Nutrition Metabolism and Cardiovascular Diseases最新文献

{"title":"Elevated serum parathyroid hormone predicts metabolic dysfunction-associated steatotic liver disease (MASLD) and progressive fibrosis.","authors":"Chao Yan, Shaojie Han, Qi Chen, Jinzheng He, Tongxu Wang, Xinxin Shen, Xiaobing Gong","doi":"10.1016/j.numecd.2025.104208","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104208","url":null,"abstract":"<p><strong>Background and aim: </strong>Insufficient researches have been conducted on the correlation between serum parathyroid hormone (PTH) levels and metabolic dysfunction-associated steatotic liver disease (MASLD), as well as the risk for advanced fibrosis. The objective of this research was to investigate the potential association between serum PTH and both MASLD and progressive fibrosis.</p><p><strong>Methods and results: </strong>A cross-sectional study utilized the datasets obtained from the National Health and Nutrition Examination Survey (NHANES) spanning the years 2003-2006 (n = 1318). The reason we chose data from this time period is that the NHANES database only contains parathyroid hormone indicators for these two survey cycles. MASLD was defined with two noninvasive indexes, namely hepatic steatosis index (HSI) and fatty liver index (FLI), corresponding to MASLD _HSI and MASLD _FLI respectively. Advanced fibrosis was evaluated with MASLD fibrosis score (MFS). We investigated the independent interaction between serum PTH and MASLD or advanced fibrosis using weighted multivariable logistic regression analysis, restricted cubic spline models, subgroup analysis and mediation analysis. Multivariable logistic regression showed that adults in the medium and high serum PTH tertiles were associated with increased values of MASLD-related indices (such as FLI, HSI and MFS) [(MASLD _HSI: OR [95 % CI], 3.16 [1.83, 5.47] and 3.97 [2.13, 7.39]; MASLD _FLI: OR [95 % CI], 2.87 [1.63, 5.06] and 4.12 [2.20, 7.74]; MFS: OR [95 % CI], 2.55 [1.14, 5.69] and 2.20 [1.11, 4.36])]. Subgroup analysis showed that these associations were more evident in subjects at middle-age, hypertension and without physical exertion (MASLD _HSI: only middle-age; MASLD _FLI: middle-age and hypertension; MFS: without physical activity; all P < 0.05). Furthermore, mediation analysis revealed that BMI and HOMA-IR mediated the link between serum PTH and MASLD (defined by HSI and FLI) or advanced fibrosis (MFS) in adults.</p><p><strong>Conclusions: </strong>In the U.S. general population, elevated PTH level is strongly associated with MASLD or advanced fibrosis and can serve as a reliable indicator in both diseases. Therefore, a high serum PTH level may predispose people to MASLD or advanced fibrosis morbidity.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104208"},"PeriodicalIF":3.3,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144620951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardioprotective effects of daidzein: Exploring the role of the NRG-1/Akt pathway in a rat model of isoproterenol-induced myocardial infarction.","authors":"Işık Tekin, Gulsah Gundogdu, Ozgen Kilic-Erkek, Ipek Buber, Hasan Akca, Yalın Tolga Yaylali, Gulcin Abban-Mete","doi":"10.1016/j.numecd.2025.104204","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104204","url":null,"abstract":"<p><strong>Background and aims: </strong>This study aimed to evaluate the cardioprotective effects of daidzein, an antioxidant and anti-inflammatory compound, focusing on its impact on the NRG-1/Akt signaling pathway in a rat model of isoproterenol (ISO)-induced myocardial infarction (MI).</p><p><strong>Methods and results: </strong>Twenty-eight male Sprague Dawley rats were divided into four groups: Control, MI, MI + DMSO, and MI + Daidzein. MI was induced with ISO (85 mg/kg) subcutaneously twice with a 24-h intervals. Daidzein was administered intraperitoneally (10 mg/kg) daily for seven days post-MI. Serum troponin were measured 24 h after MI to confirm injury. Cardiac tissues were analyzed for total antioxidant status (TAS), total oxidant status (TOS), Neuregulin-1 (NRG-1), erythroblastic leukemia viral oncogene homolog 2 (ErbB2), and Protein Kinase B (Akt) levels using ELISA. Histopathological and immunohistochemical evaluations were conducted. TOS and oxidative stablity index (OSI) levels were significantly higher in the MI group compared to the Control (P < 0.05), but daidzein treatment significantly reduced these levels (P = 0.014, P = 0.036). NRG-1 and ErbB2 levels were decreased in the MI group compared to Control (P = 0.029, P = 0.001) but restored by daidzein (P = 0.026, P = 0.01). Immunohistochemistry showed increased NRG-1 and ErbB2 in cardiac tissue following daidzein treatment, and histopathology confirmed reduced inflammation, damage, and fibrosis (P < 0.05).