Nutrition Metabolism and Cardiovascular Diseases最新文献

{"title":"Moderate alcohol consumption does not necessarily equate to cardiovascular protection","authors":"Stephan Peronard Mayntz , Kasper Emil Rosenbech","doi":"10.1016/j.numecd.2025.104022","DOIUrl":"10.1016/j.numecd.2025.104022","url":null,"abstract":"","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 6","pages":"Article 104022"},"PeriodicalIF":3.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strawberries modestly improve cognition and cardiovascular health in older adults.","authors":"Kristin Delaney, Michelle Tsang, Mark Kern, Vernon Uganiza Rayo, Nathaniel Jason, Mee Young Hong, Changqi Liu, Shirin Hooshmand","doi":"10.1016/j.numecd.2025.104018","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104018","url":null,"abstract":"<p><strong>Background and aims: </strong>Strawberry consumption may aid in improving cognitive function and cardiovascular health given their nutrient composition and antioxidant capacities. We hypothesized that 2 cups of fresh strawberries per day provided as a freeze-dried strawberry powder (26 g/d) may improve cognitive performance and cardiovascular health relative to a control.</p><p><strong>Methods and results: </strong>Using a randomized, crossover, double-blind, placebo-controlled clinical trial, 35 healthy older adults (17 women, 18 men, age 72 ± 6 years, BMI 26.4 ± 3.9 kg/m²) consumed 26 g of freeze-dried strawberry powder (strawberry) and a control powder (control) daily for 8 weeks each with a 4-week washout period. Strawberry supplementation was expected to improve cardiometabolic health parameters, and cognitive performance measured with the National Institutes of Health Toolbox. Processing speed (p < 0.001) improved during the strawberry phase and episodic memory (p = 0.002) improved during the control phase. For cardiovascular measures, strawberry consumption reduced systolic blood pressure (p = 0.044) and a significant main effect of time for reduced waist circumference (p = 0.043) was detected. Serum triglycerides increased in the control group (p = 0.012) but not after consuming strawberries. Total antioxidant capacity significantly decreased during the control phase (p = 0.032) and significantly increased with strawberry consumption (p = 0.047).</p><p><strong>Conclusion: </strong>This study demonstrated that 26 g of freeze dried strawberries improve cognitive processing speed, lower systolic blood pressure, and increase antioxidant capacity, potentially promoting cognitive function and improving cardiovascular risk factors in cognitively healthy individuals.</p><p><strong>Clinical trial registry: </strong>NCT04786665.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104018"},"PeriodicalIF":3.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the letter on the article: Effect of moderate alcohol intake on blood apolipoproteins concentrations: A meta-analysis of human intervention studies.","authors":"Anila Khatiwada, Anju Rawal, Gabriele Berg-Beckhoff, Trine Levring Wilkens","doi":"10.1016/j.numecd.2025.104021","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104021","url":null,"abstract":"","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104021"},"PeriodicalIF":3.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of whole-body vibration exercise on cardiorespiratory fitness, muscular strength and body fat in women with overweight and obesity: A randomized pilot study","authors":"Seongmin Kim ,&nbsp;Serim Cho ,&nbsp;SoJung Lee","doi":"10.1016/j.numecd.2025.104019","DOIUrl":"10.1016/j.numecd.2025.104019","url":null,"abstract":"<div><h3>Background and aim</h3><div>Whole-body vibration (WBV) exercise has been acknowledged as an alternative exercise method for improving functional capacity. We examined the effects of an 8-week WBV exercise on cardiorespiratory fitness (CRF), muscular strength (MS) and body composition in young women.