Journal of Trace Elements in Medicine and Biology最新文献

{"title":"FESTEM","authors":"","doi":"10.1016/S0946-672X(24)00197-4","DOIUrl":"10.1016/S0946-672X(24)00197-4","url":null,"abstract":"","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"86 ","pages":"Article 127577"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143148081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SFERETE","authors":"","doi":"10.1016/S0946-672X(24)00196-2","DOIUrl":"10.1016/S0946-672X(24)00196-2","url":null,"abstract":"","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"86 ","pages":"Article 127576"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143148080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial distribution and the ecological risks posed by heavy metals and total petroleum hydrocarbons (TPHs) in the sediments of mangrove and coral habitats of Northeast Persian Gulf","authors":"Mohammad Seddiq Mortazavi,&nbsp;Sana Sharifian,&nbsp;Seyedeh Laili Mohebbi Nozar,&nbsp;Hadi Koohkan","doi":"10.1016/j.jtemb.2024.127574","DOIUrl":"10.1016/j.jtemb.2024.127574","url":null,"abstract":"<div><h3>Background</h3><div>Heavy metals and total petroleum hydrocarbons (TPHs) are important pollutants in the aquatic ecosystem, and their long-term resistance, bio-accumulation, and bio-magnification during the food chain may cause adverse ecological and health risks.</div></div><div><h3>Methods</h3><div>In here, the distribution and risk assessment of six heavy metals Cd, Pb, Ni, Cu, Zn, Cr, and TPHs were performed in the sediments of 32 regions situated in two mangroves (Tiab and Azini estuaries, Hara Mangrove forest protected area) and coral habitats (Larak and Hengam Islands) in Northeast of the Persian Gulf during 2020–2021. An atomic absorption device was used to determine the concentrations of heavy metals. Ecological risk of heavy metals is assessed through indices contamination factor (CF), contamination degree (CD), modified contamination degree (MCD), pollution load index (PLI), potential ecological risk index (PERI), and geoaccumulation index (Igeo). The spatial distribution of heavy metals was mapped through the inverse distance weighting (IDW) method in ArcMap.</div></div><div><h3>Results</h3><div>The concentration of heavy metals indicated significant differences in spatial distribution. The maximum concentration of Cd 1.64 ± 0.001, Cr 18.41 ± 0.41 and Cu 40.5 ± 0.28 µg/g was observed at the regions situated in the Hara Mangrove forest protected area. Azini estuary had the maximum value of Zn 94.61 ± 30.74 and TPHs 4.47 ± 1.93 µg/g and finally, the highest value of concentration Ni 135.22 ± 1.85 µg/g and Pb 17.87 ± 2.17 g/gµ was found in Tiab estuary. The studied regions in the Tiab estuary and Hara Mangrove forest protected area were more contaminated than others and had considerable risks of Ni and Cd. Average ecological indices indicated the sediments of these areas especially Tiab, Hara Mangrove forest protected area, and Azini are moderately to considerably contaminated with Cd and Ni. Tiab was identified as the most contaminated area and all stations except Hengam Island were exposed to considerable ecological risks. Cadmium was found to be the riskiest heavy metal in the investigated region. The distribution of TPHs indicated there is no pollution of TPHs in the region. In all studied stations, the PELq (Toxicity of TPHs) and CF values showed the absence of potential risks of TPHs in sediments.</div></div><div><h3>Conclusions</h3><div>The findings indicated considerable contamination of Cd and Ni in the mangrove areas, especially Tiab, and it seems necessary to identify, manage, and control possible sources of contamination.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127574"},"PeriodicalIF":3.6,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between serum selenium and serum lipids in adolescents aged 12–19: A cross-sectional study","authors":"Huan He ,&nbsp;Li Yang ,&nbsp;Bailing Liu ,&nbsp;Zhan Zhang","doi":"10.1016/j.jtemb.2024.127572","DOIUrl":"10.1016/j.jtemb.2024.127572","url":null,"abstract":"<div><h3>Background</h3><div>Selenium is an essential trace element in the human body and is important in lipid metabolism. Previous studies on the relationship between selenium and serum lipids were almost conducted in adults, and the research conclusions were inconsistent. Evidence linking selenium and lipids in adolescents is very limited. As an important stage of growth and development, studying the effects of trace elements on the body during adolescence is meaningful.