Journal of Trace Elements in Medicine and Biology最新文献

{"title":"Nerve growth factor acts as a modulator on the p38 MAPK pathway in copper-induced liver damage","authors":"Mustafa Usta ,&nbsp;Yılmaz Çiğremiş ,&nbsp;Hasan Özen","doi":"10.1016/j.jtemb.2025.127694","DOIUrl":"10.1016/j.jtemb.2025.127694","url":null,"abstract":"<div><h3>Background</h3><div>Copper (Cu) toxicity induces oxidative and nitrosative stress in hepatocytes, leading to inflammation and apoptosis. Nerve Growth Factor (NGF), known for its neuroprotective properties, may influence liver tissue via the p38 MAPK pathway; however, its role in Cu-induced hepatotoxicity remains unclear, and hence the aim of this study is to investigate the protective role of exogenous NGF in a Cu-induced liver injury model in mice, with a focus on p38 MAPK pathway.</div></div><div><h3>Methods</h3><div>Sixty-four adult male BALB/c mice were equally divided into eight groups, with each group receiving intraperitoneal injections 3 times at 24 h intervals of their respective substances at the following doses: 0.9 % NaCl (Control), 10 µg/kg NGF (NGF), 20 mg/kg SB203580 (p38MAPKi), 10 µg/kg NGF + 20 mg/kg SB203580 (NGF+p38MAPKi), 20 mg/kg CuSO₄ (Cu), 20 mg/kg CuSO₄ + 10 µg/kg NGF (Cu+NGF), 20 mg/kg CuSO₄ + 20 mg/kg SB203580 (Cu+p38MAPKi), and 20 mg/kg CuSO₄ + 10 µg/kg NGF + 20 mg/kg SB203580 (Cu+NGF+p38MAPKi). Liver tissues were analyzed using histopathological, immunohistochemical, biochemical, and molecular methods.</div></div><div><h3>Results</h3><div>CuSO₄ exposure caused severe hepatic damage, evidenced by hydropic degeneration, focal necrosis, and elevated apoptosis (Caspase 3 and 8). It also increased ALT/AST levels and oxidative/nitrosative stress markers (MDA, TOC, iNOS, nitrotyrosine), while reducing antioxidant markers (GSH, TAC). NGF administration significantly ameliorated these alterations, improved antioxidant status, and reduced pro-inflammatory cytokines (IL-1, IL-6, TNF-α). These effects were abrogated by co-treatment with SB203580, implicating p38 MAPK involvement.</div></div><div><h3>Conclusion</h3><div>NGF exerts hepatoprotective effects against Cu-induced toxicity by modulating oxidative stress, inflammation, and apoptosis through the p38 MAPK signaling pathway. These findings underscore NGF’s potential as a therapeutic candidate for oxidative liver injuries.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127694"},"PeriodicalIF":3.6,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenium exposure and risk of skin cancer: A systematic review and dose-response meta-analysis of epidemiologic evidence","authors":"Tommaso Filippini ,&nbsp;Riccardo Mazzoli ,&nbsp;Lauren A. Wise ,&nbsp;Eunyoung Cho ,&nbsp;Marco Vinceti","doi":"10.1016/j.jtemb.2025.127693","DOIUrl":"10.1016/j.jtemb.2025.127693","url":null,"abstract":"<div><h3>Background</h3><div>Controversies still exist about the effects of selenium exposure on skin cancer risk.</div></div><div><h3>Methods</h3><div>We performed a systematic literature search of non-experimental and experimental studies investigating the relation between selenium and risk of melanoma and non-melanoma skin cancers (NMSC) in adults.</div></div><div><h3>Results</h3><div>We identified 26 studies, 19 of which were suitable for quantitative meta-analysis. In non-experimental studies, serum/plasma selenium concentrations showed slightly lower risk of NMSC, while no change in risk was observed for toenail or dietary selenium. Dose-response meta-analysis showed a general decreasing NMSC risk with increasing selenium serum/plasma concentrations, while there was no change in risk at any level of toenail selenium concentration. In experimental studies, we observed a higher risk for squamous cell carcinoma (risk ratio 1.25, 95 % confidence interval 1.04–1.49), but not basal cell carcinoma or NMSC overall in selenium-supplemented participants. In dose-response analysis of non-experimental studies, we observed little association between selenium exposure and melanoma risk, with limited evidence of increased risk for low (&lt;100 µg/L) serum selenium. Using toenail concentrations, we found an inverted U-shaped pattern, with a lower melanoma risk at both low and high selenium concentrations, likely due to differences in risk across cohort and case-control studies showing positive and null associations, respectively. An excess risk following environmental selenium exposure through drinking water was noted. In experimental studies, selenium supplementation was associated with higher but imprecise melanoma risk (risk ratio 1.24, 95 % confidence interval 0.57–2.68).