</div></div><div><h3>Methods and results</h3><div>Twenty-six inactive women with overweight and obesity (age: 30.2 ± 8.0 years, BMI: 25.7 ± 1.9 kg/m²) were randomly assigned to WBV exercise (<em>n</em> = 13) or control (<em>n</em> = 13) groups. The WBV exercise group participated in static and dynamic exercises on a vibration platform (3 sessions/week, 60 min/session) for 8 weeks. The control group maintained their usual lifestyle without structured exercise. CRF was measured by VO_2peak and MS index was measured by the 1-RM (kg) for the chest and leg press, expressed relative to body weight (kg). Body composition was assessed by bioelectrical impedance analysis. Of the 26 participants randomized, 23 participants (13 WBV and 10 controls) completed the intervention, with 94.2 % exercise adherence rate. A two-way repeated measures ANOVA revealed that the WBV exercise group had reductions (<em>p</em> &lt; 0.05 for all) in body weight (−2.4 kg), BMI (−0.9 kg/m²), body fat (−2.8 kg) and waist circumference (−3.5 cm) compared to the control group. VO_2peak (pre: 27.9 ± 4.8 vs. post: 30.7 ± 4.4 ml/kg/min, <em>p</em> = 0.005) and MS index (pre: 2.0 ± 0.4 vs. post: 3.0 ± 0.7, <em>p</em> &lt; 0.001) increased in the WBV exercise group, but not in the control group.</div></div><div><h3>Conclusion</h3><div>WBV exercise is effective for improving fitness and body fat in young women with overweight and obesity.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 6","pages":"Article 104019"},"PeriodicalIF":3.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum iron levels predict mortality risk in hypertensive patients: A prospective cohort study","authors":"Ziliang Ye,&nbsp;Manyun Long,&nbsp;Lang Li","doi":"10.1016/j.numecd.2025.104017","DOIUrl":"10.1016/j.numecd.2025.104017","url":null,"abstract":"<div><h3>Background and aim</h3><div>This study aimed to investigate the relationship between serum iron levels and mortality risk in hypertensive patients.</div></div><div><h3>Methods and results</h3><div>A total of 15,181 hypertensive patients were included and stratified into four groups based on serum iron levels (Quartile 1 to Quartile 4). Patients were followed for an average of 85.24 ± 1.16 months. The proportions of all-cause mortality across Quartiles 1 through 4 were 16.96 %, 14.65 %, 13.47 %, and 12.15 %, respectively (p &lt; 0.001), while the cardiovascular mortality rates were 5.06 %, 3.67 %, 3.46 %, and 2.84 %, respectively (p &lt; 0.001). After adjusting for confounders, the risks of all-cause and cardiovascular mortality were significantly lower in Quartile 2 (hazard ratio [HR] = 0.80, p = 0.060; HR = 0.57, p = 0.004), Quartile 3 (HR = 0.76, p = 0.050; HR = 0.58, p = 0.010), and Quartile 4 (HR = 0.64, p &lt; 0.001; HR = 0.45, p &lt; 0.001) compared to Quartile 1. Restricted cubic spline regression revealed a significant negative association between serum iron levels and the risks of all-cause and cardiovascular mortality. Additionally, mediation analysis showed that body mass index (BMI), serum creatinine, and lipid profile partially mediated the effect of serum iron on mortality risk.</div></div><div><h3>Conclusions</h3><div>Elevated serum iron levels were related to lower risks of mortality in hypertensive patients. BMI, serum creatinine, and lipid profile mediated this relationship, suggesting a potential interplay between metabolic and renal factors in modulating the effect of serum iron on mortality.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 6","pages":"Article 104017"},"PeriodicalIF":3.3,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity and sleep disorders: A bidirectional relationship","authors":"Michela Figorilli ,&nbsp;Fernanda Velluzzi ,&nbsp;Stefania Redolfi","doi":"10.1016/j.numecd.2025.104014","DOIUrl":"10.1016/j.numecd.2025.104014","url":null,"abstract":"<div><h3>Aims</h3><div>Obesity and sleep disorders are highly prevalent conditions with profound implications for public health. Emerging evidence highlights a bidirectional relationship between these two conditions, with each exacerbating the other in a complex interplay of behavioral, physiological, and hormonal mechanisms. Sleep deprivation and poor sleep quality contribute to energy imbalance through dysregulation of appetite hormones (e.g., leptin and ghrelin), increased caloric intake, and reduced physical activity. Conversely, sleep disorders such as obstructive sleep apnea syndrome (OSAS), insomnia, and restless leg syndrome (RLS) are significantly more common in individuals with obesity.