Journal of Trace Elements in Medicine and Biology最新文献

{"title":"The close relationship between trace elements (Cu, Fe, Zn, Se, Rb, Si, Cr, and V) and Alzheimer's disease: Research progress and insights","authors":"Yuanhui Mao ,&nbsp;Lishuo Zhang ,&nbsp;Chengfu Zhang ,&nbsp;Linyin Qin ,&nbsp;Xiayun Liao ,&nbsp;Lichun Zhao","doi":"10.1016/j.jtemb.2025.127692","DOIUrl":"10.1016/j.jtemb.2025.127692","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is a typical neurodegenerative disorder primarily characterized by the deposition of β-amyloid (Aβ) plaques and the hyperphosphorylation of tau protein, leading to the formation of neurofibrillary tangles (NFTs). These pathological changes are closely associated with the imbalance of trace element homeostasis. Trace elements are extensively involved in fundamental physiological processes, including DNA synthesis, protein synthesis, energy metabolism, and enzymatic reactions, all of which are essential for cognitive function and brain development. This review summarizes the alterations in homeostasis and the biological roles of trace elements such as copper, iron, zinc, selenium, rubidium, silicon, chromium, and vanadium, as well as their relationship with the onset and progression of AD. Additionally, we discuss recent advancements in therapeutic strategies targeting the balance of trace element ions, including metal chelators, supplements, nanomedicines, and small-molecule drugs, to provide new perspectives for AD research and treatment.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127692"},"PeriodicalIF":3.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cord-blood levels of heavy metals, vitamin D and calcium and the occurrence of development defects of enamel in primary incisors: A birth cohort study","authors":"Ana Lúcia Vollú ,&nbsp;Anna Flávia Nunes Lanna ,&nbsp;Ísis Midlej Carneiro Oliveira ,&nbsp;Rayza Rodrigues Barboza ,&nbsp;Maria Fernanda Nunes Lanna ,&nbsp;Tainah Bohana de Oliveira ,&nbsp;Nataly Damasceno de Figueiredo ,&nbsp;Carmen Ildes Rodrigues Froes-Asmus ,&nbsp;Andréa Fonseca-Gonçalves","doi":"10.1016/j.jtemb.2025.127691","DOIUrl":"10.1016/j.jtemb.2025.127691","url":null,"abstract":"<div><div>This study investigated the influence of vitamin D, calcium and heavy metals on the frequency of development defects of enamel (DDE) in primary incisors of infants. Serum levels of vitamin D, calcium, arsenic, cadmium, lead, and mercury in cord blood, as well as prenatal and perinatal data, were collected during pregnancy, at birth, and in follow-ups with newborns and infants ≤ 24 months. This was done using laboratory exams, interviews, and newborns’ and infants’ records. An examiner performed dental exams using the Modified DDE. DDE type, color, location, and severity were evaluated, and logistic multiple regression models were analyzed (p &lt; 0.05). Of the infants (n = 306), 52.3 % were boys; 14.4 % were premature; 93.0 % were born to mothers taking medication, 89.9 % to mothers taking vitamin supplements, 38.1 % to mothers who used alcohol, and 11.4 % to mothers who used tobacco. Most newborns had normal weight (88.9 %), adequate size for gestational age (88.1 %), 1-minute APGAR score ≥ 7 (88.6 %), and were exclusively breastfed at discharge from maternity (90.6 %). Arsenic ≥ 0.23 µg/L (53.4 %), cadmium &lt; 0.20 µg/L (52.6 %), lead ≥ 0.8 µg/dL (60.5 %) and mercury ≥ 0.8 µg/L (55.2 %) were found in this population. Most had normal vitamin D (52.6 %) and calcium (76.3 %) levels. The incidence of DDE in infants was 27.1 % (83/306). The number of DDE per child ranged from 1 to 8 with demarcated opacity being the most common defect, while upper central incisors and the incisal third were the teeth and location most affected, respectively. Lead was associated with DDE in primary incisors, except in cases of pregnant women taking vitamin supplements and when the newborn, at the time of discharge, was being breastfed. In the present population, high cord blood levels of lead were associated with the occurrence of DDE in primary incisors.