Expert Reviews in Molecular Medicine最新文献

Extracellular Vesicles: Multimodal Tools for Diagnosis, Prognosis, and Therapy in Respiratory Diseases. 细胞外囊泡：呼吸系统疾病诊断、预后和治疗的多模式工具。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-10-21 DOI: 10.1017/erm.2025.10025

Miquéias Lopes-Pacheco

引用次数: 0

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-10-17 DOI: 10.1017/erm.2025.10022

Chengchao Wang, Yang Ja, Tiantong Liu, Kai Lin, Longyue Huang, Chaoqun Ren, Shiyu Zhou, Hongwei Sun, Hongru Kong, Zimiao Chen, Shengjie Dai

引用次数: 0

The new insights of lactate in various kidney diseases. 乳酸在各种肾脏疾病中的新发现。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-10-14 DOI: 10.1017/erm.2025.10023

Kexin Guan, Yuzhan Zhang, Shuxian Guo, Xiaoxuan Ning, Shiren Sun

引用次数: 0

Genetic and Epigenetic Approaches to Opioid Use Disorder. 阿片类药物使用障碍的遗传和表观遗传方法。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-09-25 DOI: 10.1017/erm.2025.10024

Nadeeka Dimuthu Ranadeva, Praba Jalini Wijekumar, Caroline Anastasia Fernando, Akila Randika Jayamaha, Nafeesa Noordeen, Sureka Chackrewarthy, Neluka Fernando

{"title":"Genetic and Epigenetic Approaches to Opioid Use Disorder.","authors":"Nadeeka Dimuthu Ranadeva, Praba Jalini Wijekumar, Caroline Anastasia Fernando, Akila Randika Jayamaha, Nafeesa Noordeen, Sureka Chackrewarthy, Neluka Fernando","doi":"10.1017/erm.2025.10024","DOIUrl":"10.1017/erm.2025.10024","url":null,"abstract":"Background: Opioid use disorder (OUD) is a major global-scale social issue affecting public health. The high potential for addiction and dependence makes opioid use a significant concern, contributing to substance-related disorders. Both genetic and environmental factors contribute to the predisposition to OUD, with the opioidergic, dopaminergic, and GABAergic systems playing primary roles in itsonset.Methods: This narrative review documents the association between genes and their variants related to these three systems, along with current evidence on epigenetic interventions in OUD. Relevant studies investigating candidate-gene associations and molecular mechanisms were synthesized to highlight genetic variants and epigenetic processes linked to OUD.Results: Genetic associations play a prominent role in OUD, with several single-nucleotide variants identified in affected populations. Key genes implicated include OPRM1, OPRD1, OPRK1, PDYN, OPRL1, and POMC from the opioidergic system; DRD1, DRD2, DRD3, DRD4, ANKK1, and COMT from the dopaminergic system; and GABRA2, GABRB3, GABRG2, GAD1, and GAD2 from the GABAergic system. Evidence also indicates that chronic opioid use is associated with epigenetic changes through posttranslational histone modifications and DNA methylation. However, limitations in existing studies include small sample sizes, limited replication, and potential stratification biases.Conclusions: Although many candidate-gene associations have been proposed for OUD, robust evidence remains limited. Large, ancestrally diverse genome-wide association studies (GWAS) and systematic replication studies are urgently needed. A deeper understanding of the genetic, epigenetic, and neurobiological bases of addiction will be essential for the development of precisely targeted medications to improve prevention and treatment outcomes for OUD.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":" ","pages":"e35"},"PeriodicalIF":5.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of S100 family proteins in colorectal cancer (CRC): an overview of their potential function as new biomarkers and therapeutic agents. S100家族蛋白在结直肠癌（CRC）中的作用：其作为新的生物标志物和治疗药物的潜在功能综述

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-09-23 DOI: 10.1017/erm.2025.10019

Hamideh Raeisi, Leili Rejali, Nayeralsadat Fatemi, Amir Sadeghi, Zahra Sadeghloo, Mohammad Reza Zali, Ehsan Nazemalhosseini Mojarad

