Nutrition Metabolism and Cardiovascular Diseases最新文献

{"title":"Sex- and metabolic-specific association between cumulative body mass index and incident chronic kidney disease: A prospective community-based cohort study","authors":"Yingting Zuo ,&nbsp;Zhang Xia ,&nbsp;Shuohua Chen ,&nbsp;Lulu Chu ,&nbsp;Yijun Zhang ,&nbsp;Yuhao Li ,&nbsp;Manqi Zheng ,&nbsp;Guozheng Xu ,&nbsp;Yan He ,&nbsp;Shouling Wu ,&nbsp;Anxin Wang","doi":"10.1016/j.numecd.2024.103790","DOIUrl":"10.1016/j.numecd.2024.103790","url":null,"abstract":"<div><h3>Background and aim</h3><div>Difference in metabolic status may cause inconsistent association between body mass index (BMI) and chronic kidney disease (CKD) in men and women. This study aimed to quantify sex-specific association between cumulative BMI (cumBMI) and incident CKD by different metabolic status.</div></div><div><h3>Methods and results</h3><div>Participants free of CKD from the Kailuan Study were followed biennially from baseline (June 2006 to October 2007) to December 2019. cumBMI was calculated by use of follow-up BMI and follow-up time and was divided into low weight (&lt;18.5 kg/m²), normal weight (18.5–23.9 kg/m²), overweight (24–27.9 kg/m²), and obesity (≥28 kg/m²) according to Chinese criteria. Metabolic health was defined as the absence of hypertension, dyslipidemia, and diabetes at baseline. CKD was defined as having estimated glomerular filtration rate &lt;60 mL/min/1.73 m². This study included 76984 participants, with a mean age of 50.0 ± 11.6 years and 80.0 % of men. Overweight (HR = 1.24, 95 % CI: 1.16–1.31) and obesity (HR = 1.94, 95 % CI: 1.77–2.12) were associated with higher risk of incident CKD in men regardless of metabolic status. Corresponding population attributable risk percentages for overweight and obesity were 10.3 % (95%CI: 7.1–12.9) and 12.7 % (95%CI: 10.6–14.7), respectively. However, low weight (HR = 1.56, 95 % CI: 1.05–2.30) and obesity (HR = 1.32, 95 % CI: 1.01–1.73) were associated with higher risk of incident CKD in metabolically healthy women but not in metabolically unhealthy women.</div></div><div><h3>Conclusions</h3><div>This study demonstrated sex- and metabolic-specific associations between BMI and CKD occurrence and advocates an individualized weight management strategy.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 3","pages":"Article 103790"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between brachial-ankle pulse wave velocity, obesity-related indices, and the 10-year incident risk score of atherosclerotic cardiovascular disease: The rural Chinese cohort study","authors":"MinQi Gu ,&nbsp;DongDong Zhang ,&nbsp;YuYing Wu ,&nbsp;Xi Li ,&nbsp;JinLiang Liang ,&nbsp;YaQin Su ,&nbsp;Li Yang ,&nbsp;TaiFeng Chen ,&nbsp;BoTang Guo ,&nbsp;Yang Zhao ,&nbsp;XueRu Fu ,&nbsp;LiuDing Wen ,&nbsp;ChuXia Lu ,&nbsp;YuKe Chen ,&nbsp;WanHe Huang ,&nbsp;Pei Qin ,&nbsp;FuLan Hu ,&nbsp;DongSheng Hu ,&nbsp;Ming Zhang","doi":"10.1016/j.numecd.2024.103791","DOIUrl":"10.1016/j.numecd.2024.103791","url":null,"abstract":"<div><h3>Background and aims</h3><div>Although existing evidence suggests that arterial stiffness and obesity impact cardiovascular health, limited studies have been conducted to explore the association between brachial-ankle pulse wave velocity (baPWV), obesity-related indices, and the risk of atherosclerotic cardiovascular disease (ASCVD).</div></div><div><h3>Methods and results</h3><div>The study participants were among those who completed the baPWV measurement at the second follow-up examination (during 2018–2020) of the Rural Chinese Cohort Study. Logistic regression models were employed to calculate odds ratios (ORs) and 95 % confidence intervals (CIs) of the 10-year incident risk score of ASCVD associated with baPWV and obesity-related indices. Mediation analysis was applied to investigate the role of baPWV in the obesity-induced 10-year incident risk score of ASCVD. A total of 1589 individuals, including 573 men and 1016 women, were included in the study. In logistic regression analyses, the highest quartile levels of baPWV and obesity-related indices all significantly increased the 10-year incident risk score of ASCVD compared to their corresponding lowest quartiles. The ORs (95%CIs) of ASCVD 10-year incident risk score risk were 4.21(2.55–6.94) for baPWV, 4.43(2.69–7.29) for METS-VF, 7.20(4.09–12.66) for CVAI, 3.38(2.12–5.38) for CI, and 2.40(1.54–3.75) for ABSI. The indirect effect of baPWV accounted for 5.85 %, 7.92 %, 14.56 %, and 5.08 % of the total effects for METS-VF, CVAI, CI, and ABSI, respectively.