Journal of Trace Elements in Medicine and Biology最新文献

{"title":"Portable X-ray fluorescence of zinc and selenium with nail clippings – visit 3 of the Mother and Infant Nutrition Investigation (MINI)","authors":"David E.B. Fleming ,&nbsp;Andrianna R. Scott ,&nbsp;Jasmine A. Ouellette ,&nbsp;Jong Sung Kim ,&nbsp;Abir Lefsay ,&nbsp;Ying Jin ,&nbsp;Jane Coad ,&nbsp;Louise Brough","doi":"10.1016/j.jtemb.2025.127729","DOIUrl":"10.1016/j.jtemb.2025.127729","url":null,"abstract":"<div><h3>Introduction</h3><div>Recent advances in portable X-ray fluorescence (XRF) have opened up the possibility of a rapid and cost-effective method for measuring elemental content in nail clippings.</div><div>Two elements of particular interest for intake assessment through nail clipping measurement are zinc and selenium. The New Zealand-based Mother and Infant Nutrition Investigation (MINI) provides an ideal testing ground for the application of portable XRF in the measurement of zinc and selenium. Two aspects requiring further study with portable XRF are the optimal time of measurement and the optimal approach to energy spectrum analysis.</div></div><div><h3>Methods</h3><div>A subset of nail clippings from 20 mother-infant pairings were initially selected for analysis over three separate MINI study visits. This paper considers measurements from visit 3 (12 months postpartum). For portable XRF, a mono-energetic X-ray beam was used to excite characteristic X-rays from zinc and selenium. Individual XRF measurements were made for 60 s (real time). In each case, analysis of the elemental signal was performed in four different ways: (1) automated system output concentration; (2) element signal to total signal ratio; (3) element signal to Compton scatter signal; (4) element signal to coherent scatter signal. XRF results were compared against zinc and selenium concentrations obtained from a “gold standard” method of inductively coupled plasma mass spectrometry (ICP-MS).</div></div><div><h3>Results</h3><div>ICP-MS results from the visit 3 nail clippings determined a mean zinc concentration of 104 µg/g and a mean selenium concentration of 0.606 µg/g. Analysis of XRF energy spectra from 60 s measurements showed that zinc was clearly detected in all cases. The selenium signal was more challenging, but was also detected from all spectra. For both zinc and selenium, correlations between XRF results and ICP-MS concentrations were highly significant (p &lt; 0.01) in all cases, with the zinc results more strongly correlated than selenium. Of the four approaches to XRF signal analysis, the three approaches involving an external software package provided superior results relative to the automated system output. Correlations of XRF results with ICP-MS concentrations were similar between these three approaches.</div></div><div><h3>Conclusion</h3><div>ICP-MS concentrations for both zinc and selenium were found to be lower from visit 3 relative to results from visit 1 and visit 2. This may indicate overall dietary changes postpartum. Correlations of XRF results with ICP-MS concentrations suggest that a relatively short 60 s measurement time is adequate for a reliable zinc assessment, but not for selenium. Although correlations of XRF results with ICP-MS concentrations were similar between three different methods of spectra analysis, practical considerations may favor use of the element signal to total signal approach.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127729"},"PeriodicalIF":3.6,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron dysregulation and ferroptosis are associated with pulmonary fibrosis: Insight from idiopathic pulmonary fibrosis, systemic sclerosis, and COVID-19 patients","authors":"Shuai Jiang ,&nbsp;Xiangguang Shi ,&nbsp;Xiangzhen Kong ,&nbsp;Yahui Chen ,&nbsp;Weiqing Xu ,&nbsp;Meng Hao ,&nbsp;Dong Wei ,&nbsp;Fei Gao ,&nbsp;Fudi Wang ,&nbsp;Weilin Pu ,&nbsp;Jing Liu ,&nbsp;Qingmei Liu ,&nbsp;Yanyun Ma ,&nbsp;Jingyu Chen ,&nbsp;Jiucun Wang","doi":"10.1016/j.jtemb.2025.127728","DOIUrl":"10.1016/j.jtemb.2025.127728","url":null,"abstract":"<div><h3>Background</h3><div>Pulmonary fibrosis (PF) is the leading cause of death in many lung diseases due to inflammation, tissue damage, infection, or other contributing factors. Iron metabolism and ferroptosis have been reported to participate in some PF diseases, but the universality remains elusive.