Mariana P Gabiatti, Giana Z Longo, Daniela B Hauschild, Luiza G Pinto, Fernanda Hansen
{"title":"Phase angle is associated with inflammatory parameters in young adults and adults with metabolic syndrome in a population-based study.","authors":"Mariana P Gabiatti, Giana Z Longo, Daniela B Hauschild, Luiza G Pinto, Fernanda Hansen","doi":"10.1016/j.numecd.2025.104028","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104028","url":null,"abstract":"<p><strong>Background and aims: </strong>Phase angle (PhA) is suggested to reflect cell health. PhA association with inflammation and adiposity in metabolic syndrome (MetS) presence or absence, remains unclear. In the general population, PhA association with C-reactive protein (CRP) is controversial, and studies on PhA with other inflammatory markers are a literature gap. This study aims to evaluate the association of PhA with inflammatory and adiposity-related parameters in males and females with and without MetS.</p><p><strong>Methods and results: </strong>Cross-sectional study with 597 adults (38.4 years; CI95 % 36.35-40.45) categorized into MetS (n = 126, 57.9 % female) and non-MetS (n = 471, 55.2 % female). Single-frequency bioimpedance analysis evaluated PhA. Adiposity-related (BMI, visceral adiposity index, and body fat percentage (%BF) by dual-energy x-ray emission) and serum inflammatory parameters (CRP, TNF-α, IL-6, IL-10, IL-1β, IL-8, IL-12p70) were evaluated. Regression analyses adjusted by age, and physical activity level, with or without %BF, evaluated the associations. In males MetS, PhA was negatively associated with %BF, IL-6, IL-10, IL-1β, and IL-12p70 (β = -0.07, p = 0.005, β = -0.03, p = 0.035, β = -0.06, p = 0.006, β = -0.03, p = 0.048, β = -0.02, p = 0.038, respectively) and positively associated with BMI (β = 0.07, p = 0.003) in non-MetS. In females MetS, PhA was negatively associated with TNF-α and IL-12p70 (β = -0.02, p = 0.048, β = -0.01, p = 0.016, respectively) and positively with IMC, %BF, TNF-α and IL-8 (β = 0.07, p < 0.001, β = 0.02, p = 0.021, β = 0.02, p = 0.011, β = 0.01, p = 0.035, respectively) in non-MetS.</p><p><strong>Conclusion: </strong>In MetS individuals, higher PhA values are associated with lower inflammatory parameters in both sexes and %BF in males. The different behavior of PhA in females, suggests caution when interpreting PhA in this population.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104028"},"PeriodicalIF":3.3,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yangyu Zhao, Lei Chen, Jiayang Dong, Xinyue Yang, Tenglong Hu, Na Sun, Qiang Sun, Wenyan Liang, Xiqing Wei, Zhiqiang Zhang
{"title":"Global cardiovascular disease burden attributable to high low-density lipoprotein cholesterol, 1990-2021: An age-period-cohort analysis of the global burden of disease study 2021.","authors":"Yangyu Zhao, Lei Chen, Jiayang Dong, Xinyue Yang, Tenglong Hu, Na Sun, Qiang Sun, Wenyan Liang, Xiqing Wei, Zhiqiang Zhang","doi":"10.1016/j.numecd.2025.104030","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104030","url":null,"abstract":"<p><strong>Background and aims: </strong>To deepen the understanding of global trends in the cardiovascular disease (CVD) burden attributed to high low-density lipoprotein cholesterol (LDL-C).</p><p><strong>Methods and results: </strong>Utilizing data from the Global Burden of Disease study spanning from 1990 to 2021, an age-period-cohort analysis was conducted to evaluate global trends in mortality and disability-adjusted life years (DALYs) of CVD attributed to high LDL-C. Joinpoint regression analysis was employed to identify periods of the most significant changes. The findings indicate a significant increase in the global number of deaths from CVD linked to high LDL-C from 1990 to 2021. However, both the age-standardized mortality rate and DALYs rate exhibited a downward trend, with women experiencing a more pronounced decline than men. The age-standardized rate was lower in countries with higher Socio-demographic Index (SDI) compared to those with lower SDI. Notably, there were significant reductions in CVD mortality during the periods of 1994-1998 and 2003-2007.</p><p><strong>Conclusion: </strong>This study underscores the critical role of high LDL-C as a risk factor in the global burden of CVD. Investigating gender differences, regional disparities, and variations among different age groups of CVD is essential for developing intervention strategies and health policies.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104030"},"PeriodicalIF":3.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tianjie Lai, Yiyin Liang, Fenglei Guan, Yunxian Chen, Konghe Hu
