Journal of Trace Elements in Medicine and Biology最新文献

{"title":"Vanadium shows no effect in stress-induced hyperthermia and the tail suspension test in healthy mice","authors":"Magdalena Sowa-Kućma ,&nbsp;Patrycja Pańczyszyn-Trzewik ,&nbsp;Natalia Gałka ,&nbsp;Bartosz Bobula ,&nbsp;Katarzyna Stachowicz","doi":"10.1016/j.jtemb.2025.127742","DOIUrl":"10.1016/j.jtemb.2025.127742","url":null,"abstract":"<div><div>Vanadium (V) is a trace element in the environment; it is detected in soil, water, air, dust, and food products. V-containing compounds have shown therapeutic potential in the treatment of diabetes. However, studies on the effects of V on animal behavior remain limited and sporadic. This study investigates the impact of acute (0.2, 2, 5 mg/kg, and 20 mg/kg) or repeated V administration (2 mg/kg/day; 7 days) in mice, employing stress-induced hyperthermia (SIH) as the primary behavioral assay. Additionally, its influence was assessed through single-dose administration in the tail suspension test (TST) and the Rota-rod test. The findings indicate no significant effects of V on the studied parameters, although motor coordination was notably impaired. Electrophysiological experiments were conducted to further elucidate vanadium's influence on neuronal function to assess its effects on long-term potentiation (LTP), a key process in synaptic plasticity, revealing no discernible impact. Moreover, the expression levels of gamma-aminobutyric acid (GABA) receptors, specifically GABAA1, GABAB1, and GABAB2, as well as glutamic acid decarboxylase (GAD67), were analyzed in the frontal cortex (FCx) using western blotting. Collectively, the results indicate a negligible influence of V on glutamatergic transmission and GABAergic receptor activity, after a single administration to healthy mice.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127742"},"PeriodicalIF":3.6,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between element mixtures and biomarkers of pathophysiologic pathways related to autism spectrum disorder","authors":"Shiyu Zhang ,&nbsp;Hao Zhou ,&nbsp;Junfeng (Jim) Zhang ,&nbsp;Tianqi Wang ,&nbsp;Yanbo Teng ,&nbsp;Peng-Chou Tsai ,&nbsp;Christine Ladd-Acosta ,&nbsp;Yan Lin ,&nbsp;Yi Wang","doi":"10.1016/j.jtemb.2025.127739","DOIUrl":"10.1016/j.jtemb.2025.127739","url":null,"abstract":"<div><h3>Objective</h3><div>We previously documented that exposure to a spectrum of elements is associated with autism spectrum disorder (ASD). However, there is a lack of mechanistic understanding as to how elemental mixtures contribute to the ASD development.</div></div><div><h3>Materials and methods</h3><div>Serum and urinary concentrations of 26 elements and six biomarkers of ASD-relevant pathophysiologic pathways including serum HIPK 2, serum p53 protein, urine malondialdehyde (MDA), urine 8-OHdG, serum melatonin, and urine carnitine, were measured in 21 ASD cases and 21 age-matched healthy controls of children aged 6–12 years. The Mann–Whitney U test was used to compare the differences in serum elemental levels between ASD and control groups. A principal component analysis (PCA) was used to reduce the dimensionality of multiple elements into uncorrelated predictors that may capture shared patterns. Associations of PC scores with ASD risk or pathway-specific biomarkers were examined using logistic or linear regressions, respectively. Robust linear regressions were conducted to explore the association between serum and urinary elements.