Journal of Trace Elements in Medicine and Biology最新文献

{"title":"A new approach to overcome cytotoxic effects of Cu by delivering dual therapeutic ions (Sr, Cu)","authors":"Akrity Anand ,&nbsp;Susanta Sengupta ,&nbsp;Dušan Galusek ,&nbsp;Ana M. Beltrán ,&nbsp;Dagmar Galusková ,&nbsp;Aldo R. Boccaccini","doi":"10.1016/j.jtemb.2024.127565","DOIUrl":"10.1016/j.jtemb.2024.127565","url":null,"abstract":"<div><h3>Introduction</h3><div>The incorporation of trace elements such as strontium (Sr) and copper (Cu) in the composition of mesoporous bioactive glass (MBG) is widely known to enhance its biological functionality for bone tissue regeneration</div></div><div><h3>Methods</h3><div>Two MBG powders with the composition 80SiO₂-11CaO-5P₂O₅-xCuO/SrO, one doped with 4 mol.% of CuO, the second with 4 mol.% of SrO were blended in the weight ratios of Cu-MBG: Sr-MBG; 100:0, 70: 30, 50: 50, 30: 70 and 0:100 aiming at minimizing Cu to minimize the cytotoxicity of Cu while preserving its antimicrobial activity. The synergistic effects of Sr and Cu ions on bioactivity, cytotoxicity, and antimicrobial activity were studied.</div></div><div><h3>Results</h3><div>Transmission electron microscopy (TEM) examination of Cu-MBG and Sr-MBG showed fringes related to the development of a mesoporous structure. The specific surface area values of the Cu-MBG and Sr-MBG powders were 287 and 349 m²/g, respectively. A characteristic compact layer consisting of particles with platelet-like morphology commonly associated with HAp crystals was confirmed after 7 days soaking in simulated body fluid (SBF). Mouse preosteoblast cells (MC3T3-E1) exhibited higher cell viability when exposed to a 1 % w/v eluate from blended Cu-MBG powders compared to pure Cu-MBG. Notably, the Cu-MBG: Sr-MBG ratio of 30:70 exhibited cell viability of around 85 % at this concentration. A higher cell viability (above 100 %) towards MC3T3-E1 cells was observed for all powders when tested with the 0.1 % w/v eluate. With progressive increase in the amount of Cu-MBG in the blended system the bacterial inhibitory effects were more pronounced. The Cu ions released from Cu-MBG generate hydroxyl ions and increase the pH leading to disruption of the cellular membrane of microbes, resulting in enhanced antimicrobial activity.</div></div><div><h3>Conclusion</h3><div>This newly developed blended system composed of Cu and Sr doped MBGs is expected to be more effective as bioactive filler in comparison to single ion doped MBGs for bone tissue engineering applications.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127565"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium selenite inhibits the growth of cervical cancer cells through the PI3K/AKT pathway","authors":"Yuanyuan Wang ,&nbsp;Lei Qi ,&nbsp;Sihong Guo ,&nbsp;Yuehui Jia ,&nbsp;Ruixiang Wang ,&nbsp;Cunqi Lv ,&nbsp;Qingyu Zeng ,&nbsp;Ying Gao ,&nbsp;Tong Wang ,&nbsp;Qi Li","doi":"10.1016/j.jtemb.2024.127582","DOIUrl":"10.1016/j.jtemb.2024.127582","url":null,"abstract":"<div><h3>Background</h3><div>Selenium can inhibit cervical cancers, but the specific mechanism of anti-cervical cancer is not fully understood.</div></div><div><h3>Methods</h3><div>In this study, we investigated the anti-cervical cancer effect of sodium selenite (SS) in vivo and in vitro to reveal the role of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway in terms of the mechanism. In vivo experiments, HeLa cell xenografts were constructed in BALB/c female nude mice, and then intraperitoneally injected with 3 mg/kg sodium selenite (SS) for 14 days. In vitro experiments, we detected cell viability by MTT assay and apoptosis by Annexin V-FITC/PI staining. The levels of PI3K, AKT, phosphorylated PI3K (p-PI3K), and phosphorylated Akt (p-AKT) were measured by Western Blot.</div></div><div><h3>Results</h3><div>HeLa cell xenografts in female nude mice showed delayed tumor growth and no apparent toxicity in the liver or kidney. SS reduced the viability and increased apoptosis of HeLa and SiHa cells. SS did not affect PI3K and AKT levels and decreased p-PI3K and p-AKT levels. In addition, the results also revealed that the SS combined with LY294002, a specific PI3K inhibitor, enhanced the inhibitory effect of SS on the PI3K/AKT signaling pathway, further inhibiting cervical cancer cell viability and increased apoptosis.</div></div><div><h3>Conclusions</h3><div>SS exerted its anti-cervical cancer effects by inhibiting cell proliferation, promoting apoptosis, and inhibiting the PI3K/AKT signaling pathway.