{"title":"Association between remnant cholesterol and arterial stiffness: Evidence from NHANES 1999-2018.","authors":"Tianjie Lai, Yiyin Liang, Fenglei Guan, Yunxian Chen, Konghe Hu","doi":"10.1016/j.numecd.2025.104013","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104013","url":null,"abstract":"<p><strong>Background and aim: </strong>Remnant cholesterol (RC), an emerging cardiovascular risk factor, has garnered increasing attention in atherosclerotic cardiovascular disease (ASCVD) research, though its relationship with arterial stiffness remains incompletely understood. This study investigated the association between RC and estimated pulse wave velocity (ePWV), a reliable marker of arterial stiffness, with the goal of enhancing our understanding of RC's role in cardiovascular risk assessment.</p><p><strong>Methods and results: </strong>This study utilized the National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2018, including 12,505 participants aged 20 years and above. Weighted linear regression, restricted cubic splines (RCS), and subgroup analyses were used to explore the association between RC levels and ePWV. Analysis revealed a significant positive association between RC levels and ePWV, with participants in the highest RC quintile (Q5) exhibiting substantially elevated ePWV compared to those in the lowest quintile (Q1). Notably, RCS analysis demonstrated a non-linear relationship characterized by a saturation effect (p-nonlinear <0.05). Subgroup analyses indicated stronger associations among specific demographic groups, including individuals under 40 years, females, non-Hispanic whites, and those above the poverty level (all interaction p < 0.05). Furthermore, mediation analysis found that various inflammatory markers such as neutrophil count (NEU), neutrophil-to-lymphocyte ratio (NLR), and monocyte-to-lymphocyte ratio (MLR) played a mediating role in this association.</p><p><strong>Conclusion: </strong>Increased arterial stiffness is associated with higher RC levels, demonstrating a saturation effect at elevated concentrations. This association is partially mediated by NLR, MLR, and NEU, and was stronger among younger, females, non-Hispanic whites, and non-impoverished individuals.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104013"},"PeriodicalIF":3.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xingping Li, Wenqing Wang, Huanyu Liu, Ronghui Xia, Yang Lin, Guanghui Pan
{"title":"Causal relationship between serum 25-hydroxyvitamin D and coronary heart disease: A bi-directional two-sample Mendelian randomization study.","authors":"Xingping Li, Wenqing Wang, Huanyu Liu, Ronghui Xia, Yang Lin, Guanghui Pan","doi":"10.1016/j.numecd.2025.104020","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104020","url":null,"abstract":"<p><strong>Background and aim: </strong>Coronary heart disease (CHD) is the leading cause of severe cardiovascular events, such as acute myocardial infarction. This study investigates the interaction between serum 25-hydroxyvitamin D (25(OH)D) levels and CHD. However, most current studies are observational, which may introduce bias into the results.</p><p><strong>Methods and results: </strong>We conducted a two-way, two-sample Mendelian randomization study. The CHD sample was drawn from the 2021 population in the FinnGen database (cases: 21,012; controls: 197,780), while the serum 25(OH)D sample was obtained from the 2020 European population in the GWAS Catalog database (417,580 cases). Based on the inverse variance weighted (IVW) results, we found that the risk of CHD decreased with increasing serum 25(OH)D concentrations (P < 0.05), and that higher CHD risk was associated with lower serum 25(OH)D concentrations (P = 0.04).</p><p><strong>Conclusions: </strong>Our study found that increased serum 25(OH)D concentration may serve as a protective factor against CHD. Additionally, we found that CHD can be a risk factor that affects serum 25(OH)D concentrations in humans.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104020"},"PeriodicalIF":3.3,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Serum uric acid fluctuations and cardiovascular outcomes in hospitalized acute heart failure patients.","authors":"Guang-Zhi Liao, Jia-Yu Feng, Jing-Xi Wang, Ping Zhou, Chun-Hui He, Xiao-Feng Zhuang, Yan Huang, Qiong Zhou, Mei Zhai, Yu-Hui Zhang, Jian Zhang","doi":"10.1016/j.numecd.2025.104025","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104025","url":null,"abstract":"<p><strong>Background and aims: </strong>This study examined the association between serum uric acid (SUA) fluctuation patterns during hospitalization in acute heart failure (HF) patients and clinical outcomes, a relationship not fully understood.