Expert Reviews in Molecular Medicine最新文献_第3页

Impact of diabetes mellitus on osteoarthritis: a scoping review on biomarkers 糖尿病对骨关节炎的影响：生物标志物范围综述

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2024-04-12 DOI: 10.1017/erm.2024.7

Shi Rui Seow, Sumaiyah Mat, Amalina Ahmad Azam, Nor Fadilah Rajab, Intan Safinar Ismail, Devinder Kaur Ajit Singh, Suzana Shahar, Maw Pin Tan, Francis Berenbaum

引用次数: 0

Stability-based approaches in chemoproteomics 基于稳定性的化学蛋白质组学方法

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2024-04-12 DOI: 10.1017/erm.2024.6

Amy L. George, Maria Emilia Dueñas, José Luis Marín-Rubio, Matthias Trost

引用次数: 0

Trauma diagnostic-related target proteins and their detection techniques 创伤诊断相关靶蛋白及其检测技术

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2024-04-11 DOI: 10.1017/erm.2024.3

YiLiu Wei, Xiaohan Ren, Zhitao Yuan, Jie Hong, Tao Wang, Weizhi Chen, Yuqing Xu, Jinwang Ding, Jun Lin, Wenqian Jiang, Peng Zhang, Qiaoyi Wu

{"title":"Trauma diagnostic-related target proteins and their detection techniques","authors":"YiLiu Wei, Xiaohan Ren, Zhitao Yuan, Jie Hong, Tao Wang, Weizhi Chen, Yuqing Xu, Jinwang Ding, Jun Lin, Wenqian Jiang, Peng Zhang, Qiaoyi Wu","doi":"10.1017/erm.2024.3","DOIUrl":"https://doi.org/10.1017/erm.2024.3","url":null,"abstract":"Trauma is a significant health issue that not only leads to immediate death in many cases but also causes severe complications, such as sepsis, thrombosis, haemorrhage, acute respiratory distress syndrome and traumatic brain injury, among trauma patients. Target protein identification technology is a vital technique in the field of biomedical research, enabling the study of biomolecular interactions, drug discovery and disease treatment. It plays a crucial role in identifying key protein targets associated with specific diseases or biological processes, facilitating further research, drug design and the development of treatment strategies. The application of target protein technology in biomarker detection enables the timely identification of newly emerging infections and complications in trauma patients, facilitating expeditious medical interventions and leading to reduced post-trauma mortality rates and improved patient prognoses. This review provides an overview of the current applications of target protein identification technology in trauma-related complications and provides a brief overview of the current target protein identification technology, with the aim of reducing post-trauma mortality, improving diagnostic efficiency and prognostic outcomes for patients.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"308 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140572879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regorafenib and glioblastoma: a literature review of preclinical studies, molecular mechanisms and clinical effectiveness. 瑞戈非尼与胶质母细胞瘤：关于临床前研究、分子机制和临床疗效的文献综述。

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2024-04-02 DOI: 10.1017/erm.2024.8

Maria Patrizia Mongiardi, Roberto Pallini, Quintino Giorgio D'Alessandris, Andrea Levi, Maria Laura Falchetti

{"title":"Regorafenib and glioblastoma: a literature review of preclinical studies, molecular mechanisms and clinical effectiveness.","authors":"Maria Patrizia Mongiardi, Roberto Pallini, Quintino Giorgio D'Alessandris, Andrea Levi, Maria Laura Falchetti","doi":"10.1017/erm.2024.8","DOIUrl":"10.1017/erm.2024.8","url":null,"abstract":"Glioblastoma IDH wild type (GBM) is a very aggressive brain tumour, characterised by an infiltrative growth pattern and by a prominent neoangiogenesis. Its prognosis is unfortunately dismal, and the median overall survival of GBM patients is short (15 months). Clinical management is based on bulk tumour removal and standard chemoradiation with the alkylating drug temozolomide, but the tumour invariably recurs leading to patient's death. Clinical options for GBM patients remained unaltered for almost two decades until the encouraging results obtained by the phase II REGOMA trial allowed the introduction of the multikinase inhibitor regorafenib as a preferred regimen in relapsed GBM treatment by the National Comprehensive Cancer Network (NCCN) 2020 Guideline. Regorafenib, a sorafenib derivative, targets kinases associated with angiogenesis (VEGFR 1-3), as well as oncogenesis (c-KIT, RET, FGFR) and stromal kinases (FGFR, PDGFR-b). It was already approved for metastatic colorectal cancers and hepatocellular carcinomas. The aim of the present review is to focus on both the molecular and clinical knowledge collected in these first three years of regorafenib use in GBM.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"26 ","pages":"e5"},"PeriodicalIF":6.2,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11062143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140337530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA methylation in necrotizing enterocolitis. 坏死性小肠结肠炎中的 DNA 甲基化。

