Nutrition Metabolism and Cardiovascular Diseases最新文献

{"title":"Effect of different types of coffee consumption on the risk of cardiovascular complications and related mortality events in prediabetes: an analysis from NHANES.","authors":"Dan Yang, Yaqian Mao, Shuqian Chen, Wei Lin, Liantao Li, Jixing Liang, Huibin Huang, Junping Wen, Gang Chen","doi":"10.1016/j.numecd.2025.104113","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104113","url":null,"abstract":"<p><strong>Background and aims: </strong>This study aimed to investigate the association of different types of coffee consumption on mortality, cardiovascular outcomes and prevalence in adults with prediabetes.</p><p><strong>Methods and results: </strong>This study included 5979 patients with prediabetes from the 2003-2018 National Health and Nutrition Examination Survey (NHANES) who had follow-up information. Mortality status was obtained from the National Mortality Record (NMR). A total of 748 deaths were recorded in patients with follow-up prediabetes, including 250 cardiovascular causes of death. The coffee consumption of NHANES participants was assessed using the first 24-h dietary recall interview. Among the patients with prediabetes during follow-up, there were significant survival differences between the three levels of total coffee, sugar-free coffee, and caffeinated coffee consumption (log-rank test, p < 0.05). Only for sugar-sweetened coffee consumption were there significant survival differences in cardiovascular disease (CVD) mortality across the three levels (log-rank test, p < 0.001). After multivariable adjustment, when comparing the lowest and highest consumption categories of different types of coffee, the hazard ratio for all-cause mortality among patients with prediabetes for total coffee consumption was 0.68 (95% confidence intervals [CI]: 0.55-0.85). Consumption of sugar-sweetened, sugar-free, full-fat, and fat-free coffee was negatively associated with the risk of all-cause mortality among patients with prediabetes (p < 0.05). Similar results were observed between individual types of coffee consumption and CVD mortality. Additionally, the hazard ratio for CVD mortality among patients with prediabetes for caffeinated coffee consumption was 0.47 (95% CI: 0.27-0.80). Full-fat coffee consumption was negatively associated with the prevalence risk of CVD among patients with prediabetes (OR: 0.0002, 95 % CI: 0.00-0.001, p for trend = 1.91).</p><p><strong>Conclusions: </strong>In adult patients with prediabetes, different types of coffee consumption showed varying associations with all-cause mortality, CVD outcomes, and prevalence. Higher consumption of coffee, sugar-sweetened coffee, sugar-free coffee, full-fat coffee, and fat-free coffee was associated with reduced all-cause mortality and CVD mortality in patients with prediabetes. Additionally, caffeinated coffee consumption was linked to a lower CVD mortality risk, and full-fat coffee consumption was associated with a reduced risk of CVD prevalence. These findings highlighted the potential role of choosing different types of coffee in managing the risk of CVD and premature mortality in adult patients with prediabetes.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104113"},"PeriodicalIF":3.3,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Independent effect of body fat content on inflammatory biomarkers in children and adolescents: The GENOBOX study.","authors":"Aizaz Anwar Khalid, Ayesha Parvaiz Malik, Javed Iqbal, Brijesh Sathian","doi":"10.1016/j.numecd.2025.104122","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104122","url":null,"abstract":"","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104122"},"PeriodicalIF":3.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uric acid to high-density lipoprotein cholesterol ratio in association with adverse health outcomes in patients with chronic kidney disease.","authors":"Kaixin Lei, Sihan Hu, Yuxuan Zhang, Jiaao Wang, Jun Wang","doi":"10.1016/j.numecd.2025.104161","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104161","url":null,"abstract":"<p><strong>Background and aims: </strong>The ratio of uric acid to high-density lipoprotein cholesterol (UHR) has recently been identified as a new metabolic marker and has been shown to be associated with cardiovascular disease (CVD), chronic kidney disease (CKD), and diabetes. Nonetheless, the connection between UHR and negative health outcomes in CKD is still not well understood.