Expert Reviews in Molecular Medicine最新文献_第2页

Mechanism and application of immune interventions in intracerebral haemorrhage. 免疫干预在脑出血中的机制和应用。

IF 4.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2024-10-08 DOI: 10.1017/erm.2024.22

Xiaoxiao Xu, Yuanwei Li, Shiling Chen, Xuan Wu, Jiarui Li, Gaigai Li, Zhouping Tang

{"title":"Mechanism and application of immune interventions in intracerebral haemorrhage.","authors":"Xiaoxiao Xu, Yuanwei Li, Shiling Chen, Xuan Wu, Jiarui Li, Gaigai Li, Zhouping Tang","doi":"10.1017/erm.2024.22","DOIUrl":"10.1017/erm.2024.22","url":null,"abstract":"Despite stroke being one of the major and increasing burdens to global health, therapeutic interventions in intracerebral haemorrhage (ICH) continue to be a challenge. Existing treatment methods, such as surgery and conservative treatment have shown limited efficacy in improving the prognosis of ICH. However, more and more studies show that exploring the specific process of immune response after ICH and taking corresponding immunotherapy may have a definite significance to improve the prognosis of cerebral haemorrhage. Therefore, immune interventions are currently under consideration as therapeutic interventions in the ICH. In this review, we aim to clarify unique immunological features of stroke, and consider the evidence for immune interventions. In acute ICH, activation of glial cells and cell death products trigger an inflammatory cascade that damages vessels and the parenchyma within minutes to hours of the haemorrhage. Immune interventions that ameliorate brain inflammation, vascular permeability and tissue oedema should be administered promptly to reduce acute immune destruction and avoid subsequent immunosuppression. A deeper understanding of the immune mechanisms involved in ICH is likely to lead to successful immune interventions.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"26 ","pages":"e22"},"PeriodicalIF":4.5,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11488334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ATXN3: a multifunctional protein involved in the polyglutamine disease spinocerebellar ataxia type 3. ATXN3：一种与多聚谷氨酰胺病脊髓小脑共济失调 3 型有关的多功能蛋白质。

IF 4.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2024-09-25 DOI: 10.1017/erm.2024.10

Esperanza Hernández-Carralero, Grégoire Quinet, Raimundo Freire

引用次数: 0

Epigenetic tuning of tumour-associated macrophages (TAMs): a potential approach in hepatocellular carcinoma (HCC) immunotherapy. 肿瘤相关巨噬细胞（TAMs）的表观遗传学调整：肝细胞癌（HCC）免疫疗法的一种潜在方法。

IF 4.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2024-09-25 DOI: 10.1017/erm.2024.9

Israa M Helal, Monica A Kamal, Mostafa K Abd El-Aziz, Hend M El Tayebi

{"title":"Epigenetic tuning of tumour-associated macrophages (TAMs): a potential approach in hepatocellular carcinoma (HCC) immunotherapy.","authors":"Israa M Helal, Monica A Kamal, Mostafa K Abd El-Aziz, Hend M El Tayebi","doi":"10.1017/erm.2024.9","DOIUrl":"10.1017/erm.2024.9","url":null,"abstract":"Recent development in immunotherapy for cancer treatment has substantiated to be more effective than most of the other treatments. Immunity is the first line of defence of the body; nevertheless, cancerous cells can manipulate immunity compartments to play several roles in tumour progression. Tumour-associated macrophages (TAMs), one of the most dominant components in the tumour microenvironment, are recognized as anti-tumour suppressors. Unfortunately, the complete behaviour of TAMs is still unclear and understudied. TAM density is directly correlated with the progression and poor prognosis of hepatocellular carcinoma (HCC), therefore studying TAMs from different points of view passing by all the factors that may affect its existence, polarization, functions and repolarization are of great importance. Different epigenetic regulations were reported to have a direct relation with both HCC and TAMs. Here, this review discusses different epigenetic regulations that can affect TAMs in HCC whether positively or negatively.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"26 ","pages":"e18"},"PeriodicalIF":4.5,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PARP enzymes and mono-ADP-ribosylation: advancing the connection from interferon-signalling to cancer biology. PARP酶和单ADP-核糖基化：推进从干扰素信号到癌症生物学的联系。

IF 4.5 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2024-08-27 DOI: 10.1017/erm.2024.13

Barbara Morone, Giovanna Grimaldi

引用次数: 0

Specific and shared biological functions of PARP2 – is PARP2 really a lil’ brother of PARP1? PARP2 的特定和共享生物功能--PARP2 真的是 PARP1 的小弟弟吗？

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2024-05-03 DOI: 10.1017/erm.2024.14

Magdolna Szántó, José Yélamos, Péter Bai

引用次数: 0

The multifaceted functions of long non-coding RNA HOTAIR in neuropathologies and its potential as a prognostic marker and therapeutic biotarget 长非编码 RNA HOTAIR 在神经病变中的多方面功能及其作为预后标记和治疗生物靶点的潜力

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2024-04-29 DOI: 10.1017/erm.2024.11

Faraz Ahmad, Ravi Sudesh, Atheeq Toufeeq Ahmed, Mohanapriya Arumugam, Darin Mansor Mathkor, Shafiul Haque

