Journal of Trace Elements in Medicine and Biology最新文献

{"title":"Synergistic effects of dietary selenium nanoparticles and vitamin C improve growth performance, immune response, and antioxidant status of juvenile common carp (Cyprinus carpio)","authors":"","doi":"10.1016/j.jtemb.2024.127530","DOIUrl":"10.1016/j.jtemb.2024.127530","url":null,"abstract":"<div><h3>Introduction</h3><p>This study aimed to investigate the synergistic effects of dietary selenium nanoparticles (Se-NPs) and vitamin C (VC) on growth, body composition, antioxidant defense, immunity, and serum biochemical indexes of common carp (<em>Cyprinus carp</em>) juveniles.</p></div><div><h3>Methodology</h3><p>The test diets were supplemented with three levels of Se-NPs (0, 0.5, and 1 mg/Kg) and three levels of VC (0, 500, and 1000 mg/Kg): the basal diet without supplemental Se-NPs and VC (VC₀SeNPs₀; control), 0.5 mg Se-NPs /Kg (VC₀SeNPs_0.5), 1 mg Se-NPs /Kg (VC₀SeNPs₁), 500 mg VC/Kg (VC₅₀₀SeNPs₀), 1000 mg VC/Kg (VC₁₀₀₀SeNPs₀), 500 mg VC/Kg and 0.5 mg Se-NPs (VC₅₀₀SeNPs_0.5), 1000 mg VC/Kg and 0.5 mg Se-NPs (VC₁₀₀₀SeNPs_0.5), 500 mg VC/Kg and 1 mg Se-NPs (VC₅₀₀SeNPs₁), 1000 mg VC/Kg and 1 mg Se-NPs (VC₁₀₀₀SeNPs₁). The fish were randomly divided into nine experimental groups in triplicate tanks per treatment and fed on their respective diets for 60 days.</p></div><div><h3>Results</h3><p>The findings displayed that fish fed with VC₅₀₀SeNPs₁ and VC₅₀₀SeNPs_0.5 diets had significantly (<em>P</em> &lt; 0.05) higher specific growth rates when compared to other groups. The lowest feed conversion ratio was detected in the VC₁₀₀₀SeNPs₁ group and the highest in the control group (<em>P</em> &lt; 0.05). VC, Se-NPs, and their interaction had no significant effect on serum malondialdehyde, ACH50, and IgM (<em>P</em> &gt; 0.05). However, the best parameters associated with antioxidant capacity (higher serum levels of superoxide dismutase and total reduced glutathione) and physiological status (higher concentration of serum globulin and lower amounts of aspartate aminotransferase and lactate dehydrogenase) belonged to the VC₁₀₀₀SeNPs₁ and VC₅₀₀SeNPs₁ groups. The results suggest that the Se-NPs and VC combination more efficiently influence the common carp’s growth performance, antioxidant status, immunity, and physiological parameters.</p></div><div><h3>Conclusion</h3><p>Overall, the diet enriched with 500 mg VC and 1 mg Se-NPs /Kg (VC₅₀₀SeNPs₁) is suitable for boosting the growth and immunity of common carp.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142169511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimated daily intake and health risk assessment of total and organic selenium in crops across areas with different selenium levels","authors":"","doi":"10.1016/j.jtemb.2024.127525","DOIUrl":"10.1016/j.jtemb.2024.127525","url":null,"abstract":"<div><h3>Background</h3><p>The health risk of Se has gained significant attention. Previous studies mainly focused on the health risk of total Se in high-Se area. Less attention has been paid to the health risk of organic selenium in areas with varying selenium levels.</p></div><div><h3>Methods</h3><p>A total number of 109 crop samples (edible parts) were collected in Langao County, Shannxi Province, China from 2018 to 2020, including 42 corn, 18 rice, 9 sweet potato, 25 potato, 12 radish, and 3 eggplant samples. The hydride generation atomic fluorescence spectrometry (HG-AFS) method was used to determine the total and organic Se contents.</p></div><div><h3>Result and conclusion</h3><p>(1) Corn (2.82 mg/kg), rice (0.44 mg/kg), potato (6.56 mg/kg), and eggplant (0.77 mg/kg) in high-Se area, as well as sweet potato (1.07 mg/kg) and radish (4.28 mg/kg) in medium-Se area, exhibited the highest total Se content among all crops in this county, and 5–328 times higher than the values of Se-enriched standard (2) The average daily intake of total/organic Se of residents in high-Se area reached 676/449 μg/day, which was 1–4 times higher than levels observed in medium-Se area (419/257 μg/day) and low-Se area (196/128 μg/day). The organic Se daily intakes from dietary combinations of rice + radish and rice + eggplant in high-Se area lower than 400 μg/day, which could be safely consumed. The organic Se daily intakes from dietary combinations of sweet potato + radish and sweet + eggplant in medium-Se area higher than 400 μg/day, which could not be safely consumed. The total / organic Se daily intakes of all dietary combinations in low-Se area lower than 400 μg/day, which could be safely consumed. (3) The health risk associated with crops might be overestimated due to the higher non-carcinogenic risk attributed to total Se compared to organic Se. The present study demonstrated that daily intake and health risk of total and organic Se in crops across areas with different Se levels varied significantly.