{"title":"Role of S100 family proteins in colorectal cancer (CRC): an overview of their potential function as new biomarkers and therapeutic agents.","authors":"Hamideh Raeisi, Leili Rejali, Nayeralsadat Fatemi, Amir Sadeghi, Zahra Sadeghloo, Mohammad Reza Zali, Ehsan Nazemalhosseini Mojarad","doi":"10.1017/erm.2025.10019","DOIUrl":"10.1017/erm.2025.10019","url":null,"abstract":"Colorectal cancer (CRC) is the second deadliest cancer worldwide, posing a great threat to human health and a social burden. Various genetic and epigenetic alterations can activate tumourigenesis-related signalling pathways, leading to CRC development and progression. Over the past two decades, the understanding of the role of S100 family proteins in different types of cancer has received great attention. S100 proteins, as intracellular and extracellular, play important roles in regulating various cellular processes, such as calcium homeostasis, apoptosis, tumour cell proliferation, invasion and motility. It is well documented that alteration in expression of S100 proteins can be associated with tumourigenesis and cancer progression. These proteins play important roles in CRC carcinogenesis by activating different signalling pathways, especially the nuclear factor kappa B (NF-κB) signalling pathway, which is involved in cell proliferation, invasion and migration. In this review, we describe the functions of S100 proteins in the context of inflammation, tumourigenesis, cancer progression, metastasis, and drug resistance in CRC. We also discuss the potential of targeting different S100 proteins as prognostic factors and therapeutic agents for CRC treatment. This narrative review will increase our understanding of the role of S100 proteins in the progression of CRC and provide insights into the use of S100 proteins as new biomarkers and therapeutic targets for CRC therapy.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":" ","pages":"e31"},"PeriodicalIF":5.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interplay between innate immune cells and inflammatory mediators in dengue infection: an evolving therapeutic paradigm. 先天免疫细胞和炎症介质在登革热感染中的相互作用：一种不断发展的治疗范式。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-09-23 DOI: 10.1017/erm.2025.10021

Akrite Mishra, Sudeshna Mallik, Pritam Saha, Sankhanil Dhara, Sumi Mukhopadhyay

{"title":"Interplay between innate immune cells and inflammatory mediators in dengue infection: an evolving therapeutic paradigm.","authors":"Akrite Mishra, Sudeshna Mallik, Pritam Saha, Sankhanil Dhara, Sumi Mukhopadhyay","doi":"10.1017/erm.2025.10021","DOIUrl":"10.1017/erm.2025.10021","url":null,"abstract":"Background: Dengue is one of the neglected tropical diseases endemic to tropical and subtropical regions worldwide. Due to its substantial disease burden, this arthropod-borne viral disease is a significant public health concern. Infection involving any one of the five distinct serotypes causes a wide range of disease manifestations, from self-limiting to mild to life-threatening outcomes.Methods: The current review comprehensively provides an overview of dengue virus-mediated immunopathogenesis with special emphasis on innate immune cells, their pathogen recognition sensors and their association with pathogenesis. Additionally we have also briefly discussed recent advancements in vaccine studies and the development of therapeutics over the last decade.Results: The immunological response to dengue virus involves an amalgamation of a variety of innate cells and inflammatory mediators, resulting in the favouring or dampening of the antiviral response. Viral components activating innate cells through pattern recognition receptors, such as Toll-like receptors, retinoic-acid-inducible gene I and melanoma differentiation-associated gene 5, are vital in eliciting a downstream signalling cascade, which culminates in the secretion of inflammatory proteins.Conclusion: Understanding the specific mechanisms involved in the acute phase of infection is indispensable for detecting differential biomarkers against flavivirus infections as well as designing more efficient therapeutic agents and vaccines.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":" ","pages":"e32"},"PeriodicalIF":5.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential Noninvasive Biomarkers to Assess the Aging Process. 评估衰老过程的潜在无创生物标志物。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-09-15 DOI: 10.1017/erm.2025.10020

Álvaro Pérez Muñoz, Alejandro Gonzalez-Serna, Mercedes Cano

{"title":"Potential Noninvasive Biomarkers to Assess the Aging Process.","authors":"Álvaro Pérez Muñoz, Alejandro Gonzalez-Serna, Mercedes Cano","doi":"10.1017/erm.2025.10020","DOIUrl":"10.1017/erm.2025.10020","url":null,"abstract":"Aging is a process preserved in all living beings, progressive over time and inexorable. Despite the existence of several theories that attempt to explain changes associated with aging, scientists have not managed to satisfactorily explain the causes of aging. However, during the last decade, several cellular processes involved in the aging process have been shown to be involved, allowing scientists to identify new biomolecules as aging biomarkers and control the progression of aging. Currently, there is no single biomarker sensitive and specific enough to predict aging, so it is necessary to find a set of specific biomarkers of cellular processes involved in aging. These biomarkers must be accessible for quantification in biological samples in a noninvasive way to implement them in clinical practice. By 2050, it is estimated that approximately one in six people in the world will be over 65 years old, doubling the percentage of population over 60 years old. Therefore, the research of new biomarkers represents a novel strategy to counteract against aging and improve quality of life. In this review we summarize the potential biomarkers of aging that could be used in a noninvasive manner.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":" ","pages":"e34"},"PeriodicalIF":5.5,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Medical Imaging to Bioprinted Tissues: The Importance of Workflow Optimisation for Improved Cell Function. 从医学成像到生物打印组织：优化工作流程对改善细胞功能的重要性。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-09-12 DOI: 10.1017/erm.2025.10018

