用于描述口腔癌和口腔潜在恶性疾病特征的拉曼光谱研究进展。

IF 4.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Katie Hanna, Anna-Lena Asiedu, Thomas Theurer, David Muirhead, Valerie Speirs, Yara Oweis, Rasha Abu-Eid
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引用次数: 0

摘要

过去几十年来,口腔癌的存活率几乎没有提高。这主要是由于口腔潜在恶性疾病(OPMDs)发现较晚,而且缺乏可靠的标志物来预测疾病的进展。我们需要高度特异和灵敏的筛查工具,以便及早发现恶性转变。组织的生化改变是病理过程的早期反应,表现为分子结构、浓度或构象的改变。拉曼光谱是一种强大的分析技术,可探测这些生化变化,并可用于生成新型疾病特异性生物标记物。因此,拉曼光谱具有作为辅助工具的潜力,可协助口腔癌的早期诊断和口腔黏膜病的疾病进展检测。本综述介绍了基于体外和液体活检以及体内应用的拉曼光谱在口腔癌和口腔黏膜病诊断中的应用,展示了这一强大工具从台式到椅式的发展潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advances in Raman spectroscopy for characterising oral cancer and oral potentially malignant disorders.

Oral cancer survival rates have seen little improvement over the past few decades. This is mainly due to late detection and a lack of reliable markers to predict disease progression in oral potentially malignant disorders (OPMDs). There is a need for highly specific and sensitive screening tools to enable early detection of malignant transformation. Biochemical alterations to tissues occur as an early response to pathological processes; manifesting as modifications to molecular structure, concentration or conformation. Raman spectroscopy is a powerful analytical technique that can probe these biochemical changes and can be exploited for the generation of novel disease-specific biomarkers. Therefore, Raman spectroscopy has the potential as an adjunct tool that can assist in the early diagnosis of oral cancer and the detection of disease progression in OPMDs. This review describes the use of Raman spectroscopy for the diagnosis of oral cancer and OPMDs based on ex vivo and liquid biopsies as well as in vivo applications that show the potential of this powerful tool to progress from benchtop to chairside.

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来源期刊
Expert Reviews in Molecular Medicine
Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
7.40
自引率
1.60%
发文量
45
期刊介绍: Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.
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