Expert Reviews in Molecular Medicine最新文献_第10页

The immunology and immunotherapy for COVID-19. COVID-19 的免疫学和免疫疗法。

IF 4.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2021-12-17 DOI: 10.1017/erm.2021.30

Yixin Liu, Xinsheng Zhou, Xuan Liu, Xiaotao Jiang

引用次数: 0

Biomacromolecule-mediated pulmonary delivery of siRNA and anti-sense oligos: challenges and possible solutions. 生物大分子介导的siRNA和反义寡核苷酸肺递送:挑战和可能的解决方案。

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2021-12-15 DOI: 10.1017/erm.2021.25

Yaseen Hussain, Jing-Hao Cui, Haroon Khan, Pooyan Makvandi, Waqas Alam

{"title":"Biomacromolecule-mediated pulmonary delivery of siRNA and anti-sense oligos: challenges and possible solutions.","authors":"Yaseen Hussain, Jing-Hao Cui, Haroon Khan, Pooyan Makvandi, Waqas Alam","doi":"10.1017/erm.2021.25","DOIUrl":"https://doi.org/10.1017/erm.2021.25","url":null,"abstract":"Biomacromolecules have gained much attention as biomedicine carriers in recent years due to their remarkable biophysical and biochemical properties including sustainability, non-toxicity, biocompatibility, biodegradability, long systemic circulation time and ability to target. Recent developments in a variety of biological functions of biomacromolecules and progress in the study of biological drug carriers suggest that these carriers may have advantages over carriers of synthetic materials in terms of half-life, durability, protection and manufacturing facility. Despite the full pledge advancements in the applications of biomacromolecules, its clinical use is hindered by certain factors that allow the pre-mature release of loaded cargos before reaching the target site. The delivery therapeutics are degraded by systemic nucleases, cleared by reticulo-endothelial system, cleared by pulmonary mucus cilia or engulfed by lysosome during cellular uptake that has led to the failure of clinical therapy. It clearly indicates that there is a wide range of gaps in the results of experimental work and clinical applications of biomacromolecules. This review focuses mainly on the barriers (intracellular/extracellular) and hurdles to the delivery of biomacromolecules with special emphasis on siRNA as well as the delivery of antisense oligos in multiple pulmonary diseases, particularly focusing on lung cancer. Also, the challenges posed to such delivery and possible solutions have been highlighted.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"23 ","pages":"e22"},"PeriodicalIF":6.2,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39837088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Opportunities and challenges in targeted therapy and immunotherapy for pancreatic cancer. 胰腺癌靶向治疗和免疫治疗的机遇与挑战。

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2021-12-15 DOI: 10.1017/erm.2021.26

Dujuan Cao, Qianqian Song, Junqi Li, Yuanyuan Jiang, Zhimin Wang, Shuangshuang Lu

引用次数: 19

Preclinical models of glioblastoma: limitations of current models and the promise of new developments. 胶质母细胞瘤的临床前模型:当前模型的局限性和新发展的希望。

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2021-12-02 DOI: 10.1017/erm.2021.20

Peng Liu, Scott Griffiths, Damjan Veljanoski, Philippa Vaughn-Beaucaire, Valerie Speirs, Anke Brüning-Richardson

{"title":"Preclinical models of glioblastoma: limitations of current models and the promise of new developments.","authors":"Peng Liu, Scott Griffiths, Damjan Veljanoski, Philippa Vaughn-Beaucaire, Valerie Speirs, Anke Brüning-Richardson","doi":"10.1017/erm.2021.20","DOIUrl":"https://doi.org/10.1017/erm.2021.20","url":null,"abstract":"Glioblastoma (GBM) is the most common and aggressive primary brain tumour, yet little progress has been made towards providing better treatment options for patients diagnosed with this devastating condition over the last few decades. The complex nature of the disease, heterogeneity, highly invasive potential of GBM tumours and until recently, reduced investment in research funding compared with other cancer types, are contributing factors to few advancements in disease management. Survival rates remain low with less than 5% of patients surviving 5 years. Another important contributing factor is the use of preclinical models that fail to fully recapitulate GBM pathophysiology, preventing efficient translation from the lab into successful therapies in the clinic. This review critically evaluates current preclinical GBM models, highlighting advantages and disadvantages of using such models, and outlines several emerging techniques in GBM modelling using animal-free approaches. These novel approaches to a highly complex disease such as GBM show evidence of a more truthful recapitulation of GBM pathobiology with high reproducibility. The resulting advancements in this field will offer new biological insights into GBM and its aetiology with potential to contribute towards the development of much needed improved treatments for GBM in future.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"23 ","pages":"e20"},"PeriodicalIF":6.2,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39682974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Genetic variability of the HPV16 early genes and LCR. Present and future perspectives. HPV16早期基因的遗传变异与LCR。现在和未来的观点。

