Expert Reviews in Molecular Medicine最新文献_第4页

Interplay between innate immune cells and inflammatory mediators in dengue infection: an evolving therapeutic paradigm. 先天免疫细胞和炎症介质在登革热感染中的相互作用：一种不断发展的治疗范式。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-09-23 DOI: 10.1017/erm.2025.10021

Akrite Mishra, Sudeshna Mallik, Pritam Saha, Sankhanil Dhara, Sumi Mukhopadhyay

{"title":"Interplay between innate immune cells and inflammatory mediators in dengue infection: an evolving therapeutic paradigm.","authors":"Akrite Mishra, Sudeshna Mallik, Pritam Saha, Sankhanil Dhara, Sumi Mukhopadhyay","doi":"10.1017/erm.2025.10021","DOIUrl":"10.1017/erm.2025.10021","url":null,"abstract":"Background: Dengue is one of the neglected tropical diseases endemic to tropical and subtropical regions worldwide. Due to its substantial disease burden, this arthropod-borne viral disease is a significant public health concern. Infection involving any one of the five distinct serotypes causes a wide range of disease manifestations, from self-limiting to mild to life-threatening outcomes.Methods: The current review comprehensively provides an overview of dengue virus-mediated immunopathogenesis with special emphasis on innate immune cells, their pathogen recognition sensors and their association with pathogenesis. Additionally we have also briefly discussed recent advancements in vaccine studies and the development of therapeutics over the last decade.Results: The immunological response to dengue virus involves an amalgamation of a variety of innate cells and inflammatory mediators, resulting in the favouring or dampening of the antiviral response. Viral components activating innate cells through pattern recognition receptors, such as Toll-like receptors, retinoic-acid-inducible gene I and melanoma differentiation-associated gene 5, are vital in eliciting a downstream signalling cascade, which culminates in the secretion of inflammatory proteins.Conclusion: Understanding the specific mechanisms involved in the acute phase of infection is indispensable for detecting differential biomarkers against flavivirus infections as well as designing more efficient therapeutic agents and vaccines.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":" ","pages":"e32"},"PeriodicalIF":5.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12558635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential Noninvasive Biomarkers to Assess the Aging Process. 评估衰老过程的潜在无创生物标志物。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-09-15 DOI: 10.1017/erm.2025.10020

Álvaro Pérez Muñoz, Alejandro Gonzalez-Serna, Mercedes Cano

{"title":"Potential Noninvasive Biomarkers to Assess the Aging Process.","authors":"Álvaro Pérez Muñoz, Alejandro Gonzalez-Serna, Mercedes Cano","doi":"10.1017/erm.2025.10020","DOIUrl":"10.1017/erm.2025.10020","url":null,"abstract":"Aging is a process preserved in all living beings, progressive over time and inexorable. Despite the existence of several theories that attempt to explain changes associated with aging, scientists have not managed to satisfactorily explain the causes of aging. However, during the last decade, several cellular processes involved in the aging process have been shown to be involved, allowing scientists to identify new biomolecules as aging biomarkers and control the progression of aging. Currently, there is no single biomarker sensitive and specific enough to predict aging, so it is necessary to find a set of specific biomarkers of cellular processes involved in aging. These biomarkers must be accessible for quantification in biological samples in a noninvasive way to implement them in clinical practice. By 2050, it is estimated that approximately one in six people in the world will be over 65 years old, doubling the percentage of population over 60 years old. Therefore, the research of new biomarkers represents a novel strategy to counteract against aging and improve quality of life. In this review we summarize the potential biomarkers of aging that could be used in a noninvasive manner.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":" ","pages":"e34"},"PeriodicalIF":5.5,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12558625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Medical Imaging to Bioprinted Tissues: The Importance of Workflow Optimisation for Improved Cell Function. 从医学成像到生物打印组织：优化工作流程对改善细胞功能的重要性。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-09-12 DOI: 10.1017/erm.2025.10018

Jesús Manuel Rodríguez Rego, Laura Mendoza Cerezo, Francisco de Asís Iñesta Vaquera, David Picado Tejero, Alfonso Carlos Marcos Romero

