转运到溶酶体：啤酒花铺平了道路

IF 6 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2025-04-21 DOI:10.1016/j.ceb.2025.102515

Jan van der Beek, Judith Klumperman

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引用次数: 0

摘要

内溶酶体系统通过不断地翻转细胞器、蛋白质和其他细胞内或细胞外的货物，在细胞内稳态中起着至关重要的作用。此外，它还能感知细胞内的营养状况，并通过激活或抑制信号通路来引发细胞反应。为了实现这些作用，溶酶体由生物合成途径提供燃料，并通过内吞和自噬接收货物进行降解。这些不同的溶酶体运输途径的严格调节和协调对细胞健康至关重要。在这篇综述中，我们探讨了这些途径如何在内溶酶体系统的后期阶段汇合，并强调了啤酒花复合物作为运输到溶酶体的统一守门人的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Trafficking to the lysosome: HOPS paves the way

The endo-lysosomal system plays a crucial role in cellular homeostasis by continuously turning over organelles, proteins, and other cargo of intra- or extracellular origin. Moreover, it senses the nutrient status within the cell and can ignite cellular responses by activating or repressing signaling pathways. To enable these roles, lysosomes are fueled by the biosynthetic pathway and receive cargo for degradation by endocytosis and autophagy. Tight regulation and coordination of these distinct trafficking pathways to lysosomes are critical for cellular health. In this review, we explore how these pathways converge at the late stages of the endo-lysosomal system and highlight the role of the HOPS complex as a unifying gatekeeper for trafficking to the lysosome.

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.