From Medical Imaging to Bioprinted Tissues: The Importance of Workflow Optimisation for Improved Cell Function.

IF 5.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Jesús Manuel Rodríguez Rego, Laura Mendoza Cerezo, Francisco de Asís Iñesta Vaquera, David Picado Tejero, Alfonso Carlos Marcos Romero
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引用次数: 0

Abstract

Background: The rapid advancement of 3D bioprinting is transforming possibilities in tissue engineering and personalised medicine, offering innovative solutions to critical biomedical challenges such as organ shortages and the need for precise 3D cellular models. To fully unlock the potential of this technology, anoptimised and comprehensive workflow is essential.

Methods: This review provides a systematic examination of the bioprinting process, covering key steps from medical image acquisition to the validation of bioprinted structures. The analysis includes biomaterial and cell type selection, conversion of DICOM images into 3D-printable models, and slicing techniques.

Results: Key factors influencing the precision, viability, and clinical relevance of bioprinted tissues are identified. Comparisons between planar and non-planar slicing algorithms highlight their impact on scaffold integrity. The review also discusses advancements in algorithm development, bioprinter technology, and biomaterial optimisation, emphasising their role in enhancing reproducibility and functionality.

Conclusions: This structured review offers actionable insights for researchers and practitioners aiming to refine bioprinting workflows. By integrating improvements across imaging, modelling, and material selection, 3D bioprinting can more effectively support the development of clinically relevant constructs, advancing regenerative medicine and personalisedhealthcare.

从医学成像到生物打印组织:优化工作流程对改善细胞功能的重要性。
背景:3D生物打印的快速发展正在改变组织工程和个性化医疗的可能性,为器官短缺和精确3D细胞模型的需求等关键生物医学挑战提供创新的解决方案。为了充分释放这项技术的潜力,优化和全面的工作流程是必不可少的。方法:本文综述了生物打印过程的系统研究,涵盖了从医学图像采集到生物打印结构验证的关键步骤。分析包括生物材料和细胞类型选择,将DICOM图像转换为3d可打印模型,以及切片技术。结果:确定了影响生物打印组织精度、生存能力和临床相关性的关键因素。平面和非平面切片算法的比较突出了它们对支架完整性的影响。该综述还讨论了算法开发、生物打印机技术和生物材料优化方面的进展,强调了它们在提高可重复性和功能性方面的作用。结论:这篇结构化的综述为旨在改进生物打印工作流程的研究人员和从业者提供了可操作的见解。通过整合成像、建模和材料选择方面的改进,3D生物打印可以更有效地支持临床相关结构的开发,推进再生医学和个性化医疗保健。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Expert Reviews in Molecular Medicine
Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
7.40
自引率
1.60%
发文量
45
期刊介绍: Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.
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