聚合物功能化氧化铈纳米材料促进伤口愈合和抗癌潜力

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Trace Elements in Medicine and Biology Pub Date : 2025-06-12 DOI:10.1016/j.jtemb.2025.127681

Muhammad Khawar Abbas , Yasir Javed , Naveed Akhtar Shad , Azhar Rasul , Amna Bashir , Syed Fazil Bin Farukh , Heba Taha Abdulghani , Wasim Abbas , Aisha Sethi , Muhammad Ramzan Khawar , Dongwhi Choi

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引用次数: 0

摘要

伤口恢复是治疗的重要组成部分，以防止内部细胞器可能暴露于外部病原体。近年来，不同的治疗方法已被报道以更快和更有效的组织修复来促进自然伤口愈合过程。方法采用水热法制备环保、经济的聚乙二醇（PEG）和壳聚糖（chitosan）功能化氧化铈纳米粒子（CeO2 NPs）。用绒毛尿囊膜法和家蝇研究了伤口愈合潜力，并对HuH-7.0（肝癌细胞系）进行了抗癌研究。结果通过CAM实验初步研究了伤口愈合特性，发现壳聚糖功能化的CeO2 NPs在静脉中生长。局部伤口愈合研究表明，通过恢复的皮肤质量观察，家兔的皮肤重建阶段恢复迅速，完成得更快。此外，PEGylation还提高了CeO2 NPs对HuH-7.0（肝癌细胞系）的抗癌潜力，IC50值为37.89 μg/mL。结论聚乙二醇和壳聚糖包被增强了CeO2 NPs的治疗前景。

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Boosted wound healing and anticancer potential of polymer functionalized cerium oxide nanomaterials

Background

Wound recovery is an important part of treatment to prevent internal organelles from possible exposure to outer pathogens. In recent years, different therapies have been reported to enhance the natural wound healing process with faster and more effective tissue repair.

Method

The hydrothermal method has been endeavored to synthesize eco-friendly and cost-effective polymer (polyethylene glycol (PEG) and chitosan) functionalized cerium oxide nanoparticles (CeO₂ NPs). Wound healing potential was studied on Chorioallantoic Membrane Assay and G. domesticus wheras anticancer studies were conducted against HuH-7.0 (hepatic cancer cell line).

Results

Wound healing properties are studied initially through CAM assay which shows vein growth with chitosan-functionalized CeO₂ NPs. The topical wound healing studies on G. domesticus show speedy recovery and quicker completion of the skin remodeling phase, observed through the quality of the recovered skin. Additionally, PEGylation has promoted the anticancer potential of CeO₂ NPs against HuH-7.0 (hepatic cancer cell line) and the IC₅₀ value is 37.89 μg/mL.

Conclusion

The results show that PEG and chitosan coating have enhanced the therapeutic prospects of CeO₂ NPs.

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来源期刊

Journal of Trace Elements in Medicine and Biology 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.90%

发文量

202

审稿时长

85 days

期刊介绍： The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.