</p><p><strong>Method and results: </strong>We analyzed data from the 1999-2018 National Health and Nutrition Examination Survey (NHANES), including 8071 individuals with chronic kidney disease (CKD). Wighted logistic regression models and weighted Cox proportional hazards models were employed to explore the association of UHR with health outcomes in CKD patients. A restricted cubic spline (RCS) regression model was applied to investigate potential nonlinear relationships. Additionally, subgroup analyses were conducted to examine potential interactions between UHR and other covariates. One unit increase in UHR was linked to a 4 % higher risk of cardiovascular disease (CVD), a 2 % increased risk of all-cause mortality, and a 3 % greater risk of CVD-related mortality (all P < 0.001). The RCS regression model demonstrated linear positive associations between UHR and these outcomes. The Kaplan-Meier curve revealed that individuals in the highest UHR quartile had significantly poorer outcomes in terms of both all-cause and CVD mortality. Subgroup analyses indicated that age, gender, and alcohol consumption might modulate the relationships between UHR and the three outcomes.</p><p><strong>Conclusion: </strong>UHR significantly positively correlates to CVD, all-cause mortality and CVD mortality in CKD population. Monitoring UHR at relatively low levels may protect long-term outcomes for CKD patients.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104161"},"PeriodicalIF":3.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediterranean Diet and athletic performance in elite and competitive athletes: a systematic review and meta-analysis.","authors":"Simona Fiorini, Monica Guglielmetti, Lenycia de Cassya Lopes Neri, Luca Correale, Anna Tagliabue, Cinzia Ferraris","doi":"10.1016/j.numecd.2025.104165","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104165","url":null,"abstract":"<p><strong>Aims: </strong>Mediterranean Diet (MedDiet) may represent the reference dietary pattern for athletes. Our aim was to study whether MedDiet could be associated with any changes in performance in adult athletes practicing different types of sport at various levels of competition.</p><p><strong>Data synthesis: </strong>A systematic literature review (PROSPERO n. CRD42023459039) was performed based on the PRISMA method. The search was conducted in PubMed/Medline, Scopus, Web of Science, and the Cochrane Library in October 2024. Competitive/elite healthy adult athletes performing at least 6 h/week. The risk of bias was assessed using the RoB 2.0 Cochrane tool for randomised-controlled trials, Robins-I tool for non-randomised studies and the Newcastle Ottawa Scale for the observational studies. A meta-analysis was conducted. 9 studies were included in this review (192 participants, mainly males), 5 of them had a cross-sectional design. The sample size ranged from 10 to 43 athletes performing different sports. 5 studies reported an impact of MedDiet on athletic performance; of these, 4 studies reported a positive effect. MedDiet adherence was positively related to anaerobic/aerobic power, explosive strength, and indirectly associated with body fat percentage. Reported adherence to MedDiet varied from low to high. The meta-analysis showed no MedDiet effect on the performance outcomes [SMD 0.00 (CI -0.26; 0.25)].</p><p><strong>Conclusions: </strong>The findings of this review suggest a general positive influence of the MedDiet on athletic performance, supporting its role as a beneficial dietary pattern for athletes. Quantitative analysis did not confirm these results, probably due to the few studies included, their heterogeneity and low-to-moderate quality.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104165"},"PeriodicalIF":3.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining Risk: Integrating time-varying and culturally diverse approaches to obesity and cardiovascular health.","authors":"Riza Amalia, Ronal Surya Aditya, Basti Tetteng, Eva Meizara Puspita Dewi, Harwanti Noviandari, Rusnila, Alwita Susanti","doi":"10.1016/j.numecd.2025.104162","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104162","url":null,"abstract":"","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104162"},"PeriodicalIF":3.