复制细胞核中的染色质：组蛋白变体视角

IF 6 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2024-07-08 DOI:10.1016/j.ceb.2024.102397

Tina Karagyozova, Geneviève Almouzni

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引用次数: 0

摘要

在真核生物中，染色质和 DNA 复制密切相关，染色质影响 DNA 复制控制，而基因组复制则涉及染色质组织的恢复。在这里，我们从组蛋白变体的角度回顾了这一领域的最新进展。我们强调了核糖体特征如何与起源定义相互作用，以及起源点火顺序如何与哺乳动物早期发育过程中的染色质状态相联系。接下来，我们将讨论组蛋白再循环和分叉处的从头沉积，最后讨论复制后染色质景观的恢复，以促进细胞特性的维持。

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Replicating chromatin in the nucleus: A histone variant perspective

In eukaryotes, chromatin and DNA replication are intimately linked, whereby chromatin impacts DNA replication control while genome duplication involves recovery of chromatin organisation. Here, we review recent advances in this area using a histone variant lens. We highlight how nucleosomal features interplay with origin definition and how the order of origin firing links with chromatin states in early mammalian development. We next discuss histone recycling and de novo deposition at the fork to finally open on the post-replicative recovery of the chromatin landscape to promote maintenance of cell identity.

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.