Journal of Trace Elements in Medicine and Biology最新文献

{"title":"Bioaccumulation of 137Cs in lichens: Insight into the patterns of extracellular and intracellular uptake of isotope in thalli","authors":"Piotr Osyczka ,&nbsp;Michał Saniewski ,&nbsp;Paulina Wietrzyk-Pełka","doi":"10.1016/j.jtemb.2025.127642","DOIUrl":"10.1016/j.jtemb.2025.127642","url":null,"abstract":"<div><div>This study specifies the patterns of ¹³⁷Cs bioaccumulation in three widespread lichens, i.e. <em>Cetraria islandica</em>, <em>Cladonia arbuscula</em> and <em>Ramalina siliquosa</em>. The EDTA washing procedure was involved to determine the loads of ¹³⁷Cs incorporated intracellularly. Additionally, water-holding capacity, which largely depends on the structural properties of the thalli, was assessed. The results reveal that <em>C. islandica</em> tends to efficiently accumulate ¹³⁷Cs and demonstrates the capacity for its intracellular binding, making the species a suitable bioindicator for monitoring of long-term ¹³⁷Cs contamination. In turn, <em>C. arbuscula</em> and <em>R. siliquosa</em> show a lower capacity to ¹³⁷Cs accumulation with simultaneous higher EDTA extractability, suggesting that these species possibly may be useful only in the monitoring of more recent contamination. It can be assumed that the characteristics of ¹³⁷Cs accumulation in lichens largely result from the structural specificity of their thalli. In the case of <em>C. islandica</em>, water is largely stored intracellularly and is more difficult to drain from the thallus, therefore ¹³⁷Cs is more likely to penetrate into the cells. Whereas, upon rehydration of the thalli of <em>C. arbuscula</em> and <em>R. siliquosa</em>, a large part of the water remains in the intercellular spaces, which reduces the chance of intracellular absorption of the radionuclide and at the same time facilitates its removal from the interior of the thallus. Furthermore, no significant relationship was observed between the activity concentration of ¹³⁷Cs in the thalli of epigeic lichens and its activity concentration in the host substrate, which excludes soil as the main source of isotope recorded in the thalli.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"89 ","pages":"Article 127642"},"PeriodicalIF":3.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary manganese requirement of Cirrhinus mrigala juveniles","authors":"Rubina Hayat ,&nbsp;Syed Zakir Hussain Shah ,&nbsp;Mahroze Fatima ,&nbsp;Syed Makhdoom Hussain ,&nbsp;Shahzad Ashraf ,&nbsp;Wazir Ali","doi":"10.1016/j.jtemb.2025.127639","DOIUrl":"10.1016/j.jtemb.2025.127639","url":null,"abstract":"<div><div>This experiment determined the Mn requirement of <em>Cirrhinus mrigala</em> and evaluated its effects on growth indices and health status. Six experimental diets were prepared containing 0, 5, 10, 15, 20 and 25 mg/kg Mn from MnSO₄·H₂O and analyzed Mn contents were 1.48, 6.37, 11.24, 16.35, 20.8 and 26.15 mg/kg, respectively. A total of 270 <em>C. mrigala</em> juveniles (average initial weight 12.784 ± 0.613 g) were acclimatized and distributed to eighteen aquaria (70 L capacity and 15 fish/aquarium). Each experimental diet was fed in triplicate up to satiation for 60 days. After completion of trial, growth performance and feed intake increased with increasing Mn concentrations in diets up to 26.15 mg/kg. However, feed conversion ratio (FCR) decreased with increasing Mn concentration up to 16.35 mg/kg. Furthermore, whole-body proximate composition improved with increasing Mn concentrations up to 16.35 mg/kg. Mn content in vertebrae, whole body, muscles, kidney and scales significantly increased with increments in Mn concentrations in the diet, however, Mn absorption reached at saturation at 16.35 mg/kg. Hepatic alkaline phosphatase and antioxidant enzymes activities increased significantly with increasing Mn concentrations up to16.35 mg/kg in the diet, while opposite trend was observed in thiobarbituric acid reactive substances (TBARS) content. Based on weight gain%, FCR, Mn content in vertebrae and TBARS content, dietary Mn requirements of the <em>C. mrigala</em> juveniles were assessed to be 13.18, 16.35, 17.22 and 16.45 mg/kg, respectively. In conclusion, C. mrigala require 13.18–17.22 mg/kg Mn in diet for optimum growth performance and health status.