Journal of Trace Elements in Medicine and Biology最新文献

{"title":"A review study on the effect of zinc on oxidative stress-related neurological disorders","authors":"Reyhaneh Vali ,&nbsp;Kasra Shirvanian ,&nbsp;Tahereh Farkhondeh ,&nbsp;Michael Aschner ,&nbsp;Fariborz Samini ,&nbsp;Saeed Samarghandian","doi":"10.1016/j.jtemb.2025.127618","DOIUrl":"10.1016/j.jtemb.2025.127618","url":null,"abstract":"<div><div>Zinc plays a main role in maintaining homeostasis and neuronal function. Disorders in zinc homeostasis are connected to several neurological disorders due to inflammation and oxidative stress. This review explores the effect of zinc on neurological disorders through the Nrf2 signaling pathway. The Nrf2 pathway modulates oxidative stress and regulates antioxidant defenses, which is critical in the pathogenesis of neurological diseases. We provide an overview of in vivo and in vitro studies illustrating zinc's neuroprotective effects in conditions such as Alzheimer's disease, spinal cord injury, and stroke. The dual role of zinc, where both excess and deficiency can be detrimental, is highlighted, emphasizing the need for optimal zinc levels. Limitations of current research and future perspectives are also discussed.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127618"},"PeriodicalIF":3.6,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of trace element levels in primary teeth and occurrence of Cleft lip and/or palate","authors":"Krithika Gupta ,&nbsp;M.S. Muthu ,&nbsp;Ankita Saikia ,&nbsp;Latha Nirmal ,&nbsp;Arijeet Mitra ,&nbsp;Umesh Wadgave ,&nbsp;Vineet Dhar","doi":"10.1016/j.jtemb.2025.127615","DOIUrl":"10.1016/j.jtemb.2025.127615","url":null,"abstract":"<div><h3>Background</h3><div>Cleft lip and/or palate (CL/CP) are common congenital anomalies with multifactorial origins, potentially influenced by environmental factors, including multi-trace metal exposure. Primary teeth, which form in utero, offer a unique biomatrix for assessing early-life metal exposure, yet remain underexplored in CL/CP research.</div></div><div><h3>Objective</h3><div>This case-control study aimed to investigate the association between multi-trace metal exposure and CL/CP occurrence by analyzing primary teeth using Inductively Coupled Plasma Mass Spectrometry (ICP-MS).</div></div><div><h3>Methods</h3><div>Ethical clearance was obtained for this study, which included 30 children aged 4–12 years. Non-carious central and lateral incisors were analyzed for trace metals using ICP-MS. Demographic, socioeconomic, and nutritional data were collected via a structured proforma and environmental risk factor questionnaire.</div></div><div><h3>Results</h3><div>A comprehensive analysis of 24 trace metals in primary teeth of CL/CP and control groups found no significant associations with 25Mg, 52Cr, 43Ca, and 56Fe, with odds ratios near 1. Lower 113 Cd concentrations were linked to CL/CP. However, the small sample size (n = 15 per group) limits conclusions on the relationship between cadmium levels and CL/CP. Maternal nutritional deficiencies (p = 0.031) and lower annual income (p = 0.001) were significantly associated with increased CL/CP prevalence, suggesting socioeconomic and dietary influences.</div></div><div><h3>Conclusion</h3><div>Exposure to 25Mg, 52Cr, 43Ca, and 56Fe showed no significant association with CL/CP risk, while lower 113 Cd levels suggested a potential link, though the small sample size limits interpretations. Further research is needed to elucidate the link between metal exposure and developmental anomalies, and to address cadmium's environmental and dietary sources to reduce CL/CP risk.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127615"},"PeriodicalIF":3.6,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenium pretreatment improve renal function, autophagy signaling pathway and mir21a gene expression in renal ischemia reperfusion injury model in male rat","authors":"Fatemeh Ayari ,&nbsp;Amin Abdollahzade Fard ,&nbsp;Leila Chodari","doi":"10.1016/j.jtemb.2025.127610","DOIUrl":"10.1016/j.jtemb.2025.127610","url":null,"abstract":"<div><h3>Background</h3><div>Renal ischemia-reperfusion injury (RIRI) is a major cause of acute kidney injury (AKI). Autophagy is an important mechanisms involved in this damage. In this study, we investigated effect of selenium on autophagy in kidney following IRI.