Journal of Trace Elements in Medicine and Biology最新文献

{"title":"Selected papers and report on the 8th International FESTEM Symposium on “Recent Advances in Trace Elements. From the Bench to the Bedside”, September 28th to October 1st 2022, Madrid, Spain","authors":"Montserrat González-Estecha , Dirk Schaumlöffel , María Teresa Llorente-Ballesteros , Silvia Izquierdo-Álvarez","doi":"10.1016/j.jtemb.2025.127634","DOIUrl":"10.1016/j.jtemb.2025.127634","url":null,"abstract":"","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"89 ","pages":"Article 127634"},"PeriodicalIF":3.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143706071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidimensional analysis of selected bioelements in rat's brain subjected to stroke procedure and treatment with H2S donor AP-39","authors":"Bartłomiej Rospond ,&nbsp;Agata Krakowska ,&nbsp;Joanna Piotrowska ,&nbsp;Bartosz Pomierny ,&nbsp;Weronika Krzyżanowska ,&nbsp;Bernadeta Szewczyk ,&nbsp;Przemysław Szafrański ,&nbsp;Przemysław Dorożynski ,&nbsp;Beata Paczosa-Bator","doi":"10.1016/j.jtemb.2025.127628","DOIUrl":"10.1016/j.jtemb.2025.127628","url":null,"abstract":"<div><h3>Background</h3><div>A stroke is characterized by a sudden disruption in blood flow to the brain. According to WHO statistics, stroke is the second most common cause of death. Its pathophysiology involves complex mechanisms: oxidative stress, inflammation, cytotoxicity and neuronal cell death. Middle cerebral artery occlusion (MCAO) in rats is commonly used to study the pathophysiology of stroke, as well as the efficacy of therapeutic strategies e.g. application of H₂S donors.</div></div><div><h3>Objectives</h3><div>The aim of this study was to determine the concentrations of minerals (Mg, Na, K), and trace elements (Fe, Cu, and Zn) in rats brain undergoing stroke procedure in the dorsal striatum (ischemic core) and prefrontal cortex (penumbra). We also investigate the application of AP-39 on the levels of above-mentioned minerals and trace elements.</div></div><div><h3>Methods</h3><div>Using the MCAO rat model, the impact of stroke and treatment with 100 nmol/kg b.m<em>. i.v.</em> of AP-39 was examined on minerals and trace elements levels, determined by F-AAS and F-AES methods. Results were analyzed using multidimensional statistical analysis (chemometric techniques).</div></div><div><h3>Results</h3><div>Iron, magnesium, and zinc are the most important bioelements whose concentration changes in both investigated structures were associated with stroke symptoms. The concentrations of zinc and copper showed opposing trend. The application of AP-39 mainly affected the potassium level. In the stroke structure (DS) dosage of AP-39 decreased the potassium level and in non-stroke structure AP-39 increased potassium levels.</div></div><div><h3>Conclusion</h3><div>Stroke and AP-39 treatment significantly altered bioelement concentrations. The bioelements most susceptible to changes under MCAO procedures were zinc, iron and magnesium.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127628"},"PeriodicalIF":3.6,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro assessment of selenium bioavailability from selenized lactic acid bacteria using a static INFOGEST digestion model and intestinal permeability model","authors":"Iva Mrvikova ,&nbsp;Ivana Hyrslova ,&nbsp;Vera Nesporova ,&nbsp;Barbora Lampova ,&nbsp;Klara Cejpova ,&nbsp;Ivo Doskocil ,&nbsp;Sarka Musilova ,&nbsp;Jaromir Cihlar ,&nbsp;Gabriela Krausova ,&nbsp;Antonin Kana ,&nbsp;Marek Kieliszek","doi":"10.1016/j.jtemb.2025.127632","DOIUrl":"10.1016/j.jtemb.2025.127632","url":null,"abstract":"<div><h3>Background and objective</h3><div>Microbial selenium (Se) supplementation is an essential area of biotechnological research due to differences in the bioavailability and toxicity of different forms of selenium. To date, research has focused mainly on the use of selenized yeast. However, in recent years, scientific interest has also increased in other microorganisms, such as lactic acid bacteria (LAB), which have several unique properties that can affect the quality and bioavailability of selenium. LAB, unlike yeast, can also act as probiotics, which may bring additional health benefits related to improving the intestinal microbiota and supporting the health of the gastrointestinal tract.</div></div><div><h3>Methods</h3><div>This study investigates the <em>in vitro</em> bioaccessibility and bioavailability of Se from two lactic acid bacterial strains, <em>Streptococcus thermophilus</em> CCDM 144 and <em>Enterococcus faecium</em> CCDM 922 A. We evaluated Se accumulation, speciation, and stability during simulated gastrointestinal digestion and Se permeation through a Caco-2 cell monolayer model.