Expert Reviews in Molecular Medicine最新文献

Genetic and epigenetic approaches to Opioid Use Disorder. 阿片类药物使用障碍的遗传和表观遗传方法。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-09-25 DOI: 10.1017/erm.2025.10024

Nadeeka Dimuthu Ranadeva, Praba Jalini Wijekumar, Caroline Anastasia Fernando, Akila Randika Jayamaha, Nafeesa Noordeen, Sureka Chackrewarthy, Neluka Fernando

引用次数: 0

Role of S100 family proteins in colorectal cancer (CRC): an overview of their potential function as new biomarkers and therapeutic agents. S100家族蛋白在结直肠癌（CRC）中的作用：其作为新的生物标志物和治疗药物的潜在功能综述

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-09-23 DOI: 10.1017/erm.2025.10019

Hamideh Raeisi, Leili Rejali, Nayeralsadat Fatemi, Amir Sadeghi, Zahra Sadeghloo, Mohammad Reza Zali, Ehsan Nazemalhosseini Mojarad

{"title":"Role of S100 family proteins in colorectal cancer (CRC): an overview of their potential function as new biomarkers and therapeutic agents.","authors":"Hamideh Raeisi, Leili Rejali, Nayeralsadat Fatemi, Amir Sadeghi, Zahra Sadeghloo, Mohammad Reza Zali, Ehsan Nazemalhosseini Mojarad","doi":"10.1017/erm.2025.10019","DOIUrl":"10.1017/erm.2025.10019","url":null,"abstract":"Colorectal cancer (CRC) is the second deadliest cancer worldwide, posing a great threat to human health and a social burden. Various genetic and epigenetic alterations can activate tumourigenesis-related signalling pathways, leading to CRC development and progression. Over the past two decades, the understanding of the role of S100 family proteins in different types of cancer has received great attention. S100 proteins, as intracellular and extracellular, play important roles in regulating various cellular processes, such as calcium homeostasis, apoptosis, tumour cell proliferation, invasion and motility. It is well documented that alteration in expression of S100 proteins can be associated with tumourigenesis and cancer progression. These proteins play important roles in CRC carcinogenesis by activating different signalling pathways, especially the nuclear factor kappa B (NF-κB) signalling pathway, which is involved in cell proliferation, invasion and migration. In this review, we describe the functions of S100 proteins in the context of inflammation, tumourigenesis, cancer progression, metastasis, and drug resistance in CRC. We also discuss the potential of targeting different S100 proteins as prognostic factors and therapeutic agents for CRC treatment. This narrative review will increase our understanding of the role of S100 proteins in the progression of CRC and provide insights into the use of S100 proteins as new biomarkers and therapeutic targets for CRC therapy.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":" ","pages":"e31"},"PeriodicalIF":5.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interplay between Innate Immune cells and Inflammatory Mediators in Dengue Infection: An Evolving Therapeutic paradigm. 先天免疫细胞和炎症介质在登革热感染中的相互作用：一种不断发展的治疗范式。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-09-23 DOI: 10.1017/erm.2025.10021

Akrite Mishra, Sudeshna Mallik, Pritam Saha, Sankhanil Dhara, Sumi Mukhopadhyay

引用次数: 0

Potential noninvasive biomarkers to assess the aging process. 评估衰老过程的潜在无创生物标志物。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-09-15 DOI: 10.1017/erm.2025.10020

Álvaro Pérez Muñoz, Alejandro Gonzalez-Serna, Mercedes Cano

引用次数: 0

FROM MEDICAL IMAGING TO BIOPRINTED TISSUES: THE IMPORTANCE OF WORKFLOW OPTIMISATION FOR IMPROVED CELL FUNCTION. 从医学成像到生物打印组织：优化工作流程对改善细胞功能的重要性。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-09-12 DOI: 10.1017/erm.2025.10018

Jesús Manuel Rodríguez Rego, Laura Mendoza Cerezo, Francisco de Asís Iñesta Vaquera, David Picado Tejero, Alfonso Carlos Marcos Romero

