Expert Reviews in Molecular Medicine最新文献_第10页

Lactate, histone lactylation and cancer hallmarks. 乳酸、组蛋白乳酸化和癌症标志。

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2023-01-09 DOI: 10.1017/erm.2022.42

Xinyu Lv, Yingying Lv, Xiaofeng Dai

引用次数: 9

Precision medicine for long QT syndrome: patient-specific iPSCs take the lead. 长QT综合征的精准医疗:患者特异性iPSCs领先。

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2023-01-04 DOI: 10.1017/erm.2022.43

Yang Yu, Isabelle Deschenes, Ming-Tao Zhao

{"title":"Precision medicine for long QT syndrome: patient-specific iPSCs take the lead.","authors":"Yang Yu, Isabelle Deschenes, Ming-Tao Zhao","doi":"10.1017/erm.2022.43","DOIUrl":"https://doi.org/10.1017/erm.2022.43","url":null,"abstract":"Long QT syndrome (LQTS) is a detrimental arrhythmia syndrome mainly caused by dysregulated expression or aberrant function of ion channels. The major clinical symptoms of ventricular arrhythmia, palpitations and syncope vary among LQTS subtypes. Susceptibility to malignant arrhythmia is a result of delayed repolarisation of the cardiomyocyte action potential (AP). There are 17 distinct subtypes of LQTS linked to 15 autosomal dominant genes with monogenic mutations. However, due to the presence of modifier genes, the identical mutation may result in completely different clinical manifestations in different carriers. In this review, we describe the roles of various ion channels in orchestrating APs and discuss molecular aetiologies of various types of LQTS. We highlight the usage of patient-specific induced pluripotent stem cell (iPSC) models in characterising fundamental mechanisms associated with LQTS. To mitigate the outcomes of LQTS, treatment strategies are initially focused on small molecules targeting ion channel activities. Next-generation treatments will reap the benefits from development of LQTS patient-specific iPSC platform, which is bolstered by the state-of-the-art technologies including whole-genome sequencing, CRISPR genome editing and machine learning. Deep phenotyping and high-throughput drug testing using LQTS patient-specific cardiomyocytes herald the upcoming precision medicine in LQTS.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"25 ","pages":"e5"},"PeriodicalIF":6.2,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/57/c1/S1462399422000436a.PMC10302164.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9707738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Modelling Alzheimer's disease using human brain organoids: current progress and challenges. 用人脑类器官模拟阿尔茨海默病:目前的进展和挑战。

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2022-12-15 DOI: 10.1017/erm.2022.40

Mario Yanakiev, Olivia Soper, Daniel A Berg, Eunchai Kang

{"title":"Modelling Alzheimer's disease using human brain organoids: current progress and challenges.","authors":"Mario Yanakiev, Olivia Soper, Daniel A Berg, Eunchai Kang","doi":"10.1017/erm.2022.40","DOIUrl":"https://doi.org/10.1017/erm.2022.40","url":null,"abstract":"Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by gradual memory loss and declining cognitive and executive functions. AD is the most common cause of dementia, affecting more than 50 million people worldwide, and is a major health concern in society. Despite decades of research, the cause of AD is not well understood and there is no effective curative treatment so far. Therefore, there is an urgent need to increase understanding of AD pathophysiology in the hope of developing a much-needed cure. Dissecting the cellular and molecular mechanisms of AD pathogenesis has been challenging as the most commonly used model systems such as transgenic animals and two-dimensional neuronal culture do not fully recapitulate the pathological hallmarks of AD. The recent advent of three-dimensional human brain organoids confers unique opportunities to study AD in a humanised model system by encapsulating many aspects of AD pathology. In the present review, we summarise the studies of AD using human brain organoids that recapitulate the major pathological components of AD including amyloid-β and tau aggregation, neuroinflammation, mitochondrial dysfunction, oxidative stress and synaptic and circuitry dysregulation. Additionally, the current challenges and future directions of the brain organoids modelling system are discussed.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"25 ","pages":"e3"},"PeriodicalIF":6.2,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10741425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Oral microbiota in cancer: could the bad guy turn good with application of polyphenols? 口腔微生物群在癌症中的作用:多酚的应用能让坏家伙变好吗?