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"89 ","pages":"Article 127639"},"PeriodicalIF":3.6,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copper in human health: From COVID 19 to neurodegenerative diseases","authors":"Roger Deloncle ,&nbsp;Olivier Guillard ,&nbsp;Alain Pineau","doi":"10.1016/j.jtemb.2025.127636","DOIUrl":"10.1016/j.jtemb.2025.127636","url":null,"abstract":"<div><div>Copper (Cu) exists in two oxidation states Cu+I and Cu+II yielding formation of enzymes involved in biological processes. In higher concentrations, by oxidative process and ROS production, Cu is toxic towards plants, humans and animals livers as observed in Wilson disease or sheep scrapie. Fighting according to the Fenton reaction against bacteria and viruses, has been proposed as a mean of combatting nosocomial diseases and complementary to COVID19 vaccination. In humans, Cu is stocked in liver, muscle or bound to brain protein as ß-APP, tau-protein, α-synuclein, ubiquitin or prion which present antioxidant properties when Cu-bonded. In abnormal ß-sheet conformation, they can trigger neurodegenerative diseases such as Alzheimer(AD), Parkinson(PD) and ALS. In these diseases, blood copper increase correlated with brain copper decrease has been described. In AD, abnormal D-serine has been detected in blood and cerebrospinal fluid. D-glutamate and D-alanine blood levels have been found in AD and could also be controlled with Cu and ceruloplasmin in a possible disease screening test. This abnormal D-conformation might result from epimerization of physiologically L-conformation brain peptides into protease-resistant D-enantiomers. This has previously been experimentally demonstrated for Bovine Spongiform Encephalopathy in a free Cu reductive medium with UV-induced free radicals. The Cu brain protective effect against free radicals was restored with cupric addition in oxidizing medium. Cupric supplementation in the brain, might restore Cu protection and slow down neurodegenerative processes. To lower side effects, Cu amino-acid complexes able to cross the blood brain barrier might be suggested for a Cu transfer to the brain.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"89 ","pages":"Article 127636"},"PeriodicalIF":3.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Connecting concentrations of copper, selenium, and zinc with transcriptomic and proteomic data of well-characterized human colorectal cancer cell lines","authors":"Caroline E. Meyer ,&nbsp;Natalia Vukelic ,&nbsp;John M. Mariadason ,&nbsp;Anna P. Kipp","doi":"10.1016/j.jtemb.2025.127638","DOIUrl":"10.1016/j.jtemb.2025.127638","url":null,"abstract":"<div><h3>Background</h3><div>Colorectal cancer (CRC) incidence is associated with lower circulating selenium and zinc and elevated copper concentrations. Moreover, copper and selenium accumulate within tumor tissue, indicating a disturbed homeostasis of these essential trace elements in CRC.</div></div><div><h3>Objective</h3><div>This study aimed to identify associations between CRC characteristics (based on genomic, transcriptomic and proteomic data) and trace element concentrations.</div></div><div><h3>Methods</h3><div>The concentrations of copper, selenium, and zinc were measured in 83 human CRC cell lines and correlated with transcript and protein expression levels to identify trace element-related gene signatures. By using publicly available gene expression data from The Cancer Genome Atlas we investigated the association between those signatures with the survival probability of CRC patients.</div></div><div><h3>Results</h3><div>The CRC cell lines differed in their copper (fold change 7.3), selenium (fold change 6), and zinc (fold change 2.6) concentrations. The concentrations were not associated with genetic or cellular characteristics, except for lower copper concentrations in <em>KRAS</em> mutant cells. Expression levels of known copper- and zinc-related proteins correlated significantly with the respective trace element concentrations, serving as a proxy for trace element concentrations in tumors, and with patient survival. This was not the case for selenium and selenoproteins. In addition, an unbiased approach identified novel high and low copper- and zinc-related gene expression signatures significantly associated with patient’s outcome.