</div></div><div><h3>Methods</h3><div>Herein, comparative studies were conducted among idiopathic pulmonary fibrosis (IPF), immune-associated systemic sclerosis (SSc), and infectious COVID-19. The iron level was evaluated by Perls’ staining and ferritin level. Ferroptosis was detected by immunohistochemistry (malondialdehyde, oxidizing lipids, GPX4, and FSP1) and transmission electron microscopy. The results were also validated by public datasets analysis. Furthermore, the iron homeostasis and ferroptosis signatures were studied in the SARS-Cov-2 spike protein-induced PF cell model. The iron-mediated inflammation and fibrosis in PF were evaluated both <em>in vitro</em> and <em>in vivo</em>.</div></div><div><h3>Results</h3><div>We found that COVID-19 patients showed the most severe pulmonary damage and fibrosis signature. COVID-19 and SSc-PF patients have more obvious immune cell infiltration with CD11c⁺ monocytes and CD68 ⁺ macrophages. Iron overload and ferroptosis were common in PF, while COVID-19 patients showed distinct iron metabolism signatures with higher expression of HO-1. Among all ferroptosis markers, IPF patients showed the highest E06 level, COVID-19 and SSc-PF had both higher levels of MDA and 4HNE. Further studies showed iron overload and ferroptosis occurred mainly in alveolar type II cells and macrophages. Deferoxamine (DFO) and Ferrostatin-1 (Fer1) effectively prevented malondialdehyde production and IL-6 upregulation. DFO and Fer1 alleviated fibrosis in mice.</div></div><div><h3>Conclusions</h3><div>Our study demonstrates that iron overload and ferroptosis are common signatures in PF and represent potential therapeutic targets.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127728"},"PeriodicalIF":3.6,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and accuracy of In Vivo and Ex Vivo XRF bone lead assessment wild birds: An example with black vultures, Coragyps atratus","authors":"Thomas Grier ,&nbsp;Stephanie Silva Costa ,&nbsp;Bethany Faber ,&nbsp;Sunny Cooper ,&nbsp;Kristin Dean ,&nbsp;Michael Martin ,&nbsp;Brian P. Jackson ,&nbsp;Todd E. Katzner ,&nbsp;Aaron J. Specht","doi":"10.1016/j.jtemb.2025.127730","DOIUrl":"10.1016/j.jtemb.2025.127730","url":null,"abstract":"<div><h3>Background</h3><div>Lead (Pb) contamination in wildlife remains a critical environmental concern, particularly for scavenger species, which are at high risk due to ingestion of lead-contaminated carrion. Portable XRF (pXRF) systems can be useful to evaluate lead concentration of wild animals <em>in vivo</em>. However, the accuracy of these systems has never been validated for living birds.</div></div><div><h3>Methods</h3><div>We evaluated differences in the quantification of lead in the tarsometatarsus (TMT) and femur bones of 19 wild-caught black vultures (<em>Coragyps atratus</em>) by portable (pXRF) and benchtop X-ray fluorescence (XRF) systems with validation against inductively-coupled plasma mass spectrometry (ICP-MS).</div></div><div><h3>Results</h3><div>We found a strong correlation between benchtop XRF and ICP-MS (R² = 0.92–0.95), and lower correlation between pXRF and ICP-MS (R² = 0.62–0.67), primarily because pXRF systematically underestimated lead concentrations. When compared to ICP-MS, Intraclass Correlation Coefficients (ICC) further confirmed better performance of benchtop XRF in measuring femur and TMT lead (ICC = 0.959–0.968) compared to pXRF (ICC = 0.739–0.742). pXRF <em>in vivo</em> TMT lead concentrations were highly correlated (R² = 0.85) to <em>ex vivo</em> results with the same instrument, with the soft tissue on the living animal having minimal effect on the measurement.</div></div><div><h3>Discussion</h3><div>Although pXRF offers critical advantages in field applications, its limitations necessitate careful interpretation of results. Future research could improve pXRF optimization and extend this approach to other wildlife populations. This work contributes valuable data on lead exposure in vultures and illustrates a mechanism by which lead exposure of birds can be evaluated <em>in vivo</em> in wild or captive populations.