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty increases the risk of hospitalization for atrial fibrillation in older adults: a population-based cohort study.","authors":"Caterina Trevisan, Chiara Ceolin, Davide Liborio Vetrano, Mirko Petrovic, Gregory Y H Lip, Iain Buchan, Marina De Rui, Giuseppe Sergi, Stefania Maggi, Marianna Noale, Søren Påske Johnsen, Riccardo Proietti, Pia Cordsen, Gregory Lip, Deirdre Lane, Martin O'Flaherty, Carrol Gamble, Iain Buchan, Christodoulos Kypridemos, Brendan Collins, Donato Leo, Mirko Petrovic, Delphine De Smedt, Stefanie De Buyser, Cheima Amrouch, Davide Liborio Vetrano, Amaia Calderón-Larrañaga, Lu Dai, Stefania Maggi, Marianna Noale, D A N Gheorghe-Andrei, Anca Rodica Dan, Nicola Ferri, Alessandra Buja, Giuseppe Sergi, Vincenzo Stefano Rebba, Caterina Trevisan, Tatjana Potpara, Laura Vivani, Silvia Ananstasia, Alessandro Ferri, Gehad Shehata, Nadia Rosso, Marco Cicerone, Jacek Marczyk, Trudie Lobban, Georg Ruppe, Graziano Onder, Federica Censi, Robero Da Cas, Cecilia Damiano, Guendalina Graffigna, Caterina Bosio, Lorenzo Palamenghi, Serena Barello, Aldo Pietro Maggioni, Andrea Lorimer, Donata Lucci, Dipak Kalra, Nathan Lea, John Ainsworth, Charlotte Stockton-Powdrell, Alam Sanaullah, Francisco Marín, Vanessa Roldán, José Miguel Rivera-Caravaca, Mariya Tokmakova","doi":"10.1016/j.numecd.2025.104159","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104159","url":null,"abstract":"<p><strong>Background and aims: </strong>Atrial fibrillation (AF) is more common with increasing age and older adults have greater prevalence of frailty, multimorbidity and polypharmacy, which may impact clinical outcomes. The present study aims to investigate the relationship between frailty and the risk of hospitalization for AF in older adults, and second, the possible interaction of multimorbidity in this association.</p><p><strong>Methods and results: </strong>Data from the Progetto Veneto Anziani (Pro.V.A.), an observational cohort study in north-eastern Italy, were utilised. The analyses included 2909 individuals aged ≥65 years without AF at baseline, assessed between 1995 and 1997, with follow-ups at 4.4 and 7 years. Frailty was defined according to Fried's criteria, and multimorbidity as the number of chronic diseases. AF-related hospitalizations and deaths were recorded up to December 31, 2018. Multi-adjusted mixed-effects Cox regressions were performed to test associations. Over the follow-up period, 318 (10.9 %) participants experienced AF-related hospitalizations. Compared to robust participants, the hazard ratio (HR) of hospitalizations due to AF was 1.42 (95 % Confidence Interval (95 %CI): 1.04-1.95) in pre-frail and 1.98 (95 %CI: 1.21-3.26) in frail individuals, even after adjusting for multimorbidity. The number of chronic diseases was only marginally and not significantly associated with AF-related hospitalizations (HR 1.07, 95 %CI: 0.99-1.15), but did not significantly interact with frailty in the association with AF-related hospitalizations.</p><p><strong>Conclusion: </strong>Older adults with frailty present with higher hazards of AF-related hospitalizations, irrespective of the presence of multimorbidity. Further studies are needed to evaluate whether reducing frailty may prevent AF development and improve health outcomes in older adults.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104159"},"PeriodicalIF":3.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of the uric acid to high-density cholesterol ratio (UHR) combined with atherogenic index of plasma (AIP) for abnormal bone mineral density in type 2 diabetes mellitus patients.","authors":"Qingxi Zhang, Xueting Zeng, Jingming Wang, Shishi Huang, Fei Hua, Xiaotong Zhou, Lu Chen, Ting Gong, Min Zhang","doi":"10.1016/j.numecd.2025.104156","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104156","url":null,"abstract":"<p><strong>Background and aims: </strong>Osteoporosis, characterized by systemic bone mass reduction and microstructural deterioration, is a growing clinical and economic burden. Type 2 diabetes mellitus (T2DM) has been increasingly linked to poor bone health, elevating the risk of osteoporosis and fragility fractures. The uric acid to high-density lipoprotein cholesterol ratio (UHR) and atherogenic index of plasma (AIP) have emerged as novel metabolic indicators, but their combined role in predicting abnormal bone mineral density (BMD) remains unexplored. This study aims to investigate the individual and combined contributions of UHR and AIP in predicting abnormal BMD in patients with T2DM.