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ERK1/2-MAPK signaling: Metabolic, organellar, and cytoskeletal interactions ERK1/2-MAPK信号：代谢、细胞器和细胞骨架的相互作用
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-05-08 DOI: 10.1016/j.ceb.2025.102526
Ana Martin–Vega , Melanie H. Cobb
{"title":"ERK1/2-MAPK signaling: Metabolic, organellar, and cytoskeletal interactions","authors":"Ana Martin–Vega ,&nbsp;Melanie H. Cobb","doi":"10.1016/j.ceb.2025.102526","DOIUrl":"10.1016/j.ceb.2025.102526","url":null,"abstract":"<div><div>Numerous stimuli activate the extracellular signal-regulated kinases ERK1/2, which phosphorylate a diverse range of substrates, regulating multiple cellular processes. The broad variety of functions controlled by these enzymes is enabled by complex intracellular organization, which requires precise spatiotemporal regulation. Scaffold proteins and the formation of molecular condensates by liquid–liquid phase separation (LLPS) are key in ERK1/2 signal modulation and output. This review provides an overview of ERK1/2 multifaceted actions, with a focus on the cytoskeleton, mitochondria, and metabolism, as well as ERK1/2 regulation by scaffolds and molecular condensates. We highlight recent findings that shed light on ERK1/2 regulation and discuss the implications for cellular functions, disease mechanisms, and therapeutic development.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102526"},"PeriodicalIF":6.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myosin 2 – A general contractor for the cytoskeleton 肌球蛋白2 -细胞骨架的总承包商
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-05-03 DOI: 10.1016/j.ceb.2025.102522
Joseph J. Tidei, Patrick W. Oakes, Jordan R. Beach
{"title":"Myosin 2 – A general contractor for the cytoskeleton","authors":"Joseph J. Tidei,&nbsp;Patrick W. Oakes,&nbsp;Jordan R. Beach","doi":"10.1016/j.ceb.2025.102522","DOIUrl":"10.1016/j.ceb.2025.102522","url":null,"abstract":"<div><div>Cells derive their shape, and in turn much of their behavior, from the organization of the cytoskeleton. While a myriad of proteins contribute to the regulation and organization of this dynamic structure, two of the principal components are actin filaments, which provide the structure, and myosin motors, which generate the majority of the forces. Here we review recent results on the assembly and kinetics of non-muscle myosin 2, and highlight how the cellular environment modulates local myosin behavior and signaling.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"94 ","pages":"Article 102522"},"PeriodicalIF":6.0,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A molecular systems perspective on calcium oscillations beyond ion fluxes 离子通量以外钙振荡的分子系统视角
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-04-30 DOI: 10.1016/j.ceb.2025.102523
Ding Xiong , Chee San Tong , Min Wu
{"title":"A molecular systems perspective on calcium oscillations beyond ion fluxes","authors":"Ding Xiong ,&nbsp;Chee San Tong ,&nbsp;Min Wu","doi":"10.1016/j.ceb.2025.102523","DOIUrl":"10.1016/j.ceb.2025.102523","url":null,"abstract":"<div><div>Calcium (Ca<sup>2+</sup>) oscillations, marked by periodic fluctuations in cytosolic Ca<sup>2+</sup> levels, are a universal feature of both excitable and non-excitable cells, regulating key functions like immune responses, neuronal activity and oocyte activation. Despite significant progress over the past few decades in identifying the molecular toolkits involved in Ca<sup>2+</sup> mobilization, fundamental questions remain unresolved: How do Ca<sup>2+</sup>oscillations arise? In dynamical systems, oscillations arise as closed-loop trajectories in phase space, known as limit cycles. In this framework, [Ca<sup>2+</sup>] is the variable that oscillates along the limit cycle. Is [Ca<sup>2+</sup>] also the control parameter that defines the system's stability? Understanding how oscillations arise and how instability is controlled are essential for determining what these oscillations encode. This review revisits classic categorizations of Ca<sup>2+</sup> oscillation models, focusing on the minimal mathematical models, their assumptions and gaps linking models with experimental data. We examine historical arguments in light of recent discoveries of plasma membrane lipid oscillations in non-excitable cells. While growing evidence support the pivotal role of lipid signaling in regulating Ca<sup>2+</sup> dynamics, they mostly focused on the upstream role of signaling in Ca<sup>2+</sup> mobilization, rather than viewing membrane-dependent signal transduction as the core control loop that is responsible for oscillatory Ca<sup>2+</sup> dynamics. Here we summarize recent molecular studies of phosphoinositide signaling in modulating Ca<sup>2+</sup> dynamics, by considering a broader chemical perspective as essential for understanding Ca<sup>2+</sup> oscillations beyond ion fluxes.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"94 ","pages":"Article 102523"},"PeriodicalIF":6.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Septins in animal tissue architecture: more than just peanuts 动物组织结构中的毒素：不仅仅是花生
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-04-30 DOI: 10.1016/j.ceb.2025.102525
Jyotirmayee Debadarshini, Loïc LeGoff, Manos Mavrakis
