Nutrition Metabolism and Cardiovascular Diseases最新文献_第10页

Effect of moderate alcohol intake on blood apolipoproteins concentrations: A meta-analysis of human intervention studies.

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-01-03 DOI: 10.1016/j.numecd.2025.103854

Anila Khatiwada, Sine Højlund Christensen, Anju Rawal, Lars Ove Dragsted, Gabriele Berg-Beckhoff, Trine Levring Wilkens

{"title":"Effect of moderate alcohol intake on blood apolipoproteins concentrations: A meta-analysis of human intervention studies.","authors":"Anila Khatiwada, Sine Højlund Christensen, Anju Rawal, Lars Ove Dragsted, Gabriele Berg-Beckhoff, Trine Levring Wilkens","doi":"10.1016/j.numecd.2025.103854","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.103854","url":null,"abstract":"<p><strong>Aims: </strong>This study assessed the effect of alcohol intake (up to 40 g/d) on blood apolipoproteins (APOs) concentration in human intervention studies. Additionally, it evaluates whether the effect of alcohol intake on APOs differs depending on sex.</p><p><strong>Data synthesis: </strong>The literature search was performed in PubMed, Cochrane, Embase, and Web of Science databases. The Cochrane risk of bias tool was applied. A total of 5559 articles were identified, yielding 80 articles for full-text screening. Twenty-five articles were included for data extraction. Compared to no alcohol intake, alcohol intake up to a dose of 40 g/d showed an increase in Apolipoprotein A-I levels (ApoA-I) [mean difference (MD): 7.77 mg/dl, 95 % confidence interval (CI): 4.95 mg/dl, 10.59 mg/dl] and Apolipoprotein A-II levels (ApoA-II) [MD: 1.61 mg/dl, 95 % CI: 0.33 mg/dl, 2.90 mg/dl], but no significant change in Apolipoprotein B levels (ApoB) [MD: -0.06 mg/dl, 95 % CI: -3.38 mg/dl, 3.27 mg/dl]. Males showed a significant increase, while females showed a non-significant increase in ApoA-I levels [MD: 9.70 mg/dl, 95 % CI: 6.16 mg/dl, 13.28 mg/dl vs MD: 7.31 mg/dl, 95 % CI: -0.67 mg/dl, 15.30 mg/dl]. The results had less certainty as most studies were at high risk of bias.</p><p><strong>Conclusion: </strong>Alcohol consumption up to 40 g/d increases ApoA-I and ApoA-II levels. Further research is required for ApoB. Considerations should be given when applying this research to practice. High-quality clinical trials with large sample sizes and longer intervention periods are required, focusing on including female participants. PROSPERO IDCRD42021283256.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"103854"},"PeriodicalIF":3.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Stroke Burden in China and Its Long-Term Trends: Insights from the Global Burden of Disease (GBD) Study 1990-2021.

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-01-03 DOI: 10.1016/j.numecd.2025.103848

Chenyang Ji, Xiaolei Ge, Jiale Zhang, Hongxuan Tong

{"title":"The Stroke Burden in China and Its Long-Term Trends: Insights from the Global Burden of Disease (GBD) Study 1990-2021.","authors":"Chenyang Ji, Xiaolei Ge, Jiale Zhang, Hongxuan Tong","doi":"10.1016/j.numecd.2025.103848","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.103848","url":null,"abstract":"<p><strong>Background and aim: </strong>To explore effective preventive strategies for stroke, it is of paramount importance to systematically assess its risk factors. Leveraging the Global Burden of Disease (GBD) data, this study aims to retrospectively analyze the long-term trends and epidemiological characteristics of stroke in China.</p><p><strong>Methods and results: </strong>Drawing on the GBD 2021 data, this study conducted a comprehensive analysis of the burden of stroke in the Chinese population, encompassing prevalence, incidence, mortality, years of life lost (YLL), years lived with disability (YLDs), and disability-adjusted life years (DALYs). Subsequently, we examined the temporal trends of these indicators and employed a Joinpoint regression analysis coupled with an age-period-cohort (APC) model to precisely dissect mortality and incidence patterns. Furthermore, we delved into the attributable burden of stroke. The results indicated that the prevalence of stroke in China reached 26 million in 2021, representing a 104.26 % increase since 1990. Compared to 1990, the number of DALYs attributable to stroke increased by 45.25 %. Joinpoint analysis revealed a declining trend in incidence rates, while mortality rates showed a significant reduction. The APC model fitting outcomes suggested that prevalence rates were higher in recent generations than in the past, with an increase observed within the same age cohort. Notably, in 2019, the primary burden of cardiovascular diseases (CVDs) stemmed from metabolic risks, particularly hypertension, followed by air pollution particulate matter as an environmental risk factor.</p><p><strong>Conclusions: </strong>Given China's vast population base and rapid aging process, the burden of stroke has emerged as a significant public health concern.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"103848"},"PeriodicalIF":3.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between serum uric acid and metabolic syndrome and its components: A decade follow-up in the tehran lipid and glucose study.