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2022-12-13 DOI: 10.1017/erm.2022.39

Mariya Gover Antoniraj, Kasi Pandima Devi, Ioana Berindan-Neagoe, Seyed Fazel Nabavi, Hamid Reza Khayat Kashani, Safieh Aghaabdollahian, Farzaneh Afkhami, Philippe Jeandet, Zahra Lorigooini, Maryam Khayatkashani, Seyed Mohammad Nabavi

{"title":"Oral microbiota in cancer: could the bad guy turn good with application of polyphenols?","authors":"Mariya Gover Antoniraj, Kasi Pandima Devi, Ioana Berindan-Neagoe, Seyed Fazel Nabavi, Hamid Reza Khayat Kashani, Safieh Aghaabdollahian, Farzaneh Afkhami, Philippe Jeandet, Zahra Lorigooini, Maryam Khayatkashani, Seyed Mohammad Nabavi","doi":"10.1017/erm.2022.39","DOIUrl":"https://doi.org/10.1017/erm.2022.39","url":null,"abstract":"The human oral cavity is comprised of dynamic and polynomial microbes which uniquely reside in the microenvironments of oral cavities. The cumulative functions of the symbiotic microbial communities maintain normal homeostasis; however, a shifted microbiota yields a dysbiosis state, which produces local and systemic diseases including dental caries, periodontitis, cancer, obesity and diabetes. Recent research reports claim that an association occurs between oral dysbiosis and the progression of different types of cancers including oral, gastric and pancreatic ones. Different mechanisms are proposed for the development of cancer, such as induction of inflammatory reactions, production of carcinogenic materials and alteration of the immune system. Medications are available to treat these associated diseases; however, the current strategies may further worsen the disease by unwanted side effects. Natural-derived polyphenol molecules significantly inhibit a wide range of systemic diseases with fewer side effects. In this review, we have displayed the functions of the oral microbes and we have extended the report regarding the role of polyphenols in oral microbiota to maintain healthy conditions and prevention of diseases with emphasis on the treatment of oral microbiota-associated cancer.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"25 ","pages":"e1"},"PeriodicalIF":6.2,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10506426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Irisin enhances longevity by boosting SIRT1, AMPK, autophagy and telomerase. 鸢尾素通过促进SIRT1、AMPK、自噬和端粒酶来延长寿命。

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2022-12-12 DOI: 10.1017/erm.2022.41

Begoña Sánchez, Mario F Muñoz-Pinto, Mercedes Cano

{"title":"Irisin enhances longevity by boosting SIRT1, AMPK, autophagy and telomerase.","authors":"Begoña Sánchez, Mario F Muñoz-Pinto, Mercedes Cano","doi":"10.1017/erm.2022.41","DOIUrl":"https://doi.org/10.1017/erm.2022.41","url":null,"abstract":"Ageing is characterised by the accumulation of molecular and cellular damage through time, leading to a decline in physical and mental abilities. Currently, society has experienced a rapid increase in life expectancy, which has led to an increase in age-associated diseases. Therefore, it is crucial to study the process of ageing to guarantee the best conditions in the final stages of life. In recent years, interest has increased in a myokine known as irisin, which is secreted during physical exercise. This polypeptide hormone is produced by various organs, mainly muscle, and once it is released into the blood, it performs a wide variety of functions that are involved in metabolic control and may be relevant during some of the diseases associated with ageing. The aim of this review is to highlight the recent studies of irisin, such as its mechanism of expression, blood release, distribution, tissue target and participation in various cellular metabolic reactions and the relationship with key anti-ageing pathways such as adenosine monophosphate-activated protein kinase, silent information regulator T 1, autophagy and telomerase. In conclusion, irisin is a key player during the ageing process and it could be a novel target molecule for the therapeutic approach to boost longevity pathways. However, more research will be necessary to use this promising hormone for this gain.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"25 ","pages":"e4"},"PeriodicalIF":6.2,"publicationDate":"2022-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10756659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Hepatitis B virus DNA methylation and its potential role in chronic hepatitis B. 乙型肝炎病毒DNA甲基化及其在慢性乙型肝炎中的潜在作用

