Journal of Trace Elements in Medicine and Biology最新文献

{"title":"The variability of selenium and sulphur and the impact of creatinine in blood and urine of humans","authors":"Dag G. Ellingsen ,&nbsp;Stephan Weinbruch ,&nbsp;Gerd Sallsten ,&nbsp;Balazs Berlinger ,&nbsp;Lars Barregard","doi":"10.1016/j.jtemb.2025.127700","DOIUrl":"10.1016/j.jtemb.2025.127700","url":null,"abstract":"<div><h3>Background</h3><div>Intake of selenium (Se) and sulphur (S) is mainly through meat and fish. This is also the case for creatine, which is broken down into creatinine (Crea).</div></div><div><h3>Objectives</h3><div>Objectives were to assess variability of Se and S in urine and blood, assess diurnal variation and associations with Crea in urine (U-Crea).</div></div><div><h3>Methods</h3><div>Urine was collected at six fixed times for 24 h, and repeated one week later among 29 males and 31 females. Blood was collected at both occasions.</div></div><div><h3>Results</h3><div>Mean 24 h urinary excretions of S (U-S_24 h) and Se (U-Se_24 h) on the first sampling day were 756 mg and 23 µg, respectively. U-S_24 h and U-Se_24 h were highly correlated (r = 0.75; p &lt; 0.001). Diurnal variation in the urinary excretion rate (ER) of S and Se was associated with urinary flow rate (UFR). Mean urinary concentrations of S and Se varied substantially during the day, except Crea adjusted concentrations. The 24 h U-Crea excretion was associated with U-S_24 h (r = 0.81; p &lt; 0.001) and U-Se_24 h (r = 0.60; p &lt; 0.001). The U-Crea ER were associated with those of S (r = 0.74; p &lt; 0.001) and Se (r = 0.83; p &lt; 0.001). The highest intraclass correlation coefficients (ICC) for Se was for the blood cellular fraction (0.898) and U-S_24 h (0.529) for S.</div></div><div><h3>Conclusions</h3><div>The urinary S and Se ER were highly associated with Crea ER, which has previously not been shown. This suggests that Crea corrected values should be interpreted with caution. Biomarkers of Se in blood had the highest ICC, while ICCs for S were generally lower. ICC of S and Se has rarely been studied. There was a slight diurnal variation in urinary ER of S and Se which was weakly associated with UFR.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127700"},"PeriodicalIF":3.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144703116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal and metalloid contamination, oxidative stress and genotoxicity in Nile Tilapia (Oreochromis niloticus) from an important eutrophicated lagoon in southeastern Brazil","authors":"Julia Araujo Alves ,&nbsp;Tatiana Dillenburg Saint-Pierre ,&nbsp;Rachel Ann Hauser-Davis ,&nbsp;Fábio Veríssimo Correia ,&nbsp;André Luís de Sá Salomão ,&nbsp;Enrico Mendes Saggioro","doi":"10.1016/j.jtemb.2025.127697","DOIUrl":"10.1016/j.jtemb.2025.127697","url":null,"abstract":"<div><div>Coastal lagoons are highly susceptible to chemical contamination, due to their proximity to urban and industrial areas. This seasonal cross-sectional study based on primary data collection investigated the effects of metal and metalloid exposure on Nile tilapia (<em>Oreochromis niloticus</em>) from Jacarepaguá Lagoon (LJPA), a eutrophicated and urbanized coastal ecosystem in southeastern Brazil. Fish (n = 44) were sampled over one year, covering all four seasons at five fixed locations distributed across the lagoon, concurrently with surface water collection. Metal and metalloid concentrations in liver and muscle tissues were quantified by inductively coupled plasma mass spectrometry (ICP-MS). Analyzed biomarkers included MT, SOD, GST, GSH, LPO, and DNA damage (comet assay). Poor physicochemical and microbiological water quality according to Brazilian legislation were observed. Sampling during the spring and summer revealed greater metal diversity in tissues, likely influenced by increased rainfall and runoff. Arsenic, Cd, Hg and Pb were detected in both muscle and liver. Superoxide-dismutase activity decreased by 38–66.5 % in liver and 35–78 % in muscle, while GST activity in muscle decreased by 67.1–73.5 %. Muscle MT levels increased by 39–280 % across seasons, with peak liver MT values observed during spring (C4). Hepatic CARB increased by 119–662 %, especially in summer (C5), and the highest liver LPO levels were recorded in autumn (p &lt; 0.05). Significant correlations between metal concentrations and biomarkers included negative associations between Ti and LPO (ρ = –0.93) and MT (ρ = –0.85), and between Hg and GSH (ρ = –0.90). Muscle LPO was negatively associated with Ni (ρ = –0.72), while GSH showed positive correlations with Cd, Ni, Ti and Fe. DNA damage was significantly higher in individuals collected during the summer (C5), when several metals were detected, suggesting genotoxic effects likely driven by seasonal factors. A Principal Component Analysis revealed distinct seasonal patterns of both metal bioaccumulation and physiological stress, with greater separation among muscle samples and stronger associations with oxidative biomarkers in liver. These findings highlight the need for environmental monitoring and management strategies to mitigate the impacts of metal pollution on aquatic life in urban coastal lagoons.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127697"},"PeriodicalIF":3.6,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing the anticancer action and toxicity evaluation of cobalt ferrite nanoparticles by different polyethylene glycol concentrations","authors":"Kanwal Akhtar ,&nbsp;Muhammad Khawar Abbas ,&nbsp;Nida Muzammil ,&nbsp;Naveed Akhtar Shad ,&nbsp;Qaisar Iqbal ,&nbsp;Wasim Abbas ,&nbsp;Faqir Muhammad ,&nbsp;Bushra Akhtar ,&nbsp;Yasir Javed ,&nbsp;Habiba Khadim ,&nbsp;Anam Munawar","doi":"10.1016/j.jtemb.2025.127698","DOIUrl":"10.1016/j.jtemb.2025.127698","url":null,"abstract":"<div><h3>Background</h3><div>Polyethylene glycol (PEG) as a coating agent enhances the circulation time of nanoparticles (NPs) and shields the inorganic core from the immediate cell-mediated immune response. Cobalt ferrite (CoFe₂O₄) has shown promising potential due to its magnetic properties and is also widely used to stimulate targeted responsive drug deposition mechanisms to treat localized cancerous cells.</div></div><div><h3>Methodology</h3><div>In this study, the anticancer potential of CoFe₂O₄ NPs was optimized by coating the NPs with different PEG concentrations. The synthesized CoFe₂O₄ NPs have a crystallite size of 15.7 nm, determined by X-ray diffraction (XRD) analysis. Coating concentrations were verified by Fourier Transform Infrared (FTIR) spectroscopy and Dynamic Light Scattering (DLS) analysis. The surface charge of the CoFe₂O₄ NPs increased from −16.04–43.88 mV for different PEG concentrations. The CoFe₂O₄ NPs functionalized with varying PEG concentrations, i.e., 0.1, 0.125, and 0.25 g, were used to obtain the optimum anticancer action against the human embryonic kidney cancerous (HEK293T) cell line.</div></div><div><h3>Results</h3><div>The IC₅₀ value for bare CoFe₂O₄ NPs was 76.943 μg/mL, however, the optimum response was received when CoFe₂O₄ NPs were coated with PEG_0.25 with an IC₅₀ value of 35.762 μg/mL. This indicates a significant improvement in the anticancer property of CoFe₂O₄ NPs with polymer coating. To ensure the safe application of CoFe₂O₄ NPs, in vivo toxicity studies were conducted in albino rats. Results indicated a dose-dependent hepatotoxicity and nephrotoxicity, with elevated levels of liver enzymes (AST &gt; 200 U/L and ALT &gt; 60 U/L) and increased blood urea nitrogen (BUN ≥ 70 mg/dL), signaling potential organ damage at higher doses. These findings emphasize the need for careful consideration of both the therapeutic efficacy and safety profile when using CoFe₂O₄ NPs for cancer treatment.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127698"},"PeriodicalIF":3.