Current Opinion in Cell Biology最新文献_第6页

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IF 7.5 2区生物学

Current Opinion in Cell Biology Pub Date : 2024-06-01 DOI: 10.1016/S0955-0674(24)00068-1

引用次数: 0

Chromatin plasticity in mechanotransduction 机械传导中的染色质可塑性

IF 7.5 2区生物学

Current Opinion in Cell Biology Pub Date : 2024-05-28 DOI: 10.1016/j.ceb.2024.102376

Maria Vivo , Valentina Rosti , Sara Cervone , Chiara Lanzuolo

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引用次数: 0

Nonlinear dynamics in phosphoinositide metabolism 磷脂代谢的非线性动力学

IF 7.5 2区生物学

Current Opinion in Cell Biology Pub Date : 2024-05-25 DOI: 10.1016/j.ceb.2024.102373

Suet Yin Sarah Fung , X.J. Xǔ , Min Wu

{"title":"Nonlinear dynamics in phosphoinositide metabolism","authors":"Suet Yin Sarah Fung , X.J. Xǔ , Min Wu","doi":"10.1016/j.ceb.2024.102373","DOIUrl":"https://doi.org/10.1016/j.ceb.2024.102373","url":null,"abstract":"<div><p>Phosphoinositides broadly impact membrane dynamics, signal transduction and cellular physiology. The orchestration of signaling complexity by this seemingly simple metabolic pathway remains an open question. It is increasingly evident that comprehending the complexity of the phosphoinositides metabolic network requires a systems view based on nonlinear dynamics, where the products of metabolism can either positively or negatively modulate enzymatic function. These feedback and feedforward loops may be paradoxical, leading to counterintuitive effects. In this review, we introduce the framework of nonlinear dynamics, emphasizing distinct dynamical regimes such as the excitable state, oscillations, and mixed-mode oscillations—all of which have been experimentally observed in phosphoinositide metabolisms. We delve into how these dynamical behaviors arise from one or multiple network motifs, including positive and negative feedback loops, coherent and incoherent feedforward loops. We explore the current understanding of the molecular circuits responsible for these behaviors. While mapping these circuits presents both conceptual and experimental challenges, redefining cellular behavior based on dynamical state, lipid fluxes, time delay, and network topology is likely essential for a comprehensive understanding of this fundamental metabolic network.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"88 ","pages":"Article 102373"},"PeriodicalIF":7.5,"publicationDate":"2024-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067424000528/pdfft?md5=88e9efbd9ba72bd3a08ccf5c37d2f1d4&pid=1-s2.0-S0955067424000528-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141095525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The adaptable caveola coat generates a plasma membrane sensory system 适应性强的洞穴衣产生质膜感觉系统

IF 7.5 2区生物学

Current Opinion in Cell Biology Pub Date : 2024-05-23 DOI: 10.1016/j.ceb.2024.102371

Richard Lundmark, Elin Larsson, Lauri I.A. Pulkkinen

引用次数: 0

Phosphatidylinositol 3,4-bisphosphate: Out of the shadows and into the spotlight 磷脂酰肌醇 3,4-二磷酸：走出阴影，成为焦点

IF 7.5 2区生物学

Current Opinion in Cell Biology Pub Date : 2024-05-21 DOI: 10.1016/j.ceb.2024.102372

Jayatee Ray , David G. Sapp , Gregory D. Fairn

引用次数: 0

Single molecule imaging unveils cellular architecture, dynamics and mechanobiology 单分子成像揭示细胞结构、动力学和机械生物学

IF 7.5 2区生物学

Current Opinion in Cell Biology Pub Date : 2024-05-16 DOI: 10.1016/j.ceb.2024.102369

Tianchi Chen, Grégory Giannone

引用次数: 0

The mitogen-activated protein kinase network, wired to dynamically function at multiple scales 丝裂原活化蛋白激酶网络，可在多个尺度上动态发挥作用

IF 7.5 2区生物学

Current Opinion in Cell Biology Pub Date : 2024-05-15 DOI: 10.1016/j.ceb.2024.102368

Paolo Armando Gagliardi, Olivier Pertz

{"title":"The mitogen-activated protein kinase network, wired to dynamically function at multiple scales","authors":"Paolo Armando Gagliardi, Olivier Pertz","doi":"10.1016/j.ceb.2024.102368","DOIUrl":"https://doi.org/10.1016/j.ceb.2024.102368","url":null,"abstract":"<div><p>The mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signaling network is a key transducer of signals from various receptors, including receptor tyrosine kinases (RTKs). It controls cell-cycle entry, survival, motility, differentiation, as well as other fates. After four decades of studying this pathway with biochemical methods, the use of fluorescent biosensors has revealed dynamic behaviors such as ERK pulsing, oscillations, and amplitude-modulated activity. Different RTKs equip the MAPK network with specific feedback mechanisms to encode these different ERK dynamics, which are then subsequently decoded into cytoskeletal events and transcriptional programs, actuating cellular fates. Recently, collective ERK wave behaviors have been observed in multiple systems to coordinate cytoskeletal dynamics with fate decisions within cell collectives. This emphasizes that a correct understanding of this pathway requires studying it at multiple scales.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"88 ","pages":"Article 102368"},"PeriodicalIF":7.5,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067424000474/pdfft?md5=9dc092ce14506a80c2cb96f8635a0851&pid=1-s2.0-S0955067424000474-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140947554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nuclear lipid droplet: Guardian of nuclear membrane lipid homeostasis? 核脂滴：核膜脂质平衡的守护者？

IF 7.5 2区生物学

Current Opinion in Cell Biology Pub Date : 2024-05-13 DOI: 10.1016/j.ceb.2024.102370

Toyoshi Fujimoto

引用次数: 0

Helical motion and torque generation by microtubule motors 微管马达的螺旋运动和扭矩产生

IF 7.5 2区生物学

Current Opinion in Cell Biology Pub Date : 2024-05-11 DOI: 10.1016/j.ceb.2024.102367

Laura Meißner , Lukas Niese , Stefan Diez

引用次数: 0

Mechanisms governing vesicle traffic at the Golgi apparatus 高尔基体的囊泡运输机制

IF 7.5 2区生物学

Current Opinion in Cell Biology Pub Date : 2024-05-04 DOI: 10.1016/j.ceb.2024.102365

Maryam Arab , Tong Chen , Martin Lowe

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引用次数: 0