Journal of Trace Elements in Medicine and Biology最新文献

{"title":"Essential trace element and phosphatidylcholine remodeling: Implications for body composition and insulin resistance","authors":"Wen-Ling Lin ,&nbsp;Mu-Ming Chien ,&nbsp;Sangopas Patchara ,&nbsp;Weu Wang ,&nbsp;Amelia Faradina ,&nbsp;Shih-Yi Huang ,&nbsp;Te-Hsuan Tung ,&nbsp;Chien-Sung Tsai ,&nbsp;Anatoly V. Skalny ,&nbsp;Alexey A. Tinkov ,&nbsp;Chun-Chao Chang ,&nbsp;Jung-Su Chang","doi":"10.1016/j.jtemb.2024.127479","DOIUrl":"10.1016/j.jtemb.2024.127479","url":null,"abstract":"<div><h3>Background</h3><p>Recent studies indicated that bioactive lipids of phosphatidylcholines (PCs) and lysophosphatidylcholines (LysoPCs) predict unhealthy metabolic phenotypes, but results remain inconsistent. To fill this knowledge gap, we investigated whether essential trace elements affect PC-Lyso PC remodeling pathways and the risk of insulin resistance (IR).</p></div><div><h3>Methods</h3><p>Anthropometric and blood biochemical data (glucose, insulin, and lipoprotein-associated phospholipase A2 (Lp-PLA2)) were obtained from 99 adults. Blood essential/probably essential trace elements and lipid metabolites were respectively measured by inductively coupled plasma mass spectrometry (ICP-MS), and ultra-performance liquid chromatography-mass spectrometry (UPLC-MS).</p></div><div><h3>Result and Conclusion</h3><p>Except for LysoPC (O-18:0/0:0), an inverse V shape was observed between body weight and PC and LysoPC species. A Pearson correlation analysis showed that essential/probably-essential metals (Se, Cu, and Ni: <em>r</em>=-0.4∼-0.7) were negatively correlated with PC metabolites but positively correlated with LysoPC (O-18:0/0:0) (Se, Cu, and Ni: <em>r</em>=0.85–0.64). Quantile-g computation showed that one quantile increase in essential metals was associated with a 2.16-fold increase in serum Lp-PLA2 (β=2.16 (95 % confidence interval (CI): 0.34, 3.98), <em>p</em>=0.023), which are key enzymes involved in PC/Lyso PC metabolism. An interactive analysis showed that compared to those with the lowest levels (reference), individuals with the highest levels of serum PCs (pooled, M2) and the lowest essential/probably essential metals (M1) were associated with a healthier body composition and had a 76 % decreased risk of IR (odds ratio (OR)=0.24 (95 % CI: 0.06, 0.90), <em>p</em>&lt;0.05). In contrast, increased exposure to LysoPC(O-18:0/0:0) (M2) and essential metals (M2) exhibited an 8.22-times highest risk of IR (OR= 8.22 (2.07, 32.57), <em>p</em>&lt;0.05) as well as an altered body composition. In conclusion, overexposure to essential/probably essential trace elements may promote an unhealthy body weight and IR through modulating PC/LysoPC remodeling pathways.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"85 ","pages":"Article 127479"},"PeriodicalIF":3.5,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141280834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence and health risk assessment of mineral composition and aflatoxin M1 in cow milk samples from different areas of Sicily, Italy","authors":"Laura Messina ,&nbsp;Patrizia Licata ,&nbsp;Fabio Bruno ,&nbsp;Federica Litrenta ,&nbsp;Giovanna Lucrezia Costa ,&nbsp;Vincenzo Ferrantelli ,&nbsp;Katya Peycheva ,&nbsp;Veselina Panayotova ,&nbsp;Francesco Fazio ,&nbsp;Giuseppe Bruschetta ,&nbsp;Marco Tabbì ,&nbsp;Vincenzo Nava","doi":"10.1016/j.jtemb.2024.127478","DOIUrl":"https://doi.org/10.1016/j.jtemb.2024.127478","url":null,"abstract":"<div><p>This study aimed to determine 16 mineral elements (Cd, Pb, As, Na, Mg, Al, Ca, K, Cr, Mn, Fe, Ni, Cu, Zn and Se) using inductively coupled plasma mass spectrometry (ICP-MS) and a direct mercury analyzer (DMA-80) for Hg evaluation. Aflatoxin M1 was determined by high-performance liquid chromatography with fluorescence detection (HPLC-FLD) in cow milk samples. This research considered 180 milk samples, 20 by province (Palermo, Catania, Messina), collected for a period of three years (2020–2022) to assess the potential risks for consumer, the safety status and nutritional quality related to mineral intake by consuming of milk. All samples showed a Pb concentration below the limit reported by European Regulation 915/2023. Cadmium and Hg concentrations were below the Limit Of Quantification (LOQ) in all samples analyzed. The milk samples analyzed proved to be a good source of Ca (up to 44.5 % of the dietary reference values), with well percentages also for Na (up to 7.6 %), K (up to 23.1 %) and Mg (up to 11.1 %). Regarding trace elements, the results reported that chromium requires attention; its value was always higher than 168.8 % in all samples analyzed. Levels of arsenic and lead were up to 20.2 % and up 7.1 % respectively. Aflatoxin M1 concentrations were below the limit of detection (&lt; 0,009 mcg/kg) in all milk analyzed. Therefore, further studies are needed to safeguard consumer health, the quality of the product and to assess the state of animal health.