{"title":"缺氧和硒对心肺损伤的影响","authors":"Lekang Han , Ting Huang , Zhongzhi Zhao , Zhancui Dang","doi":"10.1016/j.jtemb.2025.127767","DOIUrl":null,"url":null,"abstract":"<div><div>Selenium (Se) is an essential trace element required by the human body, existing in selenium proteins as selenocysteine (Sec) and selenomethionine (SeMet). Through these proteins, Se exerts its biological effects such as free radical metabolism, antioxidant functions, immune response, reproductive functions, apoptosis, and endocrine hormone regulation. Both selenium deficiency and excess are can cause adverse effects on human health. A growing number of evidence highlights the involvement of selenium and its proteins in the development and progression of cardiovascular diseases (CVD). During hypoxia, the body undergoes a series of changes across all organ systems. Among these, the heart, lungs, and brain—due to their high oxygen demand and metabolic activity—demonstrate particularly prominent manifestations of injury. This review summarizes the effects of selenium/selenoproteins on the cardiovascular system, emphasizing new findings on their roles in hypoxic cardiorespiratory injury. This is to provide a scientific basis for preventing and treating high-altitude illnesses from both environmental and nutritional perspectives.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"92 ","pages":"Article 127767"},"PeriodicalIF":3.6000,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cardiopulmonary injury in hypoxia and selenium: A review\",\"authors\":\"Lekang Han , Ting Huang , Zhongzhi Zhao , Zhancui Dang\",\"doi\":\"10.1016/j.jtemb.2025.127767\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Selenium (Se) is an essential trace element required by the human body, existing in selenium proteins as selenocysteine (Sec) and selenomethionine (SeMet). Through these proteins, Se exerts its biological effects such as free radical metabolism, antioxidant functions, immune response, reproductive functions, apoptosis, and endocrine hormone regulation. Both selenium deficiency and excess are can cause adverse effects on human health. A growing number of evidence highlights the involvement of selenium and its proteins in the development and progression of cardiovascular diseases (CVD). During hypoxia, the body undergoes a series of changes across all organ systems. Among these, the heart, lungs, and brain—due to their high oxygen demand and metabolic activity—demonstrate particularly prominent manifestations of injury. This review summarizes the effects of selenium/selenoproteins on the cardiovascular system, emphasizing new findings on their roles in hypoxic cardiorespiratory injury. This is to provide a scientific basis for preventing and treating high-altitude illnesses from both environmental and nutritional perspectives.</div></div>\",\"PeriodicalId\":49970,\"journal\":{\"name\":\"Journal of Trace Elements in Medicine and Biology\",\"volume\":\"92 \",\"pages\":\"Article 127767\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-09-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Trace Elements in Medicine and Biology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0946672X25001804\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Trace Elements in Medicine and Biology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0946672X25001804","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Cardiopulmonary injury in hypoxia and selenium: A review
Selenium (Se) is an essential trace element required by the human body, existing in selenium proteins as selenocysteine (Sec) and selenomethionine (SeMet). Through these proteins, Se exerts its biological effects such as free radical metabolism, antioxidant functions, immune response, reproductive functions, apoptosis, and endocrine hormone regulation. Both selenium deficiency and excess are can cause adverse effects on human health. A growing number of evidence highlights the involvement of selenium and its proteins in the development and progression of cardiovascular diseases (CVD). During hypoxia, the body undergoes a series of changes across all organ systems. Among these, the heart, lungs, and brain—due to their high oxygen demand and metabolic activity—demonstrate particularly prominent manifestations of injury. This review summarizes the effects of selenium/selenoproteins on the cardiovascular system, emphasizing new findings on their roles in hypoxic cardiorespiratory injury. This is to provide a scientific basis for preventing and treating high-altitude illnesses from both environmental and nutritional perspectives.
期刊介绍:
The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods.
Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.