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biometal concentrations, distribution and re-distribution in the thymus of healthy mice and mice with inflammatory arthritis","authors":"Theoharris Frangos ,&nbsp;Alex Griffiths ,&nbsp;Alexander Morrell ,&nbsp;Wolfgang Maret","doi":"10.1016/j.jtemb.2025.127699","DOIUrl":"10.1016/j.jtemb.2025.127699","url":null,"abstract":"<div><h3>Background and objective</h3><div>Zinc, iron and copper are important for the proper functioning of the immune system. The thymus has a critical role in autoimmune diseases. However, data on concentrations and spatial distribution of metal ions in the thymus are limited. We therefore aimed to investigate the essential metals zinc, iron, and copper, and the non-essential metal nickel in the thymus of healthy mice and two transgenic murine models that develop inflammatory arthritis resembling rheumatoid arthritis, an autoimmune disease.</div></div><div><h3>Methods</h3><div>In slices of thymus tissues from wild-type, TNFΔAREhTNFR1KI (spondyloarthritis model), and Tg197hTNFR1KI (polyarthritis model) mice, total metal analyses were performed with inductively coupled plasma mass spectrometry while metal imaging was performed with laser ablation inductively coupled plasma mass spectrometry with novel quality control, standardization, and procedures for statistical evaluation.</div></div><div><h3>Results</h3><div>Total metal analyses revealed no difference in zinc, but an about twofold increase of copper in the thymi of the diseased mice. Total iron and nickel concentrations were also increased in the TNFΔAREhTNFR1KI mice. Imaging showed a seemingly homogeneous distribution of zinc, copper, and nickel in all mice, while iron was more concentrated near the medulla/cortex boundary in the wild-type and Tg197hTNFR1KI mice. Concentration frequency distribution histograms revealed shifts in concentration ranges in inflammation.</div></div><div><h3>Conclusion</h3><div>Combining metal analyses and metal imaging with concentration frequency distribution histograms uncovered changes of metals in the thymus of mice with inflammatory arthritis. These observations underpin future mechanistic studies of the role of metals in the immunology of the thymus’ involvement in arthritic disease.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127699"},"PeriodicalIF":3.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Element status and inflammatory response in dogs with pyometra","authors":"Bahar Gezer Güneş ,&nbsp;Zeynep Günay Uçmak ,&nbsp;Lora Koenhemsi ,&nbsp;Duygu Tarhan ,&nbsp;Ibrahim Ertugrul Yalcın ,&nbsp;Mehmet Erman Or ,&nbsp;Barış Halaç ,&nbsp;Seyyal Ak","doi":"10.1016/j.jtemb.2025.127696","DOIUrl":"10.1016/j.jtemb.2025.127696","url":null,"abstract":"<div><h3>Background</h3><div>Pyometra is a life-threatening disease characterized by persistent endometrial inflammation and bacterial colonization, which occur through enzymatic and non-enzymatic antioxidant mechanisms. Minerals and trace elements have effective roles in numerous metal-dependent enzyme and protein activities. The aim of this study is to evaluate the monocyte to lymphocyte ratio (MLR), neutrophil to lymphocyte ratio (NLR), white blood cell (WBC), C-reactive protein (CRP), albumin (ALB), progesterone (P4) levels, serum and uterine tissue iron (Fe), copper (Cu), selenium (Se), zinc (Zn), magnesium (Mg), manganese (Mn) concentrations and Cu/Zn ratio in dogs with pyometra and healthy controls.</div></div><div><h3>Methods</h3><div>This study included 43 dogs divided into two groups: a Control Group (n = 23) and a Pyometra Group (n = 20), 12 with open-cervix and 8 with closed-cervix pyometra. All animals underwent ovariohysterectomy, and intrauterine swab samples were collected for bacterial culture. Mineral analysis in serum and uterine tissue was performed using inductively coupled plasma optical emission spectrometry (ICP-OES).