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127730"},"PeriodicalIF":3.6,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in copper homeostasis and copper dysregulation in diseases","authors":"Mengmeng Tang,&nbsp;Jiamei Zhang,&nbsp;Min Yu","doi":"10.1016/j.jtemb.2025.127727","DOIUrl":"10.1016/j.jtemb.2025.127727","url":null,"abstract":"<div><div>Copper (Cu), as an essential trace element in the human body, plays an important supporting role in the maintenance of various basic biological functions. Copper homeostasis in the human body is tightly regulated, and an imbalance in copper homeostasis may lead to various diseases. Recent studies have proposed the concept of cuproptosis, suggesting that cuproptosis is a regulated cell death triggered by excessive intracellular accumulation of copper, which is a recently discovered form of cell death different from the known cell death mechanisms. In this review, we systematically detailed the research progress on copper metabolism and homeostasis, cuproptosis mechanism and the relationship between copper metabolism imbalance and related diseases, aiming to provide ideas for exploring the therapeutic strategies of various diseases based on copper metabolism imbalance.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127727"},"PeriodicalIF":3.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of sublethal contaminants mixtures on the immune system of Sparus aurata: Implications for marine ecosystem health","authors":"M. Ángeles Esteban ,&nbsp;Cristóbal Espinosa-Ruiz","doi":"10.1016/j.jtemb.2025.127726","DOIUrl":"10.1016/j.jtemb.2025.127726","url":null,"abstract":"<div><div>The presence of various contaminants in aquatic environments has raised concerns regarding the potential consequences of mixtures of different agents from diverse origins, including heavy metals, polyfluorinated compounds, polychlorinated biphenyls, polybrominated diphenyl ether, as well as a wide range of pharmaceutical compounds and their byproducts. To assess the relationship between these compounds and their impact on marine organisms, varying concentrations of a blend comprising 2,2′,4,4′-tetrabromodiphenyl ether 47 (BDE-47), carbamazepine (CBZ), and cadmium chloride (CdCl₂) were introduced into the diet of gilthead seabream (<em>Sparus aurata</em>), a marine organism used as a model. Forty specimens were placed into six aquaria and fed with commercial diet containing either a vehicle (control) or a mixture of two sub-lethal doses of BDE-47, CBZ and CdCl₂ (D1 or D2). The animals were fed for 15 days and subsequently maintained for another 15 days on a control diet for a detoxification period. Liver and intestine samples were obtained at 15 and 30 days of the trial. Different parameters related to the immune system, detoxification and antioxidant defences were analysed. The findings indicate that the combined exposure to sub-lethal amounts of CBZ, CdCl₂, and BDE-47 through dietary supplementation has a significant effect on the liver and intestine structures, in addition to causing dysregulation of antioxidant and cell cycle factors. Despite the sub-lethal nature of the doses, it has been demonstrated that the interaction between this mixture of compounds and the primary detoxification organ, as well as the digestive system, indicates a prolonged impact on the organisms. Extended exposure to a mixture of various toxic substances may lead to substantial changes in the immunity of marine organisms and their overall well-being, potentially affecting marine biota in the long term.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127726"},"PeriodicalIF":3.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144890015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-dependent toxicological profiling of large-sized ZnO and Co-ZnO nanoparticles: Renal and hepatic implications in Balb/c mice","authors":"Sawera Khan Yaqoob ,&nbsp;Eman Fayad ,&nbsp;Dalal Nasser Binjawhar ,&nbsp;Maha Ali Alghamdi ,&nbsp;Hanadi A. Katouah ,&nbsp;Fahmy Gad Elsaid ,&nbsp;Rahim Ullah ,&nbsp;Akhtar Nadhman","doi":"10.1016/j.jtemb.2025.127725","DOIUrl":"10.1016/j.jtemb.2025.127725","url":null,"abstract":"<div><h3>Objective</h3><div>The current study investigated the nephrotoxic and hepatotoxic effects of large-sized zinc oxide nanoparticles [(ZnO) (93 nm)] and cobalt-doped zinc oxide [(Co-ZnO) (90 nm)] in Balb/c mice.</div></div><div><h3>Method</h3><div>Both the nanoparticles were administered intraperitoneally at 50, 100, and 200 mg/kg, respectively, for 14 days, followed by biochemical and histopathological evaluations.