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142169510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between iron status, preeclampsia and gestational hypertension: A bidirectional two-sample Mendelian randomization study","authors":"","doi":"10.1016/j.jtemb.2024.127528","DOIUrl":"10.1016/j.jtemb.2024.127528","url":null,"abstract":"<div><h3>Background</h3><p>Several recent observational studies have reported that iron overload during pregnancy is associated with preeclampsia (PE) and gestational hypertension (GH). However, the causal association between iron status, PE, and GH is still not clear.</p></div><div><h3>Methods</h3><p>We performed a two-sample Mendelian randomization (MR) study using the genome-wide association study (GWAS) summary statistics of iron status, included serum iron, ferritin, total iron-binding capacity (TIBC), and transferrin saturation (TSAT) from the largest available GWAS meta-analysis, and the summary statistics of PE and GH were obtained from the FinnGen consortium. Fixed-effect inverse variance weighted (IVW), random-effect IVW, maximum likelihood (ML), MR-Egger regression, weighted median, and MR-PRESSO methods were used.</p></div><div><h3>Results</h3><p>A total of 21, 58, 28, and 22 SNPs were used as IVs for serum iron, ferritin, TIBC, and TSAT, respectively. The F-statistics of IVs ranged from 95.23 to 421.36. The results of the fixed effects IVW method suggested that for per SD unit increase in serum iron, the risk of PE increases by 24 % (OR = 1.24, 95 % CI: 1.03–1.50, P = 0.02). No significant heterogeneity or horizontal pleiotropy was found. The association between ferritin, TIBC, TSAT and PE were statistically insignificant (P&gt;0.05). Furthermore, the results of each MR methods do not support a causal association between iron status and GH, nor a reverse causal association between PE and GH and iron status.</p></div><div><h3>Conclusion</h3><p>This two-sample MR study provides evidence supporting a causal association between serum iron level and PE.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paternal zinc deficiency alters offspring metabolic status in Drosophila melanogaster","authors":"","doi":"10.1016/j.jtemb.2024.127519","DOIUrl":"10.1016/j.jtemb.2024.127519","url":null,"abstract":"<div><h3>Background</h3><p>This study delves into the understudied yet potentially crucial role of paternal zinc deficiency in programming offspring metabolic outcomes. By examining paternal zinc deficiency, we aim to shed light on a previously unexplored avenue with the potential to significantly impact future generations. We investigated the intergenerational effects of paternal zinc deficiency on metabolic parameters in <em>Drosophila melanogaster</em>.</p></div><div><h3>Methods</h3><p>Dietary zinc deficiency was induced by supplementing the diet of Drosophila F0 male flies with TPEN (N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine) from egg stage. The F0 male flies after eclosion were mated with age-matched virgin female flies from the control group, resulting in the F1 offspring generation. The F1 generation were then cultured on a standard diet for subsequent metabolic analyses, including assessments of body weight, locomotion, and levels of glucose, trehalose, glycogen, and triglycerides as well as the expression of related genes.</p></div><div><h3>Results</h3><p>We observed an increase (p&lt;0.05) in body weight in male parent flies and female offspring. Negative geotaxis performance was also impaired in the female offspring. Paternal zinc deficiency exerted distinct effects on carbohydrate and lipid metabolism, as evidenced by a significant (p&lt;0.05) increase in trehalose and triglyceride levels in both parent and offspring. Additionally, zinc deficiency led to alterations in the expression of key metabolic genes, including significant (p&lt;0.05) increase in <em>DILP2</em> mRNA levels, highlighting potential links to insulin signaling. Also, there were reduced mRNA levels of <em>SOD1</em> and <em>CAT</em> in both parental and offspring generations. Parental zinc deficiency also increased the expression of <em>Eiger</em> and <em>UPD2</em> mRNA in the offspring, suggesting potential perturbations in the immune response system.