The adaptable caveola coat generates a plasma membrane sensory system

IF 6 2区 生物学 Q1 CELL BIOLOGY
Richard Lundmark, Elin Larsson, Lauri I.A. Pulkkinen
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引用次数: 0

Abstract

Caveolae are atypical plasma membrane invaginations that take part in lipid sorting and regulation of oxidative and mechanical plasma membrane stress. Caveola formation requires caveolin, cavin, and specific lipid types. The recent advances in understanding the structure and assembly of caveolin and cavin complexes within the membrane context have clarified the fundamental processes underlying caveola biogenesis. In addition, the curvature of the caveola membrane is controlled by the regulatory proteins EHD2, pacsin2, and dynamin2, which also function to restrain the scission of caveolae from the plasma membrane (PM). Here, this is integrated with novel insights on caveolae as lipid and mechanosensing complexes that can dynamically flatten or disassemble to counteract mechanical, and oxidative stress.

适应性强的洞穴衣产生质膜感觉系统
洞穴小泡是一种非典型的质膜内陷,它参与脂质分类以及氧化和机械质膜应力的调节。洞穴小泡的形成需要洞穴素、洞穴蛋白和特定类型的脂质。最近在了解洞穴素和洞穴蛋白复合物在膜内的结构和组装方面取得的进展,阐明了洞穴生物发生的基本过程。此外,洞穴小体膜的曲率受调控蛋白 EHD2、pacsin2 和 dynamin2 的控制,它们还具有抑制洞穴小体从质膜(PM)上脱落的功能。在这里,这与洞穴小体作为脂质和机械传感复合物的新见解相结合,这些复合物可以动态扁平化或解体,以对抗机械和氧化压力。
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来源期刊
Current Opinion in Cell Biology
Current Opinion in Cell Biology 生物-细胞生物学
CiteScore
14.60
自引率
1.30%
发文量
79
审稿时长
93 days
期刊介绍: Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.
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