IF 4.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2024-04-01 DOI: 10.1017/erm.2024.16

Lauren C Frazer, Yukihiro Yamaguchi, Dhirendra K Singh, Natalia S Akopyants, Misty Good

{"title":"DNA methylation in necrotizing enterocolitis.","authors":"Lauren C Frazer, Yukihiro Yamaguchi, Dhirendra K Singh, Natalia S Akopyants, Misty Good","doi":"10.1017/erm.2024.16","DOIUrl":"10.1017/erm.2024.16","url":null,"abstract":"Epigenetic modifications, such as DNA methylation, are enzymatically regulated processes that directly impact gene expression patterns. In early life, they are central to developmental programming and have also been implicated in regulating inflammatory responses. Research into the role of epigenetics in neonatal health is limited, but there is a growing body of literature related to the role of DNA methylation patterns and diseases of prematurity, such as the intestinal disease necrotizing enterocolitis (NEC). NEC is a severe intestinal inflammatory disease, but the key factors that precede disease development remain to be determined. This knowledge gap has led to a failure to design effective targeted therapies and identify specific biomarkers of disease. Recent literature has identified altered DNA methylation patterns in the stool and intestinal tissue of neonates with NEC. These findings provide the foundation for a new avenue in NEC research. In this review, we will provide a general overview of DNA methylation and then specifically discuss the recent literature related to methylation patterns in neonates with NEC. We will also discuss how DNA methylation is used as a biomarker for other disease states and how, with further research, methylation patterns may serve as potential biomarkers for NEC.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":" ","pages":"e16"},"PeriodicalIF":4.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11140546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140337531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of deubiquitinases in cardiac disease. 去泛素酶在心脏病中的作用

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2024-03-25 DOI: 10.1017/erm.2024.2

Xiaona Zhan, Yi Yang, Qing Li, Fan He

引用次数: 0

Pharmacogenomic and epigenomic approaches to untangle the enigma of IL-10 blockade in oncology. 用药物基因组学和表观基因组学方法解开 IL-10 在肿瘤学中的阻断之谜。

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2024-01-08 DOI: 10.1017/erm.2023.26

Noha M Elemam, Radwa Y Mekky, Gowhar Rashid, Maria Braoudaki, Rana A Youness

{"title":"Pharmacogenomic and epigenomic approaches to untangle the enigma of IL-10 blockade in oncology.","authors":"Noha M Elemam, Radwa Y Mekky, Gowhar Rashid, Maria Braoudaki, Rana A Youness","doi":"10.1017/erm.2023.26","DOIUrl":"10.1017/erm.2023.26","url":null,"abstract":"The host immune system status remains an unresolved mystery among several malignancies. An immune-compromised state or smart immune-surveillance tactics orchestrated by cancer cells are the primary cause of cancer invasion and metastasis. Taking a closer look at the tumour-immune microenvironment, a complex network and crosstalk between infiltrating immune cells and cancer cells mediated by cytokines, chemokines, exosomal mediators and shed ligands are present. Cytokines such as interleukins can influence all components of the tumour microenvironment (TME), consequently promoting or suppressing tumour invasion based on their secreting source. Interleukin-10 (IL-10) is an interlocked cytokine that has been associated with several types of malignancies and proved to have paradoxical effects. IL-10 has multiple functions on cellular and non-cellular components within the TME. In this review, the authors shed the light on the regulatory role of IL-10 in the TME of several malignant contexts. Moreover, detailed epigenomic and pharmacogenomic approaches for the regulation of IL-10 were presented and discussed.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"26 ","pages":"e1"},"PeriodicalIF":6.2,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10941350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Live birth rate of gonadotropin-releasing hormone antagonist versus luteal phase gonadotropin-releasing hormone agonist protocol in IVF/ICSI: a systematic review and meta-analysis. 促性腺激素释放激素拮抗剂与黄体期促性腺激素释放激素激动剂在体外受精/卵胞浆内单精子显微注射方案中的活产率对比：系统综述和荟萃分析。