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"85 ","pages":"Article 127478"},"PeriodicalIF":3.5,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141312944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between essential metals, adherence to healthy lifestyle behavior, and ankle-brachial index","authors":"Xiya Qin ,&nbsp;Gaojie Fan ,&nbsp;Qing Liu ,&nbsp;Mingyang Wu ,&nbsp;Jianing Bi ,&nbsp;Qing Fang ,&nbsp;Surong Mei ,&nbsp;Zhengce Wan ,&nbsp;Yongman Lv ,&nbsp;Lulu Song ,&nbsp;Youjie Wang","doi":"10.1016/j.jtemb.2024.127477","DOIUrl":"10.1016/j.jtemb.2024.127477","url":null,"abstract":"<div><h3>Background</h3><p>Ankle-brachial index (ABI) is a noninvasive diagnostic method for peripheral arterial disease (PAD) and a predictor of cardiovascular events.</p></div><div><h3>Objective</h3><p>The present study aimed to evaluate the association between individual or combined essential metals and ABI, as well as assess the collective impact of essential metals when coupled with healthy lifestyle on ABI.</p></div><div><h3>Methods</h3><p>A total of 2865 participants were recruited in Wuhan Tongji Hospital between August 2018 and March 2019. Concentrations of essential metals in urine were measured by inductively coupled plasma mass spectrometer.</p></div><div><h3>Results</h3><p>The results of general linear regression models demonstrated that after adjusting for confounding factors, there was a positive association between ABI increase and per unit increase of log 10-transformed, creatinine-corrected urinary Cr (β (95 % CI): 0.010 (0.004, 0.016), <em>P</em>_<em>FDR</em> = 0.007), Fe (β (95 % CI): 0.010 (0.003, 0.017), <em>P</em>_<em>FDR</em> = 0.018), and Co (β (95 % CI): 0.013 (0.005, 0.021), <em>P</em>_<em>FDR</em> = 0.007). The WQS regression revealed a positive relationship between the mixture of essential metals and ABI (β (95 % CI): 0.006 (0.003, 0.010), <em>P</em> &lt; 0.001), with Cr and Co contributing most to the relationship (weighted 45.48 % and 40.14 %, respectively). Compared to individuals with unfavorable lifestyle and the lowest quartile of Cr, Fe and Co, those with favorable lifestyle and the highest quartile of Cr, Fe and Co exhibited the most increase in ABI (β (95 % CI): 0.030 (0.017, 0.044) for Cr, β (95 % CI): 0.027 (0.013, 0.040) for Fe, and β (95 % CI): 0.030 (0.016, 0.044) for Co).</p></div><div><h3>Conclusion</h3><p>In summary, our study indicates that adequate essential metal intake together with healthy lifestyle behaviors perform crucial roles in PAD protection.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"85 ","pages":"Article 127477"},"PeriodicalIF":3.5,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141133105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BMAdBMSFERETE","authors":"","doi":"10.1016/S0946-672X(24)00095-6","DOIUrl":"https://doi.org/10.1016/S0946-672X(24)00095-6","url":null,"abstract":"","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"84 ","pages":"Article 127475"},"PeriodicalIF":3.5,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0946672X24000956/pdfft?md5=e922034c6fa712119bde0c61b04c0839&pid=1-s2.0-S0946672X24000956-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141084024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BMFESTEM","authors":"","doi":"10.1016/S0946-672X(24)00096-8","DOIUrl":"https://doi.org/10.1016/S0946-672X(24)00096-8","url":null,"abstract":"","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"84 ","pages":"Article 127476"},"PeriodicalIF":3.5,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0946672X24000968/pdfft?md5=d07bd67dd122b9983843550489e58823&pid=1-s2.0-S0946672X24000968-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141084025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between multiple urinary metals and metabolic syndrome: Exploring