脂滴降解机制。

IF 6 2区 生物学 Q1 CELL BIOLOGY
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引用次数: 0

摘要

脂滴(LDs)是一种亚细胞器,通过调节脂肪酸的储存和释放在脂质代谢中发挥着不可或缺的作用。脂肪分解和脂肪吞噬是 LD 的两种主要降解途径,它们介导了对储存在这些细胞器中的脂质的利用。最近的研究进一步发现了其他途径,包括溶酶体直接降解 LD 和 LD 外渗。在此,我们将重点介绍最近的研究发现,这些发现剖析了这些不同 LD 降解途径的分子基础。然后,我们将讨论这些途径之间的相互影响以及 LD 降解的潜在非常规作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mechanisms of lipid droplet degradation

Lipid droplets (LDs) are subcellular organelles that play an integral role in lipid metabolism by regulating the storage and release of fatty acids, which are essential for energy production and various cellular processes. Lipolysis and lipophagy are the two major LD degradation pathways that mediate the utilization of lipids stored in these organelles. Recent studies have further uncovered alternative pathways, including direct lysosomal LD degradation and LD exocytosis. Here, we highlight recent findings that dissect the molecular basis of these diverse LD degradation pathways. Then, we discuss speculations on the crosstalk among these pathways and the potential unconventional roles of LD degradation.

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来源期刊
Current Opinion in Cell Biology
Current Opinion in Cell Biology 生物-细胞生物学
CiteScore
14.60
自引率
1.30%
发文量
79
审稿时长
93 days
期刊介绍: Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.
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