Journal of Trace Elements in Medicine and Biology最新文献

{"title":"Association between exposure to plasma mixture of essential and toxic elements and the lipid profile in institutionalized older adults","authors":"Daniela Antunes Pacheco ,&nbsp;Angélica Lopes de Sousa Campêlo ,&nbsp;Sara Estéfani Soares de Sousa ,&nbsp;Márcia Cristina Sales ,&nbsp;Karine Cavalcanti Maurício Sena-Evangelista ,&nbsp;Fernando Barbosa Jr. ,&nbsp;Kenio Costa Lima ,&nbsp;Marcelo Rodrigo Portela Ferreira ,&nbsp;Bruna Zavarize Reis ,&nbsp;Lucia Fatima Campos Pedrosa","doi":"10.1016/j.jtemb.2024.127490","DOIUrl":"https://doi.org/10.1016/j.jtemb.2024.127490","url":null,"abstract":"<div><h3>Background</h3><p>Older adults have a progressive deficiency in the ability to detoxify chemical elements and are susceptible to dyslipidemia and changes in glycemic control. The objective was to evaluate the association of the mixture of essential and toxic elements in the plasma of institutionalized older adults and test the associations with lipid profile variables and glycemic control.</p></div><div><h3>Methods</h3><p>Data were obtained from 149 Brazilian older adults aged ≥60 living in nursing homes (NH) in Natal, Brazil. The concentrations of sixteen chemical elements in plasma and lipid profile parameters and glycemic control of 149 institutionalized older adults were measured. Bayesian kernel machine regression was used to estimate the associations of the mixture of chemical elements with total cholesterol (TC), high-density lipoprotein (HDL-c), low-density lipoprotein (LDL-c), triglycerides (TG), fasting glucose, and glycated hemoglobin.</p></div><div><h3>Results</h3><p>Non-linear responses to exposure were observed for iron (Fe) about TC, LDL-c, and TG, and for barium (Ba) and copper (Cu) about TG. The concentration of the mixture of chemical elements below the 35th percentile was associated with a decrease in TC. Fe was the main element in the effect of the mixture associated with TC.</p></div><div><h3>Conclusions</h3><p>The lower concentrations of the mixture of chemical elements in plasma had a protective effect on the increase in TC, with Fe being the main element. Considering the results, the levels of essential and toxic elements in the plasma of older adults require extensive screening, mainly to prevent dyslipidemia and monitor clinical interventions.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"85 ","pages":"Article 127490"},"PeriodicalIF":3.6,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141481099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal variability of trace elements bioaccumulation in Pacific Oysters (Crassostrea gigas) from an experimental pilot farm in the Calich Lagoon (Sardinia, Italy)","authors":"Domenico Meloni ,&nbsp;Alessandro Graziano Mudadu ,&nbsp;Maria Cesarina Abete ,&nbsp;Anna Maria Bazzoni ,&nbsp;Alessandra Griglione ,&nbsp;Rosa Avolio ,&nbsp;Simonetto Serra ,&nbsp;Nicola Fois ,&nbsp;Giuseppe Esposito ,&nbsp;Rita Melillo ,&nbsp;Stefania Squadrone","doi":"10.1016/j.jtemb.2024.127487","DOIUrl":"https://doi.org/10.1016/j.jtemb.2024.127487","url":null,"abstract":"<div><h3>Background</h3><p>Metals pollution is a worldwide environmental issue due to their persistence in the ecosystems, non-degradability, and bioaccumulation in marine biota. Pacific Oysters (<em>Crassostrea gigas</em>) are highly nutritious bivalve representing an important dietary constituent but may accumulate metals through feeding on suspended sediments from surrounding water, then represent a suitable tool for biomonitoring.</p></div><div><h3>Materials and methods</h3><p>The occurrence of trace elements (Al, As, Cd, Co, Cr, Cu, Fe, Mn, Mo, Ni, Pb, Rb, Se, Sn, V, Zn) was investigated in Pacific Oysters <em>(Cassostrea gigas)</em> collected from Calich Lagoon in each season of 2019. Samples were homogenized and subjected to microwave acid digestion before being analyzed by inductively coupled plasma-mass spectrometer (ICP-MS).</p></div><div><h3>Results</h3><p>The results showed a significant seasonal variation for temperature, dissolved oxygen, chlorophyll, and pH. Moreover, high significant seasonal variation in concentrations of Cd, Mn, Ni, and V was recorded. The highest values were found for Fe (128 mg kg^⁻1 w.w.), and Al (112 mg kg^⁻1 w.w.) in October, for Zn (113 mg kg^⁻1 w.w.) in March and May.