{"title":"From Medical Imaging to Bioprinted Tissues: The Importance of Workflow Optimisation for Improved Cell Function.","authors":"Jesús Manuel Rodríguez Rego, Laura Mendoza Cerezo, Francisco de Asís Iñesta Vaquera, David Picado Tejero, Alfonso Carlos Marcos Romero","doi":"10.1017/erm.2025.10018","DOIUrl":"10.1017/erm.2025.10018","url":null,"abstract":"Background: The rapid advancement of 3D bioprinting is transforming possibilities in tissue engineering and personalised medicine, offering innovative solutions to critical biomedical challenges such as organ shortages and the need for precise 3D cellular models. To fully unlock the potential of this technology, anoptimised and comprehensive workflow is essential.Methods: This review provides a systematic examination of the bioprinting process, covering key steps from medical image acquisition to the validation of bioprinted structures. The analysis includes biomaterial and cell type selection, conversion of DICOM images into 3D-printable models, and slicing techniques.Results: Key factors influencing the precision, viability, and clinical relevance of bioprinted tissues are identified. Comparisons between planar and non-planar slicing algorithms highlight their impact on scaffold integrity. The review also discusses advancements in algorithm development, bioprinter technology, and biomaterial optimisation, emphasising their role in enhancing reproducibility and functionality.Conclusions: This structured review offers actionable insights for researchers and practitioners aiming to refine bioprinting workflows. By integrating improvements across imaging, modelling, and material selection, 3D bioprinting can more effectively support the development of clinically relevant constructs, advancing regenerative medicine and personalisedhealthcare.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":" ","pages":"e33"},"PeriodicalIF":5.5,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12558632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human babesiosis: The past, present and future. 人类巴贝斯虫病：过去、现在和未来。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-09-05 DOI: 10.1017/erm.2025.10016

Madison Asquith, Sally Prior, Anke Brüning-Richardson

{"title":"Human babesiosis: The past, present and future.","authors":"Madison Asquith, Sally Prior, Anke Brüning-Richardson","doi":"10.1017/erm.2025.10016","DOIUrl":"10.1017/erm.2025.10016","url":null,"abstract":"Human babesiosis is a disease transmitted by the bite of an infected tick or via blood transfusions involving contaminated blood products; in humans, it can lead to severe complications and even death, depending on the clinical history, age and health status of the affected patient. Babesiosis is caused by members of the Babesia spp., protozoan parasites whose life cycle includes sexual reproduction in the arthropod vector and asexual reproduction in the mainly mammalian host. Cases of human babesiosis have been rare, but there are increasing reports of human babesiosis associated with climatic changes affecting the geographical distribution of the parasite and tick vector, enhanced vector-human interactions and improved awareness of the disease in humans. Diagnostics and treatment options for humans are based around discoveries in veterinary research, such as point-of-care testing in cases of bovine babesiosis, and include direct diagnosis by blood smears, polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA) technologies, and indirect diagnosis by ELISA, immunofluorescence tests (IFAT) and fluorescent in situ hybridisation. Treatment involves a combination of drugs such as azithromycin and atovaquone, or clindamycin and quinine, but more effective options are being investigated, including, but not limited to, trans-chalcones and tafenoquine. Improved surveillance, awareness and diagnosis, as well as advanced technologies to interrupt vector-host interactions, are crucial in managing the increased threat posed by this once-neglected disease in humans.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":" ","pages":"e30"},"PeriodicalIF":5.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12558630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prospects and challenges of salivary gland tissue engineering in Sjögren's syndrome. 唾液腺组织工程治疗Sjögren综合征的前景与挑战。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-09-05 DOI: 10.1017/erm.2025.10017

Xinying Fan, Haodong Su, Xiaoyu Tang, Siyao Yang, Jingjin Hu, Liyun Zhang, Ke Xu, Dan Ma

引用次数: 0

Mechanism of Microbiota-Gut-Brain in Perimenopausal Depression: An Inflammatory Perspective. 围绝经期抑郁的微生物-肠-脑机制：炎症的观点。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-09-04 DOI: 10.1017/erm.2025.10011