</div></div><div><h3>Conclusion</h3><div>Herein we identify gene signatures associated with intracellular copper and zinc concentrations in CRC cell lines. Extrapolating these signatures to primary colorectal tumors revealed that they can inform outcome of CRC patients.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"89 ","pages":"Article 127638"},"PeriodicalIF":3.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring fluoride's role in diabetes development: A review","authors":"Ruhi Thakur,&nbsp;Srishti Rana,&nbsp;Rashi Baltoo","doi":"10.1016/j.jtemb.2025.127635","DOIUrl":"10.1016/j.jtemb.2025.127635","url":null,"abstract":"<div><h3>Purpose</h3><div>The element fluorine, which is never found in nature in a free state, is the source of the fluoride ion. When fluoride intake is excessive, it can cause various impairments in living organism. This review aims to assess the relationship between fluoride exposure and glucose metabolism, considering positive, negative, and null findings, with a focus on its potential role in insulin resistance and diabetes-related complications.</div></div><div><h3>Methods</h3><div>Numerous studies that have demonstrated changes in blood glucose and insulin variations due to fluoride are included in our analysis on the bases of their relevance. Twenty significant research papers from Pubmed, Google Scholar, and Research Gate are included up to January 2025 using search terms such as “Fluoride,” “Toxicity,” “Diabetes,” “Insulin resistance,” “fluoride and diabetes,” “fluoride and insulin,” “fluoride and blood glucose” in this review. Of the 20 research papers, 14 involve normal organisms unaffected by diabetes or complications connected to the disease, serving as standard animal models, while 5 involve animals exposed to diabetes and 1 is a human population study.</div></div><div><h3>Results</h3><div>The findings suggest a negative association between fluoride exposure and diabetes, as studies indicate fluoride’s potential role in impairing glucose homeostasis and increasing insulin resistance. These research studies showed how fluoride affected the participants' blood sugar and diabetes-related complications.</div></div><div><h3>Conclusion</h3><div>This study highlights how important it is to comprehend how fluoride may contribute to diabetes or diabetes-related complications, and it makes recommendations for future research directions that might lead to the discovery of efficient treatment measures to avoid them.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"89 ","pages":"Article 127635"},"PeriodicalIF":3.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure assessments of cadmium and lead with age-related eye disease: A systematic review and meta-analysis","authors":"Zhao Chenjin","doi":"10.1016/j.jtemb.2025.127631","DOIUrl":"10.1016/j.jtemb.2025.127631","url":null,"abstract":"<div><h3>Background</h3><div>Age-related eye diseases, such as macular degeneration, cataracts, and glaucoma, are significant causes of vision loss in older adults. Emerging evidence suggests that environmental exposure to heavy metals, particularly Cadmium and lead, may play an essential role in the onset and progression of these conditions.</div></div><div><h3>Methods</h3><div>This systematic review and meta-analysis aimed to evaluate the association between Cadmium and lead exposure and the risk of age-related eye diseases. A comprehensive literature search was conducted across multiple databases, including PubMed, Embase, Scopus, and Web of Science, covering studies published up to July 2024. The review included observational studies on the relationship between Cadmium or lead exposure and specific eye conditions. Data extraction and quality assessment were performed independently by two reviewers. The meta-analysis utilized a random effects model to analyze cadmium and lead levels in patient and control groups, with subgroup analyses based on the type of eye disease and study design.