</p></div><div><h3>Conclusions</h3><p>Pacific Oysters were confirmed as suitable bioindicators of the health status of coastal lagoons; trace elements concentrations were highly affected by season of collection, and according to literature the highest values were recorded in autumn and summer. The EU legal limits for Cd and Pb were not exceeded, then the farmed oysters were safe to consumers.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"85 ","pages":"Article 127487"},"PeriodicalIF":3.6,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141438048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mechanism of miR-665 targeting GNB3 in aluminum-induced neuronal apoptosis","authors":"Chanting He ,&nbsp;Jingjing Jia ,&nbsp;Yang Lei ,&nbsp;Qian Hu ,&nbsp;Yulu Xin ,&nbsp;Yafen Chu ,&nbsp;Congying Liu ,&nbsp;Qiao Niu","doi":"10.1016/j.jtemb.2024.127488","DOIUrl":"https://doi.org/10.1016/j.jtemb.2024.127488","url":null,"abstract":"<div><h3>Background</h3><p>Aluminum exerts neurotoxic effects through various mechanisms, mainly manifested as impaired learning and memory function.</p></div><div><h3>Methods</h3><p>Forty SD rats were divided into 0, 10, 20, and 40 mM maltol aluminum [Al(mal)₃] groups. Cell experiments are divided into 0, 100, 200, and 400 μM Al(mal)₃ dose group and control, Al(mal)₃, Al(mal)₃+inhibitor NC, Al(mal)₃+miR-665 inhibitor intervention group. Water maze was used to detect the learning and memory function of rats, HE staining was used to observe the morphology and number of neurons in the CA1 area of the rat hippocampus, Flow cytometry was used to detect the apoptosis of PC12 cells, PCR and Western blotting were used to detect the expression of Caspase3, miR-665 and GNB3/PI3K/AKT proteins. The target binding relationship between miR-665 and GNB3 was verified by double luciferase reporter gene experiment.</p></div><div><h3>Results</h3><p>In vivo experimental results showed that with the increase of Al(mal)₃ concentration, the escape latency of rats was prolonged, the target quadrant dwell time was shortened, and the number of crossing platform was reduced. Moreover, the arrangement of neurons was loose and the number decreased; the expression of Caspase3 and miR-665 increased, while the expression of GNB3/PI3K/AKT proteins decreased. In vitro experiments, with the increase of Al(mal)₃ concentration, apoptosis rate of PC12 cells increased, the expression of Caspase3, miR-665 and GNB3/PI3K/AKT proteins were consistent with rat results. After inhibiting miR-665 in the intervention group experiment, apoptosis rate of PC12 cells in the aluminum exposure group decreased, the expression of Caspase3 and miR-665 decreased, and the expression of GNB3/PI3K/AKT proteins increased.</p></div><div><h3>Conclusion</h3><p>MiR-665 plays an important role in aluminum induced neuronal apoptosis by targeting GNB3 and regulating the PI3K/AKT pathway.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"85 ","pages":"Article 127488"},"PeriodicalIF":3.6,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141434453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary iodine concentrations in preschoolers and cognitive development at 4 and 6 years of age, the Rhea mother-child cohort on Crete, Greece","authors":"Mariza Kampouri ,&nbsp;Katerina Margetaki ,&nbsp;Katerina Koutra ,&nbsp;Andriani Kyriklaki ,&nbsp;Vasiliki Daraki ,&nbsp;Theano Roumeliotaki ,&nbsp;Vicky Bempi ,&nbsp;Marina Vafeiadi ,&nbsp;Manolis Kogevinas ,&nbsp;Lida Chatzi ,&nbsp;Maria Kippler","doi":"10.1016/j.jtemb.2024.127486","DOIUrl":"https://doi.org/10.1016/j.jtemb.2024.127486","url":null,"abstract":"<div><h3>Background</h3><p>Evidence regarding child iodine intake and neurodevelopment is scarce.