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127691"},"PeriodicalIF":3.6,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elemental mapping of cocoa beans with laser-induced breakdown spectroscopy","authors":"Tabea Steen ,&nbsp;Frank Förste ,&nbsp;Daniel Kadow ,&nbsp;Ioanna Mantouvalou ,&nbsp;Claudia Keil ,&nbsp;Virginia Merk","doi":"10.1016/j.jtemb.2025.127690","DOIUrl":"10.1016/j.jtemb.2025.127690","url":null,"abstract":"<div><div>Cocoa and chocolate are important trading goods and serve as a source of minerals and essential trace elements, important in the human diet. The standard industry practice for quantifying elements in cocoa samples involves the use of inductively coupled plasma mass spectrometry and atomic absorption spectrometry. Within an experimental lab environment, X-ray fluorescence with micrometer resolution (µXRF) can reveal the spatial distribution of elements across cocoa beans. Over the past years, laser-induced breakdown spectroscopy (LIBS) has become an emerging analytical technique for a wide range of applications. Imaging cocoa beans with LIBS is challenging because it exhibits areas with low and high density (shell vs inner structure) and the inner structure has a very low melting point. To minimize melting and ensure an optimal lateral resolution for LIBS imaging, a thorough assessment of the experimental parameters and data preprocessing is necessary. This study reveals the capabilities and limitations of LIBS for mapping mineral and trace element distribution in cocoa beans within only 90 min. A carbon-based normalization method was adopted to rectify the experimental variations resulting from sample ablation initiated by the laser beam, thus allowing for reliable sample comparisons. A side-by-side comparison of µXRF and LIBS data from the same cocoa beans shows that both techniques yield similar elemental images, although LIBS displays somewhat lower resolution. Furthermore, detailed images of five individual cocoa beans are examined to illustrate how LIBS effectively detects variations in elemental distributions. The advantages of multi-element analysis, fast response, little to no sample preparation and ease of use position LIBS alongside µXRF as a promising technique for the cocoa sector.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127690"},"PeriodicalIF":3.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of urinary cadmium with renal injury biomarkers and optimal cut-off value of urinary cadmium in preschool children from a mining area of northwestern China","authors":"Gulipiyan Balajiang ,&nbsp;Yue Du ,&nbsp;Wenzheng Yuan ,&nbsp;Jingru Xie ,&nbsp;Wenting Zhao ,&nbsp;Ting Yu ,&nbsp;Shiwei Ai ,&nbsp;Yuhui Dang","doi":"10.1016/j.jtemb.2025.127689","DOIUrl":"10.1016/j.jtemb.2025.127689","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to explore the relationship between urinary cadmium (U-Cd) and biomarkers of renal injury, identify sensitive biomarkers associated with cadmium-exposure-related renal injury, and evaluate the optimal cut-off value for U-Cd in preschool children.</div></div><div><h3>Methods</h3><div>Morning urine samples were collected from 420 preschool children (231 boys and 189 girls) to detect urinalysis, U-Cd, and renal injury biomarkers, including urinary N-acetyl-β-D-glucosaminidase (UNAG), urinary β₂-microglobulin (Uβ₂-MG), and urinary retinol-binding protein (URBP). Pearson correlation, quantile regression, and logistic regression models were utilized to explore the relationships between U-Cd and the renal injury biomarkers. Receiver operating characteristic curves were employed to determine the optimal cut-off value of U-Cd for inducing abnormalities in renal injury biomarkers.</div></div><div><h3>Results</h3><div>U-Cd demonstrated positive associations with UNAG, Uβ₂-MG, and URBP. The optimal cut-off values of U-Cd for inducing abnormalities in UNAG, Uβ₂-MG, URBP, and combined biomarker were 7.78, 14.74, 12.75, and 10.42 μg/g cr, respectively. When the sensitivity was set at 95 %, the cut-off values were adjusted to 4.70, 10.42, 11.07, and 5.18 μg/g cr, respectively.</div></div><div><h3>Conclusion</h3><div>U-Cd was significantly associated with renal injury biomarkers. Our findings suggest that the appropriate cut-off value for U-Cd should be established based on the sensitivity and specificity of various renal injury biomarkers.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127689"},"PeriodicalIF":3.