Journal of Trace Elements in Medicine and Biology最新文献

{"title":"Association of blood trace metals with anemia in children aged 6–17 years old","authors":"Panpan Fang ,&nbsp;Yingyuan Wang ,&nbsp;Nan Chen ,&nbsp;Kaijie Gao ,&nbsp;Weihua Gong ,&nbsp;Liu Yang ,&nbsp;Qianqian Sun ,&nbsp;Xuchen Wang ,&nbsp;Tong Cai ,&nbsp;Tiewei Li ,&nbsp;Junmei Yang","doi":"10.1016/j.jtemb.2025.127655","DOIUrl":"10.1016/j.jtemb.2025.127655","url":null,"abstract":"<div><h3>Background</h3><div>Anemia significantly impacts children's health and quality of life, and may be influenced by the levels of various trace metals in the body. Current research on trace metals and anemia is mostly limited to single metals, and the association of multiple trace metals and their mixtures with anemia among children remains unclear.</div></div><div><h3>Methods</h3><div>This study utilized cross-sectional data from the 2017–2020 National Health and Nutrition Examination Survey (NHANES), including 2208 children aged 6–17 years in the United States, who were tested for five trace metals: lead(Pb), mercury(Hg), cadmium(Cd), selenium(Se), and manganese(Mn). The study used logistic regression, quantile g-computation, and Bayesian kernel machine regression models to examine how these metals individually and collectively affect anemia and to identify significant influencing factors. Age-stratified analysis was also conducted to analyze the association of trace metals with anemia in different age groups.</div></div><div><h3>Results</h3><div>Children with anemia had significantly higher blood Cd levels and significantly lower Se and Mn levels. In the univariate metal model, increasing Se levels was associated with decreased anemia risk. Mn was the main protective factor for anemia in school-age children, while Se was the main protective factor in adolescents. Both qgComp and BKMR models showed a negative association between mixed trace metal exposure and anemia. The age-specific analysis showed that the protective effect of trace metals was not as apparent in adolescents.</div></div><div><h3>Conclusion</h3><div>This research discovered that mixed trace metal exposure was associated with a reduced risk of anemia in children, with Se acting as a protective factor across all populations. Mn played a protective role in school-age children but may become a risk factor in adolescents.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"89 ","pages":"Article 127655"},"PeriodicalIF":3.6,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of chromium supplementation on cardio-metabolic risk factors in overweight and obese patients. A systematic review and meta-analysis of randomized controlled trial","authors":"Vahid Monfared ,&nbsp;Hadiseh Rashin ,&nbsp;Sara Malekinejad ,&nbsp;Leila Sheikhi ,&nbsp;Mahsa Yousefi ,&nbsp;Mohammad Ali Vakili ,&nbsp;Motahareh Hasani","doi":"10.1016/j.jtemb.2025.127645","DOIUrl":"10.1016/j.jtemb.2025.127645","url":null,"abstract":"<div><h3>Objective</h3><div>This study was conducted with the aim of evaluating the effect of chromium supplementation on cardiovascular-metabolic risk factors including lipid profile, glycemic index, anthropometric factors, blood pressure and liver function.</div></div><div><h3>Methods</h3><div>Relevant studies were identified through electronic database searches (PubMed, Scopus, Web of Science) up to March 2024. The overall effect size was calculated using the mean changes and standard deviations for the intervention and control groups. The I2 statistic and Cochran's Q-test were used to determine the existence of heterogeneity. A non-linear modeling explored heterogeneity, dose-response relationships, and the overall impact of Chromium supplementation.</div></div><div><h3>Results</h3><div>Twenty trials, with interventions ranging from 1 to 137 participant were included. Chromium supplementation significantly reduced Fasting blood glucose (FBG) ([WMD]: −1.60 mg/dl; 95 % [CI]: −3.28, 0.07; p = 0.06) and A1C ([WMD]: −0.05 %; 95 % [CI]: −0.19, 0.07; p = 0.38) HOMO-IR ([WMD]: −0.26; 95 % [CI]: 0.48, −0.03; p = 0.02) and insulin ([WMD]: −12.55 pmol/l; 95 % [CI]: −23.62, −1.47; p = 0.02) and a slight decrease in lipid profiles and anthropometric measures. However, there were some factors that Chromium was slightly increased compared to other groups, including: HDL, ALT, Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP). Chromium has no significant effect on AST.</div></div><div><h3>Conclusion</h3><div>The results of this experiment show that chromium supplementation had a positive effect on blood sugar control and various factors including weight, BMI, SBP, DBP, triglycerides, and waist circumference, and had an effective role in improving the level of liver enzymes.