the mediating role of liver function in Chinese community-dwelling elderly","authors":"Yuqing Dai ,&nbsp;Siyu Duan ,&nbsp;Rui Wang ,&nbsp;Pei He ,&nbsp;Zhongyuan Zhang ,&nbsp;Meiyan Li ,&nbsp;Zhuoheng Shen ,&nbsp;Yue Chen ,&nbsp;Yi Zhao ,&nbsp;Huifang Yang ,&nbsp;Xiaoyu Li ,&nbsp;Rui Zhang ,&nbsp;Jian Sun","doi":"10.1016/j.jtemb.2024.127472","DOIUrl":"10.1016/j.jtemb.2024.127472","url":null,"abstract":"<div><h3>Background</h3><p>Multiple metals exposure has been revealed to be related to metabolic syndrome (MetS). However, the associations and interactions between multiple metals exposure and MetS are remains controversial, and the potential mechanism of the above-mentioned is still unclear.</p></div><div><h3>Methods</h3><p>The associations between urinary metals and the MetS were analyzed by multivariable logistic regression model and restricted cubic spline (RCS). Bayesian kernel machine regression (BKMR) model and quantile-based g-computation (qgcomp) were applied to explore the mixed exposure and interaction effect of metals. Mediation analysis was used to explore the role of liver function.</p></div><div><h3>Results</h3><p>In the single metal model, multiple metals were significantly associated with MetS. RCS analysis further verified the associations between 8 metals and MetS. BKMR model and qgcomp showed that zinc (Zn), iron (Fe), and tellurium (Te) were the main factors affecting the overall effect. In addition, mediation analysis indicated that serum alanine aminotransferase (ALT) mediated 21.54% and 13.29% in the associations of vanadium (V) and Zn with the risk of MetS, respectively.</p></div><div><h3>Conclusions</h3><p>Elevated urinary concentration of Zn, V, Te, copper (Cu), molybdenum (Mo), and thallium (Tl) were related to the increased risk of MetS. Conversely, Fe and selenium (Se) may be protective factors for MetS in mixed exposure. Liver function may play a key role in the association of V and Zn exposure with MetS.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"85 ","pages":"Article 127472"},"PeriodicalIF":3.5,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141141955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reno-protective effect of nicorandil and pentoxifylline against potassium dichromate-induced acute renal injury via modulation p38MAPK/Nrf2/HO-1 and Notch1/TLR4/NF-κB signaling pathways","authors":"Ehab A.M. El-Shoura ,&nbsp;Lobna A. Abdelzaher ,&nbsp;Ahmed A.N. Ahmed ,&nbsp;Basel A. Abdel-Wahab ,&nbsp;Souty M.Z. Sharkawi ,&nbsp;Sally Abdelhamid Mohamed ,&nbsp;Esraa A. Salem","doi":"10.1016/j.jtemb.2024.127474","DOIUrl":"https://doi.org/10.1016/j.jtemb.2024.127474","url":null,"abstract":"<div><h3>Background</h3><p>Occupational and environmental exposure to chromium compounds such as potassium dichromate (PDC) (K₂Cr₂O₇) has emerged as a potential aetiologic cause for renal disease through apoptotic, and inflammatory reactions. The known potent antioxidants such as nicorandil (NIC) and/or pentoxifylline (PTX) were studied for their possible nephroprotective effect in PDC-treated rats.</p></div><div><h3>Methods</h3><p>Forty male Wistar rats were divided into five groups; control, PDC group, NIC+PDC, PTX+PDC group, and combination+PDC group. Nephrotoxicity was evaluated histopathologically and biochemically. Invasive blood pressure, renal function parameters urea, creatinine, uric acid and albumin, glomerular filtration rate markers Cys-C, Kim-1 and NGAL, inflammatory markers IL-1β, IL-6, TNF-α, TGF-β, COX-II, p38MAPK, NF-κB and TLR4, oxidative stress SOD, GSH, MDA, MPO, HO-1 and Nrf2 and apoptotic mediators Notch1 and PCNA were evaluated. Besides, renal cortical histopathology was assayed as well.</p></div><div><h3>Results</h3><p>PDC led to a considerable increase in indicators for kidney injury, renal function parameters, invasive blood pressure, oxidative stress, and inflammatory markers. They were markedly reduced by coadministration of PDC with either/or NIC and PTX. The NIC and PTX combination regimen showed a more significant improvement than either medication used alone. Our results demonstrated the nephroprotective effect of NIC, PTX, and their combined regimen on PDC-induced kidney injury through suppression of oxidative stress, apoptosis, and inflammatory response.