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127582"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trace-elements driven up-regulation of secreted proteases expression in the human-pathogenic fungus Trichophyton rubrum","authors":"Oliver Blechert ,&nbsp;Shanyu Lan ,&nbsp;Shuzhen Xiong ,&nbsp;Yuning Zou ,&nbsp;Peicong Li ,&nbsp;Jiewei Hu ,&nbsp;Jiayuan Li ,&nbsp;Ping Zhan","doi":"10.1016/j.jtemb.2024.127580","DOIUrl":"10.1016/j.jtemb.2024.127580","url":null,"abstract":"<div><h3>Background</h3><div><em>Trichophyton rubrum</em> is a widespread human pathogenic fungus, colonizing keratinized tissue of outer body-parts. Thereby, the pathogen is relying on nutrients available from the host. The invasive mechanism of the pathogen is relaying on secreted proteases, which hydrolyze skin-proteins for subsequent up-take.</div></div><div><h3>Methods</h3><div>In this study, we analyzed the gene expression of secreted proteases by RNAseq. In the results, we show the expression profile of 31 secreted protease genes under three conditions: keratin medium and keratin medium with trace-elements or with glucose.</div></div><div><h3>Results</h3><div>By adding trace-elements to keratin medium, the expression of secreted proteases increased from 1.8 % to 3.3 %. Across all groups of secreted proteases, higher expression was observed. The genes <em>SUB4</em>, <em>MEP1</em>, <em>MEP3</em>, <em>MEP5</em>, <em>MEP9</em>, <em>LAP1</em>, <em>LAP2</em> and <em>MCPA</em> were significantly stronger expressed, whereby <em>MEP5</em> (∼6 fold) and <em>SUB4</em> (∼5.8 fold) were strongest up-regulated.</div></div><div><h3>Discussion</h3><div>We discuss the influence and significance of trace-elements on secreted proteases. Further, we speculate about the disturbed nutritional immunity in psoriatic and atopic skin as factor for increased risk of getting severe <em>T. rubrum</em> infections.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127580"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the role of hepcidin in iron metabolism and anemia management","authors":"Palak Kesharwani ,&nbsp;Debabrata Dash ,&nbsp;Raj Kumar Koiri","doi":"10.1016/j.jtemb.2025.127591","DOIUrl":"10.1016/j.jtemb.2025.127591","url":null,"abstract":"<div><div>One of the most common diseases worldwide is anemia, which is characterized by insufficient erythrocyte production. Numerous complex factors, such as chronic diseases, genetic mutations, and nutritional inadequacies, contribute to this widespread syndrome. This review focuses specifically on anemias caused by defective hepcidin production. Hepcidin, a peptide hormone produced primarily by liver cells, plays a crucial role in regulating iron levels by controlling its absorption. Hepcidin's mechanism of action involves binding to the ferroportin iron transporter, causing its internalization. Disturbances in iron metabolism can have far-reaching consequences, affecting not only the blood but also organs like the liver, kidneys, and brain. Iron homeostasis is crucial for maintaining optimal physiological function. Several blood-based markers are employed to assess iron stores. However, these markers have inherent limitations. Hepcidin, a key regulator of iron metabolism, plays a pivotal role in preventing iron release into the plasma from absorptive enterocytes and macrophages. Elucidating the structure and function of hepcidin is essential for understanding its role in iron homeostasis, which has significant implications for the diagnosis and management of various anemia subtypes. A well-established correlation exists between hepcidin dysregulation and iron deficiency. Despite its potential as a biomarker, the clinical application of hepcidin is hindered by the lack of a commercially available, clinically validated assay. This review aims to provide a comprehensive overview of hepcidin's role in regulating blood iron concentrations and elucidate its implications in the pathogenesis of various anemia subtypes, paving the way for its future applications in research and clinical practice.