先天免疫细胞和炎症介质在登革热感染中的相互作用:一种不断发展的治疗范式。

IF 5.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Akrite Mishra, Sudeshna Mallik, Pritam Saha, Sankhanil Dhara, Sumi Mukhopadhyay
{"title":"先天免疫细胞和炎症介质在登革热感染中的相互作用:一种不断发展的治疗范式。","authors":"Akrite Mishra, Sudeshna Mallik, Pritam Saha, Sankhanil Dhara, Sumi Mukhopadhyay","doi":"10.1017/erm.2025.10021","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Dengue is one of the neglected tropical diseases endemic to tropical and subtropical regions worldwide. Due to its substantial disease burden, this arthropod-borne viral disease is a significant public health concern. Infection involving any one of the five distinct serotypes causes a wide range of disease manifestations, from self-limiting to mild to life-threatening outcomes.</p><p><strong>Methods: </strong>The current review comprehensively provides an overview of dengue virus-mediated immunopathogenesis with special emphasis on innate immune cells, their pathogen recognition sensors and their association with pathogenesis. Additionally we have also briefly discussed recent advancements in vaccine studies and the development of therapeutics over the last decade.</p><p><strong>Results: </strong>The immunological response to dengue virus involves an amalgamation of a variety of innate cells and inflammatory mediators, resulting in the favouring or dampening of the antiviral response. Viral components activating innate cells through pattern recognition receptors, such as Toll-like receptors, retinoic-acid-inducible gene I and melanoma differentiation-associated gene 5, are vital in eliciting a downstream signalling cascade, which culminates in the secretion of inflammatory proteins.</p><p><strong>Conclusion: </strong>Understanding the specific mechanisms involved in the acute phase of infection is indispensable for detecting differential biomarkers against flavivirus infections as well as designing more efficient therapeutic agents and vaccines.</p>","PeriodicalId":50462,"journal":{"name":"Expert Reviews in Molecular Medicine","volume":" ","pages":"e32"},"PeriodicalIF":5.5000,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Interplay between innate immune cells and inflammatory mediators in dengue infection: an evolving therapeutic paradigm.\",\"authors\":\"Akrite Mishra, Sudeshna Mallik, Pritam Saha, Sankhanil Dhara, Sumi Mukhopadhyay\",\"doi\":\"10.1017/erm.2025.10021\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Dengue is one of the neglected tropical diseases endemic to tropical and subtropical regions worldwide. Due to its substantial disease burden, this arthropod-borne viral disease is a significant public health concern. Infection involving any one of the five distinct serotypes causes a wide range of disease manifestations, from self-limiting to mild to life-threatening outcomes.</p><p><strong>Methods: </strong>The current review comprehensively provides an overview of dengue virus-mediated immunopathogenesis with special emphasis on innate immune cells, their pathogen recognition sensors and their association with pathogenesis. Additionally we have also briefly discussed recent advancements in vaccine studies and the development of therapeutics over the last decade.</p><p><strong>Results: </strong>The immunological response to dengue virus involves an amalgamation of a variety of innate cells and inflammatory mediators, resulting in the favouring or dampening of the antiviral response. Viral components activating innate cells through pattern recognition receptors, such as Toll-like receptors, retinoic-acid-inducible gene I and melanoma differentiation-associated gene 5, are vital in eliciting a downstream signalling cascade, which culminates in the secretion of inflammatory proteins.</p><p><strong>Conclusion: </strong>Understanding the specific mechanisms involved in the acute phase of infection is indispensable for detecting differential biomarkers against flavivirus infections as well as designing more efficient therapeutic agents and vaccines.</p>\",\"PeriodicalId\":50462,\"journal\":{\"name\":\"Expert Reviews in Molecular Medicine\",\"volume\":\" \",\"pages\":\"e32\"},\"PeriodicalIF\":5.5000,\"publicationDate\":\"2025-09-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Expert Reviews in Molecular Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1017/erm.2025.10021\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Expert Reviews in Molecular Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1017/erm.2025.10021","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

背景:登革热是一种被忽视的热带病,多发于热带和亚热带地区。由于其巨大的疾病负担,这种节肢动物传播的病毒性疾病是一个重大的公共卫生问题。涉及五种不同血清型中的任何一种的感染都会引起广泛的疾病表现,从自限性到轻度到危及生命的后果。方法:本文全面综述了登革热病毒介导的免疫发病机制,特别强调了先天免疫细胞、病原体识别传感器及其与发病机制的关系。此外,我们还简要讨论了过去十年来疫苗研究和治疗方法发展的最新进展。结果:对登革热病毒的免疫反应涉及多种先天细胞和炎症介质的合并,导致有利或抑制抗病毒反应。病毒成分通过模式识别受体激活先天细胞,如toll样受体、视黄酸诱导基因I和黑色素瘤分化相关基因5,在引发下游信号级联反应中至关重要,最终导致炎症蛋白的分泌。结论:了解感染急性期的具体机制对于检测黄病毒感染的差异生物标志物以及设计更有效的治疗药物和疫苗是必不可少的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Interplay between innate immune cells and inflammatory mediators in dengue infection: an evolving therapeutic paradigm.

Background: Dengue is one of the neglected tropical diseases endemic to tropical and subtropical regions worldwide. Due to its substantial disease burden, this arthropod-borne viral disease is a significant public health concern. Infection involving any one of the five distinct serotypes causes a wide range of disease manifestations, from self-limiting to mild to life-threatening outcomes.

Methods: The current review comprehensively provides an overview of dengue virus-mediated immunopathogenesis with special emphasis on innate immune cells, their pathogen recognition sensors and their association with pathogenesis. Additionally we have also briefly discussed recent advancements in vaccine studies and the development of therapeutics over the last decade.

Results: The immunological response to dengue virus involves an amalgamation of a variety of innate cells and inflammatory mediators, resulting in the favouring or dampening of the antiviral response. Viral components activating innate cells through pattern recognition receptors, such as Toll-like receptors, retinoic-acid-inducible gene I and melanoma differentiation-associated gene 5, are vital in eliciting a downstream signalling cascade, which culminates in the secretion of inflammatory proteins.

Conclusion: Understanding the specific mechanisms involved in the acute phase of infection is indispensable for detecting differential biomarkers against flavivirus infections as well as designing more efficient therapeutic agents and vaccines.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Expert Reviews in Molecular Medicine
Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
7.40
自引率
1.60%
发文量
45
期刊介绍: Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信