</p></div><div><h3>Methods</h3><p>We aimed to assess the impact of child iodine intake at 4 years of age on cognitive and motor development at 4 and 6 years among 304 children from the Rhea cohort on Crete, Greece. Child iodine intake was assessed via urinary iodine concentrations (UIC) measured using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and adjusted for specific gravity. Child cognitive and motor development was assessed using the <em>McCarthy Scales of Children's Abilities (MSCA)</em> at 4 years of age and <em>Raven’s Coloured Progressive Matrices</em> (<em>RCPM</em>), <em>Finger Tapping Test</em> (<em>FTT</em>)<em>,</em> and <em>Trail Making Test</em> (<em>TMT</em>) at 6 years. Associations were explored using multivariable-adjusted linear regression analyses with UIC categorized according to WHO criteria [insufficient intake &lt;100 µg/L, adequate 100–299 µg/L (reference group), excessive ≥300 µg/L].</p></div><div><h3>Results</h3><p>The children’s median UIC was 249 µg/L (25–75th percentile: 181–344 μg/L). Children with UIC &lt;100 μg/L had lower scores in the motor scale at 4 years (<em>MSCA-motor scale</em>: B=-10.3; 95 %CI −19.9, −0.6; n=10) and in intelligence at 6 years (<em>RCPM-total score:</em> B=-3.6, 95 %CI −6.8, −0.5; n=9) than children in the reference group. No associations were found with the general cognitive scale at 4 years or with <em>TMT</em> and <em>FTT</em> scales at 6 years. Children with UIC ≥300 μg/L had lower cognitive scores both at 4 (<em>MSCA</em>; B= −3.5; 95 %CI −6.9, −0.1; n =101) and 6 years of age (<em>RCPM-total score</em>; B= −1.2; 95 %CI −2.3, −0.0; n =98) than children in the reference group. No associations were observed with the motor scale at 4 years or with <em>TMT</em> and <em>FTT</em> scales at 6 years.</p></div><div><h3>Conclusion</h3><p>Our findings indicate that both low and excessive iodine intake at preschool age may adversely affect child cognitive abilities. Additionally, low iodine intake may also impact motor abilities.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"85 ","pages":"Article 127486"},"PeriodicalIF":3.5,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141424090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction between depression and non-essential heavy metals (Cd, Pb, and Hg) on metabolic diseases","authors":"Yanfang Wang,&nbsp;Tong Xu,&nbsp;Yuan Zhang,&nbsp;Yue He,&nbsp;Jiaxin Fang,&nbsp;Yan Xu,&nbsp;Lina Jin","doi":"10.1016/j.jtemb.2024.127484","DOIUrl":"10.1016/j.jtemb.2024.127484","url":null,"abstract":"<div><h3>Objectives</h3><p>Metal exposure and depression have each been associated with adverse metabolic diseases, but no study has examined the potential interaction between them. We examined the interaction of depression on the association between metals and metabolic diseases among adults.</p></div><div><h3>Study design</h3><p>The interaction of depression in the relationship between metal and metabolic disease in adults was investigated using NHANES, a cross-sectional survey design.</p></div><div><h3>Methods</h3><p>By employing data from the NHANES database spanning the years 2007–2018, regression models were employed to investigate the independent impacts of heavy metals (cadmium, lead, and mercury) and depression on metabolic diseases (type 2 diabetes, hypertension, hyperlipidemia, metabolic syndrome). Subsequently, the association between metals and metabolic diseases was explored stratified by depression, and the interaction between heavy metals and depression was explored. Because of the complex NHANES design, statistical evaluations were adjusted through weighting to represent the populace of the United States.</p></div><div><h3>Results</h3><p>We found log transformed-urinary lead was significantly associated with type 2 diabetes (OR: 2.33; 95 % CI: 1.23, 4.41) in adults with depression. Log transformed-urinary lead was not associated with type 2 diabetes (OR: 0.84; 95 % CI: 0.56, 1.27) in adults without depression. The interaction between Pb and depression in type 2 diabetes was significant (<em>P</em> for interaction = 0.033). Log transformed-urinary lead * depression was significantly associated with type 2 diabetes (OR: 1.82; 95 % CI: 1.01, 3.34) in adults. There was no significant interaction between cadmium and mercury exposure and depression in patients with type 2 diabetes, hypertension, hyperlipidemia, and metabolic syndrome (<em>P</em> for interaction &gt; 0.05).