</div></div><div><h3>Conclusion</h3><div>Overall, selenium exposure does not appear to influence basal cell carcinoma risk, but is associated with increased risk of squamous cell carcinoma and potentially melanoma.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127693"},"PeriodicalIF":3.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The close relationship between trace elements (Cu, Fe, Zn, Se, Rb, Si, Cr, and V) and Alzheimer's disease: Research progress and insights","authors":"Yuanhui Mao ,&nbsp;Lishuo Zhang ,&nbsp;Chengfu Zhang ,&nbsp;Linyin Qin ,&nbsp;Xiayun Liao ,&nbsp;Lichun Zhao","doi":"10.1016/j.jtemb.2025.127692","DOIUrl":"10.1016/j.jtemb.2025.127692","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is a typical neurodegenerative disorder primarily characterized by the deposition of β-amyloid (Aβ) plaques and the hyperphosphorylation of tau protein, leading to the formation of neurofibrillary tangles (NFTs). These pathological changes are closely associated with the imbalance of trace element homeostasis. Trace elements are extensively involved in fundamental physiological processes, including DNA synthesis, protein synthesis, energy metabolism, and enzymatic reactions, all of which are essential for cognitive function and brain development. This review summarizes the alterations in homeostasis and the biological roles of trace elements such as copper, iron, zinc, selenium, rubidium, silicon, chromium, and vanadium, as well as their relationship with the onset and progression of AD. Additionally, we discuss recent advancements in therapeutic strategies targeting the balance of trace element ions, including metal chelators, supplements, nanomedicines, and small-molecule drugs, to provide new perspectives for AD research and treatment.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127692"},"PeriodicalIF":3.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cord-blood levels of heavy metals, vitamin D and calcium and the occurrence of development defects of enamel in primary incisors: A birth cohort study","authors":"Ana Lúcia Vollú ,&nbsp;Anna Flávia Nunes Lanna ,&nbsp;Ísis Midlej Carneiro Oliveira ,&nbsp;Rayza Rodrigues Barboza ,&nbsp;Maria Fernanda Nunes Lanna ,&nbsp;Tainah Bohana de Oliveira ,&nbsp;Nataly Damasceno de Figueiredo ,&nbsp;Carmen Ildes Rodrigues Froes-Asmus ,&nbsp;Andréa Fonseca-Gonçalves","doi":"10.1016/j.jtemb.2025.127691","DOIUrl":"10.1016/j.jtemb.2025.127691","url":null,"abstract":"<div><div>This study investigated the influence of vitamin D, calcium and heavy metals on the frequency of development defects of enamel (DDE) in primary incisors of infants. Serum levels of vitamin D, calcium, arsenic, cadmium, lead, and mercury in cord blood, as well as prenatal and perinatal data, were collected during pregnancy, at birth, and in follow-ups with newborns and infants ≤ 24 months. This was done using laboratory exams, interviews, and newborns’ and infants’ records. An examiner performed dental exams using the Modified DDE. DDE type, color, location, and severity were evaluated, and logistic multiple regression models were analyzed (p &lt; 0.05). Of the infants (n = 306), 52.3 % were boys; 14.4 % were premature; 93.0 % were born to mothers taking medication, 89.9 % to mothers taking vitamin supplements, 38.1 % to mothers who used alcohol, and 11.4 % to mothers who used tobacco. Most newborns had normal weight (88.9 %), adequate size for gestational age (88.1 %), 1-minute APGAR score ≥ 7 (88.6 %), and were exclusively breastfed at discharge from maternity (90.6 %). Arsenic ≥ 0.23 µg/L (53.4 %), cadmium &lt; 0.20 µg/L (52.6 %), lead ≥ 0.8 µg/dL (60.5 %) and mercury ≥ 0.8 µg/L (55.2 %) were found in this population. Most had normal vitamin D (52.6 %) and calcium (76.3 %) levels. The incidence of DDE in infants was 27.1 % (83/306). The number of DDE per child ranged from 1 to 8 with demarcated opacity being the most common defect, while upper central incisors and the incisal third were the teeth and location most affected, respectively. Lead was associated with DDE in primary incisors, except in cases of pregnant women taking vitamin supplements and when the newborn, at the time of discharge, was being breastfed. In the present population, high cord blood levels of lead were associated with the occurrence of DDE in primary incisors.