</div></div><div><h3>Results</h3><div>Co-ZnO at 200 mg/kg induced significant hepatic toxicity, as evidenced by elevated ALP, AST, and ALT levels (p &lt; 0.01) and histopathological alterations. In contrast, renal function remained unaffected across all doses, as determined by stable creatinine levels and unremarkable kidney histology. Lower doses of both nanoparticles did not result in significant toxicity or behavioral changes.</div></div><div><h3>Conclusion</h3><div>The current study suggests that large-sized ZnO and Co-ZnO exhibit a favorable safety profile at moderate doses but are toxic at higher concentrations. Future studies are needed to explore clinical applicability and long-term effects in nanomedicine.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127725"},"PeriodicalIF":3.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144890016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manganese overexposure: Unveiling its neurotoxic potential and involvement in pathogenesis of Parkinson's disease","authors":"Shivani Chib ,&nbsp;Shamsher Singh ,&nbsp;Randhir Singh ,&nbsp;Muhammed Amanat","doi":"10.1016/j.jtemb.2025.127721","DOIUrl":"10.1016/j.jtemb.2025.127721","url":null,"abstract":"<div><h3>Background</h3><div>The modern era has brought increased availability of luxurious goods and conveniences, but manufacturing processes of metals and chemicals, including manganese (Mn), pose health risks. Overexposure of Mn is toxic, leading to neurodegenerative diseases like Parkinson’s disease (PD) which is characterized by dopaminergic neuronal loss. This study aims to investigates the neurotoxic effects of Mn alone and in combination with rotenone in PD-like pathology.</div></div><div><h3>Material and methods</h3><div>Male Wistar rats were treated with manganese chloride (MnCl₂; 15 mg/kg, <em>i.p</em>.) for 28 days. Motor coordination and grip strength were assessed using the strength glass chamber test and string test, respectively. Oxidative stress markers malondialdehyde (MDA) and lactate dehydrogenase (LDH) were measured. Inflammatory marker interleukin-6 (IL-6) and apoptotic marker caspase-3 were quantified using ELISA. Dopamine and glutamate levels were analysed in brain homogenates via reversed-phase high-performance liquid chromatography (RP-HPLC).</div></div><div><h3>Results</h3><div>MnCl₂ exposure significantly impaired motor coordination and grip strength. Oxidative stress markers (MDA and LDH) and IL-6 levels were markedly elevated in MnCl₂-treated rats compared to controls (p &lt; 0.05). Apoptosis was evident with increased caspase-3 levels (p &lt; 0.05). Neurotransmitter analysis revealed reduced dopamine and elevated glutamate concentrations (p &lt; 0.05). Notably, combining MnCl2 with lower dose of rotenone successfully mimicked PD-like pathology.</div></div><div><h3>Conclusion</h3><div>Chronic Mn exposure induces oxidative stress, inflammation, and neurotransmitter dysregulation, mimicking Parkinsonian neurotoxicity. This study highlights MnCl₂ as a safer alternative to high-dose rotenone for inducing PD-like symptoms for preclinical PD research. The findings underscore the health risks associated with Mn overexposure and its critical role in PD pathogenesis.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127721"},"PeriodicalIF":3.6,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The emerging potential of gallium compounds in medical research: A promising frontier","authors":"Samad Khaksar ,&nbsp;Alireza Aliabadi ,&nbsp;Rasoul Motahari ,&nbsp;Elham Motieiyan ,&nbsp;Domenica Marabello ,&nbsp;Sara Abdolmaleki","doi":"10.1016/j.jtemb.2025.127724","DOIUrl":"10.1016/j.jtemb.2025.127724","url":null,"abstract":"<div><div>Gallium-based compounds have become increasingly important in medicine due to their remarkable antimicrobial, anti-cancer, and anti-inflammatory properties. In terms of antimicrobial activity, these compounds inhibit the growth of microorganisms by interfering with their essential iron-dependent processes. Gallium competes with iron for binding sites in microbial cells, leading to iron deficiency and subsequent inhibition of microbial growth and replication. In addition, gallium-based compounds have been shown to inhibit the proliferation of cancer cells and induce programmed cell death in various cancer cell lines. Gallium disrupts the iron metabolism of cancer cells, leading to oxidative stress and DNA damage, which ultimately results in cell death. Gallium-based radiotracers have been used for non-invasive imaging of tumors in patients, enabling accurate diagnosis and staging of cancer. In addition, gallium-based compounds have been shown to inhibit the production of inflammatory cytokines and reduce inflammation in various disease models. In this review, many promising results from studies on the medicinal properties of gallium-based compounds are presented, and the structures and mechanisms of action of these compounds are explained as well as possible. However, the toxicity of these compounds is an important factor in exploring their clinical application, which is addressed in this review in the context of the studies conducted in this area.