</div></div><div><h3>Results</h3><div>We observed significantly higher serum levels of chromium, titanium, lithium, vanadium, calcium, cobalt, magnesium, and arsenic, but lower levels of cadmium and palladium in ASD children. We identified four PCs. PC1 reflects a mixture of 14 elements that were significantly elevated in ASD. PC2 reflects a mixture of elements that were significantly affected by urinary excretion. PC3 reflects a mixture of 5 elements within the 14 elements in PC1. PC4 reflects barium and palladium, both lower in ASD children. PC1 and PC2 were differentially associated with pathway-specific biomarkers. Each interquartile range (IQR) increase in PC1 was associated with increases in HIPK2 (12.96 %, 95 % CI: 3.98 %, 21.94 %) and p53 (8.34 %, 95 % CI: 0.30 %, 16.38 %), and a decrease in urinary carnitine (-24.85 %, 95 % CI: −46.36 %, −3.34 %). An IQR increase in PC2 was associated with increased urinary carnitine by 19.27 % (95 % CI: 3.08 %, 35.47 %). PC4 was not associated with any biomarkers. No PCs were associated with oxidative stress biomarkers of 8-OHdG or MDA. Additionally, increased excretion of essential elements (e.g. phosphorus, calcium, zinc) and the accumulation of metals with higher molecular weight (lead, tin, molybdenum, palladium, and bismuth) were observed in ASD group.</div></div><div><h3>Conclusions</h3><div>Increased levels of element mixtures of chromium, calcium, magnesium, arsenic, and antimony were associated with pro-apoptotic increases in HIPK2 and p53, whereas increased levels of cobalt, lead, and cadmium were associated with carnitine excretion. Increased urinary excretion of essential elements may contribute to ASD risk through modulating blood elemental levels. The role of oxidative stress was not observed.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127739"},"PeriodicalIF":3.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin ameliorates motor and non-motor parkinsonian-like deficits induced by chronic manganese exposure in wistar rats: Involvement of oxidative stress","authors":"Hala Harifi ,&nbsp;Mouloud Lamtai ,&nbsp;Oussama Zghari ,&nbsp;Mohamed Yassine El Brouzi ,&nbsp;Nabila Loukili ,&nbsp;Hinde Hami ,&nbsp;Abdelhalem Mesfioui ,&nbsp;Leila Bikjdaouene","doi":"10.1016/j.jtemb.2025.127738","DOIUrl":"10.1016/j.jtemb.2025.127738","url":null,"abstract":"<div><h3>Background</h3><div>Chronic exposure to manganese (Mn) is linked to motor and affective disorders known as manganism, a disease similar to Parkinson's disease. However, the mechanisms underlying such impairments remain unknown, and no specific treatment is available. Oxidative stress (OS) is considered one of the principal causes of Mn-provoked neurotoxicity. In recent years, melatonin (MEL) has exhibited antioxidant and neuroprotective properties in several animal models of neurological damage. Thus, the present study investigated the neuroprotective action of MEL against Mn-induced motor and non-motor parkinsonian-like deficits such as anxiety and depressive-like behaviors, locomotor activity, motor coordination, and olfactory impairment.</div></div><div><h3>Methods</h3><div>The three experimental groups, namely, the control group (0.9 % NaCl), the Mn alone group (25 mg/kg), and the Mn (25 mg/kg) + MEL (4 mg/kg) group, consisted of seven rats given intraperitoneal doses for 12 weeks. After the administration period, the rats underwent a series of neurobehavioral, locomotor, and olfactory tests. Subsequently, OS parameters (nitric oxide, lipid peroxidation, and catalase activity) in the brain structures involved in the onset of symptoms were analyzed.</div></div><div><h3>Results</h3><div>Mn decreased motor coordination and locomotor activity and impaired olfaction in parallel with the onset of anxiety and depressive-like behaviors. These alterations were associated with increased oxidative damage in the hippocampus, frontal cortex, prefrontal cortex, striatum, and olfactory bulb of Mn-treated rats. Interestingly, MEL administration attenuates the Mn-induced changes.</div></div><div><h3>Conclusion</h3><div>Our findings indicate that the regulation of OS by MEL may be a key mechanism of Mn-induced neurotoxicity.