</div></div><div><h3>Results</h3><div>Both strains accumulated Se, metabolizing it predominantly into selenium nanoparticles (SeNPs, 64–77 % of total Se), with only a minor fraction (&lt;5 % of total Se) of organic Se species. Experiments revealed that while organic Se species had high bioavailability (up to 90 %), their bioaccessibility during digestion was very low (&lt;0.1 % of total Se). In contrast, SeNPs showed high bioaccessibility (∼90 %) and moderate transport efficiency through the intestinal model (16–19 % after 4 hours).</div></div><div><h3>Conclusion</h3><div>These results highlight the potential of SeNPs produced by lactic acid bacteria as a bioaccessible form of Se for dietary supplementation. Further research is required to explore the behavior of SeNPs within the human body to fully understand how they can be used safely and effectively in nutrition or other applications.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127632"},"PeriodicalIF":3.6,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Serum iodine concentration in pregnant women and its association with thyroid function” [J. Trace Elem. Med. Biol. 87 (2025) 127584]","authors":"Dongdong Yu ,&nbsp;Yinyin He ,&nbsp;Hongsen He ,&nbsp;Zhengyan Hu ,&nbsp;Yun Huang ,&nbsp;Jun Tang","doi":"10.1016/j.jtemb.2025.127630","DOIUrl":"10.1016/j.jtemb.2025.127630","url":null,"abstract":"","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127630"},"PeriodicalIF":3.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-cancer effects of boron derivatives on non-small cell lung cancer","authors":"Emre Cebeci ,&nbsp;Büşra Yüksel ,&nbsp;Fikrettin Şahin","doi":"10.1016/j.jtemb.2025.127627","DOIUrl":"10.1016/j.jtemb.2025.127627","url":null,"abstract":"<div><div>Lung cancer is the most frequently diagnosed cancer globally, with 2.5 million new cases representing 12.4 % of the total number of new cases. Small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) are two main subtypes of lung cancer that have different growth and dissemination capacities. Treatment options for lung cancer include surgery, radiation therapy, chemotherapy, and targeted therapy, including Bortezomib, an FDA-approved boron-derived agent. To bring novel boron-containing compounds to the armamentarium of lung cancer therapy, this study aimed to unravel the anti-cancer potential of Boric Acid (BA) and Sodium pentaborate pentahydrate (NaB) on Non-Small Cell Lung Cancer cell line A549. According to the results, the survival rates of A549 cells decreased after BA and NaB treatments by 5.5-fold and 5.2-fold, respectively. The number of colony-forming units was reduced by 3-fold and 2.4-fold after BA and NaB treatments, respectively. Gene expressions and protein levels of some pro-apoptotic and tumor suppressor genes were upregulated and some anti-apoptotic genes were downregulated. Cell cycle arrest at the G2/M phase was detected after treatment with both boron. Proliferation markers Ki-67 and PCNA, and checkpoint regulators CDK1 and CDK2 gene expression levels were downregulated after BA and NaB treatments in the A549 cells. Our findings point to a promising selective anti-cancer activity of BA and NaB in the A549 cells without exerting any adverse effects on normal cells. Further in vitro and in vivo studies are required to get detailed information about the anti-cancer mechanism of BA, and NaB on lung cancer.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127627"},"PeriodicalIF":3.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenium in bread wheat (Triticum aestivum L.) grown in Buenos Aires, Argentina","authors":"Andrés Fabián Pighín ,&nbsp;Emiliano Camilli ,&nbsp;Ana Clara Chirillano ,&nbsp;María Emilia Villanueva ,&nbsp;Laura Natalia Rigacci","doi":"10.1016/j.jtemb.2025.127629","DOIUrl":"10.1016/j.jtemb.2025.127629","url":null,"abstract":"<div><h3>Background</h3><div>Selenium (Se) is an essential micronutrient for humans, but little information is available on its nutritional status in the Argentine population.</div></div><div><h3>Objective</h3><div>The aim of this study is to obtain reliable and representative data on Se content in bread wheat (<em>Triticum aestivum</em> L.) from the Buenos Aires province.</div></div><div><h3>Methods</h3><div>The content of the micronutrient Se was determined in 242 samples of bread wheat grains (<em>Triticum aestivum</em> L.) from 75 districts in Buenos Aires, Argentina (representing 75 % of the wheat-producing districts in the province). Se determination was carried out by atomic absorption with hydride generation.</div></div><div><h3>Results</h3><div>The Se content varied across the districts; in some of them, the Se levels were below the LOD (10 µg kg⁻¹), while the highest content found was around 114 µg kg⁻¹. The average content ( ± standard deviation) of Se in the analyzed grains was 29.90 ( ± 51.30) µg kg⁻¹. This concentration is considered marginal or deficient according to various authors. It reflects both a low contribution of Se to diets and its low bioavailability in soils.