Jesús Manuel Rodríguez Rego, Laura Mendoza Cerezo, Francisco de Asís Iñesta Vaquera, David Picado Tejero, Alfonso Carlos Marcos Romero

{"title":"From Medical Imaging to Bioprinted Tissues: The Importance of Workflow Optimisation for Improved Cell Function.","authors":"Jesús Manuel Rodríguez Rego, Laura Mendoza Cerezo, Francisco de Asís Iñesta Vaquera, David Picado Tejero, Alfonso Carlos Marcos Romero","doi":"10.1017/erm.2025.10018","DOIUrl":"10.1017/erm.2025.10018","url":null,"abstract":"Background: The rapid advancement of 3D bioprinting is transforming possibilities in tissue engineering and personalised medicine, offering innovative solutions to critical biomedical challenges such as organ shortages and the need for precise 3D cellular models. To fully unlock the potential of this technology, anoptimised and comprehensive workflow is essential.Methods: This review provides a systematic examination of the bioprinting process, covering key steps from medical image acquisition to the validation of bioprinted structures. The analysis includes biomaterial and cell type selection, conversion of DICOM images into 3D-printable models, and slicing techniques.Results: Key factors influencing the precision, viability, and clinical relevance of bioprinted tissues are identified. Comparisons between planar and non-planar slicing algorithms highlight their impact on scaffold integrity. The review also discusses advancements in algorithm development, bioprinter technology, and biomaterial optimisation, emphasising their role in enhancing reproducibility and functionality.Conclusions: This structured review offers actionable insights for researchers and practitioners aiming to refine bioprinting workflows. By integrating improvements across imaging, modelling, and material selection, 3D bioprinting can more effectively support the development of clinically relevant constructs, advancing regenerative medicine and personalisedhealthcare.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":" ","pages":"e33"},"PeriodicalIF":5.5,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human babesiosis: The past, present and future. 人类巴贝斯虫病：过去、现在和未来。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-09-05 DOI: 10.1017/erm.2025.10016

Madison Asquith, Sally Prior, Anke Brüning-Richardson

{"title":"Human babesiosis: The past, present and future.","authors":"Madison Asquith, Sally Prior, Anke Brüning-Richardson","doi":"10.1017/erm.2025.10016","DOIUrl":"10.1017/erm.2025.10016","url":null,"abstract":"Human babesiosis is a disease transmitted by the bite of an infected tick or via blood transfusions involving contaminated blood products; in humans, it can lead to severe complications and even death, depending on the clinical history, age and health status of the affected patient. Babesiosis is caused by members of the Babesia spp., protozoan parasites whose life cycle includes sexual reproduction in the arthropod vector and asexual reproduction in the mainly mammalian host. Cases of human babesiosis have been rare, but there are increasing reports of human babesiosis associated with climatic changes affecting the geographical distribution of the parasite and tick vector, enhanced vector-human interactions and improved awareness of the disease in humans. Diagnostics and treatment options for humans are based around discoveries in veterinary research, such as point-of-care testing in cases of bovine babesiosis, and include direct diagnosis by blood smears, polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA) technologies, and indirect diagnosis by ELISA, immunofluorescence tests (IFAT) and fluorescent in situ hybridisation. Treatment involves a combination of drugs such as azithromycin and atovaquone, or clindamycin and quinine, but more effective options are being investigated, including, but not limited to, trans-chalcones and tafenoquine. Improved surveillance, awareness and diagnosis, as well as advanced technologies to interrupt vector-host interactions, are crucial in managing the increased threat posed by this once-neglected disease in humans.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":" ","pages":"e30"},"PeriodicalIF":5.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prospects and challenges of salivary gland tissue engineering in Sjögren's syndrome. 唾液腺组织工程治疗Sjögren综合征的前景与挑战。

IF 5.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2025-09-05 DOI: 10.1017/erm.2025.10017

Xinying Fan, Haodong Su, Xiaoyu Tang, Siyao Yang, Jingjin Hu, Liyun Zhang, Ke Xu, Dan Ma

引用次数: 0