</p><p><strong>Methods and results: </strong>This retrospective study included 290 patients with T2DM, recruited from a single center between February 2016 and August 2018. Clinical data, including UHR, AIP, and BMD, were analyzed. Multivariable regression and receiver operating characteristic (ROC) analyses were performed to evaluate the associations between UHR, AIP, and abnormal BMD. Both UHR and AIP were independently associated with abnormal BMD, with stronger associations observed in females and individuals without a history of smoking or drinking. ROC analyses demonstrated modest predictive value for UHR (AUC = 0.5969) and AIP (AUC = 0.6224), with the combined metrics achieving an AUC of 0.6329.</p><p><strong>Conclusions: </strong>The study highlights that UHR and AIP are negatively associated with total BMD, which can serve as potential predictive markers for abnormal BMD in T2DM patients. A novel clinical prediction model integrating these markers may aid in the early assessment of abnormal BMD risk, facilitating timely preventive interventions.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104156"},"PeriodicalIF":3.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of advanced glycation end products consumption and nutritional parameters in cardiovscular rehabilitation patients.","authors":"Maria Izabel de Castro Magalhães Fortes, Vitória Ellen Ladeira, Cicília Alves de Souza, Mariana da Silveira Quaresma, Tatiane Moreira Alves Garcia, Luciana de Abreu Silva, Gabriella Duarte de Oliveira, Rackel Aguiar Mendes de Oliveira, Adriane Moreira Machado, Camila Kümmel Duarte","doi":"10.1016/j.numecd.2025.104152","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104152","url":null,"abstract":"<p><strong>Background and aim: </strong>Advanced glycation end products (AGEs) are formed during the cooking process or endogenous metabolism. AGEs contribute to the progression of many chronic diseases. This study hypothesizes that a greater AGEs intake would be associated with worse health habits and nutritional status, and therefore aims to analyze the consumption of AGEs in patients with cardiovascular disease (CVD) and identify eating habits and nutritional characteristics related to greater consumption of AGEs.</p><p><strong>Methods and results: </strong>We conducted a cross-sectional study with a sample composed of patients with cardiovascular disease. Patients' food consumption was evaluated by recording each meal in a span of 24 h. The quantification of AGEs consumption was obtained by calculating the amount of carboxymethyl lysine (CML) by each portion of food registered each day, in accordance with the AGEs index. The data concerning AGEs are expressed in kilounits (KU) by 100 g of food. The calculus of mean macronutrients ingested during the three days of evaluation was obtained using the Avanutri® software. The statistical analysis was conducted using the software IBM SPSS version 20.0. In total, 132 patients were analyzed. The mean estimated AGEs consumption was 9595.0 kU of CML/day (6256.25-16153.25). The consumption of total energy (r = 0.394; p = 0.001) and saturated fats (r = 0.323; p = 0.001) showed direct and stronger correlations with AGEs. It was observed that eating meals with distractions (p = 0.002) and present a greater neck (NC) (p = 0.008) was associated with higher AGEs intake.</p><p><strong>Conclusions: </strong>This study observed a significant consumption of AGEs associated with greater consumption of calories and saturated fats, and conversely with carbohydrates. Furthermore, the greater consumption of AGEs by patients with high NC and abdominal circumference highlights the importance of nutritional guidance in this patient profile. Even so, aspects related to eating habits also suggest that they favor greater consumption of AGEs, such as the presence of distractions during meals.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104152"},"PeriodicalIF":3.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood-to-adolescence weight trajectories and adult hypertension: A systematic review and meta-analysis.","authors":"Tao Xu, Yuexian Tao, Yuling Lei","doi":"10.1016/j.numecd.2025.104160","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104160","url":null,"abstract":"<p><strong>Aims: </strong>Given the global burden of obesity, it is critically important to understand how different life-course weight trajectories influence the risk of hypertension in adulthood. Body weight changes across developmental stages may exert varying impacts on long-term cardiovascular health. This study aimed to evaluate the association between weight changes from childhood to adolescence and the subsequent risk of developing hypertension in adulthood.