</div></div><div><h3>Conclusion</h3><div>Further research on the Se nutritional status of the population is needed. So far, existing studies suggest a sub-optimal nutritional status, and regarding the Se content of wheat grown in Buenos Aires, it seems to be lower than the minimum recommended to maintain an adequate nutritional status through the consumption of dry plant foods. If these results are confirmed, it would be appropriate to implement strategic policies to promote the increase of Se consumption by the population. Fertilisation of wheat crops is recommended because it is a sure way to increase the Se content in the whole food chain.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"89 ","pages":"Article 127629"},"PeriodicalIF":3.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esculin mitigates nickel chloride-induced generation of ROS, hemoglobin oxidation, and alterations in redox status in human red blood cells","authors":"Monika Sharma,&nbsp;Fahim Halim Khan,&nbsp;Riaz Mahmood","doi":"10.1016/j.jtemb.2025.127626","DOIUrl":"10.1016/j.jtemb.2025.127626","url":null,"abstract":"<div><h3>Background</h3><div>Nickel (Ni) is a heavy metal and an environmental pollutant that is harmful to humans because of its carcinogenicity and toxic effects on several tissues and organs. Due to their widespread use concerns have been raised about the potential adverse effects of Ni and its compounds on human health. Ni compounds induce oxidative stress in cells by modifying the redox equilibrium. This work studied the protective role of the plant antioxidant esculin (ES) against nickel chloride (NiCl₂)-induced oxidative damage and cytotoxicity in isolated human red blood cells (RBC).</div></div><div><h3>Methods</h3><div>Human RBC were first incubated with varying concentrations of ES (0.25–1.0 mM) for 2 h at 37 °C, followed by addition of 0.5 mM NiCl₂ and further incubation for 24 h at 37 °C.</div></div><div><h3>Results</h3><div>Treatment of RBC with NiCl₂ alone increased the production of reactive oxygen species and significantly enhanced methemoglobin level, heme degradation, free iron release and hydrogen peroxide content. It also led to oxidation of cellular thiol groups, proteins and lipids. The glutathione content, total sulfhydryl groups, nitric oxide level and free amino groups were decreased. The activities of antioxidant, metabolic and plasma membrane enzymes were inhibited and the antioxidant capacity of RBC was lowered. However, pre-incubation of RBC with ES greatly mitigated the NiCl₂-induced alterations in these parameters in an ES concentration-dependent manner. In all cases ES alone did not exhibit any significant toxic effect. This was confirmed by electron microscopic analysis of RBC. Treatment with NiCl₂ alone resulted in the conversion of biconcave discoidal RBC to echinocytes but this change in cell morphology was greatly prevented in the presence of ES. The ES alone treated RBC did not show altered cell morphology.</div></div><div><h3>Conclusion</h3><div>These results suggest that ES can be potentially used as a cytoprotectant against Ni-induced toxicity.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127626"},"PeriodicalIF":3.6,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term effects of SARS-CoV-2 infection on metal homeostasis","authors":"Luyao Zhang ,&nbsp;Fang Li ,&nbsp;Xiaoxiong Liu ,&nbsp;Xin-An Liu ,&nbsp;Dawei Lu ,&nbsp;Qian Luo ,&nbsp;Qian Liu ,&nbsp;Guibin Jiang","doi":"10.1016/j.jtemb.2025.127625","DOIUrl":"10.1016/j.jtemb.2025.127625","url":null,"abstract":"<div><div>The outbreak of COVID-19 pandemic has caused substantial health loss worldwide, and the long-term sequelae of COVID, resulting from repeated coronavirus infection, have emerged as a new public health concern. We report the widespread presence of abnormal metallomic profiles in the sera of patients who have recovered from SARS-CoV-2 coronavirus infection, even after 6 months post-discharge from hospital. We measured the concentrations of Fe, Cu, Zn, Se, Cr, Mn, Ba, Ni, Pb, Ag, As, Cd, Co, and V in the sera of 25 recovered participants and 38 healthy controls in the cross-sectional study. Higher concentrations of Cu, Ag, As, Ba, Cd, Ni, Pb, Cr and V were observed in the recovered participants, whereas lower concentrations of Fe and Se were obtained in these participants. Except for Zn, Mn, and Co, all other elements showed significant differences (<em>p</em> &lt; 0.05) between the two groups, with variations dependent on age and gender. Further correlation analysis between metallome and metabolome indicated that SARS-CoV-2 infection continues to disrupt metallic homeostasis and affect metabolic processes, such as lipid metabolism and cell respiration, as well as the functions of certain organs (e.g., liver, kidney, and heart), even after 6 months recovery. Our findings provide novel insights into the potential long-term effect of COVID-19 on the human body from a new perspective of metallomics.