Nutrition Metabolism and Cardiovascular Diseases最新文献

{"title":"Incremental reach of 30-year PREVENT-ASCVD risk assessment in adults with MASLD and low 10-year risk: population implications of the 2026 dyslipidemia guideline.","authors":"Hao Chen, Shenghui Jin, Jiajun Tang, Junqi Xiao, Xiangtai Zeng, Jiayou Liao","doi":"10.1016/j.numecd.2026.105013","DOIUrl":"https://doi.org/10.1016/j.numecd.2026.105013","url":null,"abstract":"<p><strong>Background and aims: </strong>Low 10-year ASCVD risk can coexist with substantial long-horizon risk in younger adults. The 2026 dyslipidemia guideline introduced 30-year PREVENT-ASCVD risk ≥10% as a criterion for considering moderate-intensity statin therapy in adults aged 30-59 years with 10-year risk <3%. We aimed to quantify the population scale and incremental classification reach of this criterion among U.S. adults with metabolic dysfunction-associated steatotic liver disease (MASLD).</p><p><strong>Methods and results: </strong>We analyzed NHANES 2017-March 2020 and August 2021-August 2023 as independent complex surveys. Adults aged 30-59 years with VCTE-defined operational MASLD, no clinical ASCVD, no lipid-lowering therapy, LDL-C 70-189 mg/dL, no observable automatic-treatment indication, and 10-year PREVENT-ASCVD risk <3% were included. G1 was defined as 30-year risk ≥10% with LDL-C <160 mg/dL. The complete primary cores included 529 and 303 participants. G1 prevalence was 33.3% and 27.9%, representing 5.85 and 4.50 million U.S. adults. Among participants leaving G0 through either the long-horizon or LDL-C 160-189 mg/dL criterion, 85.7% and 75.1% were identified uniquely by 30-year risk. In the broader operational MASLD pathway, G1 accounted for 15.8% and 13.9% of the weighted distribution and was more concentrated than in confirmed non-MASLD. Findings were stable across alternative specifications and neighboring thresholds.</p><p><strong>Conclusion: </strong>Among adults with operational MASLD who remained at low 10-year ASCVD risk, the 30-year PREVENT criterion identified a substantial population not captured by the parallel LDL-C 160-189 mg/dL pathway and accounted for most downstream classification beyond G0. These findings define the disease-specific population reach of long-horizon risk assessment in MASLD.</p><p><strong>Clinical trial registration: </strong>Not applicable.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"105013"},"PeriodicalIF":3.9,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement precision in physical activity trajectory research.","authors":"Jinmei Li, Chong Liu","doi":"10.1016/j.numecd.2026.105009","DOIUrl":"https://doi.org/10.1016/j.numecd.2026.105009","url":null,"abstract":"","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"105009"},"PeriodicalIF":3.9,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time to redefine serum uric acid levels in women: A call for sex-specific cardiometabolic risk thresholds.","authors":"Anna Vittoria Mattioli, Claudio Borghi","doi":"10.1016/j.numecd.2026.104986","DOIUrl":"https://doi.org/10.1016/j.numecd.2026.104986","url":null,"abstract":"<p><strong>Aims: </strong>Serum uric acid (SUA) is routinely measured in clinical practice, but its interpretation remains largely anchored to conventional, gout-oriented or sex-neutral thresholds. This Viewpoint discusses why this approach may underestimate cardiometabolic and vascular risk in women.</p><p><strong>Data synthesis: </strong>SUA in women is influenced by hormonal status, renal urate handling, age, adiposity, insulin resistance, inflammation, and menopause. Population-based evidence shows a marked sex- and age-specific trajectory of SUA, with a sharper increase in women after midlife, while outcome studies suggest that women may experience cardiovascular risk at lower SUA concentrations than men. Emerging data also link SUA to arterial stiffness and microvascular dysfunction even within ranges traditionally considered physiological.</p><p><strong>Conclusions: </strong>SUA should be interpreted as a dynamic, sex-sensitive cardiometabolic biomarker rather than as a fixed biochemical value. Redefining SUA levels in women does not imply urate-lowering therapy for all asymptomatic women, but rather the distinction between gout thresholds and cardiometabolic risk thresholds. Prospective studies are needed to validate sex-, age-, and hormone-specific SUA thresholds for cardiovascular prevention.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104986"},"PeriodicalIF":3.9,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steatotic liver disease phenotypes and cardiac autonomic dysfunction: a community-based study in China.","authors":"Bo Liu, Zhengyu Zhang, Ruhan Xu, Fang Zhang, Xiuying Zhang, Yufeng Li, Xianghai Zhou, Linong Ji","doi":"10.1016/j.numecd.2026.104869","DOIUrl":"https://doi.org/10.1016/j.numecd.2026.104869","url":null,"abstract":"<p><strong>Background and aims: </strong>Steatotic liver disease (SLD) is increasingly recognized as a systemic disorder linked to cardiometabolic risk. Cardiac autonomic dysfunction may represent an early mechanistic pathway connecting hepatic steatosis with adverse cardiovascular outcomes. We investigated the associations between contemporary SLD phenotypes and cardiac autonomic function, assessed by heart rate variability (HRV).