</div></div><div><h3>Results</h3><div>The results revealed a significant association between cadmium exposure and an increased risk of eye diseases, particularly cataracts and glaucoma. Lead exposure was also linked to a higher risk of cataracts and macular degeneration. The study found substantial heterogeneity among the included studies, highlighting the variability in exposure assessment and population characteristics.</div></div><div><h3>Conclusions</h3><div>Despite these variations, the findings underscore the importance of addressing environmental exposures to toxic metals as potential risk factors for age-related eye diseases. Further research is needed to clarify the underlying mechanisms and to develop targeted interventions for reducing these risks.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"89 ","pages":"Article 127631"},"PeriodicalIF":3.6,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concentrations of arsenic (As), cadmium (Cd) and lead (Pb) in blood, hair and semen of stallions in Finland","authors":"Turkan Oztas ,&nbsp;Melih Akar ,&nbsp;Juhani Virkanen ,&nbsp;Christoph Beier ,&nbsp;Sandra Goericke-Pesch ,&nbsp;Olli Peltoniemi ,&nbsp;Maria Kareskoski ,&nbsp;Stefan Björkman","doi":"10.1016/j.jtemb.2025.127633","DOIUrl":"10.1016/j.jtemb.2025.127633","url":null,"abstract":"<div><div>Heavy metal contamination poses significant environmental and health risks to both humans and animals. This study investigates the concentrations of arsenic (As), cadmium (Cd), and lead (Pb) in blood, hair, and semen samples collected from 16 breeding stallions in Western Finland to assess whether concentrations in hair and serum samples represent concentrations in semen. The analysis was conducted using an inductively coupled plasma mass spectrometry (ICP-MS) system. Results showed that hair samples exhibited the highest concentrations of heavy metals, particularly Pb and As, while semen showed the lowest levels. No significant correlations were found between the concentrations of heavy metals in blood and semen, or between hair and semen, indicating that blood and hair may not reliably predict metal content in semen. This study is the first to compare Pb, As, and Cd levels in hair, blood, and semen of Finnish stallions and highlights hair as a promising non-invasive biomarker of heavy metal exposure. The results underline hair's potential as a reliable long-term biomarker due to its ability to accumulate metals over time.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"89 ","pages":"Article 127633"},"PeriodicalIF":3.6,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selected papers and report on the 8th International FESTEM Symposium on “Recent Advances in Trace Elements. From the Bench to the Bedside”, September 28th to October 1st 2022, Madrid, Spain","authors":"Montserrat González-Estecha ,&nbsp;Dirk Schaumlöffel ,&nbsp;María Teresa Llorente-Ballesteros ,&nbsp;Silvia Izquierdo-Álvarez","doi":"10.1016/j.jtemb.2025.127634","DOIUrl":"10.1016/j.jtemb.2025.127634","url":null,"abstract":"","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"89 ","pages":"Article 127634"},"PeriodicalIF":3.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143706071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidimensional analysis of selected bioelements in rat's brain subjected to stroke procedure and treatment with H2S donor AP-39","authors":"Bartłomiej Rospond ,&nbsp;Agata Krakowska ,&nbsp;Joanna Piotrowska ,&nbsp;Bartosz Pomierny ,&nbsp;Weronika Krzyżanowska ,&nbsp;Bernadeta Szewczyk ,&nbsp;Przemysław Szafrański ,&nbsp;Przemysław Dorożynski ,&nbsp;Beata Paczosa-Bator","doi":"10.1016/j.jtemb.2025.127628","DOIUrl":"10.1016/j.jtemb.2025.127628","url":null,"abstract":"<div><h3>Background</h3><div>A stroke is characterized by a sudden disruption in blood flow to the brain. According to WHO statistics, stroke is the second most common cause of death. Its pathophysiology involves complex mechanisms: oxidative stress, inflammation, cytotoxicity and neuronal cell death. Middle cerebral artery occlusion (MCAO) in rats is commonly used to study the pathophysiology of stroke, as well as the efficacy of therapeutic strategies e.g. application of H₂S donors.