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127591"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hesperidin alleviates ZBP1-drived PANoptosis induced by copper nanoparticles in immune organs of gallus","authors":"Luna Su,&nbsp;Shaofeng Wang,&nbsp;Quanwei Li,&nbsp;Pan Guo,&nbsp;Yijin Wu,&nbsp;Lijiao Zhao,&nbsp;Lianmei Hu,&nbsp;Ying Li,&nbsp;Jianying Guo,&nbsp;Hui Zhang,&nbsp;Jiaqiang Pan,&nbsp;Zhaoxin Tang,&nbsp;Jianzhao Liao","doi":"10.1016/j.jtemb.2024.127575","DOIUrl":"10.1016/j.jtemb.2024.127575","url":null,"abstract":"<div><div>With the application of copper nanoparticles (nano-Cu) in livestock and poultry feed addition, their biotoxicity has been gradually recognized. Therefore, it has become an urgent problem to find the effective natural antagonists to reduce the toxicity of copper nanoparticles. Here, we found that hesperidin could alleviate nano-Cu-induced pathological injury in the immune organs of chickens via the histopathological examination of the spleen, thymus, and bursa of Fabricius. Additionally, the results of western blot showed that nano-Cu exposure activated ZBP1-mediated PANoptosis in immune organs, with evidenced by the significant up-regulation of ZBP1 signal molecule and PANoptosis-related proteins (apoptosis: Caspase-7, Caspase-3, Caspase-8; pyroptosis: Caspase-1, GSDMD, GSDME; necroptosis: RIPK1 and MLKL). Besides that, immunohistochemistry and immunofluorescence also showed that the staining intensity of Caspase-9 and Caspase-8 proteins was observably elevated in nano-Cu group compared to control group, and the staining intensity of the hesperidin mixed nano-copper group was markedly lower than that of the nano-Cu group. Meanwhile, hesperidin effectively attenuated the ZBP1 expression and PANoptosis under nano-Cu exposure. These findings suggested that excessive nano-Cu could cause ZBP1-drived PANoptosis in immune organs, while hesperidin could alleviate toxic damage induced by nano-Cu exposure.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127575"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nickel-induced multimetal uptake in two microalgal species (Chlorella sorokiniana and Chlamydomonas reinhardtii) and its effect on growth and lipid unsaturation.","authors":"Georgia Panagou ,&nbsp;Evangelos Stergiou ,&nbsp;Apostolos Spyros ,&nbsp;Nikos Lydakis-Simantiris ,&nbsp;Spiros A. Pergantis","doi":"10.1016/j.jtemb.2024.127578","DOIUrl":"10.1016/j.jtemb.2024.127578","url":null,"abstract":"&lt;div&gt;&lt;div&gt;As the concern for Ni contamination in the aquatic environment escalates, efforts for microalgal use in environmental monitoring and bioremediation are increasing. This study aims to evaluate the potential of &lt;em&gt;Chlorella sorokiniana&lt;/em&gt; and &lt;em&gt;Chlamydomonas reinhardtii&lt;/em&gt; for Ni bioremediation by investigating their physiological stress responses in Ni-contaminated environments. The analysis focuses on how Ni(II) uptake affects cell growth, nutrient metal homeostasis, and lipid unsaturation levels, as these parameters are critical indicators of metabolic stability and resilience essential for effective bioremediation. The microalgae were grown under mixotrophic conditions in a tris-acetate-phosphate (TAP) medium enriched with Ni(II), at concentrations (1–6 mg∙L&lt;sup&gt;−1&lt;/sup&gt;) exceeding those typically found in wastewater, providing insights into metal stress under severe contamination conditions. Even though increased uptake of Ni(II) was observed for both algal species, accompanied by growth suppression at high Ni(II) concentrations, multi-elemental trace analysis revealed a significant, Ni concentration-dependent, uptake of growth media essential metals as well. Specifically, for both algal species, Zn uptake concentrations increased by approximately 20 times when going from control cultures, with no Ni(II) added, to cultures incubated with increasing Ni(II) concentrations. Overall, Zn uptake was determined to be approximately 3 orders of magnitude higher than Ni(II) uptake when high concentrations of Ni(II) were present, making Zn the metal with the most significant uptake. Similar uptake trends were observed for Cu and Co for both algal species, with Cu uptake being approximately 2 orders of magnitude higher, while Co remained below the Ni(II) concentrations at high added Ni(II) concentrations. For &lt;em&gt;Chlorella sorokiniana&lt;/em&gt;, increased Fe uptake relative to Ni(II) uptake was observed (2 orders of magnitude higher), as was the case for Mn (1 order of magnitude higher). This induced increase in uptake of some of the growth media metals was attributed to their liberation from ethylenediaminetetraacetic acid (EDTA) in tris-acetate-phosphate (TAP) medium, following the addition of Ni(II), which has a higher stability constant (&lt;em&gt;K&lt;/em&gt;&lt;sub&gt;&lt;em&gt;f&lt;/em&gt;&lt;/sub&gt;&lt;em&gt;)&lt;/em&gt; with EDTA and was added at concentrations comparable or higher