Post-transcriptional regulation as a conserved driver of neural crest and cancer-cell migration

IF 6 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2024-07-19 DOI:10.1016/j.ceb.2024.102400

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引用次数: 0

Abstract

Cells have evolved mechanisms to migrate for diverse biological functions. A process frequently deployed during metazoan cell migration is the epithelial–mesenchymal transition (EMT). During EMT, adherent epithelial cells undergo coordinated cellular transitions to mesenchymalize and reduce their intercellular attachments. This is achieved via tightly regulated changes in gene expression, which modulates cell–cell and cell–matrix adhesion to allow movement. The acquisition of motility and invasive properties following EMT allows some mesenchymal cells to migrate through complex environments to form tissues during embryogenesis; however, these processes may also be leveraged by cancer cells, which often co-opt these endogenous programs to metastasize. Post-transcriptional regulation is now emerging as a major conserved mechanism by which cells modulate EMT and migration, which we discuss here in the context of vertebrate development and cancer.

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转录后调控是神经嵴和癌细胞迁移的保守驱动因素

细胞进化出了具有多种生物功能的迁移机制。上皮-间质转化（EMT）是元类动物细胞迁移过程中经常使用的一个过程。在 EMT 过程中，粘附的上皮细胞会发生协调的细胞转变，使细胞间质化并减少细胞间的粘附。这是通过严格调控的基因表达变化实现的，这种变化调节了细胞-细胞和细胞-基质之间的粘附，从而使细胞得以移动。胚胎发育过程中，一些间充质细胞通过EMT获得了运动性和侵袭性，从而能在复杂的环境中迁移，形成组织；然而，癌细胞也可能利用这些过程，它们通常会利用这些内源性程序进行转移。转录后调控正在成为细胞调控 EMT 和迁移的一种主要保守机制，我们将在这里结合脊椎动物的发育和癌症讨论这一机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.