Ljubinko Đenić , Jovana Jagodić , Katarina Kozlica , Aleksandar Lukač , Aleksandar Ristanović , Janez Ščančar , Aleksandar Stojsavljević
{"title":"吸烟者肺癌组织中44种元素的综合分析:与对照肺组织的比较研究","authors":"Ljubinko Đenić , Jovana Jagodić , Katarina Kozlica , Aleksandar Lukač , Aleksandar Ristanović , Janez Ščančar , Aleksandar Stojsavljević","doi":"10.1016/j.jtemb.2025.127760","DOIUrl":null,"url":null,"abstract":"<div><div>Lung cancer remains one of the leading causes of morbidity and mortality worldwide, yet the baseline status of trace elements in healthy/control lung tissues is largely unresolved, with no comprehensive elemental profile established for lung cancer. This study aimed to characterize baseline concentrations of 44 elements in healthy lung tissues (n = 92) and investigate changes in elemental composition in cancerous lung tissues (n = 92). The second aim was to observe possible differences in elemental concentrations in healthy and cancerous lung tissues based on age and sex. Additionally, this study aimed to identify trace elements potentially involved in lung cancer pathophysiology. Through detailed elemental analysis, this study revealed significant differences between healthy and cancerous lung tissues. Specifically, concentrations of Mn, Co, Ni, Cd, and U were significantly higher in healthy lung tissues, while Cu, Tl, Pb, Rh, Pd, and Bi were significantly higher in cancerous lung tissues. Age-related analysis of the control tissue group showed that healthy lung tissue from older individuals (above 64 years) had lower concentrations of elements Mn, Zn, Be, Al, Sb, Ba, Tl, Ga, Rb, Y, Re, Eu, Tb, Dy, Ho, Er, Yb, La, and Bi than healthy tissues from younger individuals (below 64 years). In cancerous lung tissues, those from females (n = 40) exhibited significantly lower concentrations of Cr, Cu, As, and Pb but higher Pt concentrations than cancerous lung tissues from males (n = 52). Furthermore, in cancerous lung tissues, those from younger patients displayed lower concentrations of As, Sb, and Au compared to equivalent tissues from older individuals. These findings offer valuable insights into the elemental composition of lung cancer tissue, enhancing the understanding of how trace elements could influence lung cancer pathophysiology.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"92 ","pages":"Article 127760"},"PeriodicalIF":3.6000,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comprehensive analysis of 44 elements in the lung cancer tissues of smokers: A comparative study with control lung tissues\",\"authors\":\"Ljubinko Đenić , Jovana Jagodić , Katarina Kozlica , Aleksandar Lukač , Aleksandar Ristanović , Janez Ščančar , Aleksandar Stojsavljević\",\"doi\":\"10.1016/j.jtemb.2025.127760\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Lung cancer remains one of the leading causes of morbidity and mortality worldwide, yet the baseline status of trace elements in healthy/control lung tissues is largely unresolved, with no comprehensive elemental profile established for lung cancer. This study aimed to characterize baseline concentrations of 44 elements in healthy lung tissues (n = 92) and investigate changes in elemental composition in cancerous lung tissues (n = 92). The second aim was to observe possible differences in elemental concentrations in healthy and cancerous lung tissues based on age and sex. Additionally, this study aimed to identify trace elements potentially involved in lung cancer pathophysiology. Through detailed elemental analysis, this study revealed significant differences between healthy and cancerous lung tissues. Specifically, concentrations of Mn, Co, Ni, Cd, and U were significantly higher in healthy lung tissues, while Cu, Tl, Pb, Rh, Pd, and Bi were significantly higher in cancerous lung tissues. Age-related analysis of the control tissue group showed that healthy lung tissue from older individuals (above 64 years) had lower concentrations of elements Mn, Zn, Be, Al, Sb, Ba, Tl, Ga, Rb, Y, Re, Eu, Tb, Dy, Ho, Er, Yb, La, and Bi than healthy tissues from younger individuals (below 64 years). In cancerous lung tissues, those from females (n = 40) exhibited significantly lower concentrations of Cr, Cu, As, and Pb but higher Pt concentrations than cancerous lung tissues from males (n = 52). Furthermore, in cancerous lung tissues, those from younger patients displayed lower concentrations of As, Sb, and Au compared to equivalent tissues from older individuals. These findings offer valuable insights into the elemental composition of lung cancer tissue, enhancing the understanding of how trace elements could influence lung cancer pathophysiology.</div></div>\",\"PeriodicalId\":49970,\"journal\":{\"name\":\"Journal of Trace Elements in Medicine and Biology\",\"volume\":\"92 \",\"pages\":\"Article 127760\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-09-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Trace Elements in Medicine and Biology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0946672X25001737\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Trace Elements in Medicine and Biology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0946672X25001737","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Comprehensive analysis of 44 elements in the lung cancer tissues of smokers: A comparative study with control lung tissues
Lung cancer remains one of the leading causes of morbidity and mortality worldwide, yet the baseline status of trace elements in healthy/control lung tissues is largely unresolved, with no comprehensive elemental profile established for lung cancer. This study aimed to characterize baseline concentrations of 44 elements in healthy lung tissues (n = 92) and investigate changes in elemental composition in cancerous lung tissues (n = 92). The second aim was to observe possible differences in elemental concentrations in healthy and cancerous lung tissues based on age and sex. Additionally, this study aimed to identify trace elements potentially involved in lung cancer pathophysiology. Through detailed elemental analysis, this study revealed significant differences between healthy and cancerous lung tissues. Specifically, concentrations of Mn, Co, Ni, Cd, and U were significantly higher in healthy lung tissues, while Cu, Tl, Pb, Rh, Pd, and Bi were significantly higher in cancerous lung tissues. Age-related analysis of the control tissue group showed that healthy lung tissue from older individuals (above 64 years) had lower concentrations of elements Mn, Zn, Be, Al, Sb, Ba, Tl, Ga, Rb, Y, Re, Eu, Tb, Dy, Ho, Er, Yb, La, and Bi than healthy tissues from younger individuals (below 64 years). In cancerous lung tissues, those from females (n = 40) exhibited significantly lower concentrations of Cr, Cu, As, and Pb but higher Pt concentrations than cancerous lung tissues from males (n = 52). Furthermore, in cancerous lung tissues, those from younger patients displayed lower concentrations of As, Sb, and Au compared to equivalent tissues from older individuals. These findings offer valuable insights into the elemental composition of lung cancer tissue, enhancing the understanding of how trace elements could influence lung cancer pathophysiology.
期刊介绍:
The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods.
Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.