</div></div><div><h3>Conclusion</h3><div>This study found that elevated levels of both baPWV and obesity-related indices were associated with a higher 10-year incident risk score of ASCVD. Additionally, baPWV partially mediated the obesity-related increase in 10-year incident risk score of ASCVD.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 3","pages":"Article 103791"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction to the debate","authors":"Claudio Borghi (Prof)","doi":"10.1016/j.numecd.2025.103910","DOIUrl":"10.1016/j.numecd.2025.103910","url":null,"abstract":"","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 3","pages":"Article 103910"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel metabolic indicators and the risk of cardiovascular disease in patients with hypertension: A primary-care cohort study","authors":"Deliang Lv ,&nbsp;Zhen Liu ,&nbsp;Xiaobing Wu ,&nbsp;Fengzhu Xie ,&nbsp;Qinggang Shang ,&nbsp;Wei Xie ,&nbsp;Ziyang Zhang ,&nbsp;Zhiguang Zhao","doi":"10.1016/j.numecd.2024.09.019","DOIUrl":"10.1016/j.numecd.2024.09.019","url":null,"abstract":"<div><h3>Background and aims</h3><div>Data are limited on whether several easily measured indices serve as effective tools for Cardiovascular disease (CVD) risk assessment in hypertensive patients. This study aimed to assess the associations of metabolic score for insulin resistance (METS-IR), lipid accumulation product (LAP), and visceral adiposity index (VAI) with CVD risk in hypertensive patients.</div></div><div><h3>Methods and results</h3><div>Our data were drawn from the medical records of primary-care institutions in China. The present study included 306,680 individuals with hypertension attending primary healthcare centers. Cox regression analyses were applied to assess the associations of novel metabolic indicators with the risk of CVD. During a median follow-up of 1.98 years, 5820 participants developed CVD. When comparing with the lowest quartile of the indices, the highest quartile of METS-IR, LAP, and VAI was associated with 1.25-fold (95 % CI: 1.16–1.35), 1.15-fold (95 % CI: 1.05–1.25), and 1.19-fold (95 % CI: 1.10–1.28) risk of CVD after adjusting for potential confounders.</div></div><div><h3>Conclusion</h3><div>This study provided additional evidence that novel metabolic indicators like METS-IR, LAP, and VAI were associated with the risk of CVD. These results suggest that proactive assessment of visceral adiposity and insulin resistance could be helpful for the effective clinical management of the hypertensive population.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 3","pages":"Article 103749"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep: The silent hero in cardiometabolic health","authors":"Jean-Philippe Chaput ,&nbsp;Saverio Stranges","doi":"10.1016/j.numecd.2024.10.020","DOIUrl":"10.1016/j.numecd.2024.10.020","url":null,"abstract":"<div><div>The essential role of sleep in overall health is increasingly recognized, yet it remains underemphasized in both clinical and public health contexts. Despite extensive research linking poor sleep health to chronic conditions such as cardiovascular disease, type 2 diabetes, and cognitive decline, sleep health is not routinely assessed or integrated into standard care practices. Sleep problems, including insomnia, sleep apnea, and poor sleep quality, are prevalent globally, affecting over 30 % of the population and contributing to significant public health burdens like cardiometabolic disease, mental health disorders and multimorbidity. The economic implications are substantial, with insufficient sleep imposing significant societal and financial costs worldwide. Recognizing this, recent initiatives like the American Heart Association's inclusion of sleep