</div></div><div><h3>Methods</h3><div>In this study, 24 Wistar male rats (200 ± 20 gr) were divided into 4 groups: 1) Sham 2) Sham+ Sodium selenite (0.5 mg/kg) 3) Ischemia-reperfusion (I/R) 4) I/R + sodium selenite. RIRI induces by vascular microclamp for 45 min. At the end of study, blood was taken from the heart tissue and used to measure BUN and Creatinine with the kit, the left kidney tissue was frozen for measurement of LC3II, LC3I, Beclin1, Rab11a, P62, and Caspase3 by western blot technique and measurement of mir21a by RT-PCR method. In addition, right kidney tissue was placed in formalin for histological studies with Haematoxylin‎‎-eosin staining.</div></div><div><h3>Result</h3><div>According to the results, in the I/R group compared to the sham group, serum levels of creatinine and urea, amount of autophagy including expression levels of Lc3II/Lc3I, beclin1, Rab11a, Cleaved Caspase3/Pro Caspase3 proteins significantly increased and expression of p62 decreased. Also, mir21a gene expression significantly decreased in the I/R group. According to histological results, ischemia-reperfusion has caused kidney tissue damage, such as destruction of the brush border of renal tubules, congestion, and leukocyte filtration. Our results showed that pretreatment with selenium reduced tissue damage and moderated the expression changes of the mentioned proteins.</div></div><div><h3>Conclusion</h3><div>It seems selenium inhibits autophagy by changing the expression levels of mediator molecules Rab11a and mir21a, and it can apply its healing effects in the damage caused by ischemia and reperfusion of kidney tissue in an animal model.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127610"},"PeriodicalIF":3.6,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143428640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerium-doped mesoporous bioactive glass nanoparticles reduce oxidative stress and adipogenic differentiation in human bone marrow-derived mesenchymal stromal cells","authors":"V. Jacobsen ,&nbsp;E. Kunisch ,&nbsp;C. Merle ,&nbsp;B. Xue ,&nbsp;K. Zheng ,&nbsp;T. Renkawitz ,&nbsp;A.R. Boccaccini ,&nbsp;F. Westhauser","doi":"10.1016/j.jtemb.2025.127617","DOIUrl":"10.1016/j.jtemb.2025.127617","url":null,"abstract":"<div><div>Increased levels of reactive oxygen species (ROS) favor adipogenic over osteogenic differentiation in human bone-marrow derived mesenchymal stromal cells (BMSCs). Therefore, biomaterials containing ROS-suppressing elements such as Cerium (Ce) have been introduced to cell-based bone-tissue-engineering (BTE) approaches. This study was conducted to assess the efficacy of Ce-doped mesoporous bioactive glass nanoparticles (MBGNs) in reducing ROS levels and subsequently inhibiting the adipogenic differentiation of BMSCs. To this end, BMSCs were cultivated in adipogenesis inducing medium (AIM) and exposed to ions released from Ce-free MBGNs (composition in mol%: 86SiO₂-14CaO), Low-Ce-MBGNs (composition in mol%: 86.6SiO₂-12.1CaO-1.3CeO₂) and High-Ce-MBGNs (composition in mol%: 86.0SiO₂-11.8CaO-2.2CeO₂). The influence of the different MBGNs on the expression of adipogenic and ROS-scavenging genes was assessed as well as their influence on lipid formation and the physical presence of ROS. Ce-MBGNs significantly reduced lipid production and the expression of adipogenic marker genes when compared to BMSCs cultivated in the presence of MBGNs or AIM alone. Furthermore, ROS levels were decreased by Ce-MBGNs alongside an upregulation of the expression of genes encoding for ROS-scavenging enzymes. Ce-MBGNs have proven their antioxidative potential. Mediated by the reduction of ROS, the undesired differentiation of BMSCs towards adipogenic lineage within BTE applications has been effectively suppressed. Ce-MBGNs target differentiation pathways in BMSCs precisely and therefore constitute an attractive biomaterial in the field of ion-based BTE.