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"89 ","pages":"Article 127645"},"PeriodicalIF":3.6,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex difference in the association between dietary iron intake and bone mineral density in adolescents aged 12–19: A cross-sectional study","authors":"Keyi Li ,&nbsp;Jun Han ,&nbsp;Jinyu Zhu ,&nbsp;Xiang Zhu ,&nbsp;Yanfang Zhong ,&nbsp;Zefeng Zhu","doi":"10.1016/j.jtemb.2025.127654","DOIUrl":"10.1016/j.jtemb.2025.127654","url":null,"abstract":"<div><h3>Background</h3><div>This cross-sectional study investigated the relationship between dietary iron intake and bone mineral density (BMD) in adolescents, exploring how dietary iron intake and other variables collectively influence BMD.</div></div><div><h3>Methods</h3><div>We analyzed data from participants aged 12–19 years in the National Health and Nutrition Examination Survey (NHANES) conducted from 2005 to 2010. Multivariate linear regression, incorporating multiple covariates, assessed the association between dietary iron intake and BMD at the lumbar and femoral sites. The analysis was stratified by sex, with separate assessments for males and females, and examined the impact of sex on these outcomes, including interactions between dietary iron intake and BMD at both sites.</div></div><div><h3>Results</h3><div>The study included 2520 adolescents. Dietary iron intake was positively correlated with BMD at the lumbar spine (β = 0.006, 95 % confidence interval [CI] = 0.001–0.011) and femoral regions (β = 0.008, 95 % CI = 0.002–0.013). However, the strength of this association differed significantly by sex. In males, dietary iron intake was positively associated with lumbar (β = 0.006, 95 % CI = 0.001–0.011) and femoral BMD (β = 0.010, 95 % CI = 0.004–0.017). In contrast, no significant correlation was observed between dietary iron intake and BMD at either site in females (P for interaction = 0.005).</div></div><div><h3>Conclusion</h3><div>Our findings suggest that increased dietary iron intake is associated with higher BMD in adolescent males but not in females.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"89 ","pages":"Article 127654"},"PeriodicalIF":3.6,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium intake and risk of prostate cancer: A systematic review and dose-response meta-analysis of prospective cohort studies","authors":"Kai Xiong ,&nbsp;Linjie Lu ,&nbsp;Pingyu Ge ,&nbsp;Shenglan Yuan ,&nbsp;Bangwei Che ,&nbsp;Jiancheng Zhai ,&nbsp;Kaifa Tang ,&nbsp;Hongyan Zhang","doi":"10.1016/j.jtemb.2025.127652","DOIUrl":"10.1016/j.jtemb.2025.127652","url":null,"abstract":"<div><h3>Background</h3><div>The association between high calcium intake and prostate cancer (PCa) risk is only weak, and the dose–response relationship between the two remains unclear. Therefore, we conducted a systematic review and dose-response meta-analysis to evaluate the relationship between calcium intake and PCa risk.</div></div><div><h3>Methods</h3><div>The databases were searched up to September 2024. Random-effects models were employed to pool effect sizes (ESs) with 95 % confidence intervals (CIs) for the highest versus lowest intakes of total, dietary, supplemental, dairy and non-dairy calcium. Linear and non-linear dose-response analyses were performed to assess the relationships between them.</div></div><div><h3>Results</h3><div>21 prospective cohort studies were included in this meta-analysis. High intakes of total, dietary, and dairy calcium were associated with an increased risk of PCa. The summary ESs were 1.08 (95 % CI 1.01–1.15), 1.16 (95 % CI 1.08–1.24), and 1.13 (95 % CI 1.02–1.24), respectively. Supplemental calcium and non-dairy calcium intakes were not significantly associated with PCa risk. Linear dose-response analysis indicated that dietary (P-linear &lt; 0.001) and dairy calcium intakes (P-linear = 0.02) were positively associated with PCa risk, and total calcium intake was possibly linearly related to PCa risk (P-linear = 0.06). An additional intake of 300 mg/day of total, dietary, and dairy calcium is linked to approximately 2 %, 6 %, and 5 % increases in PCa risk, respectively. No non-linear dose-response relationships were observed between calcium intake and PCa risk.</div></div><div><h3>Conclusions</h3><div>These results demonstrate higher intakes of total, dietary, and dairy calcium were associated with an increased risk of PCa. Future research should provide more detailed results, including risks between different sources of calcium and PCa subtypes.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"89 ","pages":"Article 127652"},"PeriodicalIF":3.