in the Life's Essential 8 framework highlight the importance of sleep in cardiometabolic health. Integrating sleep into clinical and public health strategies is crucial, due to the wide-ranging impact of sleep on cardiometabolic health. Social, environmental, and demographic factors also play significant roles in sleep health, with lower socioeconomic groups and women often experiencing poorer sleep, further exacerbating health disparities. Adopting a life course approach and promoting healthy sleep behaviors early in life are essential for mitigating long-term cardiometabolic risks. Effective evidence-based strategies for improving sleep behaviors and cardiometabolic health, beyond addressing sleep disorders, include prioritizing sleep hygiene, managing stress, promoting physical activity, maintaining a healthy diet, and reducing substance use, all of which contribute to overall well-being. In conclusion, incorporating sleep health into routine cardiometabolic risk stratification, prevention, and management is essential for improving overall health outcomes.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 3","pages":"Article 103782"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of nutritional scores in non-valvular atrial fibrillation patients: Insights from the AFTER-2 study","authors":"Serdar Söner ,&nbsp;Tuncay Güzel ,&nbsp;Adem Aktan ,&nbsp;Raif Kılıç ,&nbsp;Bayram Arslan ,&nbsp;Muhammed Demir ,&nbsp;Hamdullah Güzel ,&nbsp;Ercan Taştan ,&nbsp;Metin Okşul ,&nbsp;Adnan Duha Cömert ,&nbsp;Faruk Ertaş","doi":"10.1016/j.numecd.2024.103794","DOIUrl":"10.1016/j.numecd.2024.103794","url":null,"abstract":"<div><h3>Background and aim</h3><div>Many scoring systems are used to evaluate malnutrition, but there is no consensus on which scoring system would be more appropriate. We aimed to investigate the effect of malnutrition in patients with non-valvular atrial fibrillation (NVAF) and to compare three scoring systems.</div></div><div><h3>Methods and results</h3><div>A total of 2592 patients with non-valvular AF from 35 different centers in Turkey were included in this prospective study. All participants were divided into two groups: 761 patients who died and 1831 patients who were alive. The malnutrition status of all participants was evaluated with three scoring systems. The primary outcome was all-cause mortality. The mean age of the population was 68.7 ± 11.1 years, and 55.5 % were female. According to Cox regression analysis, the geriatric nutritional risk index (GNRI) (HR = 0.989, 95 % CI: 0.982–0.997, p = 0.007), controlling nutritional status (CONUT) score (HR = 1.121, 95 % CI: 1.060–1.185, p &lt; 0.001), and prognostic nutritional index (PNI) (HR = 0.980, 95 % CI: 0.962–0.999, p = 0.036) were found to be significant mortality predictors. ROC curve analysis indicated GNRI (AUC = 0.568), CONUT (AUC = 0.572), and PNI (AUC = 0.547) had moderate predictive values. Kaplan-Meier analysis showed that increasing the risk class based on GNRI (p &lt; 0.001) and CONUT (p &lt; 0.001) was associated with decreased survival, while PNI staging had no statistically significant effect (p = 0.266).</div></div><div><h3>Conclusions</h3><div>Malnutrition, determined by three scoring systems, was found to be an independent predictor of all-cause mortality in NVAF patients. Nutritional examination may provide useful information for prognosis and risk stratification in patients with NVAF.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 3","pages":"Article 103794"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of novel inflammatory and metabolic markers with mortality in individuals with overweight and obesity","authors":"Abdul-Quddus Mohammed ,&nbsp;Lu Liu ,&nbsp;Jiasuer Alifu ,&nbsp;Guoqing Yin ,&nbsp;Wen Zhang ,&nbsp;Yawei Xu ,&nbsp;Fuad A. Abdu ,&nbsp;Wenliang Che","doi":"10.1016/j.numecd.2025.103859","DOIUrl":"10.1016/j.numecd.2025.103859","url":null,"abstract":"<div><h3>Background and aims</h3><div>Stress hyperglycemia ratio (SHR) and pan-immune-inflammation value (PIV) are novel prognostic markers associated with metabolic changes and chronic inflammation, but their association with mortality risk in individuals with overweight and obesity remains unknown. We aimed to investigate impact of SHR and PIV on mortality risk in individuals with overweight and obesity.