心肌细胞信号传导功能障碍与心脏病

IF 6 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2025-04-16 DOI:10.1016/j.ceb.2025.102517

Zara L. Ridgway, Xuan Li

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引用次数: 0

摘要

心肌细胞信号通路是维持心脏结构和功能完整性的核心。这些通路的失调有助于心脏疾病的发生和发展，包括心力衰竭、心律失常和心肌病。本文综述了近年来心肌细胞信号传导功能异常及其在心脏病病理生理中的作用。我们讨论了关键的信号通路，包括心肌细胞内的免疫信号通路、与微管功能障碍相关的信号通路、希波蛋白相关的蛋白质信号通路和单磷酸腺苷激活的蛋白激酶信号通路，强调了它们的调节异常如何导致心肌细胞功能受损，并指出了这些通路中潜在的治疗机会。这篇综述强调了心肌细胞信号网络的复杂性，并强调了进一步剖析信号通路以预防心肌细胞功能障碍的必要性。

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Dysfunctional cardiomyocyte signalling and heart disease

Cardiomyocyte signalling pathways are central to maintaining the structural and functional integrity of the heart. Dysregulation of these pathways contributes to the onset and progression of heart diseases, including heart failure, arrhythmias and cardiomyopathies. This review focuses on very recent work on dysfunctional cardiomyocyte signalling and its role in the pathophysiology of heart disease. We discuss key pathways, including immune signalling within cardiomyocytes, signalling associated with microtubule dysfunction, Hippo-yes-associated protein signalling and adenosine monophosphate-activated protein kinase signalling, highlighting how aberrations in their regulation lead to impaired cardiomyocyte functions and pinpointing the potential therapeutic opportunities in these pathways. This review underscores the complexity of cardiomyocyte signalling networks and emphasises the need for further dissecting signalling pathways to prevent cardiomyocyte dysfunction.

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.