</div></div><div><h3>Objective</h3><div>This study examined the association between serum selenium and serum lipids in adolescents aged 12–19.</div></div><div><h3>Methods</h3><div>This cross-sectional study analyzed 2209 adolescents aged 12–19 years from NHANES 2011 to 2016. Multiple linear regression analyses were performed to evaluate selenium’s association with serum lipids (containing TC, TG, LDL-C, and HDL-C). Moreover, a generalized additive model (GAM) and a fitted smoothing curve (penalized spline method) were conducted to explore the exact curve shape between them.</div></div><div><h3>Results</h3><div>In the fully adjusted model, it showed a positive association between selenium and TC, TG, LDL-C [TC (β = 0.144 (, 95 % CI (0.084, 0.204), P &lt; 0.001), TG (β = 0.285, 95 % CI (0.134, 0.437), P &lt; 0.001), LDL-C (β = 0.098, 95 % CI (0.022, 0.174), P = 0.011)], whereas a negative association [(β = -0.031, 95 % CI (-0.054, − 0.009), P = 0.006)] between Se and HDL-C. Subgroup analysis showed that the above associations were more significant in females aged 12–19 (P for trend &lt; 0.05). Furthermore, linear associations were performed in Se between TC and LDL-C.</div></div><div><h3>Conclusion</h3><div>This is the first study to find evidence demonstrating associations between serum Se and serum lipids in adolescents aged 12–19. The validation of our findings will require further research.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127572"},"PeriodicalIF":3.6,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The gut microbiota: A key player in cadmium toxicity - implications for disease, interventions, and combined toxicant exposures","authors":"Zahra Shamsipour Nehzomi,&nbsp;Kobra Shirani","doi":"10.1016/j.jtemb.2024.127570","DOIUrl":"10.1016/j.jtemb.2024.127570","url":null,"abstract":"<div><div>Cadmium (Cd) is a highly toxic heavy metal contaminant found in soil and water due to human activities such as mining and industrial discharge. Cd can accumulate in the body, leading to various health risks such as organ injuries, osteoporosis, renal dysfunction, Type 2 diabetes (T2DM), reproductive diseases, hypertension, cardiovascular diseases, and cancers. The gut is particularly sensitive to Cd toxicity as it acts as the primary barrier against orally ingested Cd. Even at low concentrations, Cd can cause oxidative stress, inflammation, and intestinal bleeding. Cd also disrupts the gut microbiota, affecting its structure, taxonomic composition, and metabolic functions. Cd exposure alters the structure of the gut microbial community, reducing diversity and upregulating certain phyla and genera. This disturbance can lead to physiological and metabolic imbalances, including disruptions in energy homeostasis, amino acid, lipid, nucleotide, and short-chain fatty acid (SCFAs) metabolism. The effects of Cd on the gut microbiota depend on the duration of exposure, the dose of Cd, and can vary based on sex and age. Cd-induced gut dysbiosis has been linked to various diseases, including diabetes, adiposity, atherosclerosis, liver damage, infections, cancer, and neurodegenerative diseases. Interventions targeting the gut microbiota, such as probiotics, specific diets, melatonin, selenium, vitamin D3, and certain compounds, have shown potential in reducing the health risks associated with Cd exposure. However, combined exposure to Cd and other toxicants, such as microplastics (MPs), heavy metals, and antibiotics, can amplify the toxicity and dysbiosis in the gut microbiota.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127570"},"PeriodicalIF":3.6,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organ-specific renal tissue damage manifested by single-walled carbon-nanotubes and single-walled carbon-nanotubes-silver-titania nanocomposite: Cellular toxicity at high doses","authors":"Khalid Ali Obaid ,&nbsp;Ameer A. Imarah ,&nbsp;Hydar M. Khalfa ,&nbsp;Ghassan M. Sulaiman ,&nbsp;Majid S. Jabir ,&nbsp;Mustafa K.A. Mohammed ,&nbsp;Duha S. Ahmed ,&nbsp;Hayder M. Al-Kuraishy ,&nbsp;Uday M. Nayef ,&nbsp;Hamdoon A. Mohammed ,&nbsp;Riaz A. Khan ,&nbsp;Sabrean F. Jawad","doi":"10.1016/j.jtemb.2024.127569","DOIUrl":"10.1016/j.jtemb.2024.127569","url":null,"abstract":"<div><h3>Background</h3><div>Single-walled (SWCNTs) and multi-walled carbon nanotubes (MWCNTs) can pose risks in biological systems leading to harmful effects, such as, reactive oxygen species (ROS) formation, DNA damage, mitochondrial dysfunction, and ultimately, the cell death through apoptosis.