</p><p><strong>Methods and results: </strong>A total of 2792 participants from the Pinggu Metabolic Disease Study were included. Hepatic steatosis was defined by computed tomography (liver-spleen ratio ≤1.1). Metabolic dysfunction-associated SLD (MASLD), MASLD with moderate alcohol intake (MetALD), and alcohol-associated liver disease (ALD) were classified according to the 2024 EASL-EASD-EASO criteria. HRV indices (MeanNN, SDNN, RMSSD) were derived from digitized electrocardiograms. Sex-stratified multivariable ordinal logistic regression models were used. The prevalence of MASLD, MetALD, and ALD was 17.8%, 2.1%, and 2.5%, respectively. SLD phenotypes were generally associated with adverse HRV profiles. After adjustment, SLD phenotypes remained associated with lower MeanNN. In men, MASLD and the combined MetALD/ALD group were associated with lower SDNN quartiles, with a stronger association for MetALD/ALD (OR 2.19, 95% CI 1.55-3.09), which was also associated with lower RMSSD quartiles (OR 2.08, 95% CI 1.47-2.94). In women, MASLD was associated with lower RMSSD quartiles (OR 1.57, 95% CI 1.23-2.02). Sensitivity analyses showed generally consistent findings.</p><p><strong>Conclusions: </strong>SLD phenotypes were associated with higher heart rate. In men, MASLD, MetALD, and ALD were associated with impaired overall cardiac autonomic function, whereas in women, MASLD was associated with impaired cardiac parasympathetic function.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104869"},"PeriodicalIF":3.9,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149009136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary melatonin and obesity incidence: a non-linear association in the Brazilian cohort (CUME+ Study).","authors":"Gilmara Alves Zanirate, Josefina Bressan, Arieta Carla Gualandi Leal, Adriano Marçal Pimenta, Helen Hermana Miranda Hermsdorff","doi":"10.1016/j.numecd.2026.105006","DOIUrl":"https://doi.org/10.1016/j.numecd.2026.105006","url":null,"abstract":"<p><strong>Background and aims: </strong>Obesity is a major global health challenge, with rising prevalence and complex etiology. Bioactive dietary components with antioxidant and anti-inflammatory properties may help prevent obesity. We examined the prospective association between dietary melatonin and obesity incidence in adults.</p><p><strong>Methods and results: </strong>This cohort study included 3736 participants followed for a mean of 4.4 years (2016-2024); dietary melatonin intake was estimated using a validated food frequency questionnaire. We defined obesity as body mass index (BMI) ≥30 kg/m². Associations were assessed using multivariable Cox models and restricted cubic spline analyses (3 knots). During follow-up, 294 participants (7.9%) developed obesity. Most were women (65.8%), with a mean age of 36.5 years and a mean BMI 24.5 kg/m². Obesity incidence ranged from 6.3% in Q3 to 10.0% in Q5 (p = 0.032). In the fully adjusted multivariable Cox model, compared with Q1, participants in Q3 (20,894.5-26,276.5 ng/day) had a 49% lower risk of incident obesity (HR 0.51; 95% CI 0.34-0.75; p = 0.001). Restricted cubic spline analysis (3 knots) confirmed a statistically significant non-linear association (p-overall = 0.0396; p-nonlinearity = 0.0186), demonstrating an intermediate protective window.</p><p><strong>Conclusion: </strong>Intermediate dietary melatonin intake was prospectively associated with a lower incidence of obesity, exhibiting a significant non-linear dose-response relationship. These findings suggest a potential protective window at moderate consumption levels, independent of smoking status and caffeine intake.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"105006"},"PeriodicalIF":3.9,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiome composition and cardiometabolic risk among healthcare workers: findings from the EXPONIT study.","authors":"Raquel Galan, Gemma Castaño-Vinyals, Elisa Rubio-Garcia, Rubén Lopez-Aladid, Ana Espinosa, Mariona Bustamante, Kyriaki Papantoniou, Parveen Bhatti, Camille Lassale, Cristina Márquez, Ana Alfaro, Kathryn E Coakley, Climent Casals-Pascual, Manolis Kogevinas, Barbara N Harding","doi":"10.1016/j.numecd.2026.105002","DOIUrl":"https://doi.org/10.1016/j.numecd.2026.105002","url":null,"abstract":"<p><strong>Background and aims: </strong>The gut microbiome plays an important role in metabolic regulation and has been linked to cardiometabolic disorders. Circadian-related factors (night shift work, sleep quality, chronotype) may influence gut microbiome characteristics and cardiometabolic health. We aimed to investigate the associations between gut microbiome diversity and composition and cardiometabolic outcomes, and evaluate whether these associations differ by work schedule, sleep quality, and chronotype.