</div></div><div><h3>Data synthesis</h3><div>This review explores the pathophysiological mechanisms underlying this relationship, including the roles of inflammation, autonomic dysregulation, and neuroendocrine pathways. Sleep loss exacerbates metabolic syndrome components, including insulin resistance and dyslipidemia, further perpetuating weight gain. Similarly, obesity-induced sleep disorders lead to pro-inflammatory states, vascular dysfunction, and sympathetic overactivation, compounding cardiometabolic risks. Specific conditions like OSA and RLS are examined as models of this interdependence, emphasizing their shared pathways and clinical implications.</div></div><div><h3>Conclusions</h3><div>The bidirectional link between obesity and sleep disorders underscores the importance of integrating sleep assessment and management into obesity treatment strategies. Addressing this relationship could mitigate the progression of cardiometabolic comorbidities and improve overall health outcomes. Moreover, the intertwined dynamics between obesity, sleep disorders, and mental health—mediated by inflammatory pathways, hormonal dysregulation, and neurobehavioral factors—highlight the critical need for integrated treatment approaches targeting physical, psychological, and sleep-related dimensions to enhance health and quality of life.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 6","pages":"Article 104014"},"PeriodicalIF":3.3,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social isolation and loneliness in non-communicable chronic diseases: Impact of COVID-19 pandemic, population aging and technological progress","authors":"Valeria Guglielmi ,&nbsp;Luca Colangeli ,&nbsp;Maria Eugenia Parrotta ,&nbsp;Azzurra Ciammariconi ,&nbsp;Ilaria Milani ,&nbsp;Monica D'Adamo ,&nbsp;Paolo Sbraccia ,&nbsp;Danila Capoccia","doi":"10.1016/j.numecd.2025.104015","DOIUrl":"10.1016/j.numecd.2025.104015","url":null,"abstract":"<div><h3>Aims</h3><div>Social isolation and loneliness have increasingly emerged as closely linked to onset and progression of non-communicable chronic diseases (NCDs). The aim of this review is to highlight the importance of addressing social isolation in the prevention and management of NCDs such as obesity, type 2 diabetes, and cardiovascular diseases in order to hinder their development and improve their outcomes.</div></div><div><h3>Data synthesis</h3><div>Social isolation and loneliness affect a significant portion of the older adult population, due to decrease in social interactions, chronic illnesses and sensory impairments. However, many other vulnerable populations may experience social isolation because of psychiatric or disabling health conditions, substances abuse, low socioeconomic status, unemployment and belonging to ethnic or marginalized minorities.</div><div>The unprecedented COVID-19-related social distancing can be taken as a proof-of-concept of the detrimental role of poor interactions in NCDs prevention and management not only at individual level but also in a public health perspective. Indeed, social isolation has been linked to unhealthy lifestyle choices, disrupted sleep quality, low utilization of healthcare, preventive services and adherence to treatments. Underlying mechanisms like inflammation and stress responses may also play a role in the association between social isolation and worse NCDs outcomes.</div></div><div><h3>Conclusions</h3><div>Social isolation negatively impacts on the development, progression and management of NCDs. Effective interventions for social isolation should address both societal factors and healthcare-related needs. To counteract the detrimental effects of social distancing during COVID-19 pandemic, the use of telemedicine was implemented. However, telemedicine is not always available, and legislative and age-related barriers persist.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 6","pages":"Article 104015"},"PeriodicalIF":3.3,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Associations of the hs-CRP/HDL-C ratio with cardiovascular disease among US adults: Evidence from NHANES 2015–2018″","authors":"Wenlong Wang,&nbsp;Lina Wang,&nbsp;Jianguo Cui,&nbsp;Dong Wang","doi":"10.1016/j.numecd.2025.103978","DOIUrl":"10.1016/j.numecd.2025.103978","url":null,"abstract":"","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 6","pages":"Article 103978"},"PeriodicalIF":3.