</p></div><div><h3>Conclusion</h3><p>These findings underscore the link between zinc status and various physiological and molecular processes, revealing both immediate and intergenerational impacts on metabolic, antioxidant, and inflammatory pathways and providing valuable insights on the implications of paternal zinc deficiency in <em>Drosophila melanogaster</em>.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of fluoride toxicity on the male reproductive system: A review","authors":"","doi":"10.1016/j.jtemb.2024.127522","DOIUrl":"10.1016/j.jtemb.2024.127522","url":null,"abstract":"<div><h3>Background</h3><p>Fluoride toxicity and fluorosis is an emerging global problem. Fluoride has long been added to water for dental caries prevention; however, it has a variety of damaging consequences on human bodies. The aim of this paper is to analyse all the literature available on the effects of fluoride toxicity on male reproductive system.</p></div><div><h3>Methods</h3><p>Research papers were collected using various methods of data collection like Pubmed, Scopus, and Google Scholar from 1980 to 2024, and then reviewed thoroughly.</p></div><div><h3>Results</h3><p>Fluoride is known to cause various histopathological and biochemical alterations in the male reproductive system. It also affects fertility, semen quality, sperm number and quality,the process of spermatogenesis and spermiogenesis. Key changes caused by fluoride in male reproductive system include structural defects in the flagellum, acrosome, and nucleus of spermatids and epididymal spermatozoa. Degenerative changes in Leydig cells result in reduced testosterone production, causing regression of seminiferous tubules and structural damage to the epididymis, ultimately terminating spermatogenesis which leads to infertility. Decrease in levels of testosterone and activities of various antioxidant enzymes resulting in greater oxidative stress was also seen.</p></div><div><h3>Conclusions</h3><p>Fluoride has various detrimental effects on male reproductive system and overall reproductive health. This type of study is important for understanding the effects of fluoride toxicity so that health officials can guide public about safe fluoride exposure limits and the damages it can cause in higher concentrations. Studies using various natural and synthetic ameliorative substances mentioned in the text later can prove to be helpful for development of various therapeutic approaches to mitigate the effects of fluoride toxicity.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142229665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum trace elements and osteoarthritis: A meta-analysis and Mendelian randomization study","authors":"","doi":"10.1016/j.jtemb.2024.127520","DOIUrl":"10.1016/j.jtemb.2024.127520","url":null,"abstract":"<div><h3>Objective</h3><p>This study aims to establish the correlation between shifts in serum trace element (TE) levels and the progression of osteoarthritis (OA), while also exploring the underlying causal relationship between these variables.</p></div><div><h3>Methods</h3><p>An investigation was conducted, which included a systematic review, a meta-analysis of observational studies, and a two-sample Mendelian randomization (MR) study.</p></div><div><h3>Results</h3><p>This meta-analysis revealed significant differences in serum levels of copper, manganese, cadmium, and selenium between OA patients and healthy controls, after adjusting for heterogeneity. Specifically, significant disparities were observed for copper (SMD 0.118 [95 % <em>CI</em>: 0.061 ∼ 0.175], <em>P</em> &lt; 0.001), manganese (SMD −0.180 [95 % <em>CI</em>: −0.326 ∼ −0.034], <em>P</em> = 0.016), cadmium (SMD 0.227 [95 % <em>CI</em>: 0.131 ∼ 0.322], <em>P</em> &lt; 0.001), and selenium (SMD −0.138 [95 % <em>CI</em>: −0.209 ∼ −0.068], <em>P</em> &lt; 0.001), while zinc levels did not show a significant difference (SMD −0.02 [95 % <em>CI</em>: −0.077 ∼ 0.038], <em>P</em> = 0.503). Further, MR analysis suggested a causal link between genetically predicted serum copper level changes and OA development, but not for other TEs.