracellular fluids, plays a central role in nutrient scavenging, allowing cancer cells to sustain their growth in the hypoxic and nutrient-deprived microenvironment often found in solid tumours. The lack of soluble nutrients and several oncogenic signalling pathways, with RAS being the most studied, push MP-dependent internalisation of extracellular proteins, which are then digested in the lysosomes, replenishing the intracellular nutrient pools. This review will highlight recent advances in understanding how MP is regulated in hypoxic cancers, how it impinges on chemoresistance, and how different MP cargos facilitate tumour growth. Finally, I will highlight the crosstalk between MP and extracellular matrix receptors.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"88 ","pages":"Article 102359"},"PeriodicalIF":7.5,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067424000383/pdfft?md5=85d95ea9e805d8b05a3b3d4e7a293de2&pid=1-s2.0-S0955067424000383-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140552473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular cartography within axons 轴突内的分子制图
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-04-12 DOI: 10.1016/j.ceb.2024.102358
A. King Cada , Naoko Mizuno
{"title":"Molecular cartography within axons","authors":"A. King Cada ,&nbsp;Naoko Mizuno","doi":"10.1016/j.ceb.2024.102358","DOIUrl":"https://doi.org/10.1016/j.ceb.2024.102358","url":null,"abstract":"<div><p>Recent advances in imaging methods begin to further illuminate the inner workings of neurons. Views of the axonal landscape through the lens of <em>in situ</em> cryo-electron tomography (cryo-ET) provide a high-resolution atlas of the macromolecular organization in near-native conditions, leading to our growing understanding of the vital roles of compositional and structural organization in maintaining neuronal homeostasis. In this review, we discuss the latest observations concerning the fundamental components found within neuronal compartments, with special emphasis on the axon, branch points, and growth cone. We describe the similarity and difference in organization of organelles and molecules in varying compartments. Finally, we highlight outstanding questions on the dynamics and localization of various components along the axon that may be answered using orthogonal approaches.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"88 ","pages":"Article 102358"},"PeriodicalIF":7.5,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140545820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信