{"title":"Septins in animal tissue architecture: more than just peanuts","authors":"Jyotirmayee Debadarshini,&nbsp;Loïc LeGoff,&nbsp;Manos Mavrakis","doi":"10.1016/j.ceb.2025.102525","DOIUrl":"10.1016/j.ceb.2025.102525","url":null,"abstract":"<div><div>Septins are cytoskeletal guanosine triphosphate (GTP)-binding proteins that were discovered in budding yeast and are conserved from algae and protists to mammals. Septins assemble into heteromeric complexes, which can polymerize into filaments and higher-order filament architectures, and perform functions in a wide range of biological processes, including cell division and motility and tissue morphogenesis. Although septin dysfunction in animals is linked to infertility, defective organogenesis, neurodegenerative diseases, and cancer, the molecular mechanisms underlying septin function are not clear. Studies of septins <em>in vivo</em> in whole animals provide a powerful approach for gaining insights into the role of septins in animal pathophysiology and unraveling the molecular and cell biological basis of septin function.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"94 ","pages":"Article 102525"},"PeriodicalIF":6.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vimentin – Force regulator in confined environments Vimentin -密闭环境中的力调节器
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-04-26 DOI: 10.1016/j.ceb.2025.102521
Maxx Swoger , Minh Tri Ho Thanh , Alison E. Patteson
{"title":"Vimentin – Force regulator in confined environments","authors":"Maxx Swoger ,&nbsp;Minh Tri Ho Thanh ,&nbsp;Alison E. Patteson","doi":"10.1016/j.ceb.2025.102521","DOIUrl":"10.1016/j.ceb.2025.102521","url":null,"abstract":"<div><div>Cells must navigate crowded and confining 3D environments during normal function <em>in vivo</em>. Essential to their ability to navigate these environments safely and efficiently is their ability to mediate and endure both self-generated and external forces. The cytoskeleton, composed of F-actin, microtubules, and intermediate filaments, provides the mechanical support necessary for force mediation. The role of F-actin and microtubules in this process has been well studied, whereas vimentin, a cytoplasmic intermediate filament associated with mesenchymal cells, is less studied. However, there is growing evidence that vimentin has functions in both force transmission and protection of the cell from mechanical stress that actin and microtubules cannot fulfill. This review focuses on recent reports highlighting vimentin's role in regulating forces in confining environments.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"94 ","pages":"Article 102521"},"PeriodicalIF":6.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The cell biology of Extracellular Vesicles: A jigsaw puzzle with a myriad of pieces 细胞外囊泡的细胞生物学：一个有无数块的拼图
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-04-22 DOI: 10.1016/j.ceb.2025.102519
G. D'Angelo , P.D. Stahl , G. Raposo
{"title":"The cell biology of Extracellular Vesicles: A jigsaw puzzle with a myriad of pieces","authors":"G. D'Angelo ,&nbsp;P.D. Stahl ,&nbsp;G. Raposo","doi":"10.1016/j.ceb.2025.102519","DOIUrl":"10.1016/j.ceb.2025.102519","url":null,"abstract":"<div><div>Extracellular vesicle (EV) research has expanded beyond traditional boundaries, evolving into an inter-kingdom endeavor. First described over 50 years ago, EVs are now recognized as playing diverse roles in basic cellular functions, such as intercellular communication, transport, and cell migration. Their biogenesis and secretion involve complex molecular processes, with cargos that include proteins, lipids, and genetic material. Despite advances, isolation and purification methods are still developing. EVs are present in all body fluids, with different subtypes fulfilling distinct roles. Nonetheless, in biological ecosystems, vesicle diversity can be seen as a strength where each one complements the other in the dialogue between cells and tissues. The involvement of EVs in homeostasis and disease and their well-recognized potential for diagnosis and therapeutics will continue to boost investigations to reveal their fundamental biology.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"94 ","pages":"Article 102519"},"PeriodicalIF":6.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trafficking to the lysosome: HOPS paves the way 转运到溶酶体：啤酒花铺平了道路
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-04-21 DOI: 10.1016/j.ceb.2025.102515
Jan van der Beek, Judith Klumperman
{"title":"Trafficking to the lysosome: HOPS paves the way","authors":"Jan van der Beek,&nbsp;Judith Klumperman","doi":"10.1016/j.ceb.2025.102515","DOIUrl":"10.1016/j.ceb.2025.102515","url":null,"abstract":"<div><div>The endo-lysosomal system plays a crucial role in cellular homeostasis by continuously turning over organelles, proteins, and other cargo of intra- or extracellular origin. Moreover, it senses the nutrient status within the cell and can ignite cellular responses by activating or repressing signaling pathways. To enable these roles, lysosomes are fueled by the biosynthetic pathway and receive cargo for degradation by endocytosis and autophagy. Tight regulation and coordination of these distinct trafficking pathways to lysosomes are critical for cellular health. In this review, we explore how these pathways converge at the late stages of the endo-lysosomal system and highlight the role of the HOPS complex as a unifying gatekeeper for trafficking to the lysosome.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"94 ","pages":"Article 102515"},"PeriodicalIF":6.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathogen-induced rerouting of host membrane trafficking 病原体诱导的宿主膜转运的改道