than those of the other metals. Calculated levels of free Ni(II) and free metals in the medium matched the observed metal uptake trends as determined using multielemental inductively coupled plasma mass spectrometry. Negative ion electrospray mass spectrometry also revealed that EDTA-metal complexes in the TAP media decreased as Ni(II) concentrations increased. The lipid unsaturation level and relative ω-3 fatty acids concentration of both microalgal species, based on &lt;sup&gt;1&lt;/sup&gt;H Nuclear Magnetic Resonance analysis, decreased with increasing Ni(II) concentration, with the decrease being more pronounce","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127578"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of heavy metals concentration and health risk in four species of Persian Gulf sharks in Hormozgan Province","authors":"Hassan heidarieh ,&nbsp;Amin Gholamhosseini ,&nbsp;Siyavash Soltanian ,&nbsp;Marzieh Heidarieh ,&nbsp;Mahdi Banaee ,&nbsp;Nima Shiry","doi":"10.1016/j.jtemb.2024.127581","DOIUrl":"10.1016/j.jtemb.2024.127581","url":null,"abstract":"<div><div>Marine pollution is a growing concern that threatens ecosystems and endangers human health. This study investigated the bioaccumulation of six heavy metals, including zinc (Zn), copper (Cu), lead (Pb), mercury (Hg), nickel (Ni), and cadmium (Cd) in the muscle tissue of <em>Codium arabicum</em>, <em>Coilia dussumieri</em>, <em>Rhizoprionodon oligolinx</em>, and <em>R. acutus</em> from in Hormozgan province, Iran, between November 2023 and March 2024. The primary focus was to provide insights into these elements' distribution and accumulation patterns in Persian Gulf sharks. Moreover, it aimed to assess the potential risks of chemical contamination in the Persian Gulf. Samples were collected, prepared through acid digestion, and analyzed using Atomic absorption spectrometry (AAS) to qualitatively and quantitatively determine Zn, Cu, Ni, Pb, Cd, and Hg concentrations. The mean heavy metal concentrations in the examined sharks follow the order Zn &gt; Cu &gt; Ni &gt; Pb &gt; Cd &gt; Hg. The highest mean concentrations of all the tested heavy metals were observed in <em>C. arabica</em>. Furthermore, the THQ value for Hg (1.07) in <em>C. arabica</em> raised concerns, particularly for individuals with high fish consumption, such as fishermen. With the THQ value exceeding 1, there is a clear need for heightened concern regarding the carcinogenic risk associated with dietary mercury exposure. Consequently, our findings showed the initial account of metal concentrations in Persian Gulf sharks, indicating elevated concentrations in individuals that may lead to sub-lethal effects. In conclusion, these results emphasized the potential toxicity of <em>C. arabica</em> meat and held significant implications for human consumers.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127581"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review on selenium and blood pressure: Recent advances and research perspectives","authors":"Pusong Tang ,&nbsp;Rui Huang ,&nbsp;Xing Zhong ,&nbsp;Xin Chen ,&nbsp;Yuhua Lei","doi":"10.1016/j.jtemb.2025.127607","DOIUrl":"10.1016/j.jtemb.2025.127607","url":null,"abstract":"<div><h3>Background</h3><div>Globally, approximately 31.1 % of adults are affected by hypertension(HTN), and there is currently no effective treatment for this condition. Selenium (Se), an essential trace element in the human body, has been shown to play a role in various biological processes, including anti-inflammation, antioxidative stress, anti-ferroptosis, and regulation of immune response. Research suggests that Se may have potential hypotensive effects.</div></div><div><h3>Objective</h3><div>This review aims to comprehensively investigate the relationship between Se and blood pressure(BP), elucidate the mechanisms through which Se influences BP, and explore its prospective applications in clinical practice.</div></div><div><h3>Methods</h3><div>We conducted a systematic search on PubMed for a thorough review of articles concerning the relationship between Se and BP, as well as the mechanisms by which Se may lower BP.</div></div><div><h3>Results and Conclusions</h3><div>Although some findings indicate that Se might increase BP, its anti-inflammatory, anti-oxidant, anti-vascular remodeling, anti-atherosclerotic, anti-ferroptosis, and regulation of immune response effects suggest that maintaining an appropriate level of Se may contribute to BP reduction and possibly lower the risk of pregnancy-induced hypertension(PIH). While Se shows promise in the management of HTN, further exploration is necessary for its development. Future studies should clarify the mechanisms involved and identify relevant targets through clinical research, which may provide adjunctive therapies for HTN.