</p></div><div><h3>Conclusions</h3><p>The presence of depression positively modified the adverse associations between urinary lead and type 2 diabetes.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"85 ","pages":"Article 127484"},"PeriodicalIF":3.6,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141395982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying heavy metal and radionuclide contamination in fish and water proximal to a uranium tailings facility: A Linshui River basin investigation, China","authors":"Yan Jin ,&nbsp;Bo Fu ,&nbsp;Xiaofeng Wang","doi":"10.1016/j.jtemb.2024.127485","DOIUrl":"10.1016/j.jtemb.2024.127485","url":null,"abstract":"<div><h3>Background</h3><p>The objective of this study is to evaluate the concentrations of heavy metals and radionuclides in water and fish samples collected from six designated sampling stations along the Linshui River, in close proximity to a Uranium Tailing Pond situated in China. Additionally, it seeks to estimate the bioaccumulation of heavy metals and conduct risk assessments, both carcinogenic and non-carcinogenic, for consumers.</p></div><div><h3>Methods</h3><p>Water and fish samples (yellowhead catfish and common carp) were systematically collected from six stations along the river from January to June 2023, adhering to ethical standards and standard protocols for assessing water quality. Samples underwent chemical preparation and analysis for heavy metals using Graphite Furnace Atomic Absorption Spectrophotometry and Cold Vapor Atomic Absorption Spectroscopy, and for radionuclides using gamma spectrometry, with all methods validated for accuracy.</p></div><div><h3>Results</h3><p>The water samples showed metal and radionuclide concentrations within acceptable limits, except for higher levels of U and Th compared to background values. Heavy metal concentrations were higher in common carp compared to yellowhead catfish, with both species exhibiting a similar trend. While non-carcinogenic health risk, as indicated by target hazard quotients, was low for consumers, the health risk data emphasized the carcinogenic threats posed by U238 and Th234.</p></div><div><h3>Conclusions</h3><p>The study highlights the importance of implementing comprehensive river restoration measures. Additionally, the bioconcentration factor values indicate minimal accumulation of heavy metals in the muscle tissue of fish.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"85 ","pages":"Article 127485"},"PeriodicalIF":3.5,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141416080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The possible association of mitochondrial fusion and fission in copper deficiency-induced oxidative damage and mitochondrial dysfunction of the heart","authors":"Tianlong Wei ,&nbsp;Qinxu Wang ,&nbsp;Tao Chen ,&nbsp;Zhiyuan Zhou ,&nbsp;Shuangfei Li ,&nbsp;Zhengfeng Li ,&nbsp;Dayong Zhang","doi":"10.1016/j.jtemb.2024.127483","DOIUrl":"https://doi.org/10.1016/j.jtemb.2024.127483","url":null,"abstract":"<div><h3>Introduction</h3><p>As an essential trace element, Copper (Cu) participates in numerous physiological and biological reactions in the body. Cu is closely related to heart health, and an imbalance of Cu will cause cardiac dysfunction. The research aims to examine how Cu deficiency affects the heart, assess mitochondrial function in the hearts, and disclose possible mechanisms of its influence.</p></div><div><h3>Methods</h3><p>Weaned mice were fed Cu-deficient diets and intraperitoneally given copper sulfate (CuSO₄) to correct the Cu deficiency. The pathological change of the heart was assessed using histological inspection. Cardiac function and oxidative stress levels were evaluated by biochemical assay kits. ELISA and ATP detection kits were used to detect the levels of complexes I-IV in the mitochondrial respiratory chain (MRC) and ATP, respectively. Real time PCR was utilized to determine mRNA expressions, and Western blotting was adopted to determine protein expressions, of molecules related to mitochondrial fission and fusion.