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2023-12-14 DOI: 10.1017/erm.2023.25

Chenhong Liu, Tian Tian, Yanru Lou, Jia Li, Ping Liu, Rong Li, Jie Qiao, Yuanyuan Wang, Rui Yang

{"title":"Live birth rate of gonadotropin-releasing hormone antagonist versus luteal phase gonadotropin-releasing hormone agonist protocol in IVF/ICSI: a systematic review and meta-analysis.","authors":"Chenhong Liu, Tian Tian, Yanru Lou, Jia Li, Ping Liu, Rong Li, Jie Qiao, Yuanyuan Wang, Rui Yang","doi":"10.1017/erm.2023.25","DOIUrl":"10.1017/erm.2023.25","url":null,"abstract":"In vitro fertilization (IVF) and embryo transfer and intracytoplasmic sperm injection (ICSI) have allowed millions of infertile couples to achieve pregnancy. As an essential part of IVF/ICSI enabling the retrieval of a high number of oocytes in one cycle, controlled ovarian stimulation (COS) treatment mainly composes of the standard long gonadotrophin-releasing hormone agonist (GnRH-a) protocol and the gonadotrophin-releasing hormone antagonist (GnRH-ant) protocol. However, the effectiveness of GnRH-ant protocol is still debated because of inconsistent conclusions and insufficient subgroup analyses. This systematic review and meta-analysis included a total of 52 studies, encompassing 5193 participants in the GnRH-ant group and 4757 in the GnRH-a group. The findings of this study revealed that the GnRH-ant protocol is comparable with the long GnRH-a protocol when considering live birth as the primary outcome, and it is a favourable protocol with evidence reducing the incidence of ovarian hyperstimulation syndrome in women undergoing IVF/ICSI, especially in women with polycystic ovary syndrome. Further research is needed to compare the subsequent cumulative live birth rate between the two protocols among the general and poor ovarian response patients since those patients have a lower clinical pregnancy rate, fewer oocytes retrieved or fewer high-grade embryos in the GnRH-ant protocol.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":" ","pages":"e2"},"PeriodicalIF":6.2,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10941349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138812681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strategies and rules for tuning TCR-derived therapy. 调整 TCR 衍生疗法的策略和规则

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2023-12-14 DOI: 10.1017/erm.2023.27

Guoheng Mo, Xinyu Lu, Sha Wu, Wei Zhu

引用次数: 0

Molecular mechanisms of action of negative pressure wound therapy: a systematic review. 负压创伤治疗作用的分子机制：系统综述。

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2023-10-19 DOI: 10.1017/erm.2023.24

Bharadhwaj Ravindhran, Nicole Schafer, Annabel Howitt, Daniel Carradice, George Smith, Ian Chetter

{"title":"Molecular mechanisms of action of negative pressure wound therapy: a systematic review.","authors":"Bharadhwaj Ravindhran, Nicole Schafer, Annabel Howitt, Daniel Carradice, George Smith, Ian Chetter","doi":"10.1017/erm.2023.24","DOIUrl":"10.1017/erm.2023.24","url":null,"abstract":"Negative pressure wound therapy (NPWT) has significantly advanced wound care and continues to find new applications. Its effects at a molecular level however, remain a subject of debate. The aim of this systematic review is to summarize the current evidence regarding the molecular mechanisms of action of NPWT. Medline, Embase, EBSCO databases and clinical trial registries were searched from inception to January 2023. Clinical studies, animal models or in-vitro studies that quantitatively or semi-quantitatively evaluated the influence of NPWT on growth factors, cytokine or gene-expression in the circulation or wound-bed were included. Risk of Bias assessment was performed using the RoBANS tool for non-randomized studies, the COCHRANE's Risk of Bias 2(ROB-2) tool for randomized clinical studies, OHAT tool for in-vitro studies or the SYRCLE tool for animal model studies. A descriptive summary was collated and the aggregated data is presented as a narrative synthesis. This review included 19 clinical studies, 11 animal studies and 3 in-vitro studies. The effects of NPWT on 43 biomarkers and 17 gene expressions were studied across included studies. NPWT stimulates modulation of numerous local and circulating cytokines and growth factor expressions to promote an anti-inflammatory profile. This is most likely achieved by downregulation of TNFα, upregulation of VEGF, TGF-β and fibronectin.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"25 ","pages":"e29"},"PeriodicalIF":6.2,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49684451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0