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127738"},"PeriodicalIF":3.6,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Albumin mediates the association between maternal exposure to multiple metals and gestational diabetes mellitus: Findings from the Guangxi Birth Cohort Study","authors":"Hualong Qiu ,&nbsp;Yu Bao ,&nbsp;Shengzhu Huang ,&nbsp;Yuen Zhong ,&nbsp;Caitong He ,&nbsp;Long Tian ,&nbsp;Yu Zhang ,&nbsp;Bangzhu Luo ,&nbsp;Tao Liang ,&nbsp;Baohong Pang ,&nbsp;Mujun Li ,&nbsp;Hong Cheng ,&nbsp;Longman Li ,&nbsp;Zengnan Mo ,&nbsp;Chaoqun Liu ,&nbsp;Xiaobo Yang","doi":"10.1016/j.jtemb.2025.127736","DOIUrl":"10.1016/j.jtemb.2025.127736","url":null,"abstract":"<div><h3>Background</h3><div>Metals are significantly associated with the risk of gestational diabetes mellitus (GDM). However, the effects of liver function on the relationships between metals and GDM risk remain unexplored. This study aimed to investigate whether maternal liver function mediates the association between exposure to multiple metals and GDM among pregnant women.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 1321 pregnant women from the Guangxi Birth Cohort Study. The concentrations of 22 metals in the blood and the levels of 12 liver function biomarkers in the serum were measured in pregnant women at less than 24 gestational weeks. GDM was diagnosed by an oral glucose tolerance test (OGTT) at 24–28 weeks of gestation. A total of 292 pregnant women with GDM and 1029 pregnant women without GDM were included. After least absolute shrinkage and selection operator (LASSO) regression screening, a Bayes kernel machine regression (BKMR) model was used to study the combined effect of maternal blood polymetallic exposure on the risk of GDM, and restricted cubic spline analysis, a quantile g-computation model and a generalized linear regression model were used to evaluate the associations between metals and GDM. Moreover, mediation analyses were performed to determine whether liver function biomarkers mediate the associations between metals and GDM risk.</div></div><div><h3>Results</h3><div>LASSO regression analysis revealed that 10 metals were associated with GDM risk, and BKMR analysis suggested a positive association between combined exposure to multiple metals and GDM risk (OR: 1.275, 95 % CI: 1.004–1.618). Blood chromium (Cr) and cobalt (Co) were protective factors for GDM (OR: 0.575, 95 % CI: 0.394–0.835; OR: 0.838, 95 % CI: 0.705–0.995), whereas blood lead (Pb) and nickel (Ni) were risk factors for GDM (OR: 1.695, 95 % CI: 1.110–2.257; OR: 1.444, 95 % CI: 1.080–1.930) in the generalized linear model. According to the mediation analysis, albumin mediated the association between blood Pb exposure and GDM risk by 13.2 % (<em>P</em> = 0.039) and the association between blood Co exposure and GDM risk by 8.3 % (<em>P</em> = 0.027).</div></div><div><h3>Conclusion</h3><div>The results suggest that exposure to Pb and Ni during pregnancy increases the risk of GDM, whereas exposure to the trace elements Cr and Co can reduce the risk of GDM. Albumin may play a key role in the association of Pb and Co exposure with GDM.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127736"},"PeriodicalIF":3.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144931851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary levels of selected metals and associated individual-level characteristics in Tuscany, Italy: The EPIMETAL study","authors":"Saverio Caini ,&nbsp;Daniela Nuvolone ,&nbsp;Nora de Bonfioli Cavalcabo ,&nbsp;Maria Cristina Aprea ,&nbsp;Ilaria Ermini ,&nbsp;Benedetta Bendinelli ,&nbsp;Flavia Cozzolino ,&nbsp;Emma Bortolotti ,&nbsp;Manila Raffaelli ,&nbsp;Cinzia Trane ,&nbsp;Ida Lureti ,&nbsp;Fabio Voller ,&nbsp;Claudia Cosma ,&nbsp;Giovanna Berti ,&nbsp;Luigi Facchini ,&nbsp;Calogero Saieva ,&nbsp;Giovanna Masala","doi":"10.1016/j.jtemb.2025.127737","DOIUrl":"10.1016/j.jtemb.2025.127737","url":null,"abstract":"<div><div>Several metallic elements pose a significant threat to health, as they are causally linked to numerous diseases. Within the EPIMETAL project, we conducted a cross-sectional investigation in Tuscany, Italy, aiming at quantifying urinary levels of selected metals among 300 older individuals from the EPIC-Florence cohort and identifying associated individual-level characteristics. Urinary metals levels were also compared with those of two surveys previously conducted in