</p></div><div><h3>Results</h3><p>Cu deficiency gave rise to elevated heart index, cardiac histological alterations and oxidation injury, increased serum levels of creatine kinase (CK), lactic dehydrogenase (LDH), and creatine kinase isoenzyme MB (CK-MB) together with increased malondialdehyde (MDA) production, decreased the glutathione (GSH), Superoxide Dismutase (SOD), and Catalase (CAT) activities or contents. Besides, Cu deficiency caused mitochondrial damage characterized by decreased contents of complexes I-IV in the MRC and ATP in the heart. In the meantime, Cu deficiency also reduced protein and mRNA expressions of factors associated with mitochondrial fusion, including Mfn1 and Mfn2, while significantly increased factors Drip1 and Fis1 related to mitochondrial fission. However, adding CuSO₄ improved the above changes significantly.</p></div><div><h3>Conclusion</h3><p>According to research results, Cu deficiency can cause heart damage in mice, along with oxidative damage and mitochondrial dysfunction, which are closely related to mitochondrial fusion and fission disorders.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"85 ","pages":"Article 127483"},"PeriodicalIF":3.5,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141325885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Appraisal of potentially toxic metals contamination in protein supplements for muscle growth: A chemometric approach and associated human health risks","authors":"Misbah Irshad ,&nbsp;Mahmood Ahmed ,&nbsp;Muhammad Ramzan ,&nbsp;Mehreen Fatima ,&nbsp;Fatima Aftab ,&nbsp;Mudassar Sanaullah ,&nbsp;Shaista Qamar ,&nbsp;Zohaib Iftikhar ,&nbsp;Tanveer A. Wani ,&nbsp;Seema Zargar","doi":"10.1016/j.jtemb.2024.127481","DOIUrl":"https://doi.org/10.1016/j.jtemb.2024.127481","url":null,"abstract":"<div><h3>Background</h3><p>The use of protein supplements by athletes has risen due to their effectiveness in meeting dietary needs. However, there is a growing concern about the presence of potentially toxic metals (PTMs. Al, Cr, Mn, Ni, Cu, Zn, Cd, and Pb) in these supplements. Consequently, it is crucial to evaluate the levels of these PTMs to ensure the safety of the supplements.</p></div><div><h3>Methods</h3><p>The objective of the current study was to assess the PTMs concentrations in protein supplements and examine any possible health hazards. Twenty-five samples of protein supplements were purchased from different pharmacies to screen them for metals. Inductively coupled plasma-optical emission spectrometry (ICP-OES) was utilized to analyze metal content. Additionally, chemometric methods such as Pearson’s correlation coefficient (PCC), principal component analysis (PCA), and hierarchical cluster analysis (HCA) were employed to identify possible sources of PTMs contamination in protein supplements.</p></div><div><h3>Results</h3><p>Concentration ranges for PTMs were found as, Al (0.03–3.05 mg/kg), Cr (0.11–0.89 mg/kg), Mn (1.13–8.40 mg/kg), Ni (0.06–0.71 mg/kg), Cu (1.05–5.51 mg/kg), Zn (2.14–27.10 mg/kg), Cd (0.01–0.78 mg/kg), and Pb (0.06–0.57 mg/kg). The weekly intake of Cd exceeded the level of tolerable weekly intake (TWI) set by the European Food Safety Authority (EFSA).</p></div><div><h3>Conclusion</h3><p>Athletes, bodybuilders, fitness enthusiasts, dieters, young adults and adolescents, and health-conscious individuals should be conscious of Cd concentration as it does not compliance the TWI set by EFSA. Target hazard quotient (THQ &lt; 1), hazard index (HI &lt; 1), margin of exposure (MOE ≥ 1), percentile permitted daily exposure (% PDE &lt; 100), and cumulative cancer risk (CCR &lt; 1 × 10⁻³) analyses revealed that there are no appreciable non-carcinogenic and carcinogenic health risks associated with the use of these products.