</div></div><div><h3>Results</h3><div>All dogs in this study were multiparous and at the luteal phase of the estrous stage. Isolated microbial agents in Group PYO were Gram-negative bacteria. Increase in P4 (P = 0.01), CRP, WBC, MLR, NLR, and decrease in ALB levels observed in Group PYO (P &lt; 0.001). Significant rise in serum and uterine Cu, Fe, and Mg concentrations and decrease in serum and uterine Se and Zn concentrations were determined in pyometra cases (P &lt; 0.001). Also, Cu/Zn ratio both in serum and uterine tissue samples were significantly higher in Group PYO than in Group C (P &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Changes in CRP, WBC, MLR, NLR, P4 and ALB reflected the inflammatory response and immune deficiency in the presence of canine pyometra. Significant differences in serum and uterine Cu, Fe, Mg, Se, and Zn concentrations in pyometra cases proved that these elements can be used as non-enzymatic antioxidant biomarkers. To our knowledge, the present study explored firstly Cu/Zn ratio in canine pyometra cases as an oxidative stress biomarker. It was concluded that Mg, Cu/Zn and trace elements can be effective markers to assess the non-enzymatic antioxidant status in canine pyometra cases.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127696"},"PeriodicalIF":3.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of selenium supplementation on inflammatory markers and joint symptoms in patients with rheumatoid arthritis: A meta-analysis and systematic review","authors":"Manyu Long ,&nbsp;Shaohong Xu ,&nbsp;Songyuan Tie ,&nbsp;Shuming Dong ,&nbsp;Hui Liang ,&nbsp;Jing Wang ,&nbsp;Shuya Wang","doi":"10.1016/j.jtemb.2025.127695","DOIUrl":"10.1016/j.jtemb.2025.127695","url":null,"abstract":"<div><h3>Objective</h3><div>The objective of this study was to further evaluate the efficacy of selenium supplementation in patients with rheumatoid arthritis, aiming to provide more reliable evidence-based support for nutritional supplementation in these patients.</div></div><div><h3>Methods</h3><div>Four databases, the Cochrane Library, Web of Science, PubMed and Embase, were searched for only randomized controlled trials on selenium supplementation in patients with rheumatoid arthritis. The search date ranged from the build date to February 12, 2025. The literature was screened by two researchers according to the appropriate criteria. The assessment of the quality of the studies was conducted using Risk of Bias 2.0. The data were analyzed in this study using RevMan 5.4.</div></div><div><h3>Results</h3><div>Seven studies including a total of 367 patients with rheumatoid arthritis were included in the study. The results showed that selenium supplementation was effective in reducing the VAS score (MD = -12.68, 95 % CI [-19.08, − 6.28], P = 0.0001) and the Ritchie index (MD = -1.13, 95 % CI [-2.22, − 0.05], P = 0.04) in patients with RA. However, selenium supplementation in patients with rheumatoid arthritis reduced the erythrocyte sedimentation rate (MD = − 8.87, 95 % CI [-3.60, 1.85], P = 0.53), and the C-reactive protein levels (MD = − 0.67, 95 % CI [-1.43, 0.1], P = 0.09), relieved morning stiffness (MD = 0.00, 95 % CI [-0.13, 0.13], P = 0.95), and joint swelling (MD = − 0.06, 95 % CI [-0.54, 0.42], P = 0.81) but these effects were not statistically significant.</div></div><div><h3>Conclusions</h3><div>Meta-analysis revealed that selenium supplementation has beneficial effects on joint pain in patients with rheumatoid arthritis. However, further clinical trials are needed to elucidate its effects on the erythrocyte sedimentation rate, C-reactive protein levels, morning stiffness, and joint swelling in rheumatoid arthritis patients.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127695"},"PeriodicalIF":3.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nerve growth factor acts as a modulator on the p38 MAPK pathway in copper-induced liver damage","authors":"Mustafa Usta ,&nbsp;Yılmaz Çiğremiş ,&nbsp;Hasan Özen","doi":"10.1016/j.jtemb.2025.127694","DOIUrl":"10.1016/j.jtemb.2025.127694","url":null,"abstract":"<div><h3>Background</h3><div>Copper (Cu) toxicity induces oxidative and nitrosative stress in hepatocytes, leading to inflammation and apoptosis. Nerve Growth Factor (NGF), known for its neuroprotective properties, may influence liver tissue via the p38 MAPK pathway; however, its role in Cu-induced hepatotoxicity remains unclear, and hence the aim of this study is to investigate the protective role of exogenous NGF in a Cu-induced liver injury model in mice, with a focus on p38 MAPK pathway.