</div></div><div><h3>Methods and results</h3><div>This cohort study included 16,703 U S adults with overweight and obesity. SHR and PIV were estimated, and Cox regression, ROC, and Kaplan-Meier curves analyzed their associations with all-cause and cause-specific mortality. Subgroup and interaction analyses tested SHR and PIV consistency. Over a median follow-up of 110 months, there were 2432 all-cause deaths (14.6 %), including 677 cardiovascular, 577 cancer, and 130 cerebrovascular deaths. Participants were categorized by optimal SHR (≥1.038 or &lt;1.038) and PIV (≥301 or &lt;301) cutoffs. High SHR was associated with higher overall and cause-specific mortality (log-rank p &lt; 0.001). High PIV was linked to increased risks of overall, cardiovascular, and cancer mortality (log-rank p &lt; 0.001). Multivariate Cox models showed elevated SHR was associated with increased all-cause, cardiovascular, and cancer mortality (HR:1.59; 95%CI: 1.34–1.89; HR:1.45; 95%CI: 1.03–2.04; HR:1.66; 95%CI: 1.15–2.38, respectively). Elevated PIV was linked to higher all-cause and cardiovascular mortality (HR: 1.18; 95%CI: 1.02–1.37; HR:1.35; 95%CI: 1.02–1.79, respectively). Poorer survival was noted in obesity + high SHR and overweight + high PIV subgroups (log-rank p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Elevated SHR and PIV are significant predictors of increased all-cause and cause-specific mortality in individuals with overweight and obesity.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 3","pages":"Article 103859"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of dietary assessment methods used for South Asian migrants in high-income host countries","authors":"Purva Gulyani ,&nbsp;Sabrina Gupta ,&nbsp;Ashley H. Ng ,&nbsp;Gina Trakman","doi":"10.1016/j.numecd.2024.103795","DOIUrl":"10.1016/j.numecd.2024.103795","url":null,"abstract":"<div><h3>Aim</h3><div>The increased risk of chronic diseases and migration to high-income countries in South Asians has been well established. Considering exposure to changing dietary intake and lifestyle upon migration, accurate nutrition assessment is crucial in this population. The present review aims to summarise dietary assessment methods and nutrient databases for South Asian (SA) migrants in high-income countries.</div></div><div><h3>Data Synthesis</h3><div>A systematic search of Medline, Web of Sciences, Embase, CINHAL and Cochrane Central Library databases was conducted in August 2023. Eligible studies were critically appraised using Joanna Briggs Institute Critical Appraisal Tools. Data was extracted using a purpose-built spreadsheet. This systematic review has been registered with PROSPERO (Reg ID: CRD42021274929).</div></div><div><h3>Conclusions</h3><div>A total of 12991 studies were identified, of which 46 met the eligibility criteria. Dietary assessment methods were categorised as newly validated, previously validated, and not validated. Only ten studies used a validated culturally appropriate dietary assessment tool. This review shows that FFQ and 24-hour (24hr) dietary recall are the most utilised dietary assessment tools for SA migrants. The findings highlight the limited culturally appropriate dietary assessment tools available for SA migrants. Specific design and validation issues, such as cultural specificity, were identified that researchers should consider when developing new nutritional assessment tools for SA migrants.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 3","pages":"Article 103795"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is isocaloric intermittent fasting superior to calorie restriction? A systematic review and meta-analysis of RCTs","authors":"Mohammed Hamsho ,&nbsp;Wijdan Shkorfu ,&nbsp;Yazan Ranneh ,&nbsp;Abdulmannan Fadel","doi":"10.1016/j.numecd.2024.103805","DOIUrl":"10.1016/j.numecd.2024.103805","url":null,"abstract":"<div><h3>Background and aim</h3><div>Intermittent fasting (IF) has been demonstrated to enhance human health through several mechanisms. However, it is still unclear whether those health benefits are independent of caloric restriction (CR)-induced weight loss. This systematic review and meta-analysis aimed to compare isocaloric IF and CR regarding anthropometric measurements, adherence, metabolic profile, inflammatory biomarkers, and adipokines in adults and elderlies.