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127724"},"PeriodicalIF":3.6,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenium nanoparticles attenuates silver nanoparticles toxicity in mice Sertoli cells via modulation of SOD and Kindlin-2","authors":"Setayesh Safaei ,&nbsp;Mahnaz Azarnia ,&nbsp;Elaheh Amini ,&nbsp;Mohammad Nabiuni ,&nbsp;Media Abdollahian","doi":"10.1016/j.jtemb.2025.127720","DOIUrl":"10.1016/j.jtemb.2025.127720","url":null,"abstract":"<div><div>The rapid increase in male infertility has raised concerns about the potential risks of nanoparticles to male reproductive health. Previous studies have shown that high concentrations of selenium nanoparticles (SeNPs) possess antioxidant properties and can mitigate oxidative stress. However, the impact of SeNPs on supporting Sertoli cells affected by AgNPs has not been studied. This study aimed to investigate the effects of SeNPs on mouse Sertoli cells exposed to AgNPs. Sertoli cells were surgically extracted from NMRI mouse testicles and characterized by flow cytometry. The cells were treated with AgNPs and SeNPs, and their cytotoxicity was analyzed using the MTT assay. The levels of reactive oxygen species (ROS) and malondialdehyde (MDA) were measured, and real-time PCR was used to measure the expression of superoxide dismutase (SOD) and Kindlin-2. AgNPs were lethal at a concentration of 10 µg/ml. However, when AgNPs and SeNPs were used together, an increase in the dose of SeNPs (24–64 µg/ml) resulted in improved survival rates of the Sertoli cells (P*** ≤ 0.001). The combination of AgNPs and SeNPs (10 µg/ml + 64 µg/ml, respectively) reduced ROS and MDA levels and upregulated SOD and Kindlin-2 at the transcriptional level (P*** ≤ 0.001). These results suggest that SeNPs can attenuate AgNPs-induced toxicity in Sertoli cells, likely by enhancing the expression of antioxidant genes, reducing the production of ROS and improving reproductive capacity in supportive Sertoli cells. Therefore SeNPs could be suggested as a potential therapeutic agents for reducing the toxic effects of AgNPs <em>in vivo</em>.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127720"},"PeriodicalIF":3.6,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144879572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term toxic effects of nanoparticles on human microbiota","authors":"Shiva Sanati ,&nbsp;Azam Bakhti ,&nbsp;Fatemeh Mohammadipanah","doi":"10.1016/j.jtemb.2025.127723","DOIUrl":"10.1016/j.jtemb.2025.127723","url":null,"abstract":"<div><div>Synthetic nanomaterials can penetrate various organs, such as the skin, lungs, and gastrointestinal tract, enter systemic circulation, and ultimately reach tissues and human cells. Nanomaterials used in medicine, food, cosmetics, and agricultural processes can accumulate in our intestines and cause dysbiosis. The direct and indirect detrimental impacts of nanomaterials on humans by altering our cells and microbiota are discussed in this paper. These adverse effects of nanomaterials can be slightly reduced by changing their physicochemical characteristics. Some of the gut microbiota can reduce or mitigate the toxicity of nanomaterials through various strategies providing approaches for pro- or postbiotics with detoxifying function. Moreover, nanomaterials influence the rate of horizontal gene transfer. The use of nanomaterials in food, water, and medicines needs to be legitimized based on the duration, dose, type, and level of toxicity. The negative implications of nanomaterials in human cells and their microbiota are surveyed in this paper.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"91 ","pages":"Article 127723"},"PeriodicalIF":3.6,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}