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heavy metals and cardiovascular health: Uncovering links and health challenges","authors":"Yogita Ozarde,&nbsp;Dishank Purandare,&nbsp;Shreya Deshmukh,&nbsp;Ranjit Gadhave","doi":"10.1016/j.jtemb.2025.127648","DOIUrl":"10.1016/j.jtemb.2025.127648","url":null,"abstract":"<div><h3>Background</h3><div>Heavy metals, including lead, mercury, cadmium, and arsenic, along with emerging contaminants, pose significant threats to cardiovascular health. These metals are linked to oxidative stress, endothelial dysfunction, inflammation, and epigenetic alterations, contributing to various cardiovascular diseases.</div></div><div><h3>Aim</h3><div>This review synthesizes current research on the pathways by which heavy metal exposure affects cardiovascular health, highlighting epidemiological trends, vulnerable populations, and potential preventive strategies.</div></div><div><h3>Methods</h3><div>A comprehensive review of molecular mechanisms, epidemiological studies, and public health data was conducted to elucidate the links between heavy metal exposure and cardiovascular health.</div></div><div><h3>Results</h3><div>Mechanisms of Toxicity: Heavy metals induce oxidative stress and inflammation, impair endothelial function, and disrupt calcium signaling. These effects culminate in hypertension, atherosclerosis, myocardial dysfunction, and other cardiovascular pathologies.</div><div>Epidemiological Trends: Evidence links even low-level exposures to increased Cardio Vascular Disease risk. Regional trends show elevated risks in areas with significant industrial activity or contaminated water supplies.</div><div>Vulnerable Populations: Children, the elderly, and individuals in low-income or industrially polluted regions exhibit heightened susceptibility.</div><div>Preventive Strategies: Regulatory actions, improved water safety, dietary interventions, and community awareness are critical in mitigating exposure and its health impacts.</div></div><div><h3>Conclusions</h3><div>Environmental exposure to heavy metals significantly elevates cardiovascular disease risk, particularly among vulnerable groups. Urgent public health measures and further research are needed to address the cumulative and synergistic effects of these toxicants.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"89 ","pages":"Article 127648"},"PeriodicalIF":3.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between mixture exposure to metals in urine and cognitive function in older adults in the United States: NHANES 2011–2014","authors":"Zihan Li ,&nbsp;Yuxin Lin ,&nbsp;Weikang Wang ,&nbsp;Manling Xie ,&nbsp;Yixian Jiang ,&nbsp;Zheng Wang ,&nbsp;Xiao Huang ,&nbsp;Qian Zhang","doi":"10.1016/j.jtemb.2025.127643","DOIUrl":"10.1016/j.jtemb.2025.127643","url":null,"abstract":"<div><h3>Aims</h3><div>The effects of exposure to individual metals on cognitive function have been widely reported, but research on the effects of metal mixtures is rare. This study aims to investigate the association of exposure to both individual metals and multiple metals in urine on cognitive function in US elderly.</div></div><div><h3>Methods</h3><div>Data derived from the National Health and Nutrition Examination Survey 2011–2014 were utilized in this cross-sectional study. A total of 13 urinary metals were determined using inductively coupled plasma mass spectrometry. Cognitive function assessments included the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) word learning test, the CERAD word recall test, the animal fluency test, and the Digit Symbol Substitution test (DSST). To assess the relationships between multiple metal exposures and cognitive performance, linear regression and Bayesian kernel machine regression (BKMR) and the weighted quantile sum (WQS) regression models were employed.</div></div><div><h3>Results</h3><div>A total of 1018 older adults were included. The participants’ mean scores on the CERAD word learning test, the CERAD word recall test, the animal fluency test, and the DSST were 19.04 ± 4.62, 5.96 ± 2.30, 16.71 ± 5.57 and 45.56 ± 17.07, respectively. There were 10 metals with detection rates higher than 80 %. The linear regression model revealed that higher levels of barium (Ba), cadmium (Cd), lead (Pb), and tungsten (W) were associated with a decline in cognitive function scores. Conversely, increased levels of molybdenum (Mo), cobalt (Co), strontium (Sr), and thallium (Tl) were associated with improved cognitive function scores. Furthermore, BKMR model demonstrated that the slope of the dose-response curve between Mo and animal fluency test score decreased with increasing concentrations of Cd, suggesting an interaction effect of Mo and Cd exposure on cognitive function. WQS regression model demonstrated a significant negative association between exposure to metal mixtures and DSST score (β=-2.42, p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Our study suggests significant associations between several metals, such as Ba, Cd, Pb, W, Mo, Co, Sr and Tl, and cognitive function in older adults. Moreover, there is an interaction between Mo and Cd on cognitive function under metal co-exposure conditions. Prospective studies are needed to confirm the potential causal relationship.