缺氧和硒对心肺损伤的影响

IF 3.6 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Lekang Han , Ting Huang , Zhongzhi Zhao , Zhancui Dang
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引用次数: 0

摘要

硒(Se)是人体必需的微量元素,以硒半胱氨酸(Sec)和硒代蛋氨酸(SeMet)的形式存在于硒蛋白中。硒通过这些蛋白发挥自由基代谢、抗氧化功能、免疫应答、生殖功能、细胞凋亡和内分泌激素调节等生物学作用。硒缺乏和过量都会对人体健康造成不良影响。越来越多的证据强调了硒及其蛋白质在心血管疾病(CVD)的发生和进展中的作用。在缺氧期间,身体所有器官系统都会发生一系列变化。其中,心脏、肺和大脑——由于它们的高需氧量和代谢活动——表现出特别突出的损伤表现。本文综述了硒/硒蛋白对心血管系统的影响,重点介绍了其在缺氧性心肺损伤中的新发现。从环境和营养两个方面为防治高原病提供科学依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cardiopulmonary injury in hypoxia and selenium: A review
Selenium (Se) is an essential trace element required by the human body, existing in selenium proteins as selenocysteine (Sec) and selenomethionine (SeMet). Through these proteins, Se exerts its biological effects such as free radical metabolism, antioxidant functions, immune response, reproductive functions, apoptosis, and endocrine hormone regulation. Both selenium deficiency and excess are can cause adverse effects on human health. A growing number of evidence highlights the involvement of selenium and its proteins in the development and progression of cardiovascular diseases (CVD). During hypoxia, the body undergoes a series of changes across all organ systems. Among these, the heart, lungs, and brain—due to their high oxygen demand and metabolic activity—demonstrate particularly prominent manifestations of injury. This review summarizes the effects of selenium/selenoproteins on the cardiovascular system, emphasizing new findings on their roles in hypoxic cardiorespiratory injury. This is to provide a scientific basis for preventing and treating high-altitude illnesses from both environmental and nutritional perspectives.
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来源期刊
CiteScore
6.60
自引率
2.90%
发文量
202
审稿时长
85 days
期刊介绍: The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.
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