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Follow the flow: Actin and membrane act as an integrated system to globally coordinate cell shape and movement 跟随流动：肌动蛋白和膜作为一个综合系统，在全球范围内协调细胞的形状和运动。
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-07-10 DOI: 10.1016/j.ceb.2024.102392
Henry De Belly , Orion D. Weiner
{"title":"Follow the flow: Actin and membrane act as an integrated system to globally coordinate cell shape and movement","authors":"Henry De Belly ,&nbsp;Orion D. Weiner","doi":"10.1016/j.ceb.2024.102392","DOIUrl":"10.1016/j.ceb.2024.102392","url":null,"abstract":"<div><p>Migratory cells are polarized with protrusive fronts and contractile rears. This spatial organization necessitates long-range coordination of the signals that organize protrusions and contractions. Cells leverage reciprocal interactions of short-range biochemical signals and long-range mechanical forces for this integration. The interface between the plasma membrane and actin cortex is where this communication occurs. Here, we review how the membrane and cortex form an integrated system for long-range coordination of cell polarity. We highlight the role of membrane-to-cortex-attachment proteins as regulators of tension transmission across the cell and discuss the interplay between actin-membrane and polarity signaling complexes. Rather than presenting an exhaustive list of recent findings, we focus on important gaps in our current understanding.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"89 ","pages":"Article 102392"},"PeriodicalIF":6.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relationship between nucleosome positioning and higher-order genome folding 核小体定位与高阶基因组折叠之间的关系。
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-07-10 DOI: 10.1016/j.ceb.2024.102398
Abrar Aljahani , Clemens Mauksch , A. Marieke Oudelaar
{"title":"The relationship between nucleosome positioning and higher-order genome folding","authors":"Abrar Aljahani ,&nbsp;Clemens Mauksch ,&nbsp;A. Marieke Oudelaar","doi":"10.1016/j.ceb.2024.102398","DOIUrl":"10.1016/j.ceb.2024.102398","url":null,"abstract":"<div><p>Eukaryotic genomes are organized into 3D structures, which range from small-scale nucleosome arrays to large-scale chromatin domains. These structures have an important role in the regulation of transcription and other nuclear processes. Despite advances in our understanding of the properties, functions, and underlying mechanisms of genome structures, there are many open questions about the interplay between these structures across scales. In particular, it is not well understood if and how 1D features of nucleosome arrays influence large-scale 3D genome folding patterns. In this review, we discuss recent studies that address these questions and summarize our current understanding of the relationship between nucleosome positioning and higher-order genome folding.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"89 ","pages":"Article 102398"},"PeriodicalIF":6.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067424000772/pdfft?md5=2743774526aece3b70d92a7cb45d2cc4&pid=1-s2.0-S0955067424000772-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Canonical and noncanonical regulators of centromere assembly and maintenance 中心粒组装和维护的规范和非规范调节因子
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-07-08 DOI: 10.1016/j.ceb.2024.102396
Catalina Salinas-Luypaert, Daniele Fachinetti
{"title":"Canonical and noncanonical regulators of centromere assembly and maintenance","authors":"Catalina Salinas-Luypaert,&nbsp;Daniele Fachinetti","doi":"10.1016/j.ceb.2024.102396","DOIUrl":"10.1016/j.ceb.2024.102396","url":null,"abstract":"<div><p>Centromeres are specialized chromosomal domains where the kinetochores assemble during cell division to ensure accurate transmission of the genetic information to the two daughter cells. The centromeric function is evolutionary conserved and, in most organisms, centromeres are epigenetically defined by a unique chromatin containing the histone H3 variant CENP-A. The canonical regulators of CENP-A assembly and maintenance are well-known, yet some of the molecular mechanisms regulating this complex process have only recently been unveiled. We review the most recent advances on the topic, including the emergence of new and unexpected factors that favor and regulate CENP-A assembly and/or maintenance.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"89 ","pages":"Article 102396"},"PeriodicalIF":6.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067424000759/pdfft?md5=0b9b53cc9cc79cf83008658a5f0cbd6c&pid=1-s2.0-S0955067424000759-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Replicating chromatin in the nucleus: A histone variant perspective 复制细胞核中的染色质：组蛋白变体视角
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-07-08 DOI: 10.1016/j.ceb.2024.102397
Tina Karagyozova, Geneviève Almouzni
{"title":"Replicating chromatin in the nucleus: A histone variant perspective","authors":"Tina Karagyozova,&nbsp;Geneviève Almouzni","doi":"10.1016/j.ceb.2024.102397","DOIUrl":"10.1016/j.ceb.2024.102397","url":null,"abstract":"<div><p>In eukaryotes, chromatin and DNA replication are intimately linked, whereby chromatin impacts DNA replication control while genome duplication involves recovery of chromatin organisation. Here, we review recent advances in this area using a histone variant lens. We highlight how nucleosomal features interplay with origin definition and how the order of origin firing links with chromatin states in early mammalian development. We next discuss histone recycling and <em>de novo</em> deposition at the fork to finally open on the post-replicative recovery of the chromatin landscape to promote maintenance of cell identity.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"89 ","pages":"Article 102397"},"PeriodicalIF":6.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067424000760/pdfft?md5=722307f9db9f16d02345431531b010ea&pid=1-s2.0-S0955067424000760-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New advances in innate immune endosomal trafficking 先天性免疫内体贩运的新进展。