areas of Tuscany with known environmental contamination. Urine samples were collected in 2021–2022, and inductively coupled plasma-mass spectrometry was used for metals quantification. Extensive information was collected on multiple potential sources and routes of exposure to metals. The statistical analysis was conducted by fitting regression models adjusted by sex, age, and urinary creatinine. The geometric mean of urinary metals levels in the EPIMETAL study was lower than both the reference values for the Italian population, and the levels recorded in the other areas of Tuscany. Factors associated with higher urinary levels included female sex (Cd, Hg); cigarette smoking (Cd, Pb); consumption of seafood (As, Hg, Tl), plant-based foods (As, Ni, Tl), and wine (Pb); dental fillings and wearing jewelry (Hg); and regular use of various medications (As, Cd, Cr, Hg, Ni, Tl). Our study provides a broad picture of the degree of contamination to multiple metallic elements in Tuscany, while also identifying the main sources and routes of exposure. These findings are instrumental in setting public health priorities and devising interventions aiming at reducing exposure to toxic metals in Tuscany.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127737"},"PeriodicalIF":3.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitigating cadmium-induced oxidative stress in Satureja hortensis using selenium and biochar: Impacts on plant growth and essential oil yield","authors":"Sajedeh Sadat Tabatabaei,&nbsp;Marzieh Ghanbari Jahromi,&nbsp;Weria Weisany","doi":"10.1016/j.jtemb.2025.127735","DOIUrl":"10.1016/j.jtemb.2025.127735","url":null,"abstract":"<div><div>Cadmium (Cd) contamination is an escalating threat to medicinal-crop production, yet practical mitigation strategies for <em>Satureja hortensis</em> L. remain unexplored. Here we tested the hypothesis that co-applying biochar and foliar selenium (Se) can synergistically alleviate Cd-induced oxidative damage and sustain essential oil (EO) yield. A full factorial pot experiment was conducted with three ecologically relevant Cd levels (0, 10, and 20 mg kg⁻¹ soil), two biochar rates (0 and 5 % of pot volume; 3 L pots), and three aqueous sodium selenate sprays (0, 5, and 10 mg L⁻¹, applied at 15-day intervals). Severe Cd exposure (20 mg kg⁻¹) depressed shoot fresh and dry biomass, total phenolics, flavonoids, relative water content (RWC), and EO yield by 21–38 % while accelerating osmolyte accumulation and antioxidant enzyme activity. Biochar or Se alone partially offsets these losses. However, the combined treatment was most effective: in mildly contaminated soil (10 mg kg⁻¹ Cd) the 5 % biochar + 5 mg L⁻¹ Se regime restored biomass to control levels and produced the highest EO content (0.98 %, +27 % versus untreated Cd stress). Across Cd doses, the dual amendment improved RWC (up to +19 %), total phenolics (+23 %), and flavonoids (+26 %) relative to Cd-only plants, indicating strengthened osmotic balance and antioxidant capacity. These results demonstrate, for the first time in summer savory, that a low-cost biochar–selenium combination can counteract Cd toxicity and safeguard both growth and EO profitability. The approach offers a scalable option for phytoprotection in Cd-affected agroecosystems and merits field-scale validation.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127735"},"PeriodicalIF":3.6,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144931852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenite protects human peripheral blood mononuclear cells (PBMCs) from CdCl2 cytotoxicity","authors":"Anieli Golin ,&nbsp;Ana Barbosa Viana ,&nbsp;Valderi Luiz Dressler ,&nbsp;Daniel Lázaro Gallindo Borges ,&nbsp;Michael Aschner ,&nbsp;Alexey Tinkov ,&nbsp;João Batista Teixeira da Rocha","doi":"10.1016/j.jtemb.2025.127734","DOIUrl":"10.1016/j.jtemb.2025.127734","url":null,"abstract":"<div><div>The potential role of selenium (Se) in modulating cadmium (Cd) cytotoxicity in human peripheral blood mononuclear cells (PBMCs) was