跟随流动:肌动蛋白和膜作为一个综合系统,在全球范围内协调细胞的形状和运动。

IF 6 2区 生物学 Q1 CELL BIOLOGY
Henry De Belly , Orion D. Weiner
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引用次数: 0

摘要

迁移细胞具有极化的突起前部和收缩后部。这种空间组织方式需要对组织突起和收缩的信号进行长程协调。细胞利用短程生化信号和长程机械力的相互影响来实现这种整合。质膜和肌动蛋白皮层之间的界面就是这种交流发生的地方。在此,我们回顾了膜和皮层如何形成一个综合系统,以实现细胞极性的长程协调。我们强调了膜到皮层附着蛋白作为张力在细胞间传递的调节因子的作用,并讨论了肌动蛋白-膜和极性信号复合体之间的相互作用。我们并没有详尽无遗地列举最新研究成果,而是重点讨论了我们目前认识中的重要空白。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Follow the flow: Actin and membrane act as an integrated system to globally coordinate cell shape and movement

Migratory cells are polarized with protrusive fronts and contractile rears. This spatial organization necessitates long-range coordination of the signals that organize protrusions and contractions. Cells leverage reciprocal interactions of short-range biochemical signals and long-range mechanical forces for this integration. The interface between the plasma membrane and actin cortex is where this communication occurs. Here, we review how the membrane and cortex form an integrated system for long-range coordination of cell polarity. We highlight the role of membrane-to-cortex-attachment proteins as regulators of tension transmission across the cell and discuss the interplay between actin-membrane and polarity signaling complexes. Rather than presenting an exhaustive list of recent findings, we focus on important gaps in our current understanding.

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来源期刊
Current Opinion in Cell Biology
Current Opinion in Cell Biology 生物-细胞生物学
CiteScore
14.60
自引率
1.30%
发文量
79
审稿时长
93 days
期刊介绍: Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.
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