</div></div><div><h3>Methods and results</h3><div>Comprehensive research was conducted usin four major databases including Embase, PubMed, Scopus, and Google Scholar without date restriction. Mean differences of the change from baseline ± change SD were calculated as the differences between IF and CR groups. Subgroup analysis was performed according to intervention duration (short-, medium-, and long-term). To determine the reliability of our findings, GRADE assessment was performed. As a result, 20 RCTs were included in this systematic review and meta-analysis. IF groups had significant reductions in fat mass (kg) (P = 0.006) and Interleukin-6 (P &lt; 0.00001) in the short term and fat mass (%) (P = 0.0002), waist circumference (P = 0.005), fasting blood insulin (P &lt; 0.00001) and HOMA-IR (P = 0.04) in the long term. CR groups had significantly lower hunger (P = 0.003), fatigue (P = 0.04), and TG (P = 0.03).</div></div><div><h3>Conclusions</h3><div>IF may be an effective alternative to CR but is not superior to CR in enhancing human health. Due to the low number of long-term studies, future studies should focus on conducting longitudinal randomized trials comparing IF and CR in different populations, age groups, and IF patterns.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 3","pages":"Article 103805"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abdominal obesity and cardiometabolic risk markers: A comparative analysis of waist circumference, dual-energy X-ray absorptiometry, and magnetic resonance imaging techniques","authors":"Giulianna Regeni Ruano ,&nbsp;Guilherme Augusto Nogueira ,&nbsp;Prince Dadson ,&nbsp;Sandra R.G. Ferreira ,&nbsp;Marcelo Tatit Sapienza ,&nbsp;Licio A. Velloso ,&nbsp;Milena Monfort-Pires","doi":"10.1016/j.numecd.2024.103801","DOIUrl":"10.1016/j.numecd.2024.103801","url":null,"abstract":"<div><h3>Background and aims</h3><div>This study compares three methods to determine central adiposity (waist circumference –WC - and visceral adipose tissue – VAT - estimated by dual-energy x-ray absorptiometry – DXA, and by magnetic resonance imaging - MRI) in their ability to predict increases in cardiometabolic risk (CMR) markers in young individuals. We examined their associations with CMR in 47 men and women aged 25–40.</div></div><div><h3>Methods and results</h3><div>VAT mass was assessed using DXA and MRI. Blood samples were analyzed for CMR markers. Associations between central adiposity measurements and CMR factors were analyzed using Spearman's correlation coefficient, and the ability of these three central adiposity measurements to detect increased CMR was compared using receiver operating characteristic (ROC) curves. Similar to what was observed for the MRI-DXA and VAT-DXA, WC showed strong correlations with LDL-c and triglycerides (TG) and an inverse correlation with HDL-c (rho = −0.657 MRI, rho = −0.628 DXA, and rho = −0.604 WC, p &lt; 0.01). On the other hand, only MRI-VAT and WC were associated with insulin and HOMA-IR (rho = 0.341 MRI and rho = 0.421 WC, p &lt; 0.01). Central adiposity measurements were negatively associated with cold-induced ¹⁸F-FDG uptake in subcutaneous adipose tissue and positively associated with VAT TG content. No significant differences were observed when comparing the three central adiposity measurements in ROC curve analysis, and all measurements could predict increases in CMR markers and the combined CMR index.</div></div><div><h3>Conclusions</h3><div>This study reinforces the importance of using WC to assess increases in CMR markers among young adults. Given its practicality and efficacy, WC should be recommended in health centers to assess CMR risk.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 3","pages":"Article 103801"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}