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144491287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echinochrome guarding effect against sodium arsenite-induced hepatorenal toxicity in rats","authors":"Hader I. Sakr ,&nbsp;Tarek Atia ,&nbsp;Neamat A. Mahmoud ,&nbsp;Islam Ahmed Abdelmawgood ,&nbsp;Marina Lotfy Khalaf ,&nbsp;Bassam Waleed Ebeed ,&nbsp;Ahmed Mohamed Abdelmohsen ,&nbsp;Mohamed A. Kotb ,&nbsp;Abdeljalil Mohamed Al Shawoush ,&nbsp;Ahmed A. Damanhory ,&nbsp;Abdallah Mohammed Elagali ,&nbsp;Ayman Saber Mohamed ,&nbsp;Hadeer Hesham Abdelfattah","doi":"10.1016/j.jtemb.2025.127682","DOIUrl":"10.1016/j.jtemb.2025.127682","url":null,"abstract":"<div><h3>Background</h3><div>The persistent and accumulative qualities of the poisonous metalloid arsenic make it a ubiquitous environmental threat. Echinochrome (Ech) is a natural product that possesses antioxidative, antiviral, antialgal, anti-allergic, and antibacterial effects.</div></div><div><h3>Aim</h3><div>The work investigates the beneficial impact of Ech on sodium arsenite-induced hepatorenal toxicity in rats. Eighteen male rats dispersed equally among three groups: control, sodium arsenite (AS), and AS + Ech. Rats were administered AS (10 mg/kg) and Ech (1 mg/kg BW) by gavage for the experimental duration of 30 days. Ech inhibits oxidative stress by improving antioxidant levels, including glutathione, catalase, and glutathione-S-transferase, with a concomitant decrease in the amounts of malondialdehyde and nitric oxide in kidney and liver tissues. Moreover, it reduced blood concentrations of aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase, alkaline phosphatase, serum urea, uric acid, and creatinine. Concurrently, Ech resulted in a substantial increase in albumin and total protein levels. Additionally, Ech inhibits inflammation by reducing serum concentrations of tumor necrosis factor-α, cyclooxygenase 2, and prostaglandin E2.</div></div><div><h3>Conclusion</h3><div>Ech mitigates arsenic-induced hepatorenal damage by inhibiting oxidative stress and inflammatory pathways.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127682"},"PeriodicalIF":3.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Four new bright members of the ZinPyr zinc fluorescence sensor family for live cell imaging","authors":"Marisa F. Jakobs ,&nbsp;Annika M. Pick ,&nbsp;Max Carlsson ,&nbsp;Simon Wittmann ,&nbsp;Jörg Fahrer ,&nbsp;Sabine Becker","doi":"10.1016/j.jtemb.2025.127683","DOIUrl":"10.1016/j.jtemb.2025.127683","url":null,"abstract":"<div><div>As the second most abundant trace element, zinc plays numerous roles in the human body. Not only tightly bound as structural component and co-factor of more than 3000 proteins, but also as labile bound zinc, so-called mobile Zn (<em>mZn)</em>. This <em>mZn</em> occurs especially in the central nervous system, where it plays a fundamental role in signal transduction. Accordingly, dysregulated zinc homeostasis is linked to the pathogenesis of neurodegenerative diseases. Fluorescence sensors have emerged as powerful tools to unravel its role on the molecular level. With 20 members, the most prominent sensor family is the ZinPyr family that exploits a fluorescein platform equipped with usually two bis(2-pyridylmethyl)amine (DPA) as zinc binding units. Within this article, we report four new bright members of the ZinPyr family, ZP1(5-en), ZP1(6-en), ZP1(5-Me₂en), and ZP1(6-Me₂en), which are derived from the known sensors ZP1(5-CO₂H) and ZP1(6-CO₂H). Modification of these parent sensors with ethane-1,2-diamine (en) or <em>N</em>¹,<em>N</em>²-dimethylethane-1,2-diamine (Me₂en) yielded cell-permeable sensors that combine the low quantum yield of the zinc-free state Φ_free (0.165(0) – 0.190(9)) of the parent sensors with a high turn-on (5) and dynamic range (4.2 – 5.4). These properties make the new sensors among the brightest sensors in the ZinPyr family. Live cell imaging demonstrated their ability to detect intracellular zinc with an approximate turn-on of 2–3. The sensors showed a vesicular localization, with ZP1(6-en) and ZP1(5-Me₂en) also localizing in the nuclei.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127683"},"PeriodicalIF":3.