</p></div><div><h3>Conclusion</h3><p>The study suggests that there is an association between the occurrence of OA and variations in serum levels of copper, manganese, cadmium, and selenium. Elevated serum copper may play a pivotal role. Further research is needed to explore the therapeutic potential of TE level modulation in OA management.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0946672X24001408/pdfft?md5=bf9347d54d74b16b9623dc76a3fda78e&pid=1-s2.0-S0946672X24001408-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of lead exposure effects on tissue accumulation, behavior, morphological and hemato-biochemical changes in common carp, Cyprinus carpio","authors":"","doi":"10.1016/j.jtemb.2024.127523","DOIUrl":"10.1016/j.jtemb.2024.127523","url":null,"abstract":"<div><h3>Background</h3><p>Heavy metal pollution, particularly lead (Pb), poses a significant threat to aquatic ecosystems and their inhabitants, threatening their delicate balance and long-term viability. This study highlights the urgent need to mitigate heavy metal pollution in aquatic ecosystems.</p></div><div><h3>Objective</h3><p>This study investigates Pb(NO₃)₂ exposure effects on tissue accumulation, behavioral abnormalities, and hemato-biochemical parameters in common carp (<em>Cyprinus carpio</em>), a widely distributed freshwater fish species.</p></div><div><h3>Methodology</h3><p>Fish (115 ± 5.23 g) were exposed to various Pb(NO₃)₂ concentrations for 10 and 20 days, representing control (0 %), 25 %, 50 %, and 75 % of the LC₅₀ equivalent to 19.33, 38.66, and 58.0 mg/l, respectively. The standard manual procedure was used for blood sampling. The lead concentration in fish tissue was determined using an atomic absorption spectrophotometer.</p></div><div><h3>Results</h3><p>Results revealed that fish gills showed significant (<em>P &lt; 0.05</em>) increase in Pb(NO₃)₂ after 10 days, further rising after 20 days. Liver concentrations also rose significantly (<em>P &lt; 0.05</em>) with prolonged exposure and increasing Pb levels. Muscle had lower concentrations. Hematological parameters (RBC, WBC, HB, HCT) decreased with higher Pb(NO₃)₂ levels. Behavioral and morphological changes were significantly more pronounced in the exposure groups when compared to the control group. Hepatic enzyme activities (AST, ALT), glucose, and lipid levels increased, while total protein decreased.</p></div><div><h3>Conclusions</h3><p>The study highlights Pb(NO₃)₂ harmful effects on common carp, impacting tissue accumulation, hematological parameters, and biochemical disruptions. It emphasizes the need to monitor and mitigate heavy metal pollution in aquatic environments to safeguard freshwater organisms and ecosystems, and to further increase our understanding of Pb toxicity in freshwater ecosystems.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The novel prognostic analysis of AML based on ferroptosis and cuproptosis related genes","authors":"","doi":"10.1016/j.jtemb.2024.127517","DOIUrl":"10.1016/j.jtemb.2024.127517","url":null,"abstract":"<div><h3>Background</h3><p>Acute myeloid leukemia (AML) is a hematological malignancy. The aim of this research was to develop a ferroptosis and cuproptosis related novel prognostic signature associated with AML.</p></div><div><h3>Methods</h3><p>The ferroptosis and cuproptosis related genes correlated with the prognosis of AML were identified by univariate Cox analysis. The consistent cluster analysis was performed for 150 AML patients in TCGA dataset. The key module genes associated with GSVA score of ferroptosis and cuproptosis were identified by WGCNA. univariate Cox and LASSO regression analysis were adopted to build a ferroptosis and cuproptosis AML prognostic signature. Finally, the expression of five prognostic genes in clinical tissue samples were verified by RT-qPCR.</p></div><div><h3>Results</h3><p>A grand total of 27 FCRGs associated with AML prognosis were identified.Then, two AML sub-types with significantly different survival were obtained. We found 3 significantly differential expressed immune cells (naive CD4 cells, regulatory T cells and resting mast cells) between two risk sub-groups. Meanwhile, ‘IL6 JAK STAT3 signaling’ and ‘P53 pathway’ were enriched in low-risk group. A ferroptosis and cuproptosis related prognostic signature was build based on 8 prognostic genes. RT-qPCR results indicated that there was no significant difference in the expression of OLFML2A and CD109 between AML and normal samples. However, compared to the control group, LGALS1, SOCS1, and RHOC showed significantly lower expression in the AML group.