微管马达的螺旋运动和扭矩产生

IF 6 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2024-05-11 DOI:10.1016/j.ceb.2024.102367

Laura Meißner , Lukas Niese , Stefan Diez

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引用次数: 0

摘要

微管马达在运输、有丝分裂和细胞运动等细胞功能中发挥着关键作用。它们以 ATP 水解为动力，将化学能转化为机械功，从而在微管上运动。虽然人们已经对它们沿微管长轴的运动进行了广泛研究，但有些马达还显示出轴外分量，这导致它们围绕微管进行螺旋运动，并在产生线性力的同时产生扭矩。对这些细微运动的了解扩展了我们对马达蛋白质动力学及其对细胞过程影响的理解。

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Helical motion and torque generation by microtubule motors

Microtubule motors play key roles in cellular functions, such as transport, mitosis and cell motility. Fueled by ATP hydrolysis, they convert chemical energy into mechanical work, which enables their movement on microtubules. While their motion along the long axis of microtubules has been studied extensively, some motors display an off-axis component, which results in helical motion around microtubules and the generation of torque in addition to linear forces. Understanding these nuanced movements expands our comprehension of motor protein dynamics and their impact on cellular processes.

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.