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-01-03 DOI: 10.1016/j.numecd.2025.103847

Ameneh Ahmadi, Farzad Esmaeili, Mitra Hasheminia, Parto Hadaegh, Farzad Hadaegh, Fereidoun Azizi, Maryam Tohidi

{"title":"The association between serum uric acid and metabolic syndrome and its components: A decade follow-up in the tehran lipid and glucose study.","authors":"Ameneh Ahmadi, Farzad Esmaeili, Mitra Hasheminia, Parto Hadaegh, Farzad Hadaegh, Fereidoun Azizi, Maryam Tohidi","doi":"10.1016/j.numecd.2025.103847","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.103847","url":null,"abstract":"<p><strong>Background and aims: </strong>Prospective studies found associations between serum uric acid (SUA) and incident metabolic syndrome (MetS) with high heterogeneity. We investigated the association between SUA and incident MetS and its components in a region highly burdened by cardiometabolic disorders.</p><p><strong>Methods and results: </strong>The study included 1999 adults (1297 women). MetS was defined according to the Joint Interim Societies' criteria. Multivariate adjusted Cox proportional hazard analyses were applied to examine the association between SUA and outcomes. During a median follow-up of 9.7 years, 833 (510 women) incident MetS cases occurred. Among the whole population, a higher risk of MetS was observed across quartiles (Q1-4) of SUA even after adjustment for Homeostasis Model Assessment for Insulin Resistance (HOMA-IR), [multivariate hazard ratio (95 % confidence interval) in Q4: 1.58 (1.17-2.14), Q1: as reference]. Generally, same association was found for women. Similarly, a 1-standard deviation (SD) increase of SUA was associated with a higher risk of incident MetS in the whole population, and women [1.19 (1.06-1.34) and 1.14 (1.02-1.28), respectively]. Among men, the association was just in the age-adjusted analysis, however, no effect modification of gender was found. Moreover, a 1-SD increase in SUA elevated the risk of incident high-waist circumference (20 %), -fasting plasma glucose (19 %), -triglycerides (17 %), and low-high-density lipoprotein cholesterol (12 %) after adjustment for other MetS components and HOMA-IR in the whole population (all Ps < 0.05).</p><p><strong>Conclusion: </strong>SUA was associated with incident MetS and its components, excluding hypertension, and might be a potential biomarker for identifying individuals at risk of developing MetS.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"103847"},"PeriodicalIF":3.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of egg consumption on health outcomes: An updated umbrella review of systematic reviews and meta-analysis of observational and intervention studies.

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-01-03 DOI: 10.1016/j.numecd.2025.103849

Elena Formisano, Lenycia de Cassya Lopes Neri, Irene Caffa, Consuelo Borgarelli, Maria Regina Ferrando, Elisa Proietti, Federica Turrini, Daniela Martini, Donato Angelino, Anna Tagliabue, Livia Pisciotta