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127625"},"PeriodicalIF":3.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidants against oxidative stress induced by sodium fluoride toxicity in murine models: A systematic review","authors":"Gladys Ortiz-Barroso ,&nbsp;Ricardo E. Ramírez-Orozco ,&nbsp;Vicente Esparza-Villalpando ,&nbsp;Mayra Macedo-Mendoza ,&nbsp;Tonatiuh Barrios-García ,&nbsp;Nayeli Amalinalli Pulido-Hornedo","doi":"10.1016/j.jtemb.2025.127619","DOIUrl":"10.1016/j.jtemb.2025.127619","url":null,"abstract":"<div><h3>Introduction</h3><div>Fluorosis, a condition resulting from excessive fluoride intake, leads to dental, skeletal, and soft tissue alterations through mechanisms that induce oxidative stress. With its potential to significantly impact the field, this review aims to assess the efficacy of antioxidant agents in murine models exhibiting fluorosis-induced toxicity. By transferring electrons to oxidizing agents, antioxidants can attenuate oxidation reactions and mitigate cellular damage.</div></div><div><h3>Methodology</h3><div>This systematic review adheres to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, encompassing articles investigating the impact of antioxidant substances on murine fluorosis models, explicitly focusing on oxidative stress markers and antioxidant levels across various tissues.</div></div><div><h3>Results</h3><div>A qualitative synthesis of 79 articles highlights antioxidant agents such as vitamin C, vitamin E, selenium, carotenoids, polyphenolic compounds (including flavonoids and polyphenolic acids), amino acids, and others among animals with fluorosis induction showed variations in oxidative stress markers and antioxidant activity levels under different administration protocols compared to those receiving prophylactic, concomitant concurrent, or therapeutic antioxidant treatments.</div></div><div><h3>Conclusion</h3><div>Fluoride administration across diverse doses and durations elicits heightened oxidative stress markers in multiple rodent tissues. The current evidence suggests that some antioxidants are effective as a prophylactic and concurrent in murine models of fluorosis. However, the methodological differences between studies prevent the establishment of a protocol for potential standardized use.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127619"},"PeriodicalIF":3.6,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of urinary essential metals and their mixture with metabolic syndrome and its components among Chinese community-dwelling older adults","authors":"Panpan Wang ,&nbsp;Xuqiu Cheng ,&nbsp;Chen Zhang ,&nbsp;Jingyuan Lei ,&nbsp;Hongli Wang ,&nbsp;Yuan Wang ,&nbsp;Liang Sun ,&nbsp;Bing Hu ,&nbsp;Guangbo Qu ,&nbsp;Dongmei Zhang ,&nbsp;Guimei Chen ,&nbsp;Chunmei Liang ,&nbsp;Fangbiao Tao ,&nbsp;Qingsi Wu ,&nbsp;Yuyou Yao ,&nbsp;Linsheng Yang","doi":"10.1016/j.jtemb.2025.127623","DOIUrl":"10.1016/j.jtemb.2025.127623","url":null,"abstract":"<div><h3>Background</h3><div>Little is known regarding the joint effect of multiple essential metals (EMs) on metabolic syndrome (MetS). This study aimed to investigate individual and overall correlations of EMs with MetS and its components among Chinese community-dwelling older adults.</div></div><div><h3>Methods</h3><div>Six urine EMs, including molybdenum (Mo), vanadium (V), selenium (Se), calcium (Ca), cobalt (Co), and magnesium (Mg), were measured using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) in 2222 older adults. Logistic regression and restricted cubic spline (RCS) models were utilized to assess single EM effects. Quantile-based g-computation (Qgcomp) and Bayesian kernel machine regression (BKMR) models were applied to estimate the overall effects of multiple EMs.</div></div><div><h3>Results</h3><div>After controlling for potential confounders, Mo was significantly inversely connected to MetS (<em>OR</em> = 0.852, 95 % <em>CI</em>: 0.750 ∼ 0.967). RCS displayed a negative linear association of Mo with MetS (<em>P</em> _{for overall} = 0.039, <em>P</em> _{for nonlinearity} = 0.942). Both BKMR and Qgcomp models showed that EM mixture was inversely related to MetS, with Mo having the highest weight. Furthermore, Mo was inversely linked with high blood pressure, and V and Se were inversely linked with low high-density lipoprotein cholesterol (HDL-C), whereas Mg was positively linked with low HDL-C. The EM mixture was negatively correlated with high blood pressure and low HDL-C.</div></div><div><h3>Conclusions</h3><div>Urine Mo is in a linearly inverse correlation with MetS, individually and as a mixture. The EM mixture is connected to decreased MetS risk, mainly driven by Mo, which decreases the risk of high blood pressure.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127623"},"PeriodicalIF":3.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}