</p><p><strong>Conclusion: </strong>Daidzein demonstrated cardioprotective effects by reducing oxidative stress and improving molecular and structural cardiac parameters post-MI, likely through activation of the NRG-1/Akt pathway. Further research is needed to explore its therapeutic potential in cardiovascular disease.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104204"},"PeriodicalIF":3.3,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144620949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired sensitivity to thyroid hormone was associated with increased continuous metabolic syndrome score.","authors":"Zongbao Li, Fan Hu, Han Yu, Yao Yao, Yanhui Lu","doi":"10.1016/j.numecd.2025.104203","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104203","url":null,"abstract":"<p><strong>Background and aim: </strong>The relationship between thyroid hormone sensitivity and overall metabolic risk remains unclear.</p><p><strong>Methods and results: </strong>Using National Health and Nutrition Examination Survey (NHANES) 2007-2012 data, we validated the continuous metabolic syndrome (MetS) severity score model and calculated MetS scores. Weighted linear regression assessed associations between thyroid sensitivity indices and MetS scores. Restricted cubic splines (RCS) examined nonlinearity in sensitivity analyses and age-stratified analyses evaluated association stability across groups. Thyroid hormone sensitivity was significantly associated with the severity score of persistent metabolic syndrome (MetS). Compared with the first quartile, the MetS score in the fourth quartile of each sensitivity indicator was markedly increased: free triiodothyronine/free thyroxine ratio (FT3/FT4: β = 0.15, P = 0.01), thyroid stimulating hormone T4 resistance index (TT4RI: β = 0.15, P < 0.01), thyroid stimulating hormone index (TSHI: β = 0.15, P < 0.01), thyroid feedback quantile index based on FT4 and FT3 (TFQI_FT4: β = 0.11, P = 0.04; TFQI_FT3: β = 0.27, P < 0.001). Subgroup analysis by age demonstrated a stable association among participants aged under 50 years. In the 50-69 years age group, only TFQI_FT3 exhibited a significant trend (P = 0.02), whereas no significant association was observed among subjects aged ≥70 years. Among all thyroid sensitivity indices examined, only TT4RI exhibited a statistically significant nonlinear association with the MetS score.</p><p><strong>Conclusion: </strong>Thyroid hormone sensitivity indices, particularly the TFQI_FT3, provide a straightforward tool for assessing metabolic disorder severity in individuals under 70 years, facilitating early identification and intervention of metabolic dysregulation in this population.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104203"},"PeriodicalIF":3.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quick fixes, lasting problems: Rethinking obesity management through a public health lens beyond pharmacological solutions.","authors":"Sarah Cuschieri, Andrea Cuschieri, Shehzad Ali, Saverio Stranges","doi":"10.1016/j.numecd.2025.104205","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104205","url":null,"abstract":"<p><strong>Aim: </strong>This viewpoint aims to critically examine the growing reliance on pharmacological treatments for obesity and highlight the limitations of such an approach.</p><p><strong>Data synthesis: </strong>Literature from reputable databases and public health registries were sought and used to formulate an evidence-based viewpoint, critically synthesizing current research on obesity pharmacotherapy and its implications within a broader socio-environmental context.