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127691"},"PeriodicalIF":3.6,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elemental mapping of cocoa beans with laser-induced breakdown spectroscopy","authors":"Tabea Steen ,&nbsp;Frank Förste ,&nbsp;Daniel Kadow ,&nbsp;Ioanna Mantouvalou ,&nbsp;Claudia Keil ,&nbsp;Virginia Merk","doi":"10.1016/j.jtemb.2025.127690","DOIUrl":"10.1016/j.jtemb.2025.127690","url":null,"abstract":"<div><div>Cocoa and chocolate are important trading goods and serve as a source of minerals and essential trace elements, important in the human diet. The standard industry practice for quantifying elements in cocoa samples involves the use of inductively coupled plasma mass spectrometry and atomic absorption spectrometry. Within an experimental lab environment, X-ray fluorescence with micrometer resolution (µXRF) can reveal the spatial distribution of elements across cocoa beans. Over the past years, laser-induced breakdown spectroscopy (LIBS) has become an emerging analytical technique for a wide range of applications. Imaging cocoa beans with LIBS is challenging because it exhibits areas with low and high density (shell vs inner structure) and the inner structure has a very low melting point. To minimize melting and ensure an optimal lateral resolution for LIBS imaging, a thorough assessment of the experimental parameters and data preprocessing is necessary. This study reveals the capabilities and limitations of LIBS for mapping mineral and trace element distribution in cocoa beans within only 90 min. A carbon-based normalization method was adopted to rectify the experimental variations resulting from sample ablation initiated by the laser beam, thus allowing for reliable sample comparisons. A side-by-side comparison of µXRF and LIBS data from the same cocoa beans shows that both techniques yield similar elemental images, although LIBS displays somewhat lower resolution. Furthermore, detailed images of five individual cocoa beans are examined to illustrate how LIBS effectively detects variations in elemental distributions. The advantages of multi-element analysis, fast response, little to no sample preparation and ease of use position LIBS alongside µXRF as a promising technique for the cocoa sector.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127690"},"PeriodicalIF":3.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of urinary cadmium with renal injury biomarkers and optimal cut-off value of urinary cadmium in preschool children from a mining area of northwestern China","authors":"Gulipiyan Balajiang ,&nbsp;Yue Du ,&nbsp;Wenzheng Yuan ,&nbsp;Jingru Xie ,&nbsp;Wenting Zhao ,&nbsp;Ting Yu ,&nbsp;Shiwei Ai ,&nbsp;Yuhui Dang","doi":"10.1016/j.jtemb.2025.127689","DOIUrl":"10.1016/j.jtemb.2025.127689","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to explore the relationship between urinary cadmium (U-Cd) and biomarkers of renal injury, identify sensitive biomarkers associated with cadmium-exposure-related renal injury, and evaluate the optimal cut-off value for U-Cd in preschool children.</div></div><div><h3>Methods</h3><div>Morning urine samples were collected from 420 preschool children (231 boys and 189 girls) to detect urinalysis, U-Cd, and renal injury biomarkers, including urinary N-acetyl-β-D-glucosaminidase (UNAG), urinary β₂-microglobulin (Uβ₂-MG), and urinary retinol-binding protein (URBP). Pearson correlation, quantile regression, and logistic regression models were utilized to explore the relationships between U-Cd and the renal injury biomarkers. Receiver operating characteristic curves were employed to determine the optimal cut-off value of U-Cd for inducing abnormalities in renal injury biomarkers.</div></div><div><h3>Results</h3><div>U-Cd demonstrated positive associations with UNAG, Uβ₂-MG, and URBP. The optimal cut-off values of U-Cd for inducing abnormalities in UNAG, Uβ₂-MG, URBP, and combined biomarker were 7.78, 14.74, 12.75, and 10.42 μg/g cr, respectively. When the sensitivity was set at 95 %, the cut-off values were adjusted to 4.70, 10.42, 11.07, and 5.18 μg/g cr, respectively.</div></div><div><h3>Conclusion</h3><div>U-Cd was significantly associated with renal injury biomarkers. Our findings suggest that the appropriate cut-off value for U-Cd should be established based on the sensitivity and specificity of various renal injury biomarkers.