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"85 ","pages":"Article 127481"},"PeriodicalIF":3.5,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141325886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is chromium(III) supplementation beneficial for dietary rodent models of prediabetes?","authors":"John B. Vincent","doi":"10.1016/j.jtemb.2024.127482","DOIUrl":"https://doi.org/10.1016/j.jtemb.2024.127482","url":null,"abstract":"<div><p>Chromium as the trivalent ion is believed to pharmaceutically active, increasing insulin sensitivity in high doses in genetic rodent models of diabetes. However, contradictory results have been obtained chemical rodent models of diabetes. The current review analyses the effects of dietary Cr supplementation of rodent models of prediabetes, where the condition is administered using a high-fat or high-sugar diet. Rat model studies display a range of quality, with studies utilizing basal diets of known Cr content suggesting Cr beneficially affects insulin sensitivity. Mouse model studies display too much heterogeneity in results for any firm conclusions to be drawn. Comparison of these results with those of clinical trials suggest that the effective dose of Cr may be proportionally lower for rodents than humans, if one exists for humans.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"85 ","pages":"Article 127482"},"PeriodicalIF":3.5,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141303420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of oxidative stress and apoptosis by alteration of bioactive lipids in the pancreas, and effect of zinc chelation in a rat model of Alzheimer's disease","authors":"Alev Duygu Acun,&nbsp;Deniz Kantar","doi":"10.1016/j.jtemb.2024.127480","DOIUrl":"https://doi.org/10.1016/j.jtemb.2024.127480","url":null,"abstract":"<div><h3>Introduction</h3><p>Increasing epidemiological evidence highlights the association between systemic insulin resistance and Alzheimer's disease (AD). It is known that peripheral insulin resistance in the early stages of AD precedes and is a precursor to amyloid-β (Aβ) deposition. Although it is known that improving the CNS insulin sensitivity of AD patients is an important therapeutic goal and that the majority of insulin in the brain comes from the periphery, there has been little attention to the changes that occur in the pancreatic tissue of AD patients. Therefore, it is crucial to elucidate the mechanisms affecting insulin resistance in pancreatic tissue in AD. It is known that zinc (Zn2+) chelation is effective in reducing peripheral insulin resistance, cell apoptosis, cell death, and oxidative stress.</p></div><div><h3>Objective</h3><p>It was aimed to determine the changes in bioactive lipids, amylin (AIPP), oxidative stress and apoptosis in pancreatic cells in the early stages of Alzheimer's disease. The main aim is to reveal the therapeutic effect of the Cyclo-Z agent on these changes seen in the pancreas due to AD disease.</p></div><div><h3>Methods</h3><p>AD and ADC rats were intracerebroventricular (i.c.v.) Aβ1–42 oligomers. Cyclo-Z gavage was applied to ADC and SHC rats for 21 days. First of all, the effects of AIPP, bioactive ceramides, apoptosis and oxidative stress on the pancreatic tissue of AD group rats were evaluated. Then, the effect of Cyclo-Z treatment on these was examined. ELISA kit was used in biochemical analyses.</p></div><div><h3>Results</h3><p>AIPP and ceramide (CER) levels and CER/ sphingosine-1 phosphate (S1P) ratio were increased in the pancreatic tissue of AD rats. It also increased the level of CER kinase (CERK), which is known to increase the concentration of CER 1-phosphate (C1P), which is known to be toxic to cells in the presence of excessive CER concentration. Due to the increase in CER level, it was observed that apoptosis and oxidative stress increased in the pancreatic cells of AD group rats.</p></div><div><h3>Conclusion</h3><p>Cyclo-Z, which has Zn2+ chelating properties, reduced AD model rats' AIPP level and oxidative stress and could prevent pancreatic apoptosis. Similar therapeutic effects were not observed in the pancreatic tissue of Cyclo-Z administered to the SH group. For this reason, it is thought that Cyclo-Z agent may have a therapeutic effect on the peripheral hyperinsulinemia observed in the early stages of AD disease and the resulting low amount of insulin transported to the brain, by protecting pancreatic cells from apoptosis and oxidative stress by regulating their bioactive metabolites.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"85 ","pages":"Article 127480"},"PeriodicalIF":3.5,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141313253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}