Competing Endogenous RNAs (ceRNAs) in Colorectal Cancer: A Review.

IF 4.5 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Expert Reviews in Molecular Medicine Pub Date : 2022-06-24 DOI:10.1017/erm.2022.21

Mohammad Hossein Akhbari, Zahra Zafari, Mohsen Sheykhhasan

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引用次数: 10

Abstract

Colorectal cancer (CRC) is a common type of cancer and the second leading cause of cancer-related deaths worldwide. Competing endogenous RNAs (ceRNAs) that contain microRNA response elements (MREs) are involved in CRC progression. They can compete with microRNAs (miRNAs) via their MREs, which can combine non-coding and coding RNAs via complex ceRNA networks. This molecular interaction has the potential to affect a wide variety of biological processes, and many cancers can occur as a result of an imbalanced ceRNA network. Recent research indicates that numerous dysregulated RNAs in CRC may function as ceRNAs, regulating multiple biological functions of the tumour, including proliferation, apoptosis, metastasis, invasion and migration. In this review, we discuss the role of protein-coding and non-coding RNAs, such as long non-coding RNAs, circular RNAs and pseudogenes, in the occurrence of ceRNA networks in CRC, and their function in cancer-related pathways, such as Wnt/β-catenin, mitogen-activated protein kinase and transforming growth factor-β signalling pathways. Additionally, we discuss validated ceRNAs associated with CRC biological functions and their potential role as novel prognostic and diagnostic biomarkers. Examining the role of ceRNAs in CRC sheds new light on cancer treatment and pathogenesis.

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结直肠癌中竞争内源性rna (ceRNAs)的研究进展

结直肠癌(CRC)是一种常见的癌症类型，也是全球癌症相关死亡的第二大原因。含有microRNA应答元件(MREs)的竞争性内源性rna (ceRNAs)参与了CRC的进展。它们可以通过MREs与microrna (mirna)竞争，MREs可以通过复杂的ceRNA网络将非编码rna和编码rna结合起来。这种分子相互作用有可能影响各种各样的生物过程，许多癌症可能是由于ceRNA网络不平衡而发生的。最近的研究表明，CRC中许多失调的rna可能具有cerna的功能，调节肿瘤的多种生物学功能，包括增殖、凋亡、转移、侵袭和迁移。在这篇综述中，我们讨论了蛋白质编码和非编码rna，如长链非编码rna，环状rna和假基因，在CRC中ceRNA网络的发生中的作用，以及它们在癌症相关通路中的功能，如Wnt/β-catenin，丝裂原活化蛋白激酶和转化生长因子-β信号通路。此外，我们还讨论了与结直肠癌生物学功能相关的经过验证的cerna及其作为新型预后和诊断生物标志物的潜在作用。研究cerna在结直肠癌中的作用为癌症的治疗和发病机制提供了新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

7.40

自引率

1.60%

发文量

期刊介绍： Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.