</p><p><strong>Conclusions: </strong>In response to the obesity epidemic, pharmacological treatments have gained significant attention for their ability to produce substantial weight loss in the short-term. However, the increasing reliance on these medication risks narrowing the understanding, prevention and management of obesity to a purely clinical issue, overlooking its deeper individual-level and societal causes. While pharmacological interventions may offer short-term benefits, they do not address the root causes of obesity, such as the socio-environmental drivers influencing food choices with over-reliance on high-calorie and processed foods, sedentary lifestyles, and socio-economic disparities. Additionally, the high cost of these treatments exacerbates health inequities, limiting access for vulnerable populations. Obesity must be approached as a complex, multifaceted condition, requiring multisectoral approaches as well as integrated care models that combine pharmacological treatments with behavioural interventions, lifestyle modifications, and systemic policy changes. Population-wide strategies are crucial for long-term prevention. This viewpoint argues for comprehensive, multisectoral approaches to obesity prevention and management that moves beyond pharmacological solutions to address the broader socio-environmental factors contributing to the obesity epidemic. Only through systemic changes can we expect to improve public health outcomes and reduce the global burden of obesity.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104205"},"PeriodicalIF":3.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity trajectories and incidence of cardiovascular risk factors: a prospective study.","authors":"Nour Naoum, Pedro Marques-Vidal","doi":"10.1016/j.numecd.2025.104201","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104201","url":null,"abstract":"<p><strong>Background and aims: </strong>Physical activity (PA) is a protective factor against cardiovascular disease (CVD), but the association between changes in PA and CVD are less studied. We assessed the effect of PA on CVD risk factors.</p><p><strong>Methods and results: </strong>Data from the CoLaus|PsyCoLaus study, a prospective, population-based study in Lausanne, Switzerland, for periods 2009-2012 and 2014-2017 (subjective PA) and 2014-2017 and 2018-2021 (objective PA). Subjective and objective PA trajectories were assessed by questionnaire and wrist-worn triaxial accelerometer, respectively. Two different software (GENEActive and GGIR) assessed objective PA from raw accelerometry data. 1856 participants (53.2 % women, 55.8 ± 9.4 years) had subjective PA trajectories. Participants who became sedentary lost more weight, while no association was found between PA trajectories and changes in blood pressure (BP) or diabetes markers. 1446 participants (51.9 % women, 61.4 ± 9.4 years) had objective PA trajectories assessed by GENEActive, and 1447 participants (51.5 % women, 61.6 ± 9.4 years) had objective PA trajectories assessed by GGIR. For both software, a lower BMI and a lower likelihood or presenting with hypertension was found among participants who improved or who maintained a high PA level, while no association was found between PA trajectories and changes in BP or diabetes markers.</p><p><strong>Conclusions: </strong>in this population-based study, participants who increased or maintained a high PA level had lower BMI increase than participants who decreased their PA or remained in the lower PA level. No association was found between PA trajectories and changes in BP or glucose markers.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104201"},"PeriodicalIF":3.3,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Widespread lipoprotein alterations in a REDUCE-IT like population: The icosapent ethyl (IPE)-NMR avatar study.","authors":"Lluís Masana, Pol Torné, Xavier Garcia-Moll, Ernesto Dalli, Núria Amigó","doi":"10.1016/j.numecd.2025.104199","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104199","url":null,"abstract":"<p><strong>Background and aim: </strong>Triglycerides (TG) are independent cardiovascular risk markers, yet TG-lowering therapies have failed to reduce major adverse cardiovascular events. However, high-dose icosapent ethyl (IPE) significantly reduces cardiovascular events in high-risk patients with controlled low-density lipoprotein cholesterol (LDL-C) and TG > 1.7 mmol/L. Elevated TG levels contribute to widespread lipoprotein metabolism disruptions, which remain undetectable by standard lipid measures but can be characterized using proton nuclear magnetic resonance (¹H NMR) spectroscopy. This study retrospectively analyses lipoprotein alterations in secondary prevention patients with characteristics similar to those in REDUCE-IT, using ¹H NMR spectroscopy (Liposcale® test).