吸烟者肺癌组织中44种元素的综合分析:与对照肺组织的比较研究

IF 3.6 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Ljubinko Đenić , Jovana Jagodić , Katarina Kozlica , Aleksandar Lukač , Aleksandar Ristanović , Janez Ščančar , Aleksandar Stojsavljević
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引用次数: 0

摘要

肺癌仍然是世界范围内发病率和死亡率的主要原因之一,但健康/对照肺组织中微量元素的基线状况在很大程度上尚未确定,没有建立全面的肺癌元素谱。本研究旨在表征健康肺组织(n = 92)中44种元素的基线浓度,并研究癌性肺组织(n = 92)中元素组成的变化。第二个目的是观察健康和癌变肺组织中元素浓度根据年龄和性别可能存在的差异。此外,本研究旨在确定可能参与肺癌病理生理的微量元素。通过详细的元素分析,这项研究揭示了健康和癌变肺组织之间的显著差异。其中,健康肺组织中Mn、Co、Ni、Cd和U的浓度显著高于正常肺组织,而癌肺组织中Cu、Tl、Pb、Rh、Pd和Bi的浓度显著高于正常肺组织。对照组织组的年龄相关性分析表明,老年人(64岁以上)的健康肺组织中Mn、Zn、Be、Al、Sb、Ba、Tl、Ga、Rb、Y、Re、Eu、Tb、Dy、Ho、Er、Yb、La和Bi元素的浓度低于年轻人(64岁以下)的健康组织。在癌变肺组织中,女性(n = 40)的Cr、Cu、As和Pb浓度显著低于男性(n = 52),而Pt浓度显著高于男性(n = 52)。此外,在癌变的肺组织中,来自年轻患者的肺组织中砷、锑和金的浓度低于来自老年人的肺组织。这些发现为肺癌组织的元素组成提供了有价值的见解,增强了对微量元素如何影响肺癌病理生理的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comprehensive analysis of 44 elements in the lung cancer tissues of smokers: A comparative study with control lung tissues
Lung cancer remains one of the leading causes of morbidity and mortality worldwide, yet the baseline status of trace elements in healthy/control lung tissues is largely unresolved, with no comprehensive elemental profile established for lung cancer. This study aimed to characterize baseline concentrations of 44 elements in healthy lung tissues (n = 92) and investigate changes in elemental composition in cancerous lung tissues (n = 92). The second aim was to observe possible differences in elemental concentrations in healthy and cancerous lung tissues based on age and sex. Additionally, this study aimed to identify trace elements potentially involved in lung cancer pathophysiology. Through detailed elemental analysis, this study revealed significant differences between healthy and cancerous lung tissues. Specifically, concentrations of Mn, Co, Ni, Cd, and U were significantly higher in healthy lung tissues, while Cu, Tl, Pb, Rh, Pd, and Bi were significantly higher in cancerous lung tissues. Age-related analysis of the control tissue group showed that healthy lung tissue from older individuals (above 64 years) had lower concentrations of elements Mn, Zn, Be, Al, Sb, Ba, Tl, Ga, Rb, Y, Re, Eu, Tb, Dy, Ho, Er, Yb, La, and Bi than healthy tissues from younger individuals (below 64 years). In cancerous lung tissues, those from females (n = 40) exhibited significantly lower concentrations of Cr, Cu, As, and Pb but higher Pt concentrations than cancerous lung tissues from males (n = 52). Furthermore, in cancerous lung tissues, those from younger patients displayed lower concentrations of As, Sb, and Au compared to equivalent tissues from older individuals. These findings offer valuable insights into the elemental composition of lung cancer tissue, enhancing the understanding of how trace elements could influence lung cancer pathophysiology.
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来源期刊
CiteScore
6.60
自引率
2.90%
发文量
202
审稿时长
85 days
期刊介绍: The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.
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