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-07-05 DOI: 10.1016/j.ceb.2024.102395
Claudia J. Stocks, Xichun Li, Jennifer L. Stow
{"title":"New advances in innate immune endosomal trafficking","authors":"Claudia J. Stocks,&nbsp;Xichun Li,&nbsp;Jennifer L. Stow","doi":"10.1016/j.ceb.2024.102395","DOIUrl":"10.1016/j.ceb.2024.102395","url":null,"abstract":"<div><p>The exocytic and endocytic intracellular trafficking pathways in innate immune cells are known for mediating the secretion of key inflammatory mediators or the internalization of growth factors, nutrients, antigens, cell debris, pathogens and even therapeutics, respectively. Inside cells, these pathways are intertwined as an elaborate network that supports the regulation of immune functions. Endosomal membranes host dynamic platforms for molecular complexes that control signaling and inflammatory responses. High content screens, coupled with elegant microscopy across the scale of resolving molecular complexes to tracking live cellular organelles, have been employed to generate the studies highlighted here. With a focus on deactivation of STING, scaffolding by SLC15A4/TASL complexes and macropinosome shrinkage via the chloride channel protein TMEM206, new studies are identifying molecules, molecular interactions and mechanisms for immune regulation throughout endosomal pathways.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"89 ","pages":"Article 102395"},"PeriodicalIF":6.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067424000747/pdfft?md5=ef50e6df175b3f34abf26f1735356ff0&pid=1-s2.0-S0955067424000747-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transient, nano-scale, liquid-like molecular assemblies coming of age 瞬态、纳米尺度、液态分子组装的时代即将到来。
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-07-03 DOI: 10.1016/j.ceb.2024.102394
Akihiro Kusumi , Taka A. Tsunoyama , Kenichi G.N. Suzuki , Takahiro K. Fujiwara , Amine Aladag
{"title":"Transient, nano-scale, liquid-like molecular assemblies coming of age","authors":"Akihiro Kusumi ,&nbsp;Taka A. Tsunoyama ,&nbsp;Kenichi G.N. Suzuki ,&nbsp;Takahiro K. Fujiwara ,&nbsp;Amine Aladag","doi":"10.1016/j.ceb.2024.102394","DOIUrl":"10.1016/j.ceb.2024.102394","url":null,"abstract":"<div><p>This review examines the dynamic mechanisms underlying cellular signaling, communication, and adhesion via transient, nano-scale, liquid-like molecular assemblies on the plasma membrane (PM). Traditional views posit that stable, solid-like molecular complexes perform these functions. However, advanced imaging reveals that many signaling and scaffolding proteins only briefly reside in these molecular complexes and that micron-scale protein assemblies on the PM, including cell adhesion structures and synapses, are likely made of archipelagoes of nanoliquid protein islands. Borrowing the concept of liquid–liquid phase separation to form micron-scale biocondensates, we propose that these nano-scale oligomers and assemblies are enabled by multiple weak but specific molecular interactions often involving intrinsically disordered regions. The signals from individual nanoliquid signaling complexes would occur as pulses. Single-molecule imaging emerges as a crucial technique for characterizing these transient nanoliquid assemblies on the PM, suggesting a shift toward a model where the fluidity of interactions underpins signal regulation and integration.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"89 ","pages":"Article 102394"},"PeriodicalIF":6.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067424000735/pdfft?md5=d085efe9ac347419a36769efda9d4dff&pid=1-s2.0-S0955067424000735-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomolecular condensates as drivers of membrane trafficking and remodelling 作为膜贩运和重塑驱动因素的生物分子凝聚物
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-06-26 DOI: 10.1016/j.ceb.2024.102393
Rini Ravindran, Stephen W. Michnick
{"title":"Biomolecular condensates as drivers of membrane trafficking and remodelling","authors":"Rini Ravindran,&nbsp;Stephen W. Michnick","doi":"10.1016/j.ceb.2024.102393","DOIUrl":"10.1016/j.ceb.2024.102393","url":null,"abstract":"<div><p>Membrane remodelling is essential for the trafficking of macromolecules throughout the cell, a process that regulates various aspects of cellular health and pathology. Recent studies implicate the role of biomolecular condensates in regulating multiple steps of the membrane trafficking pathway including but not limited to the organization of the trafficking machinery, dynamic remodeling of membranes, spatial and functional regulation, and response to cellular signals. The implicated proteins contain key structural elements, most notably prion-like domains within intrinsically disordered regions that are necessary for biomolecular condensate formation at fusion sites in processes like endocytic assembly, autophagy, organelle biosynthesis and synaptic vesicle fusion. Experimental and theoretical advances in the field continue to demonstrate that protein condensates can perform mechanical work, the implications of which can be extrapolated to diverse areas of membrane biology.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"89 ","pages":"Article 102393"},"PeriodicalIF":6.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067424000723/pdfft?md5=b15433b0d15dc0adceb00f39c63f2c5d&pid=1-s2.0-S0955067424000723-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial motility modulators coordinate quality control dynamics to promote neuronal health 线粒体运动调节剂协调质量控制动态，促进神经元健康