</p></div><div><h3>Conclusion</h3><p>Renal recovery from PDC injury was achieved through enhanced MAPK/Nrf2/HO-1 and suppressed Notch1/TLR4/NF-κB signaling pathways. This study highlights the role of NIC and PTX as effective interventions to ameliorate nephrotoxicity in patients undergoing PDC toxicity.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"85 ","pages":"Article 127474"},"PeriodicalIF":3.5,"publicationDate":"2024-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141084151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zinc transporters expression profile in professional handball players supplemented with zinc","authors":"Jorge Molina-López ,&nbsp;Daniela Florea ,&nbsp;Yenifer Gamarra-Morales ,&nbsp;Lourdes Herrera-Quintana ,&nbsp;Héctor Vázquez-Lorente ,&nbsp;Christer Hogstrand ,&nbsp;Elena Planells","doi":"10.1016/j.jtemb.2024.127473","DOIUrl":"10.1016/j.jtemb.2024.127473","url":null,"abstract":"<div><h3>Introduction</h3><p>Zinc (Zn) deficiency has been described not only on general human health but also within the sports context –as negatively affecting performance–. Thus, Zn status assessment is of great interest for athletes, especially in order to correct deficiency states of this mineral.</p></div><div><h3>Objective</h3><p>The overall objective of this work was to assess Zn status in professional handball players during the competitive period (through plasma levels, dietary intake and gene expression of the Zn transporters), as well as to determine the effect of Zn supplementation.</p></div><div><h3>Methods</h3><p>A total of twenty-two participants were recruited, –twelve belonged to the Control Group (CG) and ten male handball players comprised the experimental group (ATH-G)–, being monitored over a 2-month period with 2 evaluation moments: baseline (i.e., initial conditions) and follow-up (i.e., after 8 weeks of training and competition). Zn intake, plasma Zn levels, and gene expression of Zn transporters were obtained.</p></div><div><h3>Results</h3><p>Plasma Zn levels were higher in ATH-G than in CG at the end of Zn intervention (<em>p</em> ≤ 0.010). Moreover, differences in the gene expression profile of Zn transporters were observed in ATH-G –with the down-regulation of several Zn transporters–, compared to the CG at baseline (<em>p</em> ≤ 0.05). Likewise, differences in the Zn transporters expression were observed in ATH-G at 8 weeks (all, <em>p</em> ≤ 0.001) –with ZnT2, ZnT5, ZIP3, ZIP5, ZIP11, ZIP13 and ZIP14 transporters being up-regulated–.</p></div><div><h3>Conclusion</h3><p>Handball players seemed to have different nutritional needs for Zn, with differences in the gene expression of Zn transporters compared to controls. Zn intervention in our athletes may have influenced the expression of Zn transporters, indicating a potential increase in Zn transporters expression to mobilize Zn at the cellular level at 8 weeks of Zn intervention.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"85 ","pages":"Article 127473"},"PeriodicalIF":3.5,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0946672X24000932/pdfft?md5=b55b6b063665898d846a00283f024684&pid=1-s2.0-S0946672X24000932-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141038477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zinc, antioxidant enzymes in preeclampsia, and association with newborn outcome","authors":"Fernanda Teixeira Benevides ,&nbsp;Francisco Luan Fonsêca da Silva ,&nbsp;Denise Lima de Oliveira ,&nbsp;Wladiana Oliveira Matos ,&nbsp;Thaynan dos Santos Dias ,&nbsp;Kaluce Gonçalves de Sousa Almondes ,&nbsp;Maria Diana Moreira Gomes ,&nbsp;Ariclécio Cunha de Oliveira ,&nbsp;Daniela Vasconcelos de Azevedo ,&nbsp;Carla Soraya Costa Maia","doi":"10.1016/j.jtemb.2024.127471","DOIUrl":"10.1016/j.jtemb.2024.127471","url":null,"abstract":"<div><h3>Background</h3><p>The etiology of preeclampsia (PE) may be associated with the increased of production of reactive species and decreased antioxidant activity of enzymes. Inadequate intake of Zn can affect gestational health due to its biological functions, such as its role in the antioxidant defense system. The study aimed to assess the nutritional status of Zn and antioxidant enzymes in postpartum women and its correlation with neonatal outcomes.</p></div><div><h3>Methods</h3><p>A cross-sectional analytical study was carried out at a referral gynecology and obstetrics hospital. A total of 119 women (PE = 58, HP = 61) participated in the study. A quantitative food-frequency questionnaire was used to assess food consumption and further analyze the dietary Zn levels.