引用次数: 0

Human babesiosis: The past, present and future. 人类巴贝斯虫病：过去、现在和未来。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-09-05 DOI: 10.1017/erm.2025.10016

Madison Asquith, Sally Prior, Anke Brüning-Richardson

{"title":"Human babesiosis: The past, present and future.","authors":"Madison Asquith, Sally Prior, Anke Brüning-Richardson","doi":"10.1017/erm.2025.10016","DOIUrl":"10.1017/erm.2025.10016","url":null,"abstract":"Human babesiosis is a disease transmitted by the bite of an infected tick or via blood transfusions involving contaminated blood products; in humans, it can lead to severe complications and even death, depending on the clinical history, age and health status of the affected patient. Babesiosis is caused by members of the Babesia spp., protozoan parasites whose life cycle includes sexual reproduction in the arthropod vector and asexual reproduction in the mainly mammalian host. Cases of human babesiosis have been rare, but there are increasing reports of human babesiosis associated with climatic changes affecting the geographical distribution of the parasite and tick vector, enhanced vector-human interactions and improved awareness of the disease in humans. Diagnostics and treatment options for humans are based around discoveries in veterinary research, such as point-of-care testing in cases of bovine babesiosis, and include direct diagnosis by blood smears, polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA) technologies, and indirect diagnosis by ELISA, immunofluorescence tests (IFAT) and fluorescent in situ hybridisation. Treatment involves a combination of drugs such as azithromycin and atovaquone, or clindamycin and quinine, but more effective options are being investigated, including, but not limited to, trans-chalcones and tafenoquine. Improved surveillance, awareness and diagnosis, as well as advanced technologies to interrupt vector-host interactions, are crucial in managing the increased threat posed by this once-neglected disease in humans.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":" ","pages":"e30"},"PeriodicalIF":5.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prospects and challenges of salivary gland tissue engineering in Sjögren's syndrome. 唾液腺组织工程治疗Sjögren综合征的前景与挑战。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-09-05 DOI: 10.1017/erm.2025.10017

Xinying Fan, Haodong Su, Xiaoyu Tang, Siyao Yang, Jingjin Hu, Liyun Zhang, Ke Xu, Dan Ma

引用次数: 0

Mechanism of Microbiota-Gut-Brain in Perimenopausal Depression: An Inflammatory Perspective. 围绝经期抑郁的微生物-肠-脑机制：炎症的观点。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-09-04 DOI: 10.1017/erm.2025.10011

Xia Yu, Yi Zuo, Yang Yang, Wei Cheng, Mingxiu Shi, Luona Cheng, Qixiang Shao, Yongjun Xu, Li Chen

{"title":"Mechanism of Microbiota-Gut-Brain in Perimenopausal Depression: An Inflammatory Perspective.","authors":"Xia Yu, Yi Zuo, Yang Yang, Wei Cheng, Mingxiu Shi, Luona Cheng, Qixiang Shao, Yongjun Xu, Li Chen","doi":"10.1017/erm.2025.10011","DOIUrl":"https://doi.org/10.1017/erm.2025.10011","url":null,"abstract":"Background: Perimenopausal women often experience physiological and psychological decline due to the effects of oestrogen fluctuations and the decline of ovarian function, leading to significantly increased depression rates, decreases in the quality of life and mental health issues. Studies have shown that the gut microbiota exerts anti-perimenopausal depression (PMD) effects via the microbiota-gut-brain (MGB) axis, the mechanisms of which may be related to inflammation. In this review, we discuss the effects and mechanisms of gut microbiota in PMD and provide new insights for future PMD treatment.Methods: This review elaborates on the role of MGB axis in PMD from different aspects of inflammation, including gut microbiota metabolites, inflammatory signaling pathways, and clinical applications.Results: Disorders of gut microbiota and decreased levels of gut microbiota metabolites (short-chain fatty acids, monoamine neurotransmitters) may cause PMD. The mechanism of intestinal microbiota-mediated inflammation may be related to TLR4/NF-κB pathway, NOD-like receptor protein 3 (NLRP3) inflammasome pathway and JAK-STAT pathway. At the same time, it was found that gut microbiota (probiotics, prebiotics, etc.) had good therapeutic potential in the treatment of PMD.Conclusions: MGB axis mediated inflammation may play an important role in PMD. The application of gut microbiota in the treatment of PMD patients has profound clinical transformation value, but a lot of efforts are still needed.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"27 ","pages":"e28"},"PeriodicalIF":5.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endothelial Progenitor Cells in Life, Pregnancy and Disease. 内皮祖细胞在生命、妊娠和疾病中的作用。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-08-22 DOI: 10.1017/erm.2025.10015

