Differences in insulin resistance biomarkers, but not on serum zinc concentration, among individuals with different SLC30A8 genotypes: analysis of the São Paulo population-based study (2015 ISA-Nutrition)

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Trace Elements in Medicine and Biology Pub Date : 2025-06-06 DOI:10.1016/j.jtemb.2025.127679

Graziela Biude Silva Duarte , Cristiane Cominetti , Flavia Mori Sarti , Regina Mara Fisberg , Marcelo Macedo Rogero

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Abstract

Background

Single nucleotide polymorphisms (SNPs) in the solute carrier family 30 member 8 (SLC30A8) gene related to zinc metabolism have been associated with an impaired insulin metabolic response. Objective: This study aimed to investigate variations in serum zinc concentration and insulin resistance biomarkers according to SNPs in the SLC30A8 gene among participants from the 2015 ISA-Nutrition. Methods: A total of 497 participants were genotyped for SNPs rs13266634, rs3802177, and rs11558471. Outcome variables included in the study were serum zinc concentration, fasting glucose, insulin, body mass index, and the homeostatic model assessment for insulin resistance (HOMA-IR). Results: The mean serum zinc concentration of participants was 85.5 µg/dL, without differences between sexes. The study population exhibited elevated glycemia and insulin resistance. No significant differences were found in serum zinc concentration and insulin resistance biomarkers between genotypes for all SNPs. However, men with the genotypes CC for rs13266634, GG for rs3802177, and AA for rs11558471 presented higher insulin concentration and HOMA-IR values compared to other genotypes, whereas there were no differences among women. Conclusion: These findings indicate that rs13266634, rs3802177, and rs11558471 SNPs in the SLC30A8 gene have no effect on serum zinc concentration but may contribute to insulin resistance effects in men.

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不同SLC30A8基因型个体之间胰岛素抵抗生物标志物的差异，但不包括血清锌浓度：基于圣保罗人群的研究分析（2015年ISA-Nutrition）

与锌代谢相关的溶质载体家族30成员8 （SLC30A8）基因的单核苷酸多态性（snp）与胰岛素代谢反应受损有关。目的：本研究旨在研究2015年ISA-Nutrition参与者血清锌浓度和胰岛素抵抗生物标志物的SLC30A8基因snp的变化。方法：共有497名参与者对snp rs13266634、rs3802177和rs11558471进行基因分型。结果变量包括血清锌浓度、空腹血糖、胰岛素、体重指数和胰岛素抵抗的稳态模型评估（HOMA-IR）。结果：参与者的平均血清锌浓度为85.5 µg/dL，无性别差异。研究人群表现出血糖升高和胰岛素抵抗。所有snp的血清锌浓度和胰岛素抵抗生物标志物在基因型之间无显著差异。然而，与其他基因型相比，rs13266634基因型CC、rs3802177基因型GG、rs11558471基因型AA的男性胰岛素浓度和HOMA-IR值更高，而女性之间没有差异。结论：SLC30A8基因的rs13266634、rs3802177和rs11558471 snp对血清锌浓度没有影响，但可能与男性胰岛素抵抗作用有关。

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来源期刊

Journal of Trace Elements in Medicine and Biology 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.90%

发文量

202

审稿时长

85 days

期刊介绍： The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.