重新定义增强子作用：从结构、基因组和单分子角度的见解

IF 4.3 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2025-05-16 DOI:10.1016/j.ceb.2025.102527

David Llères , Andres Cardozo Gizzi , Marcelo Nollmann

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引用次数: 0

摘要

本综述探讨了最近对增强子作用的新见解，重点关注未被探索的方面，如调控元件的物理尺寸，转录因子结合和染色质结构的随机性，以及非线性过程在调和理论模型和实验观察之间长期存在的差异中的作用。总之，这些见解提供了对增强子生物学的细致入微的看法，突出了基因调控的复杂性和对进一步解码增强子机制的创新方法的需求。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives

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Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives

This review explores recent emerging insights into enhancer action, focusing on underexplored aspects such as the physical size of regulatory elements, the stochasticity of transcription factor binding and chromatin structure, and the role of nonlinear processes in reconciling longstanding discrepancies between theoretical models and experimental observations. Together, these insights provide a nuanced view of enhancer biology, highlighting the complexity of gene regulation and the need for innovative methodologies to further decode enhancer mechanisms.

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.