</p><p><strong>Methods and results: </strong>Patients from our institutional databases who had undergone advanced lipoprotein and glycoprotein profiling by ¹H NMR spectroscopy were included. Criteria required a history of major cardiovascular events, lipid-lowering therapy, LDL-C between 1.04 and 2.6 mmol/L, and TG 1.7-5.7 mmol/L. Lipoprotein particle number, size, and composition and glycoproteins A and B were analysed by nuclear magnetic resonance (NMR). A total of 100 patients (25 % female, mean age 63 years, 39 % with diabetes) were selected. The Liposcale test identified significant lipoprotein disturbances, including increased atherogenic small TG-rich remnant lipoproteins and small LDL particles, as well as elevated remnant cholesterol and TG enrichment in high-density lipoprotein. These abnormalities were associated to increasing TG concentrations. The results were visualized through lipid silhouette analysis.</p><p><strong>Conclusion: </strong>In secondary prevention patients resembling the REDUCE-IT cohort, ¹H NMR profiling revealed extensive proatherogenic lipoprotein alterations associated to increasing TG concentrations. Further research is underway to assess whether IPE mitigates these disturbances beyond its TG-lowering effects.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104199"},"PeriodicalIF":3.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the Mediterranean diet supplemented with olive oil versus the Mediterranean diet supplemented with mixed nuts on blood pressure and serum lipid indexes among adults: a systematic review and meta-analysis of randomized controlled trials.","authors":"Behnaz Pourrajab, Artemiss Mirdar Harijani, Parastoo Asghari, Farzad Shidfar","doi":"10.1016/j.numecd.2025.104166","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104166","url":null,"abstract":"<p><strong>Background and aim: </strong>Hypertension and dyslipidemia are major risk factors for cardiovascular disease (CVD). This systematic review and meta-analysis compared the effects of two Mediterranean (MED) dietary patterns-one supplemented with olive oil and the other with mixed nuts-on blood pressure and lipid profile.</p><p><strong>Methods and results: </strong>Relevant studies published until April 24, 2024, were thoroughly searched in online databases, including PubMed/Medline, Scopus, Clarivate Analytics' Web of Science, Cochrane Central Register of Controlled Trials, and Google Scholar. The analysis included 21 trials with 25 effect sizes, calculated as standardized mean differences with 95 % confidence intervals (CI). The findings indicated that the MED diet supplemented with olive oil has no significant effect on lipid indices and diastolic blood pressure (DBP) when contrasted with the MED diet supplemented with mixed nuts. However, the olive oil group had slightly higher systolic blood pressure levels than the mixed nuts group, with a significant p-value of <0.001.</p><p><strong>Conclusions: </strong>Evidence indicates no significant difference in serum lipid profile and DBP between the MED diet supplemented with olive oil and that with mixed nuts in participants at risk of CVD. However, mixed nuts significantly reduce SBP compared to olive oil. More studies on diverse populations are needed.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104166"},"PeriodicalIF":3.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144620950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential of plant sterols-enriched soy milk for blood pressure management in metabolic syndrome: Comment on Xu et al.","authors":"Juanyu Lin, Kaiyuan Cen","doi":"10.1016/j.numecd.2025.104200","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104200","url":null,"abstract":"","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104200"},"PeriodicalIF":3.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salt sensitivity of blood pressure. From renal mechanisms to immune and inflammatory pathways.","authors":"Carmine Zoccali, Francesca Mallamaci, Lanfranco D'Elia, Ferruccio Galletti, Pasquale Strazzullo","doi":"10.1016/j.numecd.2025.104194","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104194","url":null,"abstract":"<p><strong>Aims: </strong>The variability in blood pressure response to dietary salt intake, salt sensitivity (SS), is an important factor in cardiovascular health. This narrative review aims to provide an update on the mechanisms underlying SS, including impaired renal sodium handling and endothelial dysfunction, and discuss its prognostic implications for hypertension and cardiovascular risk.