</div></div><div><h3>Objectives</h3><div>The study assessed the nephrotoxicity of the SWCNTs and SWCNTs-Ag-TiO₂ nanocomposites through in vitro and in vivo experiments, assessing oxidative stress, genotoxicity, and safety for biomedical applications.</div></div><div><h3>Methodology</h3><div>In vitro, HK-2 cell lines were utilized to evaluate the effects of nanomaterials on cellular activity, apoptosis, ROS generation, and micronuclei formations. In the in vivo study, twenty male mice were divided into five groups: the first received a control injection of phosphate-buffer saline (PBS), while the second, and third groups received daily intraperitoneal injections of SWCNTs at doses of 50 mg/kg, and 100 mg/kg, respectively, for ten days. The fourth and fifth groups received the SWCNTs-Ag-TiO₂ at 50 mg/kg and 100 mg/kg, respectively, for ten days in sequence.</div></div><div><h3>Results</h3><div>SWCNTs and SWCNTs-Ag-TiO₂ significantly promoted the micronuclei formations in HK-2 cells, with rates of 48 % and 79 %, respectively, as compared to the 12.67 % of the control group. The analysis of renal tissues revealed increased levels of ROS, DNA-protein crosslinks (DPC), glutathione (GSH), malondialdehyde (MDA), creatinine, and 8-hydroxy-2′-deoxyguanosine, while the GSH levels decreased. These findings indicated renal tissue injury, and oxidative damages.</div></div><div><h3>Conclusions</h3><div>The study demonstrated the cellular toxicity of these nanomaterials, highlighting the need for caution regarding their widespread use, particularly the use of carbon nanotubes and their metallic composites at higher exposure doses in occupational, environmental, or therapeutic contexts.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"86 ","pages":"Article 127569"},"PeriodicalIF":3.6,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142719627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal contaminants in rice imported to Iran: A comprehensive assessment of carcinogenic and non-carcinogenic health risks","authors":"Samira Eslamizad ,&nbsp;Maryam Alehashem","doi":"10.1016/j.jtemb.2024.127568","DOIUrl":"10.1016/j.jtemb.2024.127568","url":null,"abstract":"<div><h3>Background</h3><div>Rice is a staple food in Iran, where significant imports from India and Pakistan are necessary to meet demand. However, imported rice has been found to contain harmful levels of heavy metals, posing health risks.</div></div><div><h3>Objectives</h3><div>This study aimed to assess the levels of 34 metals in imported rice and evaluated the associated health risks for the Iranian population.</div></div><div><h3>Methods</h3><div>Sixty samples of rice imported into the Iranian market from India, Pakistan, and Thailand were analyzed for 34 metals using inductively coupled plasma optical emission spectrometry (ICP-OES). The metals included carcinogenic elements-Arsenic (As), Lead (Pb), Nickel (Ni), and Cadmium (Cd)-and non-carcinogenic: Sodium (Na), Iron (Fe), Potassium (K), Calcium (Ca), Copper (Cu), Zinc (Zn), Magnesium (Mg), Platinum (Pt), Silicon (Si), Gold (Au), Boron (B), Bismuth (Bi), Tungsten (W), Tin (Sn), Molybdenum (Mo), Chromium (Cr), Barium (Ba), Strontium (Sr), Aluminum (Al), Selenium (Se), Manganese (Mn), Cobalt (Co), Antimony (Sb), Titanium (Ti), Lanthanum (La), Lithium (Li), Vanadium (V), Beryllium (Be), Palladium (Pd), and Mercury (Hg). The health risks associated with the consumption of rice were assessed through the Target Hazard Quotient (THQ), Hazard Index (HI), Incremental Lifetime Cancer Risk (ILCR), cumulative cancer risk (∑ILCR), and Margin of Exposure (MOE) approaches.