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127617"},"PeriodicalIF":3.6,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advancements in the application of multi-elemental profiling and ionomics in cardiovascular diseases","authors":"Yan Zhang ,&nbsp;Zaicheng Zhang ,&nbsp;Hengtao Li ,&nbsp;Yao Xiao ,&nbsp;Huimin Ying","doi":"10.1016/j.jtemb.2025.127616","DOIUrl":"10.1016/j.jtemb.2025.127616","url":null,"abstract":"<div><h3>Background</h3><div>Trace elements and minerals are crucial for human growth and health, whose imbalance is associated with a variety of diseases. Recently, multi-elemental profiling and ionomics have been rapidly developed and widely used to study the distribution, variation, and interactions of various elements in diverse physiological and pathological conditions. By utilizing high-throughput elemental analytical techniques and bioinformatics approaches, researchers can uncover the relationship between the metabolism and balance of different elements and numerous human diseases.</div></div><div><h3>Methods</h3><div>The presented work reviews recent advances in multi-elemental and ionomic profiling of human biological samples for several major types of cardiovascular diseases.</div></div><div><h3>Results</h3><div>Research indicates distinct and dynamic patterns of ion contents in these diseases. Accumulation of copper and environmental toxic metals as well as deficiencies in zinc and selenium appear to be the most significant risk factors for the majority of cardiovascular diseases, suggesting that an imbalance in these elements may play a role in the development of these illnesses. Furthermore, each type of cardiovascular disease exhibits a relatively unique distribution of ions in biofluid and hair samples from patients, potentially serving as indicators for the specific disease.</div></div><div><h3>Conclusion</h3><div>Multi-elemental profiling and ionomics not only enhance our understanding of the association between elemental dyshomeostasis and the development of cardiovascular diseases but also facilitate the discovery of novel diagnostic and prognostic markers for these conditions.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127616"},"PeriodicalIF":3.6,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143376584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Melatonin and Ginseng on rat testis and sperm quality against cadmium toxicity via inhibiting oxidative stress and autophagy pathways","authors":"Nashwa Barakat ,&nbsp;Mona A. Alkhen ,&nbsp;Yomna Khater ,&nbsp;Salma M. Khirallah","doi":"10.1016/j.jtemb.2025.127614","DOIUrl":"10.1016/j.jtemb.2025.127614","url":null,"abstract":"<div><h3>Background and aim</h3><div>Infertility constitutes a significant global health concern. Cadmium (Cd), a hazardous element, exerts deleterious effects on the reproductive system. Consequently, it is essential to devise novel pharmaceutical strategies to mitigate this adverse effect. Melatonin is linked to the regulation of spermatogenesis across several animals. Ginseng is recognized for its antioxidant capabilities and has shown superior clinical efficacy in male reproductive health. This study aimed to inspect the preventive effects of Melatonin (Mel) and Ginseng (Gin) on the quality of epididymal sperm, as well as testicular function and structure, in rats subjected to cadmium exposure.</div></div><div><h3>Methods</h3><div>Forty rats were allocated into four equal groups: Control group, Cadmium group: Rats were injected with 2.0 mg/kg, Melatonin group: animals were injected with 10 mg/kg and Ginseng group: Rats were oral gavage with 100 mg/kg. All treatments were maintained for 8 weeks. Testes were taken for histopathological examinations, sperm parameters analysis, biochemical and molecular studies.