中心粒组装和维护的规范和非规范调节因子

IF 6 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2024-07-08 DOI:10.1016/j.ceb.2024.102396

Catalina Salinas-Luypaert, Daniele Fachinetti

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引用次数: 0

摘要

中心粒是专门的染色体区域，在细胞分裂过程中，动点核在此聚集，以确保遗传信息准确地传递给两个子细胞。中心粒的功能在进化过程中得到了保留，在大多数生物体中，中心粒是由含有组蛋白 H3 变体 CENP-A 的独特染色质表观遗传定义的。众所周知，CENP-A组装和维持的典型调控因子是众所周知的，但调控这一复杂过程的一些分子机制直到最近才被揭示出来。我们回顾了这一主题的最新进展，包括有利于和调控 CENP-A 组装和/或维持的意想不到的新因素的出现。

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Canonical and noncanonical regulators of centromere assembly and maintenance

Centromeres are specialized chromosomal domains where the kinetochores assemble during cell division to ensure accurate transmission of the genetic information to the two daughter cells. The centromeric function is evolutionary conserved and, in most organisms, centromeres are epigenetically defined by a unique chromatin containing the histone H3 variant CENP-A. The canonical regulators of CENP-A assembly and maintenance are well-known, yet some of the molecular mechanisms regulating this complex process have only recently been unveiled. We review the most recent advances on the topic, including the emergence of new and unexpected factors that favor and regulate CENP-A assembly and/or maintenance.

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.