Echinochrome guarding effect against sodium arsenite-induced hepatorenal toxicity in rats

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Trace Elements in Medicine and Biology Pub Date : 2025-06-18 DOI:10.1016/j.jtemb.2025.127682

Hader I. Sakr , Tarek Atia , Neamat A. Mahmoud , Islam Ahmed Abdelmawgood , Marina Lotfy Khalaf , Bassam Waleed Ebeed , Ahmed Mohamed Abdelmohsen , Mohamed A. Kotb , Abdeljalil Mohamed Al Shawoush , Ahmed A. Damanhory , Abdallah Mohammed Elagali , Ayman Saber Mohamed , Hadeer Hesham Abdelfattah

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Abstract

Background

The persistent and accumulative qualities of the poisonous metalloid arsenic make it a ubiquitous environmental threat. Echinochrome (Ech) is a natural product that possesses antioxidative, antiviral, antialgal, anti-allergic, and antibacterial effects.

Aim

The work investigates the beneficial impact of Ech on sodium arsenite-induced hepatorenal toxicity in rats. Eighteen male rats dispersed equally among three groups: control, sodium arsenite (AS), and AS + Ech. Rats were administered AS (10 mg/kg) and Ech (1 mg/kg BW) by gavage for the experimental duration of 30 days. Ech inhibits oxidative stress by improving antioxidant levels, including glutathione, catalase, and glutathione-S-transferase, with a concomitant decrease in the amounts of malondialdehyde and nitric oxide in kidney and liver tissues. Moreover, it reduced blood concentrations of aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase, alkaline phosphatase, serum urea, uric acid, and creatinine. Concurrently, Ech resulted in a substantial increase in albumin and total protein levels. Additionally, Ech inhibits inflammation by reducing serum concentrations of tumor necrosis factor-α, cyclooxygenase 2, and prostaglandin E2.

Conclusion

Ech mitigates arsenic-induced hepatorenal damage by inhibiting oxidative stress and inflammatory pathways.

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紫锥花对亚砷酸钠致大鼠肝肾毒性的保护作用

有毒金属类砷的持久性和蓄积性使其成为无处不在的环境威胁。紫锥花（Ech）是一种天然产品，具有抗氧化、抗病毒、抗藻、抗过敏和抗菌作用。目的探讨乙酰胆碱对亚砷酸钠所致大鼠肝肾毒性的有益作用。18只雄性大鼠平均分布在三组：对照组、亚砷酸钠（AS）和AS + Ech。给大鼠灌胃AS（10 mg/kg）和Ech(1 mg/kg BW)，试验期30 d。乙酰胆碱通过提高抗氧化剂水平（包括谷胱甘肽、过氧化氢酶和谷胱甘肽- s -转移酶）来抑制氧化应激，同时降低肾脏和肝脏组织中丙二醛和一氧化氮的含量。此外，它还能降低血中天冬氨酸转氨酶、丙氨酸转氨酶、γ -谷氨酰转氨酶、碱性磷酸酶、血清尿素、尿酸和肌酐的浓度。同时，Ech导致白蛋白和总蛋白水平显著增加。此外，乙酰胆碱通过降低血清中肿瘤坏死因子-α、环氧化酶2和前列腺素E2的浓度来抑制炎症。结论乙酰胆碱可通过抑制氧化应激和炎症途径减轻砷所致的肝肾损害。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Trace Elements in Medicine and Biology 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.90%

发文量

202

审稿时长

85 days

期刊介绍： The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.