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A selenomethionine deficient, high-fructose diet does not lead to cardiometabolic disorder in the selenocysteine lyase knockout mice","authors":"BK Shimada,&nbsp;NK Apo Takayama,&nbsp;KA Hallam,&nbsp;Santiago PJD,&nbsp;JY Yew,&nbsp;N Alfulaij,&nbsp;K Nakahara-Akita,&nbsp;AG Soares,&nbsp;MJ Berry,&nbsp;LA Seale","doi":"10.1016/j.jtemb.2025.127685","DOIUrl":"10.1016/j.jtemb.2025.127685","url":null,"abstract":"<div><h3>Background/purpose</h3><div>High-fructose consumption is a driver of cardiometabolic disorders and metabolic syndrome, and selenium (Se) deficiency further increases the risk of developing these diseases. Consuming high amounts of fructose induces insulin resistance and oxidative stress, and alters the cardiac lipidome. Se may reduce the detrimental impacts of fructose through its incorporation into selenoproteins like the glutathione peroxidases 1 and 4, (GPX1,4) and the thioredoxin reductase 1 (TXNRD1) whose primary function is to curb oxidative stress. When Se levels are limited, selenocysteine lyase (SCLY) decomposes selenocysteine (Sec) to hydrogen selenide (H₂Se), and loss of <em>Scly</em> results in metabolic syndrome in mice. However, it is unknown if SCLY is required to sustain the synthesis of critical antioxidant selenoproteins to prevent oxidative stress, cardiometabolic disorders, and metabolic syndrome caused by high-fructose consumption.</div></div><div><h3>Methods</h3><div>In this study, we analyzed cardiometabolic parameters, the cardiac lipidome, and the cardiac protein levels of GPX and TXNRD in male and female whole-body <em>Scly</em> knockout (<em>Scly</em> KO) mice fed a selenomethionine (SeMet) deficient, high-fructose diet.</div></div><div><h3>Results/conclusion</h3><div>We found that selenomethionine deficiency, coupled with high-fructose consumption does not lead to cardiometabolic disorder in the <em>Scly</em> KO mice, and suggests that there are compensatory mechanisms involving Se metabolism that are protective against fructose-induced cardiometabolic disorder.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127685"},"PeriodicalIF":3.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144329690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron deficiency and iron deficiency anaemia in women of reproductive age: Sex- and gender-based risk factors and inequities","authors":"Jessie L. Burns ,&nbsp;Clara H. Miller ,&nbsp;Bénédicte Fontaine-Bisson ,&nbsp;Kristin L. Connor","doi":"10.1016/j.jtemb.2025.127684","DOIUrl":"10.1016/j.jtemb.2025.127684","url":null,"abstract":"<div><div>Iron deficiency (ID) is a serious public health problem that affects 20–25 % of the population and 52 % of pregnant people worldwide. Biologically female women (women) of reproductive age have a higher risk of developing ID due to the increased physiologic demand for iron required to support menstruation and pregnancy. If left untreated, ID can develop into iron deficiency anaemia (IDA), which affects one in three women between the ages of 15–49 years worldwide. Among women of reproductive age, those who are pregnant have the highest risk of developing ID and IDA due to increased iron requirements to support pregnancy and the developing fetus. Despite the high prevalence of ID and IDA, it remains underdiagnosed in reproductive-aged women and current treatment options are not well accepted. There is an urgent need to investigate novel strategies to ensure adequate iron status in women of reproductive age to prevent adverse health problems and promote healthy pregnancies. This review explored the critical role of iron in women's health by examining iron requirements throughout the lifespan, the physiology of iron absorption, factors affecting iron bioavailability, and the causes of ID and IDA. We discuss the limitations of current interventions for ID and IDA, and the need to develop effective and widely acceptable treatments for these conditions, particularly in women of reproductive age. The findings of this review suggest that current interventions for ID and IDA are inadequate and that sex biases exist in the diagnosis and management of ID and IDA in biologically female women.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127684"},"PeriodicalIF":3.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144491282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating role of whole epigenome DNA methylation signatures in the association between copper and SGA","authors":"Weiwei Wu ,&nbsp;Mengru Wang ,&nbsp;Shan Li ,&nbsp;Bole Zhang ,&nbsp;Weixuan Hu ,&nbsp;Yulin Li ,&nbsp;Yongliang Feng ,&nbsp;Yawei Zhang ,&nbsp;Suping Wang","doi":"10.1016/j.jtemb.2025.127688","DOIUrl":"10.1016/j.jtemb.2025.127688","url":null,"abstract":"<div><h3>Background</h3><div>Trace element Cu is associated with the risk of small for gestational age infants, but its underlying mechanism is still unclear. This study aims to explore the possible mechanism of Cu induced SGA from the perspective of DNA methylation.