investigated by assessing pro- and anti-inflammatory as well as redox biomarkers. We also examined the potential synergistic effects of SARS-CoV-2 N-protein with Cd in PBMCs. PBMCs were isolated from adults and treated for 48 h with sodium selenite (Na₂SeO₃; 0.04, 0.4, and 4 µM) and cadmium chloride (CdCl₂; 0.1 and 1 µM), in the presence or absence of SARS-CoV-2 N-protein. We measured total Se and Cd levels, cell viability, cytotoxicity, intracellular reactive oxygen species (ROS) production, and gene expression. Na₂SeO₃ antagonized CdCl₂-induced toxicity in PBMCs. This protective effect was associated with increased expression of antioxidant selenoprotein mRNAs, including GPX1, GPX4, TXNRD1, SELENOP, SELENOS, and SELENOK. Notably, even low concentrations of Na₂SeO₃ effectively protected PBMCs from Cd-induced toxicity, reversing cell death and restoring MTT reduction. Cd exposure slightly increased DCFH oxidation, which was abolished by Na₂SeO₃. While Cd did not markedly elevate ROS, it consistently increased inflammatory markers. Importantly, Na₂SeO₃ upregulated anti-inflammatory mRNAs (IL-4, IL-10), even in the presence of CdCl₂. These findings suggest that, regardless of SARS-CoV-2 N-protein presence, sufficient Se levels—and consequently, proper selenoprotein expression—are crucial for modulating inflammation, preventing ROS overproduction, and mitigating oxidative stress in human PBMCs.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127734"},"PeriodicalIF":3.6,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to low levels of hexavalent chromium in drinking water alters diet-induced steatotic liver disease in male rats","authors":"Gabrielle Griffin ,&nbsp;Morgan E. Delnicki ,&nbsp;Haiyan Lu ,&nbsp;Idoia Meaza ,&nbsp;Aggie Williams ,&nbsp;Samuel T. Vielee ,&nbsp;Oluwanifemi Esther Bolatimi ,&nbsp;Rachel M. Wise ,&nbsp;Rui Liu ,&nbsp;J. Calvin Kouokam ,&nbsp;Sandra S. Wise ,&nbsp;John Pierce Wise Sr. ,&nbsp;Matthew C. Cave ,&nbsp;John P. Wise Jr. ,&nbsp;Jamie Lynn Wise","doi":"10.1016/j.jtemb.2025.127731","DOIUrl":"10.1016/j.jtemb.2025.127731","url":null,"abstract":"<div><div>Ranked as a “top 10 cause of death”, chronic liver disease accounts for millions of deaths annually. The prevalence of the most prominent liver disease, metabolic dysfunction-associated steatotic liver disease (MASLD), has doubled over the past 20 years and continues to rise. Growing in parallel are environmental chemical exposures, emergingas key risk factors for liver disease. Hexavalent chromium [Cr(VI)] is the #1 chemical hazard in U.S. drinking water and is associated with increased liver disease incidence, including liver cancer. How Cr(VI) contributes to liver disease is poorly understood and no studies have considered whether Cr(VI) exposure together with high-fat diet, a well-established MASLD risk factor, drives liver disease. Thus, we developed an <em>in vivo</em> model to study the impact of Cr(VI) and high-fat diet on MASLD. Male Sprague Dawley rats were exposed to Cr(VI) in drinking water (0, 0.05, or 0.1 mg/L - levels that reflect the World Health Organization and U.S. Environmental Protection Agency maximum contaminant levels, respectively) and fed a normal or high-fat diet for 90 days. We observed high-fat diet significantly increased body mass, plasma lipoproteins and cholesterol, liver injury and hepatic triglycerides in rats and these outcomes were exacerbated by exposure to Cr(VI). Cr(VI) alone increased hepatic expression of alpha fetoprotein, a liver cancer biomarker, with evidence suggesting Cr(VI) and high-fat diet together increased these levels more than either exposure alone. Our results indicate Cr(VI) at very low levels combined with high-fat diet worsens liver disease, emphasizing the need to reconsider current Cr(VI) drinking water regulations.