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2021-12-01 DOI: 10.1017/erm.2021.18

G Bletsa, F Zagouri, G D Amoutzias, M Nikolaidis, E Zografos, P Markoulatos, D Tsakogiannis

{"title":"Genetic variability of the HPV16 early genes and LCR. Present and future perspectives.","authors":"G Bletsa, F Zagouri, G D Amoutzias, M Nikolaidis, E Zografos, P Markoulatos, D Tsakogiannis","doi":"10.1017/erm.2021.18","DOIUrl":"https://doi.org/10.1017/erm.2021.18","url":null,"abstract":"Human papillomavirus 16 (HPV16) infection is the aetiologic factor for the development of cervical dysplasia and is regarded as highly carcinogen, because it is implicated in more than 50% of cervical cancer cases, worldwide. The tumourigenic potential of HPV16 has triggered the extensive sequence analysis of viral genome in order to identify nucleotide variations and amino acid substitutions that influence viral oncogenicity and subsequently the initiation and progression of cervical cancer. Nowadays, specific mutations of HPV16 DNA have been associated with an increased risk of high-grade squamous intraepithelial lesions and invasive cervical cancer (ICC) development, including E6: Q14H, H78Y, L83V, Ε7: N29S, S63F, E2: H35Q, P219S, T310K, E5: I65V, whereas highly conserved regions of viral DNA have been extensively characterised. In addition, numerous novel HPV16 mutations are observed among the studied populations from various geographic regions, hence advocating that different HPV16 strains seem to emerge with different tumourigenic capacities. The present review focuses on the variability of the early genes and the long control region, emphasising on the association of specific mutations with the development of severe dysplasia. Finally, it evaluates whether specific regions of HPV16 DNA are able to serve as valuable biomarkers for cervical cancer risk.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"23 ","pages":"e19"},"PeriodicalIF":6.2,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39946896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

DLX6-AS1: a putative lncRNA candidate in multiple human cancers. DLX6-AS1:多种人类癌症的推定lncRNA候选者

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2021-11-26 DOI: 10.1017/erm.2021.17

Mohsen Sheykhhasan, Yaghoub Ahmadyousefi, Reihaneh Seyedebrahimi, Hamid Tanzadehpanah, Hamed Manoochehri, Paola Dama, Nashmin Fayazi Hosseini, Mohammad Akbari, Mohsen Eslami Farsani

引用次数: 12

Alveolar macrophages: novel therapeutic targets for respiratory diseases. 肺泡巨噬细胞:呼吸系统疾病的新治疗靶点。

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2021-11-26 DOI: 10.1017/erm.2021.21

Pamelia N Lim, Maritza M Cervantes, Linh K Pham, Alissa C Rothchild

{"title":"Alveolar macrophages: novel therapeutic targets for respiratory diseases.","authors":"Pamelia N Lim, Maritza M Cervantes, Linh K Pham, Alissa C Rothchild","doi":"10.1017/erm.2021.21","DOIUrl":"https://doi.org/10.1017/erm.2021.21","url":null,"abstract":"Alveolar macrophages (AMs) are lung-resident myeloid cells that sit at the interface of the airway and lung tissue. Under homeostatic conditions, their primary function is to clear debris, dead cells and excess surfactant from the airways. They also serve as innate pulmonary sentinels for respiratory pathogens and environmental airborne particles and as regulators of pulmonary inflammation. However, they have not typically been viewed as primary therapeutic targets for respiratory diseases. Here, we discuss the role of AMs in various lung diseases, explore the potential therapeutic strategies to target these innate cells and weigh the potential risks and challenges of such therapies. Additionally, in the context of the COVID-19 pandemic, we examine the role AMs play in severe disease and the therapeutic strategies that have been harnessed to modulate their function and protect against severe lung damage. There are many novel approaches in development to target AMs, such as inhaled antibiotics, liposomal and microparticle delivery systems, and host-directed therapies, which have the potential to provide critical treatment to patients suffering from severe respiratory diseases, yet there is still much work to be done to fully understand the possible benefits and risks of such approaches.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"23 ","pages":"e18"},"PeriodicalIF":6.2,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39659677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Tumour microenvironment: a non-negligible driver for epithelial-mesenchymal transition in colorectal cancer. 肿瘤微环境:结直肠癌上皮-间质转化的不可忽视的驱动因素。