</p><p>Zinc levels in plasma and erythrocytes samples were analyzed by flame atomic absorption spectrometry, catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels were determined by UV-Vis spectrophotometry.</p></div><div><h3>Results</h3><p>Plasma and dietary intake Zn results were considered adequate and without statistical difference between groups. SOD levels were significantly higher in the HP group (p = 0.011), and CAT levels were higher in the PE group (p = 0.050). There was a positive correlation between SOD activity in women with PE and the weight of their newborns (r = 0.336, p=0.021).</p></div><div><h3>Conclusion</h3><p>The results showed adequate Zn levels (consumption and serum levels) in the groups studied, although with a reduction of plasma Zn in the PE group compared to the PH group.</p><p>Zinc in plasma fractions and erythrocytes are important markers for oxidative stress, in particular, plasma Zn seems to be related to the rapid response to preeclampsia. The activity of antioxidant enzymes was elevated in the groups studied. Better SOD activity improves birth weight in children of pregnant women with preeclampsia.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"85 ","pages":"Article 127471"},"PeriodicalIF":3.5,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141049254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between urinary rare Earth elements with renal function: Findings from a cross-sectional study in Guangxi, China","authors":"Xingxi Luo ,&nbsp;Suyang Xiao ,&nbsp;Dongping Huang ,&nbsp;Erna Guo ,&nbsp;Yu Yang ,&nbsp;Xiaoqiang Qiu ,&nbsp;Xiaogang Wang ,&nbsp;Zhengmin Qian ,&nbsp;Michael G. Vaughn ,&nbsp;Elizabeth Bingheim ,&nbsp;Guanghui Dong ,&nbsp;Shun Liu ,&nbsp;Xiaoyun Zeng","doi":"10.1016/j.jtemb.2024.127461","DOIUrl":"10.1016/j.jtemb.2024.127461","url":null,"abstract":"<div><h3>Background</h3><p>With increased applications of rare earth elements (REEs) across various industries, evaluating the relationship between REEs exposure and potential health effects has become a public concern. In vivo experiments have established that REEs impact renal function. However, relevant epidemiological evidence on this relationship remains scarce. The objective of this study is to examine the impact of exposure to REEs on renal function.</p></div><div><h3>Methods</h3><p>In this cross-sectional study, 1052 participants were recruited from Guangxi, China. We measured urinary concentrations of 12 REEs using an inductively coupled plasma-mass spectrometer (ICP-MS). Multiple linear regression models were developed to explore the relationship between a single REEs exposure and the estimated glomerular filtration rate (eGFR), a marker of renal function. Weighted quantile sum (WQS) regression and Bayesian kernel machine regression (BKMR) were used to examine the combined effects of REE co-exposure on eGFR.</p></div><div><h3>Results</h3><p>In the multiple linear regression analysis, increasing the concentrations of lanthanum (La, β: 8.22, 95% CI: 5.67–10.77), cerium (Ce, β:6.61, 95% CI: 3.80–9.43), praseodymium (Pr, β: 8.46, 95% CI: 5.85–11.07), neodymium (Nd, β:8.75, 95% CI: 6.10–11.41), and dysprosium (Dy, β:7.38, 95% CI: 4.85–9.91) significantly increased the eGFR. In the WQS regression model, the WQS index was significantly associated with eGFR (β: 4.03, 95% CI: 2.46–5.60), with Pr having the strongest correlation with eGFR. Similar results were obtained in the BKMR model. Additionally, interactions between Pr and La, and Pr and Nd were observed.</p></div><div><h3>Conclusions</h3><p>Co-exposure to REEs is positively associated with elevated eGFR. Pr is likely to have the most significant influence on increased eGFRs and this might be exacerbated when interacting with La and Nd. Mixed exposure to low doses of REEs had a protective effect on renal function, which can provide some evidence for the exposure threshold of REEs in the environment.</p></div><div><h3>Trial registration</h3><p>The study has been approved by the Guangxi Medical University Medical Ethics Committee (#20170206–1), and all participants provided written informed consent.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"85 ","pages":"Article 127461"},"PeriodicalIF":3.6,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141045059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}