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127607"},"PeriodicalIF":3.6,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of a metal mixture and vitamin D with sleep duration among adolescents and young adults from the 2011–2018 NHANES cycles","authors":"Danelly Rodríguez ,&nbsp;Sarah M. Lima ,&nbsp;Chan Li ,&nbsp;Samantha Schildroth ,&nbsp;Muwu Xu ,&nbsp;Katarzyna Kordas","doi":"10.1016/j.jtemb.2025.127606","DOIUrl":"10.1016/j.jtemb.2025.127606","url":null,"abstract":"<div><h3>Introduction</h3><div>Heavy metal exposure has been associated with poor sleep, but little is known about the cumulative associations of multiple metals with sleep duration, particularly among adolescents. This study examined the association of blood lead (Pb), cadmium (Cd), and mercury (Hg) concentrations with sleep duration and possible effect modification by vitamin D.</div></div><div><h3>Methods</h3><div>The study sample consisted of 16–25-year-olds (n = 2637) from the 2011–2018 National Health and Nutrition Examination Survey. The association of each blood metal and serum vitamin D level with self-reported sleep duration was examined through linear regression models. Interaction terms and stratified models tested the effect modification of metal association with sleep by vitamin D level or status. Cumulative and interactive associations among the metals and serum vitamin D were also estimated using Bayesian Kernel Machine Regression (BKMR).</div></div><div><h3>Results</h3><div>In linear regressions, there was little evidence of an association between individual metals, vitamin D level, and sleep duration. Both linear regressions and BMKR models showed little indication of interactions among metals and vitamin D levels. BKMR results suggested an overall joint association, with longer sleep duration at higher percentile of the metal-vitamin D mixture (75th percentile vs 50th: <span><math><mi>β</mi></math></span>=0.07 hours; 95 % CrI: 0.01, 0.13).</div></div><div><h3>Conclusion</h3><div>In the context of low-level metal exposure, individual metals were unrelated to sleep duration. We found some evidence that higher levels of the mixture of blood Pb, Cd, Hg, and serum vitamin D level may be associated with slightly longer sleep duration, underscoring the importance of considering multiple environmental exposures. Additional analyses, especially in higher risk groups (e.g., higher exposures; higher prevalence or severity of vitamin D deficiency) are warranted.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127606"},"PeriodicalIF":3.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of zinc homeostasis in the prevention of prostate diseases","authors":"Ziqi Chen ,&nbsp;Junsheng Liu ,&nbsp;Jing Ma ,&nbsp;Xiuqiao Yu ,&nbsp;Shusong Wang ,&nbsp;Zhenxian Wang","doi":"10.1016/j.jtemb.2025.127605","DOIUrl":"10.1016/j.jtemb.2025.127605","url":null,"abstract":"<div><div>The prostate gland is the largest accessory sex gland in the male reproductive system, and is recognized for its elevated zinc concentration. Recently, the incidence of prostate diseases has increased, posing a significant threat to the health of men. Increasing evidence suggests that maintaining normal prostate function requires proper zinc homeostasis. Prostate disease can cause changes in the regulation of zinc levels in the prostate. Studies have indicated that patients with prostatitis, prostate enlargement, or prostate cancer experience an imbalance in zinc homeostasis, resulting in changes in zinc levels in the body and altered distribution of zinc in tissues. Zinc prevents the malignant transformation of normal prostate tissue by blocking citric acid oxidation, inducing apoptosis, and exhibiting antioxidant activity. Therefore, studying changes in zinc homeostasis in prostate diseases is of great clinical value for diagnosing and treating these diseases. This article reviews the distribution and content of zinc in the prostate, the mechanism underlying zinc homeostasis regulation, the role of zinc homeostasis in prostate diseases, and the clinical applications of zinc.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127605"},"PeriodicalIF":3.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}