Advances in copper homeostasis and copper dysregulation in diseases

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Trace Elements in Medicine and Biology Pub Date : 2025-08-21 DOI:10.1016/j.jtemb.2025.127727

Mengmeng Tang, Jiamei Zhang, Min Yu

引用次数: 0

Abstract

Copper (Cu), as an essential trace element in the human body, plays an important supporting role in the maintenance of various basic biological functions. Copper homeostasis in the human body is tightly regulated, and an imbalance in copper homeostasis may lead to various diseases. Recent studies have proposed the concept of cuproptosis, suggesting that cuproptosis is a regulated cell death triggered by excessive intracellular accumulation of copper, which is a recently discovered form of cell death different from the known cell death mechanisms. In this review, we systematically detailed the research progress on copper metabolism and homeostasis, cuproptosis mechanism and the relationship between copper metabolism imbalance and related diseases, aiming to provide ideas for exploring the therapeutic strategies of various diseases based on copper metabolism imbalance.

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铜稳态和铜在疾病中的失调研究进展

铜（Cu）作为人体必需的微量元素，在维持各种基本生物功能中起着重要的辅助作用。人体铜的体内平衡受到严格调控，铜体内平衡失衡可能导致多种疾病。最近的研究提出了cuprotosis的概念，认为cuprotosis是一种由细胞内铜的过量积累引发的受调控的细胞死亡，是一种新发现的不同于已知细胞死亡机制的细胞死亡形式。本文就铜代谢与体内平衡、铜代谢失衡机制以及铜代谢失衡与相关疾病的关系等方面的研究进展作一综述，旨在为探索基于铜代谢失衡的各种疾病的治疗策略提供思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Trace Elements in Medicine and Biology 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.90%

发文量

202

审稿时长

85 days

期刊介绍： The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.