</div></div><div><h3>Methods</h3><div>We performed epigenome-wide DNA methylation analysis of umbilical cord blood from small for gestational age infants (SGA, n = 35) and appropriate for gestational age infants (AGA, n = 61) at birth to explore SGA related epigenome-wide DNA methylation sites. Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) was used to detect their umbilical cord blood Cu levels. Multiple linear regression models were used to explore the effect of Cu on SGA-related DNA methylation sites, and mediation analysis was further applied to explore the potential mediating factors of DNA methylation. The false discovery rate（FDR）was used for multiple comparisons.</div></div><div><h3>Results</h3><div>Compared with AGA (452 ng/mL), SGA infants (532 ng/mL) had higher umbilical cord blood Cu concentration (<em>P</em> &lt; 0.05). Seven Cu-related CpG sites were identified from epigenome-wide DNA methylation association analysis with SGA. Among them, a significant mediation effect of FLT3（cg10763141） methylation level in the association between high exposure level of Cu and SGA (<em>P</em> = 0.024). The mediation analysis showed a mediation proportion of 44.7 %.</div></div><div><h3>Conclusions</h3><div>Consistent with previous findings, we found that Cu was associated with the risk of SGA, and seven differentially methylated sites significantly associated with Cu were observed in the epigenome wide DNA methylation association study of SGA. FLT3（cg10763141）mediates the correlation between Cu and SGA. Cu may increase the risk of SGA by altering DNA methylation in certain genes (particularly FLT3). Our study provides new clues for the mechanism of SGA.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127688"},"PeriodicalIF":3.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144329689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heavy metal exposure and hepatitis C virus infection: A cross-sectional study","authors":"Humairat H. Rahman ,&nbsp;Weston R. Stokey ,&nbsp;Jonah Green ,&nbsp;Soyoung Jeon","doi":"10.1016/j.jtemb.2025.127687","DOIUrl":"10.1016/j.jtemb.2025.127687","url":null,"abstract":"<div><h3>Background</h3><div>Hepatitis C virus (HCV) is a Flaviviridae virus transmitted through contact with infected bodily fluids or utilization of non-sterile instruments. HCV has a high probability of progressing to a chronic infection, which leaves the individual susceptible to a multitude of other complications. Exposure to metals is common and difficult to avoid in the environment because of their widespread use in multiple industries.</div></div><div><h3>Objective</h3><div>In this study, barium (Ba), cadmium (Cd), cobalt (Co), manganese (Mn), molybdenum (Mo), lead (Pb), antimony (Sb), thallium (Tl), tin (Sn), and tungsten (W) were analyzed with their association on HCV infection prevalence.</div></div><div><h3>Methods</h3><div>The prevalence of HCV infection was analyzed using the Nutrition Examination Survey (NHANES) dataset for 2013–2020, including 2017-March 2020 pre-pandemic data. Weighted complex logistic regression analysis was used to examine associations of metal levels with HCV status for 18,073 participants aged 20–80 (n = 5751 urine samples collected out of 18,073).</div></div><div><h3>Results</h3><div>HCV was associated with increasing urinary Co [odds ratio (OR) 1.179; 95 % confidence interval (CI): 1.056, 1.316]. Tungsten (W) Q3 and Q4 showed a higher prevalence of HCV compared to W values below the detection limit (dl) with ORs 13.623 and 11.687, respectively. Molybdenum (Mo) showed significant increases in ORs of being HCV-positive across quartiles Q2, Q3, and Q4 (ORs 7.186, 5.472, and 8.579, respectively), compared to the lowest quartile (Q1) of Mo.</div></div><div><h3>Conclusion</h3><div>Overall, HCV infection was positively associated with exposure to Co, W, and Mo. These findings are significant in highlighting the intersection of environmental health and disease manifestation in public health research.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127687"},"PeriodicalIF":3.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}