{"title":"The multifaceted functions of long non-coding RNA HOTAIR in neuropathologies and its potential as a prognostic marker and therapeutic biotarget","authors":"Faraz Ahmad, Ravi Sudesh, Atheeq Toufeeq Ahmed, Mohanapriya Arumugam, Darin Mansor Mathkor, Shafiul Haque","doi":"10.1017/erm.2024.11","DOIUrl":"https://doi.org/10.1017/erm.2024.11","url":null,"abstract":"Long non-coding RNAs (lncRNAs) are progressively being perceived as prominent molecular agents controlling multiple aspects of neuronal (patho)physiology. Amongst these is the HOX transcript antisense intergenic RNA, often abbreviated as HOTAIR. HOTAIR epigenetically regulates its target genes via its interaction with two different chromatin-modifying agents; histone methyltransferase polycomb-repressive complex 2 and histone demethylase lysine-specific demethylase 1. Parenthetically, HOTAIR elicits trans-acting sponging function against multiple micro-RNA species. Oncological research studies have confirmed the pathogenic functions of HOTAIR in multiple cancer types, such as gliomas and proposed it as a pro-oncological lncRNA. In fact, its expression has been suggested to be a predictor of the severity/grade of gliomas, and as a prognostic biomarker. Moreover, a propound influence of HOTAIR in other aspects of brain heath and disease states is just beginning to be unravelled. The objective of this review is to recapitulate all the relevant data pertaining to the regulatory roles of HOTAIR in neuronal (patho)physiology. To this end, we discuss the pathogenic mechanisms of HOTAIR in multiple neuronal diseases, such as neurodegeneration, traumatic brain injury and neuropsychiatric disorders. Finally, we also summarize the results from the studies incriminating HOTAIR in the pathogeneses of gliomas and other brain cancers. Implications of HOTAIR serving as a suitable therapeutic target in neuropathologies are also discussed.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"5 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140809433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding bioactive signals of the RNA secretome: the cell-free messenger RNA catalogue 解码 RNA 分泌组的生物活性信号：无细胞信使 RNA 目录

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2024-04-29 DOI: 10.1017/erm.2024.12

Rhys E. De Sota, Stephen R. Quake, John J. Sninsky, Shusuke Toden

{"title":"Decoding bioactive signals of the RNA secretome: the cell-free messenger RNA catalogue","authors":"Rhys E. De Sota, Stephen R. Quake, John J. Sninsky, Shusuke Toden","doi":"10.1017/erm.2024.12","DOIUrl":"https://doi.org/10.1017/erm.2024.12","url":null,"abstract":"Despite gene-expression profiling being one of the most common methods to evaluate molecular dysregulation in tissues, the utilization of cell-free messenger RNA (cf-mRNA) as a blood-based non-invasive biomarker analyte has been limited compared to other RNA classes. Recent advancements in low-input RNA-sequencing and normalization techniques, however, have enabled characterization as well as accurate quantification of cf-mRNAs allowing direct pathological insights. The molecular profile of the cell-free transcriptome in multiple diseases has subsequently been characterized including, prenatal diseases, neurological disorders, liver diseases and cancers suggesting this biological compartment may serve as a disease agnostic platform. With mRNAs packaged in a myriad of extracellular vesicles and particles, these signals may be used to develop clinically actionable, non-invasive disease biomarkers. Here, we summarize the recent scientific developments of extracellular mRNA, biology of extracellular mRNA carriers, clinical utility of cf-mRNA as disease biomarkers, as well as proposed functions in cell and tissue pathophysiology.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"75 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140809736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AAV-mediated gene therapies for glaucoma and uveitis: are we there yet? AAV 介导的青光眼和葡萄膜炎基因疗法：我们成功了吗？

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2024-04-15 DOI: 10.1017/erm.2024.4

Brenda Castro, Jason C. Steel, Christopher J. Layton

{"title":"AAV-mediated gene therapies for glaucoma and uveitis: are we there yet?","authors":"Brenda Castro, Jason C. Steel, Christopher J. Layton","doi":"10.1017/erm.2024.4","DOIUrl":"https://doi.org/10.1017/erm.2024.4","url":null,"abstract":"Glaucoma and uveitis are non-vascular ocular diseases which are among the leading causes of blindness and visual loss. These conditions have distinct characteristics and mechanisms but share a multifactorial and complex nature, making their management challenging and burdensome for patients and clinicians. Furthermore, the lack of symptoms in the early stages of glaucoma and the diverse aetiology of uveitis hinder timely and accurate diagnoses, which are a cause of poor visual outcomes under both conditions. Although current treatment is effective in most cases, it is often associated with low patient adherence and adverse events, which directly impact the overall therapeutic success. Therefore, long-lasting alternatives with improved safety and efficacy are needed. Gene therapy, particularly utilising adeno-associated virus (AAV) vectors, has emerged as a promising approach to address unmet needs in these diseases. Engineered capsids with enhanced tropism and lower immunogenicity have been proposed, along with constructs designed for targeted and controlled expression. Additionally, several pathways implicated in the pathogenesis of these conditions have been targeted with single or multigene expression cassettes, gene editing and silencing approaches. This review discusses strategies employed in AAV-based gene therapies for glaucoma and non-infectious uveitis and provides an overview of current progress and future directions.","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":"241 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140572974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of diabetes mellitus on osteoarthritis: a scoping review on biomarkers 糖尿病对骨关节炎的影响：生物标志物范围综述

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2024-04-12 DOI: 10.1017/erm.2024.7

Shi Rui Seow, Sumaiyah Mat, Amalina Ahmad Azam, Nor Fadilah Rajab, Intan Safinar Ismail, Devinder Kaur Ajit Singh, Suzana Shahar, Maw Pin Tan, Francis Berenbaum

引用次数: 0

Stability-based approaches in chemoproteomics 基于稳定性的化学蛋白质组学方法

IF 6.2 2区医学

Expert Reviews in Molecular Medicine Pub Date : 2024-04-12 DOI: 10.1017/erm.2024.6

Amy L. George, Maria Emilia Dueñas, José Luis Marín-Rubio, Matthias Trost

引用次数: 0