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"89 ","pages":"Article 127643"},"PeriodicalIF":3.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of essential mineral (Ca, Mg, P, K, Na, Cu, Fe, and Zn) intakes from cuban diets and their health implications: Insights from a total diet study","authors":"Luisbel González ,&nbsp;Ociel Muñoz-Fariña ,&nbsp;Yenisleidys Fernández-Guerrero ,&nbsp;Olga García ,&nbsp;María Cristina Ravanal","doi":"10.1016/j.jtemb.2025.127649","DOIUrl":"10.1016/j.jtemb.2025.127649","url":null,"abstract":"<div><div>This study focuses on evaluating the intake of selected essential minerals in the Cuban population's diet and their associated health implications. Using 24-hour recall surveys and a Total Diet Study approach, 17 food groups were established from a total of 107 foods collected from the three regions of the Cuban territory. The minerals in the 17 groups were quantified by digesting the foods through dry ashing, and the analysis was carried out using the flame atomic absorption spectroscopy method (for Ca, Mg, K, Na, Cu, Fe and Zn) and spectrophotometric method (for P). The results revealed significant variations in mineral intake among the food groups, with dairy products, meats, legumes, and condiments being the primary sources of these nutrients. Average calcium and magnesium intakes (687 and 230 mg/day) were below the recommended 1000 mg/day and 300–350 mg/day, respectively. However, phosphorus consumption was excessive, averaging 1220 mg/day, which could pose health risks, especially with inadequate calcium intake (molar ratio of 0.44:1). Despite sufficient iron intake (16.8 mg/day), sodium consumption was high (3242 mg/day), exceeding the safe limit of 2000 mg/day, and may contribute to increased cardiovascular disease risk. The assessment of the risks associated with the individual intake of each mineral indicated that the Cuban population is not currently at significant risk. However, the synergistic effect of these minerals resulted in a Total Target Hazard Quotient of 1.23, indicating potential cause for concern. In conclusion, improving the Cuban diet requires policies that ensure balanced mineral intake and reduce health risks.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"89 ","pages":"Article 127649"},"PeriodicalIF":3.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uptake, localization and dissolution of barium sulfate nanoparticles in human lung cells explored by the combination of ICP-MS, TEM and NanoSIMS","authors":"Maria Angels Subirana ,&nbsp;Sarah Thomas ,&nbsp;Gerd Hause ,&nbsp;Dirk Dobritzsch ,&nbsp;Felix Glahn ,&nbsp;Dirk Schaumlöffel ,&nbsp;Martin Herzberg","doi":"10.1016/j.jtemb.2025.127650","DOIUrl":"10.1016/j.jtemb.2025.127650","url":null,"abstract":"<div><h3>Background</h3><div>Barium sulfate nanoparticles (BaSO₄-NPs) are considered to be poorly soluble, chemically inert, and therefore relatively non-toxic. For humans, inhalative exposure represents the most significant route of uptake.</div></div><div><h3>Objective and methods</h3><div>Cellular effects after exposure to BaSO₄-NPs for 24 and 72 have been investigated in this study on primary human lung cells. To track the fate of BaSO₄-NPs in human lung cells, we used inductively coupled plasma mass spectrometry (ICP-MS) to quantify cellular uptake of NPs, as well as transmission electron microscopy (TEM) and nanoscale secondary ion mass spectrometry (NanoSIMS) to investigate subcellular distribution of NPs through high-resolution elemental imaging.</div></div><div><h3>Results and conclusions</h3><div>We show that BaSO₄ nanoparticles have been taken up by normal human bronchial epithelial cells (NHBEC) in a dose-dependent manner. However, no clear time-dependent uptake could be observed. The barium sulfate nanoparticles were visible in vesicles within the cytosol by TEM, which was confirmed by high-resolution NanoSIMS images. Nevertheless, no uptake of the particles into the nucleus was observed in this study. However, it was shown that BaSO₄-NPs were partly dissolved, and barium ions were distributed throughout the entire cell. Toxicity of the particles was indicated by a dose- and time-dependent loss of viability in human lung cells.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"89 ","pages":"Article 127650"},"PeriodicalIF":3.