{"title":"Effect of egg consumption on health outcomes: An updated umbrella review of systematic reviews and meta-analysis of observational and intervention studies.","authors":"Elena Formisano, Lenycia de Cassya Lopes Neri, Irene Caffa, Consuelo Borgarelli, Maria Regina Ferrando, Elisa Proietti, Federica Turrini, Daniela Martini, Donato Angelino, Anna Tagliabue, Livia Pisciotta","doi":"10.1016/j.numecd.2025.103849","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.103849","url":null,"abstract":"<p><strong>Aims: </strong>To evaluate the effect of egg consumption on health outcomes.</p><p><strong>Data synthesis: </strong>A systematic search in PubMed, Scopus, Lilacs, and Web of Science was developed using terms (\"egg consumption\" or \"egg intake\") and (\"health\" or \"chronic diseases\" or \"diabetes\" or \"cancer\" or \"cholesterol\" or \"dyslipidemia\"), and meta-analyses of observational or interventional studies published since January 2020 were included. The studies' quality was evaluated through AMSTAR-2 and NutriGrade, and the strength of evidence according to sample size, heterogeneity, and quality of articles. Fourteen meta-analyses were included (10 observational, 4 interventional studies). The wide range of outcomes, with substantial variability and high heterogeneity, indicated a lack of robust evidence. The overall quality of studies was critically low. The level of evidence was very weak for all the significant associations: risk of heart failure (RR 1.15; 95%CI: 1.02-1.30), cancer mortality (RR 1.13; 95%CI 1.06-1.20), higher levels of LDL cholesterol (WMD 7.39; 95%CI 5.82-8.95), total cholesterol (WMD 9.12; 95%CI 7.35-10.89), and apolipoprotein B-100 (WMD 0.06; 95%CI 0.03-0.08). Conversely, egg intake has been weakly associated with improvements in HDL cholesterol (WMD 1.37; 95%CI 0.49-2.25), apolipoprotein A1 (WMD 0.03; 95%CI 0.01-0.05), and growth parameters in children (WMD 0.47; 95%CI 0.13-0.80). No evidence of association was found among all cardiovascular outcomes and all-cause mortality risk between high vs. low egg consumption.</p><p><strong>Conclusion: </strong>Due to the critically low strength of studies, insufficient evidence is available to discourage egg consumption, suggesting eggs can be part of a healthy diet.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"103849"},"PeriodicalIF":3.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of coffee consumption on mortality in patients with cardiovascular and cerebrovascular diseases: A cohort study.

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-01-03 DOI: 10.1016/j.numecd.2025.103855

Huining Zhou, Jie Li, Chun Zhang, Yating Huang, Hua Jiang, Liang Chen

{"title":"Impact of coffee consumption on mortality in patients with cardiovascular and cerebrovascular diseases: A cohort study.","authors":"Huining Zhou, Jie Li, Chun Zhang, Yating Huang, Hua Jiang, Liang Chen","doi":"10.1016/j.numecd.2025.103855","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.103855","url":null,"abstract":"<p><strong>Background and aims: </strong>Regarding the effects of coffee intake on the prognosis of the general population and people with cardiovascular and cerebrovascular diseases (CVD), previous studies have shown inconsistent conclusions in different populations. There is no study on the association between coffee intake and the prognosis of American adults and specific disease groups.</p><p><strong>Methods and results: </strong>The influence of coffee intake on 5-year all-cause mortality was investigated by multivariate COX regression and Kaplan‒Meier curves. Subgroup analysis were used to verify whether the results were consistent across patients with different diseases. A competitive risk model was used to explore the correlation between coffee intake and CVD related death. After fully adjusting for confounders, the results suggested that coffee consumption was correlated with a 25 % lower risk of death compared with never drinking coffee (HR = 0.75, 95 % CI: 0.59-0.96, P = 0.022). Coffee intake was found to be protective against 5-year mortality (HR less than 1.0) regardless of whether participants had common chronic diseases. Drinking 1-3 cups of coffee per day was associated with a 35 % lower risk of CVD related death (HR = 0.65, 95 % CI: 0.43-0.98; P = 0.042).</p><p><strong>Conclusion: </strong>The coffee consumption of 1-3 cups per day was correlated with a significantly reduced 5-year all-cause mortality and CVD related death in U.S. adults, especially those with combined hypertension, heart disease, and stroke. This study analyzed the beneficial effects of coffee on the general population and patients with CVD, and provided dietary recommendations.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"103855"},"PeriodicalIF":3.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A stratified study of human blood metabolites and coronary artery diseases—A Mendelian randomization study 人体血液代谢物与冠状动脉疾病的分层研究--孟德尔随机研究。

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-01-01 DOI: 10.1016/j.numecd.2024.09.024

