细胞外囊泡的细胞生物学：一个有无数块的拼图

IF 6 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2025-04-22 DOI:10.1016/j.ceb.2025.102519

G. D'Angelo , P.D. Stahl , G. Raposo

{"title":"细胞外囊泡的细胞生物学：一个有无数块的拼图","authors":"G. D'Angelo , P.D. Stahl , G. Raposo","doi":"10.1016/j.ceb.2025.102519","DOIUrl":null,"url":null,"abstract":"<div><div>Extracellular vesicle (EV) research has expanded beyond traditional boundaries, evolving into an inter-kingdom endeavor. First described over 50 years ago, EVs are now recognized as playing diverse roles in basic cellular functions, such as intercellular communication, transport, and cell migration. Their biogenesis and secretion involve complex molecular processes, with cargos that include proteins, lipids, and genetic material. Despite advances, isolation and purification methods are still developing. EVs are present in all body fluids, with different subtypes fulfilling distinct roles. Nonetheless, in biological ecosystems, vesicle diversity can be seen as a strength where each one complements the other in the dialogue between cells and tissues. The involvement of EVs in homeostasis and disease and their well-recognized potential for diagnosis and therapeutics will continue to boost investigations to reveal their fundamental biology.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"94 ","pages":"Article 102519"},"PeriodicalIF":6.0000,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The cell biology of Extracellular Vesicles: A jigsaw puzzle with a myriad of pieces\",\"authors\":\"G. D'Angelo , P.D. Stahl , G. Raposo\",\"doi\":\"10.1016/j.ceb.2025.102519\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Extracellular vesicle (EV) research has expanded beyond traditional boundaries, evolving into an inter-kingdom endeavor. First described over 50 years ago, EVs are now recognized as playing diverse roles in basic cellular functions, such as intercellular communication, transport, and cell migration. Their biogenesis and secretion involve complex molecular processes, with cargos that include proteins, lipids, and genetic material. Despite advances, isolation and purification methods are still developing. EVs are present in all body fluids, with different subtypes fulfilling distinct roles. Nonetheless, in biological ecosystems, vesicle diversity can be seen as a strength where each one complements the other in the dialogue between cells and tissues. The involvement of EVs in homeostasis and disease and their well-recognized potential for diagnosis and therapeutics will continue to boost investigations to reveal their fundamental biology.</div></div>\",\"PeriodicalId\":50608,\"journal\":{\"name\":\"Current Opinion in Cell Biology\",\"volume\":\"94 \",\"pages\":\"Article 102519\"},\"PeriodicalIF\":6.0000,\"publicationDate\":\"2025-04-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Cell Biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0955067425000572\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Cell Biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0955067425000572","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

细胞外囊泡（EV）的研究已经超越了传统的界限，发展成为一个跨领域的努力。50多年前，人们首次对电动汽车进行了描述，现在人们认为电动汽车在细胞间通讯、运输和细胞迁移等基本细胞功能中发挥着多种作用。它们的生物发生和分泌涉及复杂的分子过程，其载体包括蛋白质、脂质和遗传物质。尽管取得了进步，但分离和纯化方法仍在发展中。ev存在于所有体液中，不同的亚型发挥着不同的作用。尽管如此，在生物生态系统中，囊泡多样性可以被视为一种优势，在细胞和组织之间的对话中，每一个囊泡多样性都是互补的。ev在体内平衡和疾病中的作用及其在诊断和治疗方面公认的潜力将继续推动研究以揭示其基本生物学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The cell biology of Extracellular Vesicles: A jigsaw puzzle with a myriad of pieces

Extracellular vesicle (EV) research has expanded beyond traditional boundaries, evolving into an inter-kingdom endeavor. First described over 50 years ago, EVs are now recognized as playing diverse roles in basic cellular functions, such as intercellular communication, transport, and cell migration. Their biogenesis and secretion involve complex molecular processes, with cargos that include proteins, lipids, and genetic material. Despite advances, isolation and purification methods are still developing. EVs are present in all body fluids, with different subtypes fulfilling distinct roles. Nonetheless, in biological ecosystems, vesicle diversity can be seen as a strength where each one complements the other in the dialogue between cells and tissues. The involvement of EVs in homeostasis and disease and their well-recognized potential for diagnosis and therapeutics will continue to boost investigations to reveal their fundamental biology.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.