</div></div><div><h3>Results</h3><div>The results revealed a significant decrease of sperm parameters in Cd group compared to the control group. Nevertheless, treatment with Mel and Gin significantly increased sperm concentration, motility, and viability compared to Cd group (p &lt; 0.05). Besides, Cd treatment caused a significant decrease in SOD and CAT activities and an increase in NO and MDA levels which was significantly improved with Mel and Gin administration (p &lt; 0.05). Apoptosis, inflammation and autophagy markers were significantly inhibited with Mel and Gin treatment.</div></div><div><h3>Conclusions</h3><div>Melatonin and Ginseng reduce testicular toxicity induced by Cd, via inhibiting oxidative stress, apoptosis, inflammation, and autophagy providing novel insights into combating cadmium toxicity.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127614"},"PeriodicalIF":3.6,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143194486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Key role of the CSE/transsulfuration pathway in macrophage phenotypic change under iron overload","authors":"Zhaoji Yuan ,&nbsp;Yuxuan Chen ,&nbsp;Yijun Xin ,&nbsp;Yong Zhang ,&nbsp;Zihao Dong ,&nbsp;Jianxu Wang ,&nbsp;Xiangdong Wang ,&nbsp;Guang Yang ,&nbsp;Siying Li","doi":"10.1016/j.jtemb.2025.127611","DOIUrl":"10.1016/j.jtemb.2025.127611","url":null,"abstract":"<div><h3>Background</h3><div>Iron homeostasis has a significant impact on the phenotypic transformation of macrophages and is implicated in various diseases. In this study, we evaluated the effect of cystathionine-gamma-lyase (CSE)/transsulfuration pathway in iron-overload induced macrophage phenotype change.</div></div><div><h3>Methods</h3><div>The biochemical parameters, such as qRT-PCR, western blot, fluorescence staining, were assessed both <em>in vitro</em> and <em>in vivo</em>.</div></div><div><h3>Results</h3><div>Iron overload disrupts iron metabolism and alters the expression of genes involved in iron transport, resulting in the polarization of macrophages towards the M1 phenotype and an alternating activation state of M2. Meanwhile, excessive iron led to an increase in lipid peroxidation levels and disrupted cysteine metabolism. By utilizing erastin to inhibit SLC7A11 activity and block exogenous cysteine uptake, we were able to observe the exacerbation of the proinflammatory state in macrophages under conditions of cysteine deprivation. The CSE/transsulfuration pathway, serves as the primary route for endogenous cysteine synthesis. In the presence of iron overload, the expression of CSE was upregulated and further enhanced by cysteine deprivation. Deletion of CSE in CSE-knockout mice exacerbated the inflammatory transition of iron-overloaded macrophages by impacting cysteine metabolism and ferritinophagy.</div></div><div><h3>Conclusion</h3><div>The CSE/transsulfuration pathway regulated macrophage phenotype change under iron-overload, which may offer novel insights into potential therapeutic strategies for iron overload-related disorders.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127611"},"PeriodicalIF":3.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sub-lethal toxicity effects of iron oxide nanoparticles (IONPs) on the biochemical, oxidative biomarkers, and metabolic profile in Caridina fossarum","authors":"Hamidreza Shahryari ,&nbsp;Iman Sourinejad ,&nbsp;Amin Gholamhosseini ,&nbsp;Mahdi Banaee","doi":"10.1016/j.jtemb.2025.127613","DOIUrl":"10.1016/j.jtemb.2025.127613","url":null,"abstract":"<div><h3>Backgrounds</h3><div>This study aimed to assess the toxicity effect of iron oxide nanoparticles (IONPs) on the biochemical and oxidative markers in freshwater miniature shrimp (<em>Caridina fossarum</em>).</div></div><div><h3>Materials and methods</h3><div>Based on the pre-test results, 540 shrimp were distributed into six trial groups in triplicate and exposed to sub-lethal concentrations of Fe3O4 nanoparticles at 0.0, 40, 80, 120, 160, and 320 µg L⁻¹ for 14 days. Next, biochemical parameters and oxidative biomarkers were measured.