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of hypertension, obesity, and type 2 diabetes on lacunar stroke: A network Mendelian randomization study","authors":"Zhi-Ping Wu ,&nbsp;Wei Wei ,&nbsp;Shan Liu ,&nbsp;Meng-Die Hu ,&nbsp;Heng Zhao ,&nbsp;Xiao-Feng Li ,&nbsp;Xin Chen","doi":"10.1016/j.numecd.2025.103974","DOIUrl":"10.1016/j.numecd.2025.103974","url":null,"abstract":"<div><h3>Background and aims</h3><div>Previous studies have reported an association of lacunar stroke with hypertension, obesity, and type 2 diabetes (T2D). The aim of this study was to investigate whether the association was causal and whether body mass index mediated the effect of hypertension on lacunar stroke.</div></div><div><h3>Methods and results</h3><div>The independence and causal association of hypertension, obesity, and T2D with lacunar stroke were assessed by multivariate Mendelian randomization (MVMR) and network Mendelian randomization (NMR) with inverse variance weighting (IVW). The reliability of the results was increased by sensitivity analyses including MR-Egger, Cochrane's Q test, Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO), and leave-one-out. MVMR analysis found that genetically predicted hypertension had a 42 % higher lacunar stroke risk (OR: 1.42, 95 % CI: 1.29–1.56, <em>P</em> &lt; 0.001) when adjusted for obesity and T2D, genetically predicted T2D had a 9 % higher lacunar stroke risk (OR: 1.09, 95 % CI: 1.03–1.16, <em>P</em> &lt; 0.004) when adjusted for hypertension and obesity, and genetically predicted obesity had a 15 % lower lacunar stroke risk (OR: 0.85, 95 % CI: 0.77–0.93, <em>P</em> &lt; 0.001) when adjusted for hypertension and T2D. NMR found that 44 % of the association between hypertension and lacunar stroke risk was mediated by obesity.</div></div><div><h3>Conclusion</h3><div>This genetic association study found novel independent genetic associations between hypertension and T2D with high risk of lacunar stroke, whereas obesity attenuated the risk of lacunar stroke. The findings emphasize the importance of individualized lacunar stroke prevention strategies rather than uniform weight management optimize medical care in high-risk populations.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 6","pages":"Article 103974"},"PeriodicalIF":3.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sedentary lifestyle and physical inactivity: A mutual interplay with early and overt frailty","authors":"Francesca Battista ,&nbsp;Federica Duregon ,&nbsp;Marco Vecchiato ,&nbsp;Andrea Ermolao ,&nbsp;Daniel Neunhaeuserer","doi":"10.1016/j.numecd.2025.103971","DOIUrl":"10.1016/j.numecd.2025.103971","url":null,"abstract":"<div><h3>Aims</h3><div>In recent years medical science and research are increasingly directed towards a holistic approach that considers health as global well-being rather than solely as the absence of disease. In this framework, lifestyle interventions and, in particular, physical exercise, are of crucial importance in prevention and treatment. Therefore, the purpose of this study is to describe this mutual interplay between physical behaviours, sarcopenia, and frailty, as well as to illustrate the role of structured exercise training in aging and disease.</div></div><div><h3>Data synthesis</h3><div>Physical activity and exercise training are determinants of lifelong global wellness and healthy aging. On the contrary, sedentary behaviour and physical inactivity are strictly linked to frailty and pre-frailty, both in adults and the elderly, with or without chronic diseases. On the other hand, the presence of pathological conditions is associated with a more inactive and sedentary behaviour. The co-presence of these factors is characterized by a mutual causal exchange in which they are imbricated in a continuous mechanistic interplay that involves inflammation, sarcopenia, osteopenia, functional impairment and many other pathophysiological aspects that rapidly can lead to a status of frailty.</div></div><div><h3>Conclusion</h3><div>A sedentary lifestyle and physical inactivity critically affect alterations in body composition and loss in functional capacity, typically linked to aging and accelerated by chronic diseases. However, physical activity and exercise can counteract the onset of pre-frailty and frailty by conferring beneficial effects on the individual's overall well-being.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 6","pages":"Article 103971"},"PeriodicalIF":3.3,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}