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-06-21 DOI: 10.1016/j.ceb.2024.102383
Jennifer E. Jenkins , Mohammad Fazli , Chantell S. Evans
{"title":"Mitochondrial motility modulators coordinate quality control dynamics to promote neuronal health","authors":"Jennifer E. Jenkins ,&nbsp;Mohammad Fazli ,&nbsp;Chantell S. Evans","doi":"10.1016/j.ceb.2024.102383","DOIUrl":"https://doi.org/10.1016/j.ceb.2024.102383","url":null,"abstract":"<div><p>Dysfunction in mitochondrial maintenance and trafficking is commonly correlated with the development of neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease. Thus, biomedical research has been dedicated to understanding how architecturally complex neurons maintain and transport their mitochondria. However, the systems that coordinate mitochondrial QC (quality control) dynamics and trafficking in response to neuronal activity and stress are less understood. Additionally, the degree of integration between the processes of mitochondrial trafficking and QC is unclear. Recent work indicates that mitochondrial motility modulators (i.e., anchors and tethers) help coordinate mitochondrial health by mediating distinct, stress-level-appropriate QC pathways following mitochondrial damage. This review summarizes current evidence supporting the role of two mitochondrial motility modulators, Syntaphilin and Mitofusin 2, in coordinating mitochondrial QC to promote neuronal health. Exploring motility modulators' intricate regulatory molecular landscape may reveal new therapeutic targets for delaying disease progression and enhancing neuronal survival post-insult.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"89 ","pages":"Article 102383"},"PeriodicalIF":6.0,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067424000620/pdfft?md5=08fa71fab5e55627d213dd1f2e34fc0a&pid=1-s2.0-S0955067424000620-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141434008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disruptions in axonal lysosome transport and its contribution to neurological disease 轴突溶酶体运输中断及其对神经系统疾病的影响
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-06-20 DOI: 10.1016/j.ceb.2024.102382
Jean-Michel Paumier, Swetha Gowrishankar
{"title":"Disruptions in axonal lysosome transport and its contribution to neurological disease","authors":"Jean-Michel Paumier,&nbsp;Swetha Gowrishankar","doi":"10.1016/j.ceb.2024.102382","DOIUrl":"https://doi.org/10.1016/j.ceb.2024.102382","url":null,"abstract":"<div><p>Lysosomes are central to the maintenance of protein and organelle homeostasis in cells. Optimal lysosome function is particularly critical for neurons which are long-lived, non-dividing and highly polarized with specialized compartments such as axons and dendrites with distinct architecture, cargo, and turnover requirements. In recent years, there has been a growing appreciation for the role played by axonal lysosome transport in regulating neuronal development, its maintenance and functioning. Perturbations to optimal axonal lysosome abundance leading to either strong accumulations or dearth of lysosomes are both linked to altered neuronal health and functioning. In this review we highlight how two critical regulators of axonal lysosome transport and abundance, the small GTPase Arl8 and the adaptor protein JIP3, aid in maintaining axonal lysosome homeostasis and how alterations to their levels and activity could contribute to neurodevelopmental and neurodegenerative diseases.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"89 ","pages":"Article 102382"},"PeriodicalIF":6.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141434007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The third dimension of the actin cortex 肌动蛋白皮层的第三个维度
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-06-20 DOI: 10.1016/j.ceb.2024.102381
Anumita Jawahar , Joseph Vermeil , Julien Heuvingh , Olivia du Roure , Matthieu Piel
{"title":"The third dimension of the actin cortex","authors":"Anumita Jawahar ,&nbsp;Joseph Vermeil ,&nbsp;Julien Heuvingh ,&nbsp;Olivia du Roure ,&nbsp;Matthieu Piel","doi":"10.1016/j.ceb.2024.102381","DOIUrl":"https://doi.org/10.1016/j.ceb.2024.102381","url":null,"abstract":"<div><p>The actin cortex, commonly described as a thin 2-dimensional layer of actin filaments beneath the plasma membrane, is beginning to be recognized as part of a more dynamic and three-dimensional composite material. In this review, we focus on the elements that contribute to the three-dimensional architecture of the actin cortex. We also argue that actin-rich structures such as filopodia and stress fibers can be viewed as specialized integral parts of the 3D actin cortex. This broadens our definition of the cortex, shifting from its simplified characterization as a thin, two-dimensional layer of actin filaments.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"89 ","pages":"Article 102381"},"PeriodicalIF":6.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141434035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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