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127689"},"PeriodicalIF":3.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144491287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echinochrome guarding effect against sodium arsenite-induced hepatorenal toxicity in rats","authors":"Hader I. Sakr ,&nbsp;Tarek Atia ,&nbsp;Neamat A. Mahmoud ,&nbsp;Islam Ahmed Abdelmawgood ,&nbsp;Marina Lotfy Khalaf ,&nbsp;Bassam Waleed Ebeed ,&nbsp;Ahmed Mohamed Abdelmohsen ,&nbsp;Mohamed A. Kotb ,&nbsp;Abdeljalil Mohamed Al Shawoush ,&nbsp;Ahmed A. Damanhory ,&nbsp;Abdallah Mohammed Elagali ,&nbsp;Ayman Saber Mohamed ,&nbsp;Hadeer Hesham Abdelfattah","doi":"10.1016/j.jtemb.2025.127682","DOIUrl":"10.1016/j.jtemb.2025.127682","url":null,"abstract":"<div><h3>Background</h3><div>The persistent and accumulative qualities of the poisonous metalloid arsenic make it a ubiquitous environmental threat. Echinochrome (Ech) is a natural product that possesses antioxidative, antiviral, antialgal, anti-allergic, and antibacterial effects.</div></div><div><h3>Aim</h3><div>The work investigates the beneficial impact of Ech on sodium arsenite-induced hepatorenal toxicity in rats. Eighteen male rats dispersed equally among three groups: control, sodium arsenite (AS), and AS + Ech. Rats were administered AS (10 mg/kg) and Ech (1 mg/kg BW) by gavage for the experimental duration of 30 days. Ech inhibits oxidative stress by improving antioxidant levels, including glutathione, catalase, and glutathione-S-transferase, with a concomitant decrease in the amounts of malondialdehyde and nitric oxide in kidney and liver tissues. Moreover, it reduced blood concentrations of aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase, alkaline phosphatase, serum urea, uric acid, and creatinine. Concurrently, Ech resulted in a substantial increase in albumin and total protein levels. Additionally, Ech inhibits inflammation by reducing serum concentrations of tumor necrosis factor-α, cyclooxygenase 2, and prostaglandin E2.</div></div><div><h3>Conclusion</h3><div>Ech mitigates arsenic-induced hepatorenal damage by inhibiting oxidative stress and inflammatory pathways.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127682"},"PeriodicalIF":3.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Four new bright members of the ZinPyr zinc fluorescence sensor family for live cell imaging","authors":"Marisa F. Jakobs ,&nbsp;Annika M. Pick ,&nbsp;Max Carlsson ,&nbsp;Simon Wittmann ,&nbsp;Jörg Fahrer ,&nbsp;Sabine Becker","doi":"10.1016/j.jtemb.2025.127683","DOIUrl":"10.1016/j.jtemb.2025.127683","url":null,"abstract":"<div><div>As the second most abundant trace element, zinc plays numerous roles in the human body. Not only tightly bound as structural component and co-factor of more than 3000 proteins, but also as labile bound zinc, so-called mobile Zn (<em>mZn)</em>. This <em>mZn</em> occurs especially in the central nervous system, where it plays a fundamental role in signal transduction. Accordingly, dysregulated zinc homeostasis is linked to the pathogenesis of neurodegenerative diseases. Fluorescence sensors have emerged as powerful tools to unravel its role on the molecular level. With 20 members, the most prominent sensor family is the ZinPyr family that exploits a fluorescein platform equipped with usually two bis(2-pyridylmethyl)amine (DPA) as zinc binding units. Within this article, we report four new bright members of the ZinPyr family, ZP1(5-en), ZP1(6-en), ZP1(5-Me₂en), and ZP1(6-Me₂en), which are derived from the known sensors ZP1(5-CO₂H) and ZP1(6-CO₂H). Modification of these parent sensors with ethane-1,2-diamine (en) or <em>N</em>¹,<em>N</em>²-dimethylethane-1,2-diamine (Me₂en) yielded cell-permeable sensors that combine the low quantum yield of the zinc-free state Φ_free (0.165(0) – 0.190(9)) of the parent sensors with a high turn-on (5) and dynamic range (4.2 – 5.4). These properties make the new sensors among the brightest sensors in the ZinPyr family. Live cell imaging demonstrated their ability to detect intracellular zinc with an approximate turn-on of 2–3. The sensors showed a vesicular localization, with ZP1(6-en) and ZP1(5-Me₂en) also localizing in the nuclei.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127683"},"PeriodicalIF":3.