</div></div><div><h3>Methods</h3><div>Sixty-four adult male BALB/c mice were equally divided into eight groups, with each group receiving intraperitoneal injections 3 times at 24 h intervals of their respective substances at the following doses: 0.9 % NaCl (Control), 10 µg/kg NGF (NGF), 20 mg/kg SB203580 (p38MAPKi), 10 µg/kg NGF + 20 mg/kg SB203580 (NGF+p38MAPKi), 20 mg/kg CuSO₄ (Cu), 20 mg/kg CuSO₄ + 10 µg/kg NGF (Cu+NGF), 20 mg/kg CuSO₄ + 20 mg/kg SB203580 (Cu+p38MAPKi), and 20 mg/kg CuSO₄ + 10 µg/kg NGF + 20 mg/kg SB203580 (Cu+NGF+p38MAPKi). Liver tissues were analyzed using histopathological, immunohistochemical, biochemical, and molecular methods.</div></div><div><h3>Results</h3><div>CuSO₄ exposure caused severe hepatic damage, evidenced by hydropic degeneration, focal necrosis, and elevated apoptosis (Caspase 3 and 8). It also increased ALT/AST levels and oxidative/nitrosative stress markers (MDA, TOC, iNOS, nitrotyrosine), while reducing antioxidant markers (GSH, TAC). NGF administration significantly ameliorated these alterations, improved antioxidant status, and reduced pro-inflammatory cytokines (IL-1, IL-6, TNF-α). These effects were abrogated by co-treatment with SB203580, implicating p38 MAPK involvement.</div></div><div><h3>Conclusion</h3><div>NGF exerts hepatoprotective effects against Cu-induced toxicity by modulating oxidative stress, inflammation, and apoptosis through the p38 MAPK signaling pathway. These findings underscore NGF’s potential as a therapeutic candidate for oxidative liver injuries.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127694"},"PeriodicalIF":3.6,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenium exposure and risk of skin cancer: A systematic review and dose-response meta-analysis of epidemiologic evidence","authors":"Tommaso Filippini ,&nbsp;Riccardo Mazzoli ,&nbsp;Lauren A. Wise ,&nbsp;Eunyoung Cho ,&nbsp;Marco Vinceti","doi":"10.1016/j.jtemb.2025.127693","DOIUrl":"10.1016/j.jtemb.2025.127693","url":null,"abstract":"<div><h3>Background</h3><div>Controversies still exist about the effects of selenium exposure on skin cancer risk.</div></div><div><h3>Methods</h3><div>We performed a systematic literature search of non-experimental and experimental studies investigating the relation between selenium and risk of melanoma and non-melanoma skin cancers (NMSC) in adults.</div></div><div><h3>Results</h3><div>We identified 26 studies, 19 of which were suitable for quantitative meta-analysis. In non-experimental studies, serum/plasma selenium concentrations showed slightly lower risk of NMSC, while no change in risk was observed for toenail or dietary selenium. Dose-response meta-analysis showed a general decreasing NMSC risk with increasing selenium serum/plasma concentrations, while there was no change in risk at any level of toenail selenium concentration. In experimental studies, we observed a higher risk for squamous cell carcinoma (risk ratio 1.25, 95 % confidence interval 1.04–1.49), but not basal cell carcinoma or NMSC overall in selenium-supplemented participants. In dose-response analysis of non-experimental studies, we observed little association between selenium exposure and melanoma risk, with limited evidence of increased risk for low (&lt;100 µg/L) serum selenium. Using toenail concentrations, we found an inverted U-shaped pattern, with a lower melanoma risk at both low and high selenium concentrations, likely due to differences in risk across cohort and case-control studies showing positive and null associations, respectively. An excess risk following environmental selenium exposure through drinking water was noted. In experimental studies, selenium supplementation was associated with higher but imprecise melanoma risk (risk ratio 1.24, 95 % confidence interval 0.57–2.68).</div></div><div><h3>Conclusion</h3><div>Overall, selenium exposure does not appear to influence basal cell carcinoma risk, but is associated with increased risk of squamous cell carcinoma and potentially melanoma.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127693"},"PeriodicalIF":3.