</p><p><strong>Methods and results: </strong>A cohort of 1403 acute HF patients was enrolled with a median follow-up of 20.5 months. Outcomes assessed included cardiovascular (CV) death and/or heart failure hospitalization (CV death & HHP), CV death alone, and all-cause mortality (ACM). Restricted cubic splines analyzed the relationship between admission SUA levels and outcomes. Patients were categorized based on admission and discharge SUA levels into four groups: 1) Normal SUA at both points (N&N), 2) Elevated SUA at admission, normalized at discharge (H&N), 3) Normal SUA at admission, elevated at discharge (N&H), and 4) Elevated SUA at both points (H&H). Associations between SUA categories and outcomes were assessed using COX multivariate regression analysis. Results showed elevated SUA at admission predicted poor outcomes. However, neither N&H nor H&N groups displayed significant increases in CV death & HHP, CV death, or ACM compared to N&N. The H&H group had the highest risks for CV death (adjusted HR 1.79, 95 % CI 1.10-2.93) and ACM (adjusted HR 1.64, 95 % CI 1.08-2.49), with a non-significant trend towards increased risk of CV death & HHP (adjusted HR 1.79, 95 % CI 0.99-2.93).</p><p><strong>Conclusion: </strong>Persistently elevated SUA levels during hospitalization were independently associated with adverse cardiovascular outcomes and ACM in patients with acute HF, whereas fluctuations in SUA levels did not exhibit a similar association.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104025"},"PeriodicalIF":3.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lipid profiles and their association with incident carotid atherosclerosis: A community-based prospective study in Taiwan.","authors":"Tzu-Wei Wu, Chao-Liang Chou, Chun-Chieh Liu, Chuen-Fei Chen, Chun-Fang Cheng, Li-Yu Wang","doi":"10.1016/j.numecd.2025.104023","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104023","url":null,"abstract":"<p><strong>Background and aims: </strong>Dyslipidemia, characterized by abnormal blood lipid levels, contributes to atherosclerosis, a condition involving arterial plaque buildup and cardiovascular events. While LDL-C and LDL-to-HDL-C ratios are established atherosclerosis predictors, the role of non-HDL-C is less explored.</p><p><strong>Methods and results: </strong>A cohort of 1062 participants without carotid plaque at baseline was analyzed over a 4.0-year follow-up. Age-specific incidence rates were calculated, and baseline characteristics of those who developed plaques were compared using logistic regression and area under the ROC curve (AUROC) analysis to evaluate predictive models. Carotid plaques developed in 284 participants (87 males, 197 females). Incidence rates increased with age, reaching 41.2 % in females and 60.0 % in males aged 70-74 years. Participants with plaques were older (58.2 vs. 55.4 years, p < 0.0001), had higher BMI, blood pressure, and lipid markers, and were more likely to be male, hypertensive, or hyperlipidemic. Logistic regression identified age (OR 1.26 per 5 years), BMI (OR 1.23 per 5 kg/m<sup>2</sup>), LDL-C (OR 1.07 per 10 mg/dL), and LDL-to-HDL-C ratio (OR 1.41) as significant predictors, with HDL-C offering a protective effect. Models incorporating lipid ratios (non-HDL-to-HDL-C or LDL-to-HDL-C) showed similar predictive power (AUROC 0.636).</p><p><strong>Conclusion: </strong>Carotid plaque progression correlates with age, male sex, elevated BMI, hypertension, and adverse lipid profiles. Lipid ratios and age are consistent predictors, with HDL-C demonstrating protective effects. Comparable AUROC values across models underscore the value of lipid ratios for assessing atherosclerosis risk.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104023"},"PeriodicalIF":3.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huizhen Jin, Zhuoshuai Liang, Xinmeng Hu, Xiaoyang Li, Zhantong Liu, Yichun Qiao, Yi Cheng, Hanxin Yao, Yawen Liu
{"title":"Comparative association of MAFLD/MASLD and Subtypes with Cardiovascular Diseases Outcomes.","authors":"Huizhen Jin, Zhuoshuai Liang, Xinmeng Hu, Xiaoyang Li, Zhantong Liu, Yichun Qiao, Yi Cheng, Hanxin Yao, Yawen Liu","doi":"10.1016/j.numecd.2025.104024","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104024","url":null,"abstract":"<p><strong>Background and aims: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) acts as an alternative for demarcating metabolic dysfunction-associated fatty liver disease (MAFLD). This study aimed to investigate the factors that significantly influence the relationship between MAFLD and MASLD in relation to the incidence of major cardiovascular outcomes.