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A selenomethionine deficient, high-fructose diet does not lead to cardiometabolic disorder in the selenocysteine lyase knockout mice","authors":"BK Shimada,&nbsp;NK Apo Takayama,&nbsp;KA Hallam,&nbsp;Santiago PJD,&nbsp;JY Yew,&nbsp;N Alfulaij,&nbsp;K Nakahara-Akita,&nbsp;AG Soares,&nbsp;MJ Berry,&nbsp;LA Seale","doi":"10.1016/j.jtemb.2025.127685","DOIUrl":"10.1016/j.jtemb.2025.127685","url":null,"abstract":"<div><h3>Background/purpose</h3><div>High-fructose consumption is a driver of cardiometabolic disorders and metabolic syndrome, and selenium (Se) deficiency further increases the risk of developing these diseases. Consuming high amounts of fructose induces insulin resistance and oxidative stress, and alters the cardiac lipidome. Se may reduce the detrimental impacts of fructose through its incorporation into selenoproteins like the glutathione peroxidases 1 and 4, (GPX1,4) and the thioredoxin reductase 1 (TXNRD1) whose primary function is to curb oxidative stress. When Se levels are limited, selenocysteine lyase (SCLY) decomposes selenocysteine (Sec) to hydrogen selenide (H₂Se), and loss of <em>Scly</em> results in metabolic syndrome in mice. However, it is unknown if SCLY is required to sustain the synthesis of critical antioxidant selenoproteins to prevent oxidative stress, cardiometabolic disorders, and metabolic syndrome caused by high-fructose consumption.</div></div><div><h3>Methods</h3><div>In this study, we analyzed cardiometabolic parameters, the cardiac lipidome, and the cardiac protein levels of GPX and TXNRD in male and female whole-body <em>Scly</em> knockout (<em>Scly</em> KO) mice fed a selenomethionine (SeMet) deficient, high-fructose diet.</div></div><div><h3>Results/conclusion</h3><div>We found that selenomethionine deficiency, coupled with high-fructose consumption does not lead to cardiometabolic disorder in the <em>Scly</em> KO mice, and suggests that there are compensatory mechanisms involving Se metabolism that are protective against fructose-induced cardiometabolic disorder.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127685"},"PeriodicalIF":3.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144329690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron deficiency and iron deficiency anaemia in women of reproductive age: Sex- and gender-based risk factors and inequities","authors":"Jessie L. Burns ,&nbsp;Clara H. Miller ,&nbsp;Bénédicte Fontaine-Bisson ,&nbsp;Kristin L. Connor","doi":"10.1016/j.jtemb.2025.127684","DOIUrl":"10.1016/j.jtemb.2025.127684","url":null,"abstract":"<div><div>Iron deficiency (ID) is a serious public health problem that affects 20–25 % of the population and 52 % of pregnant people worldwide. Biologically female women (women) of reproductive age have a higher risk of developing ID due to the increased physiologic demand for iron required to support menstruation and pregnancy. If left untreated, ID can develop into iron deficiency anaemia (IDA), which affects one in three women between the ages of 15–49 years worldwide. Among women of reproductive age, those who are pregnant have the highest risk of developing ID and IDA due to increased iron requirements to support pregnancy and the developing fetus. Despite the high prevalence of ID and IDA, it remains underdiagnosed in reproductive-aged women and current treatment options are not well accepted. There is an urgent need to investigate novel strategies to ensure adequate iron status in women of reproductive age to prevent adverse health problems and promote healthy pregnancies. This review explored the critical role of iron in women's health by examining iron requirements throughout the lifespan, the physiology of iron absorption, factors affecting iron bioavailability, and the causes of ID and IDA. We discuss the limitations of current interventions for ID and IDA, and the need to develop effective and widely acceptable treatments for these conditions, particularly in women of reproductive age. The findings of this review suggest that current interventions for ID and IDA are inadequate and that sex biases exist in the diagnosis and management of ID and IDA in biologically female women.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127684"},"PeriodicalIF":3.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144491282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}