</p><p><strong>Methods and results: </strong>Fecal samples were taken on a working day, and gut microbiota composition was assessed using 16S rRNA gene sequencing. Anthropometric measures (body mass index,waist-to-hip ratio, systolic and diastolic blood pressure) and blood samples (metabolic biomarkers), were obtained during study visits. Associations between microbial composition and cardiometabolic outcomes were examined using robust linear and logistic regression models. Potential interactions with shift work status, sleep quality, and chronotype were also explored. Overall, alpha diversity was not significantly associated with cardiometabolic markers. However, overall gut microbiome composition (beta diversity) was associated with excess body weight (PERMANOVA p = 0.01, R² = 0.7%). In addition, specific genera were associated with anthropometric markers: greater relative abundance of Lachnospiraceae-unclassified-genus-008 was associated with a higher body mass index; and increased relative abundance of Escherichia/Shigella and lower relative abundance of Alistipes were associated with higher waist-to-hip ratio. No associations were found between beta diversity or taxonomic composition and metabolic biomarkers.</p><p><strong>Conclusion: </strong>Specific gut microbial profiles may be associated with cardiometabolic markers, particularly obesity-related traits. Future longitudinal studies are needed to clarify the directionality and underlying mechanisms of these associations.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"105002"},"PeriodicalIF":3.9,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The trajectories of free sugar intake and its main sources during childhood and cardiometabolic clusters at 13 years of age.","authors":"Sofia Sosa, Catarina Campos Silva, Milton Severo, Carla Lopes","doi":"10.1016/j.numecd.2026.105003","DOIUrl":"https://doi.org/10.1016/j.numecd.2026.105003","url":null,"abstract":"<p><strong>Background and aim: </strong>The effect of free sugar (FS) intake trajectories in early life on later cardiometabolic health is unclear. To evaluate the association of FS intake trajectories (both total FS and primary food sources) on cardiometabolic risk clusters from childhood into adolescence.</p><p><strong>Methods and results: </strong>Participants (n = 3616) from the Generation XXI birth-cohort were assessed at ages 4, 7, 10, and 13. FS intake was assessed using food frequency questionnaires. Cardiometabolic outcomes (BMI, waist circumference, HOMA, lipids, blood pressure) were objectively measured. Gaussian mixture models identified FS trajectories and cardiometabolic risk clusters at 13y, and logistic regression models estimated their associations, adjusting for confounders and energy intake. Six FS intake trajectories were identified. Compared with the lowest FS trajectory, higher intake trajectories were positively associated with a less favorable cardiometabolic profile, with this association attenuated after adjustment for energy. Children with the highest FS intake at 4-years of age had significantly increased odds of a less favorable profile (Cluster 1, OR = 2.11,95%CI:1.04-4.22). The later the age peaks the maximum FS intake from sugar-sweetened beverages (SSBs), the lower the cardiometabolic risk (OR = 0.94,95%CI:0.87-1.02). For sweets, both a later trend reversal of minimum intake (OR = 1.09,95%CI:1.00-1.18) and a higher minimum intake (OR = 1.15,95%CI:1.05-1.25) were associated with a less favorable cardiometabolic profile, even after adjustments.</p><p><strong>Conclusion: </strong>Higher FS intake in early life and persistent intake during childhood, particularly from SSBs and sweets, is associated with a less favorable cardiometabolic profile in adolescence. This association was attenuated after adjustment for energy intake, suggesting that energy intake may partly explain the observed associations.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"105003"},"PeriodicalIF":3.9,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal validation of an original bias-reduced fat-free mass metabolic coefficient in inpatients with obesity.","authors":"Giuseppe Mazzola, Simone Perna, Clelia Russo, Valentina Nerbi, Veronica Piccinni, Sara Carovelli, Carlo Cattaneo, Michela Seniga, Luca Matteo Schiavi, Eleonora Patta, Mariangela Rondanelli","doi":"10.1016/j.numecd.2026.105000","DOIUrl":"https://doi.org/10.1016/j.numecd.2026.105000","url":null,"abstract":"<p><strong>Background and aims: </strong>In obese patients subjects, conventional resting energy expenditure (REE) normalization using the REE/fat-free mass (FFM) ratio is confounded by the metabolic contribution of adipose tissue, introducing an anthropometric bias across varying levels of adiposity. This study validates a new corrected metabolic coefficient (K_FFM) designed to neutralize this bias and evaluates its longitudinal responsiveness and clinical reliability during a 8-week multidisciplinary rehabilitation intervention.