Utilizing T1-weighted MRI intensity indices to evaluate in-vivo neurotoxicity in a South African cohort with environmental manganese exposure

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Trace Elements in Medicine and Biology Pub Date : 2025-08-22 DOI:10.1016/j.jtemb.2025.127732

Susan R. Criswell , Irene Faust , Susan Searles Nielsen , Wendy W. Dlamini , Gill Nelson , Jay R. Turner , Joshua S. Shimony , Jason Lenox-Krug , Jordan A. Killion , T. Noah Hutson , Brad A. Racette

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引用次数: 0

Abstract

Background

Excessive exposure to manganese (Mn) causes parkinsonism. Occupational Mn exposure is associated with increased T1-weighted globus pallidus signal on magnetic resonance imaging (MRI) secondary to in-vivo Mn deposition.

Methods

The present study evaluated the T1-weighted pallidal index (PI) as an in-vivo marker of Mn exposure and neurotoxicity in chronic environmental Mn exposure. A total of 53 Black South African participants with a range of residential environmental Mn exposures due to proximity to one of the world’s largest smelters underwent T1-weighted MRI.

Results

The PI was associated with parkinsonism as measured by the total Unified Parkinson’s Disease Rating Scale motor subsection part 3 (UPDRS3) in all participants (β=0.10, confidence interval 0.01, 0.18). Further, the PI was positively associated with total UPDRS3 scores (β=0.14, confidence interval 0.03, 0.25) and the lower limb rigidity subscore (β=0.04, confidence interval 0.005, 0.07) among those who regularly consumed alcohol (>3 drinks/week), but not in those who occasionally consumed alcohol (<3 drinks/week).

Conclusion

Our findings suggest T1-weighted PI is associated with clinical neurotoxicity in environmental Mn exposure. This association is amplified by regular consumption of alcohol.

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利用t1加权MRI强度指数评估南非环境锰暴露队列的体内神经毒性

过量接触锰（Mn）会导致帕金森病。职业性锰暴露与体内锰沉积引起的核磁共振成像（MRI） t1加权苍白球信号增加有关。方法本研究评估了t1加权苍白指数（PI）作为体内锰暴露和慢性环境锰暴露神经毒性的标志物。共有53名南非黑人参与者因靠近世界上最大的冶炼厂之一而受到一系列住宅环境中的锰暴露，他们接受了t1加权MRI检查。结果通过统一帕金森病评定量表运动分段第3部分（UPDRS3），所有参与者的PI与帕金森相关（β=0.10，置信区间0.01,0.18）。此外，在经常饮酒者（每周饮酒3次）中，PI与UPDRS3总分（β=0.14，置信区间0.03,0.25）和下肢僵硬亚评分（β=0.04，置信区间0.005,0.07）呈正相关，而在偶尔饮酒者（每周饮酒3次）中则无相关。结论t1加权PI与环境锰暴露的临床神经毒性有关。这种联系因经常饮酒而被放大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Trace Elements in Medicine and Biology 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.90%

发文量

202

审稿时长

85 days

期刊介绍： The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.