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2021-11-11 DOI: 10.1017/erm.2021.13

Lei Han, Shuyi Wang, Chen Wei, Yan Fang, Sihao Huang, Tailang Yin, Bin Xiong, Chaogang Yang

{"title":"Tumour microenvironment: a non-negligible driver for epithelial-mesenchymal transition in colorectal cancer.","authors":"Lei Han, Shuyi Wang, Chen Wei, Yan Fang, Sihao Huang, Tailang Yin, Bin Xiong, Chaogang Yang","doi":"10.1017/erm.2021.13","DOIUrl":"https://doi.org/10.1017/erm.2021.13","url":null,"abstract":"Cancer remains the leading cause of death worldwide, and metastasis is still the major cause of treatment failure for cancer patients. Epithelial-mesenchymal transition (EMT) has been shown to play a critical role in the metastasis cascade of epithelium-derived carcinoma. Tumour microenvironment (TME) refers to the local tissue environment in which tumour cells produce and live, including not only tumour cells themselves, but also fibroblasts, immune and inflammatory cells, glial cells and other cells around them, as well as intercellular stroma, micro vessels and infiltrated biomolecules from the nearby areas, which has been proved to widely participate in the occurrence and progress of cancer. Emerging and accumulating studies indicate that, on one hand, mesenchymal cells in TME can establish 'crosstalk' with tumour cells to regulate their EMT programme; on the other, EMT-tumour cells can create a favourable environment for their own growth via educating stromal cells. Recently, our group has conducted a series of studies on the interaction between tumour-associated macrophages (TAMs) and colorectal cancer (CRC) cells in TME, confirming that the interaction between TAMs and CRC cells mediated by cytokines or exosomes can jointly promote the metastasis of CRC by regulating the EMT process of tumour cells and the M2-type polarisation process of TAMs. Herein, we present an overview to describe the current knowledge about EMT in cancer, summarise the important role of TME in EMT, and provide an update on the mechanisms of TME-induced EMT in CRC, aiming to provide new ideas for understanding and resisting tumour metastasis.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"23 ","pages":"e16"},"PeriodicalIF":6.2,"publicationDate":"2021-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39607862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Female fertility under the impact of COVID-19 pandemic: a narrative review 新冠肺炎大流行影响下的女性生育率：叙述性综述

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2021-11-02 DOI: 10.1017/erm.2021.19

Meng Wang, Bo Zhang, L. Jin

引用次数: 2

Integrins, cadherins and channels in cartilage mechanotransduction: perspectives for future regeneration strategies. 软骨机械转导中的整合素、钙粘蛋白和通道：对未来再生策略的展望。

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2021-10-27 DOI: 10.1017/erm.2021.16

Martin Philipp Dieterle, Ayman Husari, Bernd Rolauffs, Thorsten Steinberg, Pascal Tomakidi

{"title":"Integrins, cadherins and channels in cartilage mechanotransduction: perspectives for future regeneration strategies.","authors":"Martin Philipp Dieterle, Ayman Husari, Bernd Rolauffs, Thorsten Steinberg, Pascal Tomakidi","doi":"10.1017/erm.2021.16","DOIUrl":"10.1017/erm.2021.16","url":null,"abstract":"Articular cartilage consists of hyaline cartilage, is a major constituent of the human musculoskeletal system and has critical functions in frictionless joint movement and articular homoeostasis. Osteoarthritis (OA) is an inflammatory disease of articular cartilage, which promotes joint degeneration. Although it affects millions of people, there are no satisfying therapies that address this disease at the molecular level. Therefore, tissue regeneration approaches aim at modifying chondrocyte biology to mitigate the consequences of OA. This requires appropriate biochemical and biophysical stimulation of cells. Regarding the latter, mechanotransduction of chondrocytes and their precursor cells has become increasingly important over the last few decades. Mechanotransduction is the transformation of external biophysical stimuli into intracellular biochemical signals, involving sensor molecules at the cell surface and intracellular signalling molecules, so-called mechano-sensors and -transducers. These signalling events determine cell behaviour. Mechanotransducing ion channels and gap junctions additionally govern chondrocyte physiology. It is of great scientific and medical interest to induce a specific cell behaviour by controlling these mechanotransduction pathways and to translate this knowledge into regenerative clinical therapies. This review therefore focuses on the mechanotransduction properties of integrins, cadherins and ion channels in cartilaginous tissues to provide perspectives for cartilage regeneration.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"23 ","pages":"e14"},"PeriodicalIF":6.2,"publicationDate":"2021-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39562843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18