</p><p><strong>Method and results: </strong>Longitudinal study of 167 patients subjects with Class I-III obesity undergoing an 8-week residential program. REE and body composition were assessed by indirect calorimetry and DXA. KFFM was calculated by adjusting REE for fat mass. Bias was evaluated by Pearson correlation; longitudinal changes by Linear Mixed Models; metabolic convergence by Brown-Forsythe test and bootstrapping (5000 iterations). MDC was set at 2.30 kJ/kg/day. Allometric modeling confirmed a non-linear REE-FFM relationship with an exponent of β = 0.82 (p = 0.0007). The K_FFM achieved complete bias neutralization (r = 0.098,p = 0.21), whereas the traditional REE/FFM ratio remained significantly correlated with adiposity (r = 0.25,p = 0.001). Longitudinal analysis revealed a significant overall metabolic shift (p = 0.0009), with a highly significant reduction in K_FFM specifically for Class III obesity (from 118.11 to 109.95 kJ/kg FFM/day; p = 0.0004). Furthermore, 91.02% of patients subjects exhibited changes exceeding the minimum detectable change (MDC = 2.30 kJ/kg/day), confirming true physiological signals. Bootstrap analysis confirmed the stability of inter-individual variance (95% CI: -14.74 to 7.08).</p><p><strong>Conclusions: </strong>K_FFM could be a bias-reduced, robust metric for REE normalization in obesity, showing stable inter-individual variability and sensitivity to clinically meaningful bioenergetic changes beyond traditional ratio-based methods.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"105000"},"PeriodicalIF":3.9,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149002626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher estimated cardiorespiratory fitness levels were associated with lower risk of cardiometabolic multimorbidity: a retrospective cohort study from CHARLS.","authors":"Lina Zhu, Yetong Wu, Yangzong Yu, Yake Lou, Dongmei Zhou, Shaoshen Wang","doi":"10.1016/j.numecd.2026.105001","DOIUrl":"https://doi.org/10.1016/j.numecd.2026.105001","url":null,"abstract":"<p><strong>Background and aims: </strong>Cardiometabolic multimorbidity (CMM) is significantly associated with an increased risk of all-cause mortality. However, evidence on the relationship between cardiorespiratory fitness (CRF) and CMM remains limited, particularly in Chinese populations.</p><p><strong>Methods and results: </strong>Data were derived from the China Health and Retirement Longitudinal Study. A total of 5,255 participants aged ≥45 years with up to 9 years of follow-up were included. Sex-specific body mass index (BMI)-based models were used to evaluate estimated CRF (eCRF). Skeletal muscle mass was assessed using appendicular skeletal muscle mass (ASM) and appendicular skeletal muscle mass index (ASMI). During the 9-year follow-up, 441 (8.4%) participants developed CMM. Kaplan-Meier survival analysis demonstrated that higher eCRF levels were associated with a lower cumulative risk of CMM. Multivariable Cox proportional hazards regression analysis revealed that after full adjustment for confounders, each 1-MET (1 mL kg^-1·min^-1) increase in eCRF was associated with an 18.9% (5.8%) reduction in the risk of CMM. In quartile analysis of eCRF, compared with the lowest quartile (Q1), the risk of CMM was 25.5% lower in Q2, 46.5% lower in Q3, and 61.0% lower in Q4. The fully adjusted RCS analysis indicated a linear relationship between eCRF and CMM risk. Mediation analysis suggested that skeletal muscle mass statistically mediated the association between eCRF and CMM, with mediated proportions of 22.69% for ASM and 40.54% for ASMI.</p><p><strong>Conclusion: </strong>Higher eCRF was associated with a reduced risk of CMM, and this association may be partially mediated by skeletal muscle mass.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"105001"},"PeriodicalIF":3.9,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Cardiovascular disease incidence among aging patients with rheumatoid arthritis: results from the Canadian Longitudinal Study on Aging (CLSA)\" [Nutr Metab Cardiovasc Dis 12 (2026) 104845].","authors":"Yasaman Hajiesmaeili, Osvaldo Espin Garcia, M Reza Azarpazhooh, Saverio Stranges, Lillian Barra","doi":"10.1016/j.numecd.2026.104957","DOIUrl":"10.1016/j.numecd.2026.104957","url":null,"abstract":"","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104957"},"PeriodicalIF":3.9,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148921646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}