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127731"},"PeriodicalIF":3.6,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing T1-weighted MRI intensity indices to evaluate in-vivo neurotoxicity in a South African cohort with environmental manganese exposure","authors":"Susan R. Criswell ,&nbsp;Irene Faust ,&nbsp;Susan Searles Nielsen ,&nbsp;Wendy W. Dlamini ,&nbsp;Gill Nelson ,&nbsp;Jay R. Turner ,&nbsp;Joshua S. Shimony ,&nbsp;Jason Lenox-Krug ,&nbsp;Jordan A. Killion ,&nbsp;T. Noah Hutson ,&nbsp;Brad A. Racette","doi":"10.1016/j.jtemb.2025.127732","DOIUrl":"10.1016/j.jtemb.2025.127732","url":null,"abstract":"<div><h3>Background</h3><div>Excessive exposure to manganese (Mn) causes parkinsonism. Occupational Mn exposure is associated with increased T1-weighted globus pallidus signal on magnetic resonance imaging (MRI) secondary to in-vivo Mn deposition.</div></div><div><h3>Methods</h3><div>The present study evaluated the T1-weighted pallidal index (PI) as an in-vivo marker of Mn exposure and neurotoxicity in chronic environmental Mn exposure. A total of 53 Black South African participants with a range of residential environmental Mn exposures due to proximity to one of the world’s largest smelters underwent T1-weighted MRI.</div></div><div><h3>Results</h3><div>The PI was associated with parkinsonism as measured by the total Unified Parkinson’s Disease Rating Scale motor subsection part 3 (UPDRS3) in all participants (β=0.10, confidence interval 0.01, 0.18). Further, the PI was positively associated with total UPDRS3 scores (β=0.14, confidence interval 0.03, 0.25) and the lower limb rigidity subscore (β=0.04, confidence interval 0.005, 0.07) among those who regularly consumed alcohol (<u>&gt;</u>3 drinks/week), but not in those who occasionally consumed alcohol (&lt;3 drinks/week).</div></div><div><h3>Conclusion</h3><div>Our findings suggest T1-weighted PI is associated with clinical neurotoxicity in environmental Mn exposure. This association is amplified by regular consumption of alcohol.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127732"},"PeriodicalIF":3.6,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144931853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 2 diabetes mellitus and zinc dysregulation: From basic and epidemiological evidence to interventions","authors":"Irene Martinez-Morata ,&nbsp;Katherine Dennehy ,&nbsp;Oleg Chepurny ,&nbsp;Tuncay Delibasi ,&nbsp;Kathrin Schilling ,&nbsp;Ana Navas-Acien ,&nbsp;Malek El Muayed","doi":"10.1016/j.jtemb.2025.127733","DOIUrl":"10.1016/j.jtemb.2025.127733","url":null,"abstract":"<div><h3>Background</h3><div>Complex cellular and systemic changes in Zn levels have been reported through different stages of Type 2 Diabetes (T2DM) onset and progression.</div></div><div><h3>Methods</h3><div>We summarize available evidence on Zn and T2DM, including mechanistic and epidemiological/clinical studies with a focus on Zn pathophysiology, interpretation of Zn biomarkers, and associations of Zn status and T2DM across different populations.</div></div><div><h3>Results</h3><div>Misdistribution of Zn in insulin-producing ß-cells are likely key contributors to ß-cell failure in T2DM, with genetic variants in ZnT8 transporters playing an important role. Epidemiological evidence has documented increased urinary Zn and decreased plasma and blood Zn in persons with established T2DM. Changes in Zn biomarkers have been prospectively associated with increased risk of T2DM in pre-diabetes and healthy adults before hyperglycemia occurs. Some studies suggest that Zn supplementation could modify glycemic endpoints in T2DM participants, but evidence is insufficient in healthy adults. Zn biomarkers, including isotopes, can provide novel approaches for T2DM risk assessment and management at different disease stages.</div></div><div><h3>Conclusions</h3><div>Dysregulation of Zn metabolism occurs early in T2DM development with ß-cell failure playing a central role. Additional research is needed to connect mechanistic evidence and pathophysiological changes associated with various stages of T2DM progression.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127733"},"PeriodicalIF":3.6,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}