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginsenoside Rb1 combined with Lycium barbarum polysaccharide alleviate the Tripterygium wilfordii polyglycoside-induced oligoasthenozoospermia in mice by inhibiting ZnT3-mediated oxidative stress response","authors":"Xianrui Li ,&nbsp;Jin Ding ,&nbsp;Jingshang Wang ,&nbsp;Junqin He ,&nbsp;Wen Sheng","doi":"10.1016/j.jtemb.2025.127646","DOIUrl":"10.1016/j.jtemb.2025.127646","url":null,"abstract":"<div><h3>Background</h3><div>Oligoasthenozoospermia (OAS) is one of the main causes of male infertility. Studies have shown that ginsenoside Rb1 (GRb1) and Lycium barbarum polysaccharide (LBP) have great potential in treating OAS. This study aims to investigate the effects of combined GRb1 and LBP treatment on OAS and the underlying molecular mechanisms.</div></div><div><h3>Methods</h3><div>The Tripterygium wilfordii polyglycoside (GTW)-induced mouse model and H₂O₂-induced cell model were intervened with GRb1 and LBP. HE staining and Johnson score were used to evaluate the degree of testicular injury. Then, sperm quality was evaluated, and the levels of sperm-related hormones were measured. The regulatory effect of GRb1 and LBP on oxidative stress in OAS mice and cells was explored. In addition, total zinc content in testicular tissues and GC-2 cells was measured, and the mRNA and protein expression levels of zinc transporter 3 (ZnT3) were detected.</div></div><div><h3>Results</h3><div>In the OAS model of mice treated with GRb1 and LBP, the coefficient of testis and epididymis were increased, and the degree of damage and sperm quality were significantly improved. Serum levels of T, LH, and FSH were increased in mice. Moreover, inhibition of ZnT3 signaling increased total intracellular zinc content in GC-2 cells. Overexpression of ZnT3 reversed the inhibitory effects of the combination of GRb1 and LBP on oxidative stress and the therapeutic effects in OAS mice.</div></div><div><h3>Conclusion</h3><div>The combined treatment of GRb1 and LBP could inhibit oxidative stress response by down-regulating ZnT3 signaling, thereby improving OAS mice. This provided a new strategy for the drug treatment of OAS.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"89 ","pages":"Article 127646"},"PeriodicalIF":3.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restoring wheat productivity and nutrient balance under cadmium stress through reducing toxicity, metal uptake, and oxidative damage using selenium nanoparticles","authors":"Ayesha Jamil Abbasi ,&nbsp;Muhammad Anas ,&nbsp;Minhas Elahi ,&nbsp;Amjid Khan ,&nbsp;Waseem Ahmed Khattak ,&nbsp;Muhammad Hamzah Saleem ,&nbsp;Shah Fahad ,&nbsp;Hosam O. Elansary ,&nbsp;Eman A. Mahmoud ,&nbsp;Temoor Ahmed ,&nbsp;Umar Masood Quraishi","doi":"10.1016/j.jtemb.2025.127644","DOIUrl":"10.1016/j.jtemb.2025.127644","url":null,"abstract":"<div><div>Cadmium (Cd) contamination in soil poses a significant environmental threat, reducing crop yields and compromising food safety. This study investigates the potential of selenium nanoparticles (Se-NPs) synthesized using wheat extract to mitigate Cd toxicity, reduce Cd uptake and mobility, and recover grain nutrient composition in wheat (<em>Triticum aestivum</em> L.). A pot experiment was conducted following a completely randomized design (CRD) with three replications. Treatments included control, four Se-NPs concentrations (10, 25, 50, and 100 ppm), four Cd stress levels (25, 50, 75, and 100 ppm), and their combined interactions. Various physiological, biochemical, and agronomic parameters were analyzed to assess the mitigation potential of Se-NPs against Cd toxicity in wheat. Se-NPs (36.77 nm) were characterized using FTIR, confirming functional groups for stabilization, XRD verifying crystallinity and size via the Scherrer Equation, SEM revealing spherical morphology, and EDX confirming selenium as the predominant element with minor trace elements. Under 50 ppm Cd stress, Se-NPs at 25 ppm reduced days to anthesis by 8.16 % and mitigated a 45.13 % decrease in plant height. Grain yield, which declined by 90.86 % under Cd stress, was restored by 90.86 % with 10 ppm Se-NPs. Additionally, Se-NPs improved thousand kernel weight by 32.71 %, counteracting a 25.92 % reduction due to Cd stress. Antioxidant enzyme activities, including SOD and CAT, increased by up to 333.79 % in roots with Se-NP treatment, while oxidative stress markers decreased by 28 %. Moreover, Se-NPs effectively mitigated Cd uptake and reduced its mobility within the plant. Grain protein content improved by 16.89 %, and carbohydrate levels were maintained at 4.61 % despite Cd exposure. These findings indicate that Se-NPs enhance crop resilience, supporting sustainable food production in Cd-contaminated environments.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"89 ","pages":"Article 127644"},"PeriodicalIF":3.6,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}