</div></div><div><h3>Objectives</h3><div>The aim of this study was to determine the concentrations of minerals (Mg, Na, K), and trace elements (Fe, Cu, and Zn) in rats brain undergoing stroke procedure in the dorsal striatum (ischemic core) and prefrontal cortex (penumbra). We also investigate the application of AP-39 on the levels of above-mentioned minerals and trace elements.</div></div><div><h3>Methods</h3><div>Using the MCAO rat model, the impact of stroke and treatment with 100 nmol/kg b.m<em>. i.v.</em> of AP-39 was examined on minerals and trace elements levels, determined by F-AAS and F-AES methods. Results were analyzed using multidimensional statistical analysis (chemometric techniques).</div></div><div><h3>Results</h3><div>Iron, magnesium, and zinc are the most important bioelements whose concentration changes in both investigated structures were associated with stroke symptoms. The concentrations of zinc and copper showed opposing trend. The application of AP-39 mainly affected the potassium level. In the stroke structure (DS) dosage of AP-39 decreased the potassium level and in non-stroke structure AP-39 increased potassium levels.</div></div><div><h3>Conclusion</h3><div>Stroke and AP-39 treatment significantly altered bioelement concentrations. The bioelements most susceptible to changes under MCAO procedures were zinc, iron and magnesium.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127628"},"PeriodicalIF":3.6,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro assessment of selenium bioavailability from selenized lactic acid bacteria using a static INFOGEST digestion model and intestinal permeability model","authors":"Iva Mrvikova ,&nbsp;Ivana Hyrslova ,&nbsp;Vera Nesporova ,&nbsp;Barbora Lampova ,&nbsp;Klara Cejpova ,&nbsp;Ivo Doskocil ,&nbsp;Sarka Musilova ,&nbsp;Jaromir Cihlar ,&nbsp;Gabriela Krausova ,&nbsp;Antonin Kana ,&nbsp;Marek Kieliszek","doi":"10.1016/j.jtemb.2025.127632","DOIUrl":"10.1016/j.jtemb.2025.127632","url":null,"abstract":"<div><h3>Background and objective</h3><div>Microbial selenium (Se) supplementation is an essential area of biotechnological research due to differences in the bioavailability and toxicity of different forms of selenium. To date, research has focused mainly on the use of selenized yeast. However, in recent years, scientific interest has also increased in other microorganisms, such as lactic acid bacteria (LAB), which have several unique properties that can affect the quality and bioavailability of selenium. LAB, unlike yeast, can also act as probiotics, which may bring additional health benefits related to improving the intestinal microbiota and supporting the health of the gastrointestinal tract.</div></div><div><h3>Methods</h3><div>This study investigates the <em>in vitro</em> bioaccessibility and bioavailability of Se from two lactic acid bacterial strains, <em>Streptococcus thermophilus</em> CCDM 144 and <em>Enterococcus faecium</em> CCDM 922 A. We evaluated Se accumulation, speciation, and stability during simulated gastrointestinal digestion and Se permeation through a Caco-2 cell monolayer model.</div></div><div><h3>Results</h3><div>Both strains accumulated Se, metabolizing it predominantly into selenium nanoparticles (SeNPs, 64–77 % of total Se), with only a minor fraction (&lt;5 % of total Se) of organic Se species. Experiments revealed that while organic Se species had high bioavailability (up to 90 %), their bioaccessibility during digestion was very low (&lt;0.1 % of total Se). In contrast, SeNPs showed high bioaccessibility (∼90 %) and moderate transport efficiency through the intestinal model (16–19 % after 4 hours).</div></div><div><h3>Conclusion</h3><div>These results highlight the potential of SeNPs produced by lactic acid bacteria as a bioaccessible form of Se for dietary supplementation. Further research is required to explore the behavior of SeNPs within the human body to fully understand how they can be used safely and effectively in nutrition or other applications.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127632"},"PeriodicalIF":3.6,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}