Mengling Peng, Yu Fu, Cong Qin, Lei Shi, Meiwei Zhang, Shanshan Zhou

{"title":"A stratified study of human blood metabolites and coronary artery diseases—A Mendelian randomization study","authors":"Mengling Peng, Yu Fu, Cong Qin, Lei Shi, Meiwei Zhang, Shanshan Zhou","doi":"10.1016/j.numecd.2024.09.024","DOIUrl":"10.1016/j.numecd.2024.09.024","url":null,"abstract":"<div><h3>Background and aims</h3><div>Metabolic dysregulation is closely associated with coronary artery diseases (CAD). Exploring the relationship between metabolites and CAD is helpful in identifying changes in energy metabolism during disease progression.</div></div><div><h3>Methods and results</h3><div>We use Mendelian Randomization (MR) analysis to assess the relationships between 275 serum metabolites and CAD such as angina pectoris, post-myocardial infarction complications, coronary atherosclerosis, myocardial infarction (MI), and unstable angina pectoris (UA). The inverse variance-weighted method (IVW) served as the primary approach for causal analysis, with MR-Egger and weighted median (WM) as supplementary methods. Sensitivity analyses were conducted to assess heterogeneity and multiple effects. We also analyzed potentially related metabolic pathways.We identified causal relationships between 42 known metabolites and CAD. Among them, the genetic susceptibility to elevated levels of amino acid Isobutyrylcarnitine is associated with an increased risk of coronary artery atherosclerosis; but it provides protection against the development of MI. Genetic susceptibility to elevated levels of fatty acids Stearate, Caprylate is associated with higher risk of angina pectoris, while Threonate has a protective effect in the development of angina; Stearate is associated with an increased risk of UA, whereas higher levels of the lipids Choline, 1−arachidonoylglycerophosphoinositol∗, Hexadecanedioate, Tetradecanedioate play a protective role in UA.Metabolic pathway analysis identified 6 pathways that may be associated with CAD.</div></div><div><h3>Conclusion</h3><div>We identified causal relationships between 42 serum metabolites and CAD. Specifically, changes in metabolites such as Isobutyrylcarnitine, Caprylate, and Stearate were associated with risks of CAD. These findings provide new insights into the metabolic mechanisms of CAD.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 1","pages":"Article 103754"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between estimated glucose disposal rate and subclinical coronary atherosclerosis 估计葡萄糖排出率与亚临床冠状动脉粥样硬化之间的关系

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-01-01 DOI: 10.1016/j.numecd.2024.07.004

Myung Jin Kim , Yun Kyung Cho , Eun Hee Kim , Min Jung Lee , Woo Je Lee , Hong-Kyu Kim , Chang Hee Jung

{"title":"Association between estimated glucose disposal rate and subclinical coronary atherosclerosis","authors":"Myung Jin Kim , Yun Kyung Cho , Eun Hee Kim , Min Jung Lee , Woo Je Lee , Hong-Kyu Kim , Chang Hee Jung","doi":"10.1016/j.numecd.2024.07.004","DOIUrl":"10.1016/j.numecd.2024.07.004","url":null,"abstract":"<div><h3>Background and aims</h3><div>The estimated glucose disposal rate (eGDR) is an easily accessible clinical parameter for assessing insulin resistance in patients with diabetes mellitus. In this study, we aimed to investigate the link between eGDR and subclinical coronary atherosclerosis in an asymptomatic middle-aged Korean population.</div></div><div><h3>Methods and results</h3><div>This study involved 4004 subjects who underwent routine health checkups with coronary multidetector computed tomography (MDCT) at Asan Medical Center from 2007 to 2011, among whom 913 had a follow-up analysis through 2014. The eGDR was calculated using: 21.16 − (0.09 ∗ waist circumference [cm]) − (3.41 ∗ hypertension) − (0.55 ∗ glycated hemoglobin [%]). Patients were categorized into three groups according to the tertiles of eGDR. Subclinical coronary atherosclerosis was defined by significant coronary stenosis (≥50%), presence of plaques, coronary artery calcification (CAC) score, and its progression. As a result, a lower eGDR level was associated with higher prevalence of significant coronary stenosis, plaques, moderate to severe CAC, and CAC progression. Compared to other markers or risk scores, eGDR was superior to other biomarkers of insulin resistance but did not provide additional information beyond classic cardiovascular risk models like the Framingham Risk Score and Pooled Cohort Equations.</div></div><div><h3>Conclusion</h3><div>Decreased eGDR values were significantly associated with higher subclinical coronary atherosclerosis burdens in an asymptomatic middle-aged Korean population. However, its clinical implications remain uncertain due to its weaker performance compared to established cardiovascular risk models.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 1","pages":"Article 103686"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141689547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of calorie restriction therapy on health-related outcomes in patients with heart failure, a systematic review and meta-analysis 热量限制疗法对心力衰竭患者健康相关结果的影响，系统回顾和荟萃分析。

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-01-01 DOI: 10.1016/j.numecd.2024.09.026