Xia Yu, Yi Zuo, Yang Yang, Wei Cheng, Mingxiu Shi, Luona Cheng, Qixiang Shao, Yongjun Xu, Li Chen

{"title":"Mechanism of Microbiota-Gut-Brain in Perimenopausal Depression: An Inflammatory Perspective.","authors":"Xia Yu, Yi Zuo, Yang Yang, Wei Cheng, Mingxiu Shi, Luona Cheng, Qixiang Shao, Yongjun Xu, Li Chen","doi":"10.1017/erm.2025.10011","DOIUrl":"10.1017/erm.2025.10011","url":null,"abstract":"Background: Perimenopausal women often experience physiological and psychological decline due to the effects of oestrogen fluctuations and the decline of ovarian function, leading to significantly increased depression rates, decreases in the quality of life and mental health issues. Studies have shown that the gut microbiota exerts anti-perimenopausal depression (PMD) effects via the microbiota-gut-brain (MGB) axis, the mechanisms of which may be related to inflammation. In this review, we discuss the effects and mechanisms of gut microbiota in PMD and provide new insights for future PMD treatment.Methods: This review elaborates on the role of MGB axis in PMD from different aspects of inflammation, including gut microbiota metabolites, inflammatory signaling pathways, and clinical applications.Results: Disorders of gut microbiota and decreased levels of gut microbiota metabolites (short-chain fatty acids, monoamine neurotransmitters) may cause PMD. The mechanism of intestinal microbiota-mediated inflammation may be related to TLR4/NF-κB pathway, NOD-like receptor protein 3 (NLRP3) inflammasome pathway and JAK-STAT pathway. At the same time, it was found that gut microbiota (probiotics, prebiotics, etc.) had good therapeutic potential in the treatment of PMD.Conclusions: MGB axis mediated inflammation may play an important role in PMD. The application of gut microbiota in the treatment of PMD patients has profound clinical transformation value, but a lot of efforts are still needed.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"27 ","pages":"e28"},"PeriodicalIF":5.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12558631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endothelial Progenitor Cells in Life, Pregnancy and Disease. 内皮祖细胞在生命、妊娠和疾病中的作用。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-08-22 DOI: 10.1017/erm.2025.10015

Bianca Schröder-Heurich, Julia Beckmann, Frauke von Versen-Höynck

{"title":"Endothelial Progenitor Cells in Life, Pregnancy and Disease.","authors":"Bianca Schröder-Heurich, Julia Beckmann, Frauke von Versen-Höynck","doi":"10.1017/erm.2025.10015","DOIUrl":"10.1017/erm.2025.10015","url":null,"abstract":"Endothelial progenitor cells (EPCs) are key regulators of vascular homeostasis in both health and disease, playing a crucial role in regenerating the human vascular lining throughout life. These circulating cells can differentiate into mature endothelial cells and are increasingly recognized as important biological markers of vascular function and cumulative risk for various diseases, including cardiovascular conditions. In recent decades, the role of EPCs, particularly the endothelial colony-forming cells (ECFCs) subtype, in pregnancy-related disorders and maternal and neonatal endothelial health has garnered significant attention. Evidence suggests that ECFCs may serve as predictor of future endothelial health in women and their offspring following pregnancy complications, making them particular relevant for research and therapeutic applications in adulthood, as well as potential indicators of vascular health. This review summarizes the evidence on EPCs, specifically ECFCs, as biomarkers of endothelial health in pregnancy, pregnancy-related diseases and ageing, with a focus on maternal and foetal endothelial abnormalities that may serve as prognostic factors for the development of future diseases.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":" ","pages":"e29"},"PeriodicalIF":5.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12558628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Application of iPSCs in Tumour Immunotherapy. iPSCs在肿瘤免疫治疗中的应用。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-08-11 DOI: 10.1017/erm.2025.10006

Peinan Chen, Jian Gao, Jianing Feng, Hongfei Tao, Yongkui Yu, Yijing Li, Jinlong Liu, Shuangshuang Lu, Wei Wang