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2022-11-16 DOI: 10.1017/erm.2022.38

Wei Feng Low, Yun Fong Ngeow, Jack Bee Chook, Kok Keng Tee, Seng-Kai Ong, Suat Cheng Peh, Jan Jin Bong, Rosmawati Mohamed

引用次数: 0

Effects of lifespan-extending interventions on cognitive healthspan. 延长寿命干预对认知健康的影响。

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2022-11-15 DOI: 10.1017/erm.2022.36

Luka Culig, Burcin Duan Sahbaz, Vilhelm A Bohr

{"title":"Effects of lifespan-extending interventions on cognitive healthspan.","authors":"Luka Culig, Burcin Duan Sahbaz, Vilhelm A Bohr","doi":"10.1017/erm.2022.36","DOIUrl":"https://doi.org/10.1017/erm.2022.36","url":null,"abstract":"Ageing is known to be the primary risk factor for most neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and Huntington's disease. They are currently incurable and worsen over time, which has broad implications in the context of lifespan and healthspan extension. Adding years to life and even to physical health is suboptimal or even insufficient, if cognitive ageing is not adequately improved. In this review, we will examine how interventions that have the potential to extend lifespan in animals affect the brain, and if they would be able to thwart or delay the development of cognitive dysfunction and/or neurodegeneration. These interventions range from lifestyle (caloric restriction, physical exercise and environmental enrichment) through pharmacological (nicotinamide adenine dinucleotide precursors, resveratrol, rapamycin, metformin, spermidine and senolytics) to epigenetic reprogramming. We argue that while many of these interventions have clear potential to improve cognitive health and resilience, large-scale and long-term randomised controlled trials are needed, along with studies utilising washout periods to determine the effects of supplementation cessation, particularly in aged individuals.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"25 ","pages":"e2"},"PeriodicalIF":6.2,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10850377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roles of TGF-β in cancer hallmarks and emerging onco-therapeutic design. TGF-β在癌症标志物中的作用和新出现的肿瘤联合治疗设计。

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2022-11-08 DOI: 10.1017/erm.2022.37

Xiaofeng Dai, Dong Hua, Xiaoxia Lu

{"title":"Roles of TGF-β in cancer hallmarks and emerging onco-therapeutic design.","authors":"Xiaofeng Dai, Dong Hua, Xiaoxia Lu","doi":"10.1017/erm.2022.37","DOIUrl":"https://doi.org/10.1017/erm.2022.37","url":null,"abstract":"Transforming growth factor-beta (TGF-β) is a double-edged sword in cancer treatment because of its pivotal yet complex and roles played during cancer initiation/development. Current anti-cancer strategies involving TGF-β largely view TGF-β as an onco-therapeutic target that not only substantially hinders its full utilisation for cancer control, but also considerably restricts innovations in this field. Thereby, how to take advantages of therapeutically favourable properties of TGF-β for cancer management represents an interesting and less investigated problem. Here, by categorising cancer hallmarks into four critical transition events and one enabling characteristic controlling cancer initiation and progression, and delineating TGF-β complexities according to these cancer traits, we identify the suppressive role of TGF-β in tumour initiation and early-stage progression and its promotive functionalities in cancer metastasis as well as other cancer hallmarks. We also propose the feasibility and possible scenarios of combining cold atmospheric plasma (CAP) with onco-therapeutics utilising TGF-β for cancer control given the intrinsic properties of CAP against cancer hallmarks.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"24 ","pages":"e42"},"PeriodicalIF":6.2,"publicationDate":"2022-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10498489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Preclinical activities of Cassia tora Linn against aging-related diseases. 决明子抗衰老相关疾病的临床前研究。

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2022-10-25 DOI: 10.1017/erm.2022.33

Sun-Young Hwang, Chang-Su Na, Byeong Cheol Moon, Jung-Hyun Shim, Mee-Hyun Lee

引用次数: 0

Metabolic signatures of immune cells in chronic kidney disease. 慢性肾脏疾病免疫细胞的代谢特征。

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2022-10-21 DOI: 10.1017/erm.2022.35

Jie Li, Yi Yang, Yanan Wang, Qing Li, Fan He

引用次数: 6