</p><p><strong>Data synthesis: </strong>This systematic review and meta-analysis was conducted in accordance with the PRISMA 2020 guidelines. A comprehensive literature search was performed using PubMed, EMBASE, Web of Science, and EBSCO databases from inception to July 26, 2023. Study selection and data extraction were independently carried out by two reviewers. Publication bias was assessed using Begg's and Egger's tests. Thirteen eligible studies comprising a total of 125,329 participants were included in the final analysis. Key findings were as follows: (i) Variations in weight trajectory were significantly associated with hypertension risk. (ii) Weight gain from childhood to adolescence was associated with a higher risk of hypertension (RR = 2.27; 95 % CI: 1.83-2.83). (iii) Persistent overweight status was linked to an even greater risk (RR = 3.29; 95 % CI: 2.18-5.28). (iv) Elevated BMI during youth correlated with increased adult blood pressure. (v) Females with persistent overweight had a significantly higher hypertension risk compared to males (RR = 3.23; 95 % CI: 2.35-4.43).</p><p><strong>Conclusion: </strong>Compared to maintaining a stable normal weight, both weight gain and persistent overweight from childhood to adolescence are strongly associated with an increased risk of hypertension in adulthood. Moreover, this association may differ by sex, suggesting the need for sex-specific prevention strategies targeting early-life weight management.</p><p><strong>Trial registration: </strong>PROSPERO CRD42022353522; https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=353522.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104160"},"PeriodicalIF":3.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of intermittent fasting and Mediterranean diet on older adults' physical health and quality of life: A randomized clinical trial.","authors":"Sergio Couto, María Carmen Cenit, Jesica Montero, Isabel Iguacel","doi":"10.1016/j.numecd.2025.104132","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104132","url":null,"abstract":"<p><strong>Background and aims: </strong>Non-communicable chronic diseases are on the rise globally, and diet plays a crucial role. Intermittent fasting (IF), particularly time-restricted eating (TRE), has emerged as a potential strategy to manage these conditions. Research suggests that TRE, combined with healthy diets like the Mediterranean diet, may benefit populations, including older adults.</p><p><strong>Methods and results: </strong>Seventeen adults over 60 years of age were randomly assigned to the TRE + MED group (n = 8), following a 12-h fast with the Mediterranean diet, or the MED-DIET group (n = 9), following the diet without fasting. Over three months, changes in anthropometric, biochemical, and quality of life measures were assessed. The TRE + MED group showed significant reductions in BMI (p = 0.040), waist circumference (p < 0.001), hip circumference (p = 0.025), waist-to-hip ratio (p = 0.023), and systolic blood pressure (SBP) (p = 0.020), along with changes in fasting glucose. In the MED-DIET group, only SBP decreased significantly (p = 0.022). Between-group comparisons showed greater improvements in waist circumference (p = 0.001) and waist-to-hip ratio (WHR; p = 0.036) in the TRE + MED group. Conversely, gamma-glutamyl transferase (GGT) levels improved more in the MED-DIET group (p = 0.020). However, in the between-group comparison, only the reduction in waist circumference, WHR, and GGT levels reached statistical significance. Both groups improved Mediterranean diet adherence, quality of life, and stool regularity, but only 20 % of the TRE + MED group was willing to continue fasting, compared to 100 % in the MED-DIET group.</p><p><strong>Conclusion: </strong>TRE combined with the Mediterranean diet offers superior health benefits compared to the Mediterranean diet alone. In addition, adhering to a consistent meal schedule and regulating meal timing appear to be more challenging for the studied population.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104132"},"PeriodicalIF":3.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}