{"title":"The Application of iPSCs in Tumour Immunotherapy.","authors":"Peinan Chen, Jian Gao, Jianing Feng, Hongfei Tao, Yongkui Yu, Yijing Li, Jinlong Liu, Shuangshuang Lu, Wei Wang","doi":"10.1017/erm.2025.10006","DOIUrl":"10.1017/erm.2025.10006","url":null,"abstract":"Background: Tumour immunotherapy holds great promise as a treatment for cancer, which ranks as the second highest cause of mortality worldwide. This therapeutic approach can be broadly categorized into two main types: active immunotherapy and passive or adoptive immunotherapy. Active immunotherapy, such as cancer vaccines, stimulates the patients' immune system to target tumour cells. On the other hand, adoptive immunotherapy involves supplying in vitro activated immune cells, such as T cells, natural killer cells and macrophages, to the patient to combat the tumour. Induced pluripotent stem cells are extensively utilized in both active and adoptive tumour immunotherapy due to their pluripotency and ease of gene editing. They can be differentiated into various types of immune cells for direct cancer treatment and can also function as tumour vaccines to elicit an immune response against the tumour. Importantly, iPSCs can be leveraged to develop off-the-shelf allogenic immunotherapy products.Conclusion: This article provides a comprehensive review of the application of iPSCs in tumor immunotherapy, along with a discussion of the opportunities and challenges in this evolving field.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"27 ","pages":"e26"},"PeriodicalIF":5.5,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12558626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of macrophage in endometriosis and endometriosis-associated ovarian cancer. 巨噬细胞在子宫内膜异位症和子宫内膜异位症相关卵巢癌中的作用。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-08-05 DOI: 10.1017/erm.2025.10012

Qinglin Mo, Ruoshui Chang, Yingshi Li, Haokun Li, Wei Huang, Leyi Zhang, Zhihang Deng, Zhaoyu Yang, Yingrui Luo, Zhizhong Huang, Qianbing Zhang, Xiaorui Hou, Wei Zhu, Sha Wu

引用次数: 0

Immunomodulatory Effects of Pelargonium sidoides Extract (EPs7630) in the Treatment of Acute Rhinosinusitis. 天竺葵皂苷提取物（EPs7630）治疗急性鼻窦炎的免疫调节作用。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-07-15 DOI: 10.1017/erm.2025.10013

Aleksandar Perić, Sandra Vezmar Kovačević, Aleksandra Barać, Aneta Perić, Danilo Vojvodić

{"title":"Immunomodulatory Effects of Pelargonium sidoides Extract (EPs7630) in the Treatment of Acute Rhinosinusitis.","authors":"Aleksandar Perić, Sandra Vezmar Kovačević, Aleksandra Barać, Aneta Perić, Danilo Vojvodić","doi":"10.1017/erm.2025.10013","DOIUrl":"10.1017/erm.2025.10013","url":null,"abstract":"Background: In this short narrative review, we would like to discuss the immunomodulatory effects of South African geranium (Pelargonium sidoides) root extract EPs7630 in treating acute rhinosinusitis. The plant has been used for centuries to treat respiratory tract inflammation, such as sinusitis, pharyngitis and bronchitis. South African geranium is rich in polyphenols, flavonoids, tannins, diterpenes and proanthocyanidins, but the main constituent is a type of coumarin called 'umckalin' (6-hydroxy-5,5-dimethoxy-coumarin). The substance is standardised as an aqueous-ethanolic extract from the root of this plant under the code name EPs7630.Methods: The article presents the results of in vitro and in vivo studies of administering this herbal drug in acute viral, post-viral and bacterial rhinosinusitis. The focus is on the immunomodulatory effects of EPs7630 during the therapy of this acute inflammation of the nasal mucosa.Results: According to the results of some studies, EPs7630 stimulates monocyte-dependent activity and inhibits neutrophil-dependent chemokine activity. However, given the small number of studies, the level of evidence is low, implying the need for new research.Conclusion: Particular attention should be paid to the effect of EPs7630 on bradykinin, the mediator that triggers most inflammatory processes in acute rhinosinusitis.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":" ","pages":"e25"},"PeriodicalIF":5.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0