</div></div><div><h3>Results</h3><div>The analysis revealed that the Cd level in 1 sample and Pb levels in 5 samples exceeded the maximum concentrations established by the Institute of Standards and Industrial Research of Iran. The risk of cancer in adults exposed to As and Cd at mean concentrations was found to be higher than 1 in 100,000, while for Pb and Ni, the risk was greater than 1 in 10,000. In children, the ILCR for As and Cd at mean concentrations exceeded 10⁻⁴, indicating a moderate risk level, and for Pb and Ni, it reached 1 in 1000, emphasizing the need for enhanced public health safety measures. Additionally, ∑ILCR from all metals in both adults and children exceeded the 10⁻⁴ threshold. The MOE values for mean, median, and 90th percentile exposure to As, Pb, and Ni were below 10,000 in adults and children, indicating a significant health concern from rice consumption.</div></div><div><h3>Conclusion</h3><div>These findings highlight the potential health risks of consuming rice contaminated with heavy metals, particularly arsenic. Therefore, special attention should be directed towards monitoring and reducing toxic metal levels in imported rice, with interventions aimed at mitigating these risks.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127568"},"PeriodicalIF":3.6,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacotherapeutic potential of bilobetin to combat chromium induced hepatotoxicity via regulating TLR-4, Nrf-2/Keap-1, JAK1/STAT3 and NF-κB pathway: A pharmacokinetic and molecular dynamic approach","authors":"Mahmoud El Safadi ,&nbsp;Muhammad Faisal Hayat ,&nbsp;Ali Akbar ,&nbsp;Abdullah Nisar ,&nbsp;Fuad M. Alzahrani ,&nbsp;Khalid J. Alzahrani","doi":"10.1016/j.jtemb.2024.127567","DOIUrl":"10.1016/j.jtemb.2024.127567","url":null,"abstract":"<div><h3>Background</h3><div>Chromium (Cr) is one of the top-notch noxious heavy metals that is documented to exert deleterious effects on various body organs including the liver. Bilobetin (BLB) is a natural flavonoid which exhibits a wide range of medicinal properties.</div></div><div><h3>Aim</h3><div>This trial was executed to investigate the pharmacotherapeutic potential of BLB to avert Cr instigated hepatotoxicity via modulating TLR4, JAK1/STAT3, Nrf-2/Keap-1 and NF-κB pathway.</div></div><div><h3>Research layout</h3><div>Our trial was executed on thirty-six male albino rats that were segregated into four equal groups including the control, Cr (10 mg/kg), Cr (10 mg/kg) + BLB (12 mg/kg) and BLB (12 mg/kg) alone treated group. Various biochemical parameters were assessed by using qRT-PCR, molecular docking, molecular dynamic simulation and histological approaches.</div></div><div><h3>Findings</h3><div>Our results revealed that Cr administration significantly impaired the health of hepatic tissues by reducing the gene expression of Nrf-2 and its downregulating genes while promoting the levels of oxidative stress markers (ROS and MDA). Moreover, Cr administration upregulated the hepatic enzymes including ALT, GGT, AST, and ALP while concurrently decreasing the levels of total protein and albumin. Cr exposure also elevated the gene expression of pro-inflammatory cytokines including toll-like receptor 4 (TLR4), high mobility group box 1 (HMGB1) nuclear factor kappa B (NF-κB), Janus kinase 1 (JAK1), signal transducer and activator of transcription 3 (STAT3), tumor necrosis factor alpha (TNF-α), C-reactive proteins, interferon-gamma inducible protein-10 (IP-10), Interleukin beta-1(IL-1β), monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6) and cyclooxygenase-2 (COX-2). Hepatic apoptosis was observed to be elevated following the Cr intoxication. Nonetheless, BLB treatment remarkably alleviated the hepatic damages via regulating the biochemical as well as histological profile of liver. Our findings are further endorsed by molecular docking analysis that demonstrated that BLB exhibit strong binding affinity to Keap-1 and STAT3 thus supporting its efficient hepatoprotective potential.</div></div><div><h3>Conclusion</h3><div>BLB protected the hepatic tissues via regulating Cr induced impairments. These findings were confirmed by molecular docking and molecular dynamic simulation analysis.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"86 ","pages":"Article 127567"},"PeriodicalIF":3.6,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between multiple metals exposure and metabolic dysfunction-associated fatty liver disease among Chinese adults","authors":"Qing Liu ,&nbsp;Jianing Bi ,&nbsp;Gaojie Fan ,&nbsp;Mingyang Wu ,&nbsp;Xiya Qin ,&nbsp;Qing Fang ,&nbsp;Surong Mei ,&nbsp;Zhengce Wan ,&nbsp;Yongman Lv ,&nbsp;Lulu Song ,&nbsp;Youjie Wang","doi":"10.1016/j.jtemb.2024.127566","DOIUrl":"10.1016/j.jtemb.2024.127566","url":null,"abstract":"<div><h3>Background</h3><div>Previous research has investigated the hepatotoxicity of single metal exposure. However, there is limited evidence about metal mixture and their association with metabolic dysfunction-associated fatty liver disease (MAFLD), particularly in the Chinese population.