</p></div><div><h3>Conclusion</h3><p>The prognostic signature comprised of OLFML2A, LGALS1, ABCB11, SOCS1, RHOC, CD109, RD3L and PTPN13 based on ferroptosis and cuproptosis was established, which provided theoretical basis for the research of AML.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0946672X24001378/pdfft?md5=7fa26c2b83fa0fbf8d7fc5b97e317764&pid=1-s2.0-S0946672X24001378-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142172161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salidroside prevents cadmium chloride-induced DNA damage in human fetal lung fibroblasts","authors":"","doi":"10.1016/j.jtemb.2024.127521","DOIUrl":"10.1016/j.jtemb.2024.127521","url":null,"abstract":"<div><h3>Background</h3><p>Cadmium (Cd) is an environmental pollutant and a heavy metal known for its genotoxic effects, which can lead to cancer and other related diseases. Preventing Cd-induced genotoxicity is crucial; however, there is limited research on this topic. Salidroside (SAL), a phenylpropanoid glycoside isolated from <em>Rhodiola rosea L</em>., is a popular medicinal compound with several health benefits. Nevertheless, its therapeutic effect on Cd-induced genotoxicity remains unexplored.</p></div><div><h3>Methods</h3><p>Human fetal lung fibroblasts were treated with 20 μM Cd²⁺ (CdCl₂) for 12 h and 5–20 μM SAL was used to test the anti-DNA damage effect. DNA damage was evaluated using γH2AX expression and the alkaline comet assay. Intracellular reactive oxygen species (ROS) levels were measured using flow cytometry.</p></div><div><h3>Results</h3><p>Exposure to 20 μM Cd²⁺ for 12 h induced significant DNA damage in human fetal lung fibroblasts, and this effect was notably attenuated by SAL treatment. SAL treatment did not decrease ROS levels in cells treated with Cd²⁺.</p></div><div><h3>Conclusion</h3><p>SAL effectively prevented Cd²⁺-induced DNA damage in human fetal lung fibroblasts. However, the underlying mechanism requires further investigation.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo cardioprotective effect of zinc oxide nanoparticles against doxorubicin-induced myocardial infarction by enhancing the antioxidant system and nitric oxide production","authors":"","doi":"10.1016/j.jtemb.2024.127516","DOIUrl":"10.1016/j.jtemb.2024.127516","url":null,"abstract":"<div><h3>Background</h3><p>Myocardial infarction (MI) is the result of reduced or stopped blood supply to a section of the myocardium. Regardless of its potential effectiveness in the treatment of several types of cancers, doxorubicin (DOX) capabilities are restricted because of its widespread cardiotoxic impact.</p></div><div><h3>Aim</h3><p>In this study, the protective effect of zinc oxide nanoparticles against doxorubicin-induced myocardial infarction in rats is examined.</p></div><div><h3>Methods</h3><p>Zinc oxide nanoparticles (ZnO NPs) were synthesized and characterized using X-ray diffraction, transmission electron microscope, and UV-Vis spectral analysis. A total cumulative dose of DOX (18 mg/kg body weight, i.p.) was injected once daily on days 2, 4, 6, 8, 10, and 12 (i.p.) to induce MI in rats. 24 rats were divided into 4 groups; control, MI, and MI treated with two doses of ZnO NPs (45 and 22.5 mg/kg).</p></div><div><h3>Results</h3><p>The treatment with ZnO NPs restored ST-segment near normal, ameliorated the changes in cardiac troponin T, creatine kinase, lactate dehydrogenase, aspartate aminotransferase, alanine amino transferase, alkaline phosphatase, total proteins, malondialdehyde, nitric oxide, reduced glutathione, and catalase.The histological investigation revealed that ZnO NPs treated group showed marked improvement in the examined cardiac muscle and liver in numerous sections.The lower dose of ZnO NPs (22.5 mg/kg) was significantly more effective than the higher dose (45 mg/kg).</p></div><div><h3>Conclusion</h3><p>The effect of ZnO NPs against doxorubicin-induced myocardial infarction in rats was assessed and the results revealed a successful cardioprotective potency through enhancing the antioxidant system and stimulating nitric oxide production in myocardial infarcted rats. This work implies that ZnO NPs could serve as promising agents for treating doxorubicin-induced cardiotoxicity.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}