</div></div><div><h3>Results</h3><div>The results showed that exposure to 120 µg L⁻¹ ≤ of IONPs significantly increased aspartate aminotransferase activity in <em>C. fossarum</em>. Alanine aminotransferase activity showed a significant increase at 320 µg L⁻¹ . Similarly, alkaline phosphatase activity was meaningfully elevated at 160 and 320 µg L⁻¹ . Lactate dehydrogenase activity notably increased at 120 and 320 µg L⁻¹ of IONPs. IONPs at ≥ 80 µg L⁻¹ significantly reduced gamma-glutamyl transpeptidase and butyrylcholinesterase activities. Cholesterol and triglyceride levels significantly increased at 320 µg L⁻¹ . Exposure to 80 µg L⁻¹ ≤ of IONPs significantly increased superoxide dismutase, catalase, glutathione reductase, and glutathione peroxidase activities in <em>C. fossarum</em>. Moreover, total antioxidant capacity and malondialdehyde content increased considerably in shrimp exposed to different concentrations of IONPs. Exposure to IONPs could induce oxidative stress, disrupt protein structures, oxidize sulfur-containing and essential aromatic and aliphatic amino acids, impair nucleic acid stability, and change lipid metabolism and membrane integrity.</div></div><div><h3>Conclusion</h3><div>In conclusion, significant changes in biochemical parameters, oxidative biomarkers, and metabolic profile disruptions in <em>C. fossarum</em> exposed to sub-lethal concentrations of IONPs indicated cellular damage and oxidative stress.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127613"},"PeriodicalIF":3.6,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of blood selenium with dyslipidemia in children and adolescents: a cross-sectional analysis","authors":"Feiqi Lin ,&nbsp;Zhiyuan Chen","doi":"10.1016/j.jtemb.2025.127596","DOIUrl":"10.1016/j.jtemb.2025.127596","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to examine the association between blood selenium levels and dyslipidemia in children and adolescents.</div></div><div><h3>Methods</h3><div>Data from the National Health and Nutrition Examination Survey (NHANES) 2011–2020 were analyzed, including 8191 participants aged 6–19 years. Dyslipidemia was defined by elevated total cholesterol (TC ≥ 200 mg/dL), lowered high-density lipoprotein cholesterol (HDL-C &lt; 40 mg/dL), or elevated non-HDL-C (≥ 145 mg/dL). Associations between blood selenium levels and dyslipidemia were examined using multivariate logistic regression, linear regression, and restricted cubic spline (RCS) analysis.</div></div><div><h3>Results</h3><div>The study population had a mean age of 12.33 years, with 51.21 % boys. After adjusting for multiple confounding factors, including dietary selenium intakes and supplementation, higher blood selenium levels were associated with increased odds of dyslipidemia and its components. In the highest quartile of blood selenium (&gt;193.99 μg/L), adjusted odds ratios (ORs) were 1.60 (95 % confidence interval [CI]: 1.23–2.08) for dyslipidemia, 1.70 (95 % CI: 1.19–2.43) for elevated TC, 1.38 (95 % CI: 0.97–1.96) for lowered HDL-C, and 1.73 (95 % CI: 1.20–2.48) for elevated non-HDL-C. A significant nonlinear association was observed, with dyslipidemia prevalence increasing notably above a threshold of 184.28 μg/L (<em>P</em>-nonlinearity=0.02), following a J-shaped curve. Subgroup analysis revealed significant interaction by race (<em>P</em>-interaction=0.02), with non-Hispanic White individuals showing a stronger association (OR=1.83, 95 % CI: 1.19–2.80) compared to other racial groups (OR=1.40, 95 % CI: 1.05–1.88).</div></div><div><h3>Conclusion</h3><div>Elevated blood selenium levels are associated with higher prevalence of dyslipidemia in children and adolescents, particularly among non-Hispanic White individuals. The association is nonlinear, with a notable increase in the prevalence of dyslipidemia observed above a blood selenium level of 184.28 μg/L. These findings suggest a need for further research to understand selenium's role in lipid profiles and its implications for public health.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127596"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FESTEM","authors":"","doi":"10.1016/S0946-672X(25)00022-7","DOIUrl":"10.1016/S0946-672X(25)00022-7","url":null,"abstract":"","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127609"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143103524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}