</div></div><div><h3>Objective</h3><div>To investigate the individual and combine effects of 20 metals on MAFLD in a large population in China.</div></div><div><h3>Methods</h3><div>This study included 3651 participants from the Medical Physical Examination Center of Tongji Hospital, Wuhan, China. MAFLD was identified based on ultrasonic graphic evidence of hepatic steatosis and the presence of overweight/obese, diabetes mellitus, or metabolic dysregulation. Inductively coupled plasma mass spectrometry (ICP-MS) was used to determine urinary concentrations of 20 metals. Logistic regression was used to assess the relationship between individual metal and MAFLD, with results presented as odds ratios (ORs) and 95 % confidence intervals (CIs). Weighted quantile sum (WQS) regression was performed to evaluate the combine effect of metals.</div></div><div><h3>Results</h3><div>The prevalence of MAFLD among the participants was 32.1 % (1173/3651). In singe-metal analysis, high exposure to zinc (OR =1.42; 95 % CI = 1.27, 1.59) and selenium (OR = 1.23; 95 % CI = 1.10, 1.39) were positively associated with MAFLD. No significant association was found for other metals. WQS regression analysis showed that urinary metal mixture was positively associated with MAFLD (OR = 1.32, 95 % CI: 1.15, 1.51), with zinc (50.4 %) being the largest contributor, followed by barium (10.8 %).</div></div><div><h3>Conclusions</h3><div>In conclusion, our finding suggested that exposure to the mixture of metals was positively correlated with MAFLD, with zinc being the major contributor.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"86 ","pages":"Article 127566"},"PeriodicalIF":3.6,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classification of colorectal cancer patients based on serum micronutrients: An exploratory investigation","authors":"Krishnamurthy Hari ,&nbsp;Rosanna Squitti ,&nbsp;Jophi Bosco ,&nbsp;Vasanth Jayaraman ,&nbsp;Karthik Krishna ,&nbsp;Amit Pal ,&nbsp;Anastasia De Luca ,&nbsp;Laura Di Veroli ,&nbsp;Gioia Mastromoro ,&nbsp;Gianluca Rizzo ,&nbsp;Vincenzo Tondolo ,&nbsp;Mauro Rongioletti","doi":"10.1016/j.jtemb.2024.127564","DOIUrl":"10.1016/j.jtemb.2024.127564","url":null,"abstract":"<div><h3>Background</h3><div>Colorectal cancer (CRC) is a growing global health challenge with a multifactorial etiology encompassing genetic susceptibility, nutrition, and inflammation in the bowel.</div></div><div><h3>Objective</h3><div>To examine micronutrient status in CRC patients undergoing CRC resection.</div></div><div><h3>Design</h3><div>We performed a case-control study including 13 consecutive CRC patients and 10 healthy controls (CTRL) comparing the serum levels of 29 micronutrients, namely Copper, Zinc, Selenium, Chromium, Manganese, Carnitine, Choline, Inositol, Methylmalonic acid (MMA), Vitamin (Vit) B1, Vit B2, Vit B3, Vit B5, Vit B6, Vit C, Vit A, Vit D3, Vit E, Vit K1, Vit K2 and the amino acids Serine, Valine, Leucine, Isoleucine, Asparagine, Glutamine, Arginine, Citrulline and Cysteine.</div></div><div><h3>Results</h3><div>After considering the effect of age and sex, copper, arginine, and cysteine were increased, while zinc, selenium, chromium, Vit B1, Vit K1, and Vit A were decreased in CRC patients in comparison with CTRL. Zinc levels perfectly predicted the diagnosis of CRC, and were associated with lymph nodes (pN), of the pTNM staging. Copper levels in serum were strongly associated with the pathological pTNM staging of CRC.</div></div><div><h3>Conclusion</h3><div>Though this is a preliminary study that needs confirmation with a larger longitudinal cohort, our results show that serum micronutrients are linked to tumor growth, likely caused by increased demand from tumor tissue associated with an aberrant cell proliferation and changes in the antioxidant function.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"86 ","pages":"Article 127564"},"PeriodicalIF":3.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}