</p><p><strong>Methods and results: </strong>A total of 340,998 participants in the UK Biobank study were included. Multivariable Cox proportional hazards models were used to estimate the effect of MAFLD and MASLD on the outcomes of cardiovascular diseases (CVDs) (coronary artery disease, stroke, heart failure, and CVD-related death) with hazard ratios (HRs) and 95 % confidence intervals (CIs). A total of 126,077 (36.97 %) participants had MAFLD and 97,418 (28.57 %) had MASLD. Over a median follow-up of 13.5 years (interquartile range 12.6-14.2), there were 41,548 new events of CVDs recorded. MAFLD (HR = 1.52; 95 % CI: 1.49-1.55) and MASLD (HR = 1.42; 95 % CI: 1.39-1.45) were associated with high risks of CVDs. Among the subtypes of MAFLD and steatotic liver disease (SLD), MAFLD diabetes subtype (HR = 2.26; 95 % CI: 2.17-2.35) and alcohol-associated liver disease (ALD) (HR = 1.65; 95 % CI: 1.55-1.76) exhibited the highest risk of CVDs. MAFLD overweight without MD subtype were not associated with CVDs. The effect of MAFLD on the CVD outcomes was consistent regardless of the presence of MASLD.</p><p><strong>Conclusion: </strong>The metabolic health status and alcohol consumption function as more critical factors than obesity in assessing CVD outcomes in participants with MAFLD or MASLD.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104024"},"PeriodicalIF":3.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Moderate alcohol consumption does not necessarily equate to cardiovascular protection.","authors":"Stephan Peronard Mayntz, Kasper Emil Rosenbech","doi":"10.1016/j.numecd.2025.104022","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104022","url":null,"abstract":"","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104022"},"PeriodicalIF":3.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kristin Delaney, Michelle Tsang, Mark Kern, Vernon Uganiza Rayo, Nathaniel Jason, Mee Young Hong, Changqi Liu, Shirin Hooshmand
{"title":"Strawberries modestly improve cognition and cardiovascular health in older adults.","authors":"Kristin Delaney, Michelle Tsang, Mark Kern, Vernon Uganiza Rayo, Nathaniel Jason, Mee Young Hong, Changqi Liu, Shirin Hooshmand","doi":"10.1016/j.numecd.2025.104018","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104018","url":null,"abstract":"<p><strong>Background and aims: </strong>Strawberry consumption may aid in improving cognitive function and cardiovascular health given their nutrient composition and antioxidant capacities. We hypothesized that 2 cups of fresh strawberries per day provided as a freeze-dried strawberry powder (26 g/d) may improve cognitive performance and cardiovascular health relative to a control.</p><p><strong>Methods and results: </strong>Using a randomized, crossover, double-blind, placebo-controlled clinical trial, 35 healthy older adults (17 women, 18 men, age 72 ± 6 years, BMI 26.4 ± 3.9 kg/m<sup>2</sup>) consumed 26 g of freeze-dried strawberry powder (strawberry) and a control powder (control) daily for 8 weeks each with a 4-week washout period. Strawberry supplementation was expected to improve cardiometabolic health parameters, and cognitive performance measured with the National Institutes of Health Toolbox. Processing speed (p < 0.001) improved during the strawberry phase and episodic memory (p = 0.002) improved during the control phase. For cardiovascular measures, strawberry consumption reduced systolic blood pressure (p = 0.044) and a significant main effect of time for reduced waist circumference (p = 0.043) was detected. Serum triglycerides increased in the control group (p = 0.012) but not after consuming strawberries. Total antioxidant capacity significantly decreased during the control phase (p = 0.032) and significantly increased with strawberry consumption (p = 0.047).</p><p><strong>Conclusion: </strong>This study demonstrated that 26 g of freeze dried strawberries improve cognitive processing speed, lower systolic blood pressure, and increase antioxidant capacity, potentially promoting cognitive function and improving cardiovascular risk factors in cognitively healthy individuals.</p><p><strong>Clinical trial registry: </strong>NCT04786665.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104018"},"PeriodicalIF":3.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to the letter on the article: Effect of moderate alcohol intake on blood apolipoproteins concentrations: A meta-analysis of human intervention studies.","authors":"Anila Khatiwada, Anju Rawal, Gabriele Berg-Beckhoff, Trine Levring Wilkens","doi":"10.1016/j.numecd.2025.104021","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104021","url":null,"abstract":"","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104021"},"PeriodicalIF":3.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}