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The close relationship between trace elements (Cu, Fe, Zn, Se, Rb, Si, Cr, and V) and Alzheimer's disease: Research progress and insights","authors":"Yuanhui Mao ,&nbsp;Lishuo Zhang ,&nbsp;Chengfu Zhang ,&nbsp;Linyin Qin ,&nbsp;Xiayun Liao ,&nbsp;Lichun Zhao","doi":"10.1016/j.jtemb.2025.127692","DOIUrl":"10.1016/j.jtemb.2025.127692","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is a typical neurodegenerative disorder primarily characterized by the deposition of β-amyloid (Aβ) plaques and the hyperphosphorylation of tau protein, leading to the formation of neurofibrillary tangles (NFTs). These pathological changes are closely associated with the imbalance of trace element homeostasis. Trace elements are extensively involved in fundamental physiological processes, including DNA synthesis, protein synthesis, energy metabolism, and enzymatic reactions, all of which are essential for cognitive function and brain development. This review summarizes the alterations in homeostasis and the biological roles of trace elements such as copper, iron, zinc, selenium, rubidium, silicon, chromium, and vanadium, as well as their relationship with the onset and progression of AD. Additionally, we discuss recent advancements in therapeutic strategies targeting the balance of trace element ions, including metal chelators, supplements, nanomedicines, and small-molecule drugs, to provide new perspectives for AD research and treatment.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127692"},"PeriodicalIF":3.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cord-blood levels of heavy metals, vitamin D and calcium and the occurrence of development defects of enamel in primary incisors: A birth cohort study","authors":"Ana Lúcia Vollú ,&nbsp;Anna Flávia Nunes Lanna ,&nbsp;Ísis Midlej Carneiro Oliveira ,&nbsp;Rayza Rodrigues Barboza ,&nbsp;Maria Fernanda Nunes Lanna ,&nbsp;Tainah Bohana de Oliveira ,&nbsp;Nataly Damasceno de Figueiredo ,&nbsp;Carmen Ildes Rodrigues Froes-Asmus ,&nbsp;Andréa Fonseca-Gonçalves","doi":"10.1016/j.jtemb.2025.127691","DOIUrl":"10.1016/j.jtemb.2025.127691","url":null,"abstract":"<div><div>This study investigated the influence of vitamin D, calcium and heavy metals on the frequency of development defects of enamel (DDE) in primary incisors of infants. Serum levels of vitamin D, calcium, arsenic, cadmium, lead, and mercury in cord blood, as well as prenatal and perinatal data, were collected during pregnancy, at birth, and in follow-ups with newborns and infants ≤ 24 months. This was done using laboratory exams, interviews, and newborns’ and infants’ records. An examiner performed dental exams using the Modified DDE. DDE type, color, location, and severity were evaluated, and logistic multiple regression models were analyzed (p &lt; 0.05). Of the infants (n = 306), 52.3 % were boys; 14.4 % were premature; 93.0 % were born to mothers taking medication, 89.9 % to mothers taking vitamin supplements, 38.1 % to mothers who used alcohol, and 11.4 % to mothers who used tobacco. Most newborns had normal weight (88.9 %), adequate size for gestational age (88.1 %), 1-minute APGAR score ≥ 7 (88.6 %), and were exclusively breastfed at discharge from maternity (90.6 %). Arsenic ≥ 0.23 µg/L (53.4 %), cadmium &lt; 0.20 µg/L (52.6 %), lead ≥ 0.8 µg/dL (60.5 %) and mercury ≥ 0.8 µg/L (55.2 %) were found in this population. Most had normal vitamin D (52.6 %) and calcium (76.3 %) levels. The incidence of DDE in infants was 27.1 % (83/306). The number of DDE per child ranged from 1 to 8 with demarcated opacity being the most common defect, while upper central incisors and the incisal third were the teeth and location most affected, respectively. Lead was associated with DDE in primary incisors, except in cases of pregnant women taking vitamin supplements and when the newborn, at the time of discharge, was being breastfed. In the present population, high cord blood levels of lead were associated with the occurrence of DDE in primary incisors.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"90 ","pages":"Article 127691"},"PeriodicalIF":3.6,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}