核脂滴：核膜脂质平衡的守护者？

IF 6 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2024-05-13 DOI:10.1016/j.ceb.2024.102370

Toyoshi Fujimoto

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引用次数: 0

摘要

脂滴（LDs）是细胞质细胞器，但在细胞核内也有少量存在。在核内膜（INM）上形成的核脂滴常因磷脂酸（PA）和/或二酰基甘油（DAG）的扰动而增加，这两种物质都与核内膜的各种功能有关。seipin是一种能将PA和DAG捕获在内质网中的蛋白质，当seipin下调时，核LD也会增加。值得注意的是，与 INM 相比，PA 和 DAG 似乎更密集地分布在核 LDs 表面。我认为核 LDs 在调节 INM 中的 PA 和 DAG 水平方面发挥了作用，从而促进了这一区室的脂质平衡。

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Nuclear lipid droplet: Guardian of nuclear membrane lipid homeostasis?

Lipid droplets (LDs) are cytoplasmic organelles, but they are also found within the nucleus in small numbers. Nuclear LDs that form at the inner nuclear membrane (INM) often increase in response to perturbation in phosphatidic acid (PA) and/or diacylglycerol (DAG), both implicated in various INM functions. Nuclear LDs also increase upon downregulation of seipin, a protein that can trap PA and DAG in the endoplasmic reticulum. Notably, both PA and DAG appear to be more densely distributed on the surface of nuclear LDs than in the INM. I propose that nuclear LDs play a role in regulating the PA and DAG level in the INM, thereby contributing to the lipid homeostasis in this compartment.

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.