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-04-21 DOI: 10.1016/j.ceb.2025.102520
Patrick J. Woida, Rebecca L. Lamason
{"title":"Pathogen-induced rerouting of host membrane trafficking","authors":"Patrick J. Woida,&nbsp;Rebecca L. Lamason","doi":"10.1016/j.ceb.2025.102520","DOIUrl":"10.1016/j.ceb.2025.102520","url":null,"abstract":"<div><div>Eukaryotic cell membranes are protective barriers that precisely control cargo import, trafficking, and export. In defiance of this control, intracellular bacterial pathogens forcefully invade host cells and establish intracellular niches. These pathogens require remarkable membrane remodeling events to support their large size, and a significant amount of work has examined how these pathogens co-opt cytoskeleton dynamics to remodel host membranes. Until recently, less attention was given to where the membranes came from to support remodeling around the pathogens at each stage of infection. In this review, we highlight recent examples of how bacterial pathogens reroute membrane trafficking to provide the membranes needed during invasion, intracellular growth, and eventual dissemination through host tissues. The examples discussed underscore emerging themes and areas for continued investigation rather than provide a survey of the entire field. We hope that highlighting these open questions will inspire researchers across disciplines to recognize the importance of pathogens as tools to understand both mechanisms of bacterial virulence and membrane trafficking.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"94 ","pages":"Article 102520"},"PeriodicalIF":6.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Separation of powers: A key feature underlying the neuroprotective role of Retromer in age-related neurodegenerative disease? 权力分离：Retromer在与年龄相关的神经退行性疾病中的神经保护作用的关键特征？
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-04-19 DOI: 10.1016/j.ceb.2025.102516
Brett M. Collins , Peter J. Cullen
{"title":"Separation of powers: A key feature underlying the neuroprotective role of Retromer in age-related neurodegenerative disease?","authors":"Brett M. Collins ,&nbsp;Peter J. Cullen","doi":"10.1016/j.ceb.2025.102516","DOIUrl":"10.1016/j.ceb.2025.102516","url":null,"abstract":"<div><div>The retromer complex was discovered in <em>Saccharomyces cerevisiae</em> as a multiprotein, pentameric assembly essential for recycling of integral membrane cargo proteins through the endosomal network [1,2]. We now understand how retromer is assembled, its membrane architecture, and how it selects proteins for recycling [3–6]. Conserved across eukaryotes, analyses have revealed retromer's role in organism development, and homeostasis and has linked retromer defects with age-related Alzheimer's disease and Parkinson's disease and other neurological disorders [3,5,7]. Indeed, stabilizing retromer function is now actively considered a therapeutic strategy [8]. Here, we reflect on its structural and functional evolution rather than overviewing retromer biology (see, <em>e.g.</em> [5,7]). Specifically, we clarify the organization of the human retromer to provide greater focus for future research, especially within the context of retromer's function in neuroprotection.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"94 ","pages":"Article 102516"},"PeriodicalIF":6.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dysfunctional cardiomyocyte signalling and heart disease 心肌细胞信号传导功能障碍与心脏病
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-04-16 DOI: 10.1016/j.ceb.2025.102517
Zara L. Ridgway, Xuan Li
{"title":"Dysfunctional cardiomyocyte signalling and heart disease","authors":"Zara L. Ridgway,&nbsp;Xuan Li","doi":"10.1016/j.ceb.2025.102517","DOIUrl":"10.1016/j.ceb.2025.102517","url":null,"abstract":"<div><div>Cardiomyocyte signalling pathways are central to maintaining the structural and functional integrity of the heart. Dysregulation of these pathways contributes to the onset and progression of heart diseases, including heart failure, arrhythmias and cardiomyopathies. This review focuses on very recent work on dysfunctional cardiomyocyte signalling and its role in the pathophysiology of heart disease. We discuss key pathways, including immune signalling within cardiomyocytes, signalling associated with microtubule dysfunction, Hippo-yes-associated protein signalling and adenosine monophosphate-activated protein kinase signalling, highlighting how aberrations in their regulation lead to impaired cardiomyocyte functions and pinpointing the potential therapeutic opportunities in these pathways. This review underscores the complexity of cardiomyocyte signalling networks and emphasises the need for further dissecting signalling pathways to prevent cardiomyocyte dysfunction.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"94 ","pages":"Article 102517"},"PeriodicalIF":6.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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