Immunomodulatory Effects of Pelargonium sidoides Extract (EPs7630) in the Treatment of Acute Rhinosinusitis.

IF 5.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Aleksandar Perić, Sandra Vezmar Kovačević, Aleksandra Barać, Aneta Perić, Danilo Vojvodić
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引用次数: 0

Abstract

Background: In this short narrative review, we would like to discuss the immunomodulatory effects of South African geranium (Pelargonium sidoides) root extract EPs7630 in treating acute rhinosinusitis. The plant has been used for centuries to treat respiratory tract inflammation, such as sinusitis, pharyngitis and bronchitis. South African geranium is rich in polyphenols, flavonoids, tannins, diterpenes and proanthocyanidins, but the main constituent is a type of coumarin called 'umckalin' (6-hydroxy-5,5-dimethoxy-coumarin). The substance is standardised as an aqueous-ethanolic extract from the root of this plant under the code name EPs7630.

Methods: The article presents the results of in vitro and in vivo studies of administering this herbal drug in acute viral, post-viral and bacterial rhinosinusitis. The focus is on the immunomodulatory effects of EPs7630 during the therapy of this acute inflammation of the nasal mucosa.

Results: According to the results of some studies, EPs7630 stimulates monocyte-dependent activity and inhibits neutrophil-dependent chemokine activity. However, given the small number of studies, the level of evidence is low, implying the need for new research.

Conclusion: Particular attention should be paid to the effect of EPs7630 on bradykinin, the mediator that triggers most inflammatory processes in acute rhinosinusitis.

天竺葵皂苷提取物(EPs7630)治疗急性鼻窦炎的免疫调节作用。
背景:在这篇简短的综述中,我们想讨论南非天竺葵(Pelargonium sidoides)根提取物EPs7630治疗急性鼻窦炎的免疫调节作用。几个世纪以来,这种植物一直被用来治疗呼吸道炎症,如鼻窦炎、咽炎和支气管炎。南非天竺葵富含多酚、类黄酮、单宁、二萜和原花青素,但其主要成分是一种名为“乌姆卡林”的香豆素(6-羟基-5,5-二甲氧基香豆素)。该物质被标准化为这种植物根部的水乙醇提取物,代号为EPs7630。方法:采用体外和体内研究方法对急性病毒性鼻窦炎、病毒性后鼻窦炎和细菌性鼻窦炎进行治疗。重点是EPs7630在治疗这种急性鼻黏膜炎症期间的免疫调节作用。结果:根据一些研究结果,EPs7630刺激单核细胞依赖性活性,抑制中性粒细胞依赖性趋化因子活性。然而,由于研究数量较少,证据水平较低,这意味着需要进行新的研究。结论:应特别关注EPs7630对缓激肽的影响,缓激肽是引发急性鼻窦炎大多数炎症过程的介质。
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来源期刊
Expert Reviews in Molecular Medicine
Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
7.40
自引率
1.60%
发文量
45
期刊介绍: Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.
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