Bianca Schröder-Heurich, Julia Beckmann, Frauke von Versen-Höynck

{"title":"Endothelial Progenitor Cells in Life, Pregnancy and Disease.","authors":"Bianca Schröder-Heurich, Julia Beckmann, Frauke von Versen-Höynck","doi":"10.1017/erm.2025.10015","DOIUrl":"10.1017/erm.2025.10015","url":null,"abstract":"Endothelial progenitor cells (EPCs) are key regulators of vascular homeostasis in both health and disease, playing a crucial role in regenerating the human vascular lining throughout life. These circulating cells can differentiate into mature endothelial cells and are increasingly recognized as important biological markers of vascular function and cumulative risk for various diseases, including cardiovascular conditions. In recent decades, the role of EPCs, particularly the endothelial colony-forming cells (ECFCs) subtype, in pregnancy-related disorders and maternal and neonatal endothelial health has garnered significant attention. Evidence suggests that ECFCs may serve as predictor of future endothelial health in women and their offspring following pregnancy complications, making them particular relevant for research and therapeutic applications in adulthood, as well as potential indicators of vascular health. This review summarizes the evidence on EPCs, specifically ECFCs, as biomarkers of endothelial health in pregnancy, pregnancy-related diseases and ageing, with a focus on maternal and foetal endothelial abnormalities that may serve as prognostic factors for the development of future diseases.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":" ","pages":"e29"},"PeriodicalIF":5.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Application of iPSCs in Tumour Immunotherapy. iPSCs在肿瘤免疫治疗中的应用。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-08-11 DOI: 10.1017/erm.2025.10006

Peinan Chen, Jian Gao, Jianing Feng, Hongfei Tao, Yongkui Yu, Yijing Li, Jinlong Liu, Shuangshuang Lu, Wei Wang

{"title":"The Application of iPSCs in Tumour Immunotherapy.","authors":"Peinan Chen, Jian Gao, Jianing Feng, Hongfei Tao, Yongkui Yu, Yijing Li, Jinlong Liu, Shuangshuang Lu, Wei Wang","doi":"10.1017/erm.2025.10006","DOIUrl":"https://doi.org/10.1017/erm.2025.10006","url":null,"abstract":"Background: Tumour immunotherapy holds great promise as a treatment for cancer, which ranks as the second highest cause of mortality worldwide. This therapeutic approach can be broadly categorized into two main types: active immunotherapy and passive or adoptive immunotherapy. Active immunotherapy, such as cancer vaccines, stimulates the patients' immune system to target tumour cells. On the other hand, adoptive immunotherapy involves supplying in vitro activated immune cells, such as T cells, natural killer cells and macrophages, to the patient to combat the tumour. Induced pluripotent stem cells are extensively utilized in both active and adoptive tumour immunotherapy due to their pluripotency and ease of gene editing. They can be differentiated into various types of immune cells for direct cancer treatment and can also function as tumour vaccines to elicit an immune response against the tumour. Importantly, iPSCs can be leveraged to develop off-the-shelf allogenic immunotherapy products.Conclusion: This article provides a comprehensive review of the application of iPSCs in tumor immunotherapy, along with a discussion of the opportunities and challenges in this evolving field.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"27 ","pages":"e26"},"PeriodicalIF":5.5,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0