</p><p><strong>Data synthesis: </strong>The classic Guyton theory attributes SS to impaired renal sodium handling, leading to volume expansion and increased blood pressure. The vascular dysfunction theory emphasizes endothelial dysfunction, where impaired vasodilation elevates blood pressure. Inflammation significantly impacts SS, with pro-inflammatory cytokines exacerbating vascular and renal damage. Gene variants affecting sodium handling and blood pressure regulation interact with environmental factors to shape the SS phenotype. SS predicts future hypertension risk in normotensive men with varying salt sensitivity levels. In a study of sixty-two SS and ninety-four salt-resistant (SR) hypertensive patients, SS emerged as an independent cardiovascular risk factor. A long-term follow-up involving 278 hypertensive and 430 normotensive individuals linked SS to increased mortality risk. However, evidence supporting SS as an independent prognostic factor remains weak, primarily based on two studies with limited participants. Residual confounding complicates results interpretation.</p><p><strong>Conclusions: </strong>The World Health Organization recommends public health policies of salt intake reduction. Salt intake reduction is safe and cost-effective when implemented as part of a population strategy of primary prevention. Studying genetic, inflammatory, and lifestyle factors implicated in SS remains a clinical research priority for personalizing management strategies aimed at preventing cardiovascular disease.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104194"},"PeriodicalIF":3.3,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between metabolic health and obesity status and blood pressure phenotypes in patients receiving single-pill combination treatment.","authors":"Runyu Ye, Xin Zhang, Zhipeng Zhang, Xiangyu Yang, Lu Liu, Shanshan Jia, Xianghao Zuo, Xiaoping Chen","doi":"10.1016/j.numecd.2025.104195","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104195","url":null,"abstract":"<p><strong>Background and aims: </strong>Metabolic status and obesity are considered to be related to the risk of hypertension. However, whether metabolic health and obesity status affect blood pressure (BP) control remains unknown. This study aimed to explore the prevalence of BP phenotypes in patients receiving single-pill combination (SPC) treatment and the associations of metabolic health and obesity status with BP phenotypes.</p><p><strong>Methods and results: </strong>Overall, 685 untreated patients completed the 4-week follow-up in this prospective study. Participants were divided into four groups according to their metabolic health and obesity status. The prevalence of white-coat uncontrolled hypertension, controlled hypertension, masked uncontrolled hypertension (MUCH), sustained uncontrolled hypertension (SUCH) and uncontrolled morning hypertension (UMH) was 2.6 %, 23.0 %, 44.3 %, 30.1 % and 51.1 %, respectively. The metabolically unhealthy overweight/obesity (MUO) group had the highest prevalence of SUCH and UMH, and the highest 24-h, daytime, nighttime, and morning systolic and diastolic BP. In the multivariate logistic analysis, compared with the metabolically healthy normal weight (MHNW) phenotype, the MUO phenotype was associated with increased risks of SUCH (odds ratio (OR) = 2.601, 95 % confidence interval (CI): 1.109-6.099) and UMH (OR = 2.689, 95 % CI: 1.504-4.809). The metabolically healthy overweight/obesity (MHO) phenotype had an increased risk of UMH (OR = 2.277, 95 % CI: 1.014-5.111).</p><p><strong>Conclusion: </strong>The prevalence of MUCH, SUCH and UMH was high among patients receiving SPC treatment. MHO and MUO individuals are at increased risk for uncontrolled hypertension. Therefore, metabolic health and obesity status should be taken into consideration, and the use of ABPM should be applied to intensify treatment when managing hypertension.</p><p><strong>Registration number: </strong>ChiCTR2200059719.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104195"},"PeriodicalIF":3.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}