Ming Cheng , Chenya Zhu , Huan Liu , Chenxi Pu , Yunying Hou

{"title":"Effects of calorie restriction therapy on health-related outcomes in patients with heart failure, a systematic review and meta-analysis","authors":"Ming Cheng , Chenya Zhu , Huan Liu , Chenxi Pu , Yunying Hou","doi":"10.1016/j.numecd.2024.09.026","DOIUrl":"10.1016/j.numecd.2024.09.026","url":null,"abstract":"<div><h3>Aims</h3><div>We conducted this systematic review to comprehensively assess the impact of CRT on health-related outcomes among patients with HF.</div></div><div><h3>Data synthesis</h3><div>In order to find studies investigating the effect of CRT on health-related outcomes among patients with HF, we performed a systematic search of PubMed, Cochrane Library, Embase, and Cumulative Index to Nursing and Allied Health Literature databases (inception until February 12th, 2023). A total of 10 studies including 933 individuals met the inclusion criteria. The systematic review indicated that 8 to 24 weeks of CRT intervention offered some health advantages for patients with HF. CRT significantly reduced patients’ body weight (SMD = - 0.52, 95 % CI = − 0.99 to −0.04, P = 0.03, I<sup>2</sup> = 77 %) and improved their quality of life (SMD = 0.35, 95 % CI = 0.12 to 0.58, P = 0.003, I<sup>2</sup> = 0 %). However, CRT significantly increased the risk of mortality and HF-related rehospitalization, including combined events of all-cause mortality and HF-related rehospitalization within a year (CRT group: 20 % vs. control group: 5 %), mortality rate within 1.52 years (CRT group: 34 % vs. control group: 22 %), readmission rate (CRT group: 52 % vs. control group: 17 %), and length of stay after readmission (CRT group: 124 days vs. control group:18 days).</div></div><div><h3>Conclusion</h3><div>CRT provides no significant benefits in terms of health-related outcomes among patients with HF, hence most patients with HF might not be eligible for CRT treatments. Meanwhile, there are several methodological issues among the studies included in the review, resulting in a low-to-moderate quality of evidence.</div></div><div><h3>Registration</h3><div>The PROSPERO registration number of this review is CRD 42023413992.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 1","pages":"Article 103756"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association of obesity phenotypes and risk of cardiovascular disease using time-varying and time-invariant approaches: An 18-year follow-up cohort study 使用时变和时不变方法研究肥胖表型与心血管疾病风险的关联：一项为期 18 年的跟踪队列研究。

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-01-01 DOI: 10.1016/j.numecd.2024.09.025

Fatemeh kokabeh , Zahra Bahadoran , Maryam Mahdavi , Majid Valizadeh , Maryam Barzin , Fereidoun Azizi , Farhad Hosseinpanah

{"title":"The association of obesity phenotypes and risk of cardiovascular disease using time-varying and time-invariant approaches: An 18-year follow-up cohort study","authors":"Fatemeh kokabeh , Zahra Bahadoran , Maryam Mahdavi , Majid Valizadeh , Maryam Barzin , Fereidoun Azizi , Farhad Hosseinpanah","doi":"10.1016/j.numecd.2024.09.025","DOIUrl":"10.1016/j.numecd.2024.09.025","url":null,"abstract":"<div><h3>Background and aim</h3><div>Our aim was risk estimation for cardiovascular disease (CVD) across obesity phenotypes over 18 years of follow-up using both time-invariant and time-varying approaches.</div></div><div><h3>Methods and results</h3><div>This prospective cohort study included 9752 participants aged ≥30 years examined in the first and second phases of the Tehran Lipid and Glucose Study (1999–2001 and 2002–2005). Six phenotypes [i.e., metabolically healthy normal weight (MHNW), overweight (MHOW), and obese (MHO), as well as metabolically unhealthy normal weight (MUNW), overweight (MUOW), and obese (MUO)] were defined based on the body mass index (BMI) and metabolic status. Incident CVD was documented until March 2018. Time-invariant and time-varying Cox regression models were used to estimate CVD hazard ratio (HRs) for obesity phenotypes.</div><div>Mean age of the participants was 46.6 ± 12.0 years, and 53.9 % of them were women. During 18 years of follow-up, 1083 new CVD events occurred. In metabolically unhealthy individuals, but not metabolically healthy people, multivariable-adjusted HRs for CVD events increased by BMI according to time-varying (HR = 1.6, 95 % CI = 1.13–2.26 for MUNW; HR = 1.92, 95 % CI = 1.43–2.58 for MUOW; HR = 1.94, 95 % CI = 1.4–2.68 for MUO) and time-invariant (HR = 1.85, 95 % CI = 1.01–3.39 for MUNW; HR = 2.75, 95 % CI = 1.63–4.63 for MUOW, and HR = 3.26, 95 % CI = 1.95–5.47 for MUO) models.</div></div><div><h3>Conclusion</h3><div>Metabolically unhealthy overweight and obese individuals are at increased risk of CVD and should be regularly screened to prevent possible cardiovascular events.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 1","pages":"Article 103755"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between cardiovascular risk factors and dilated and hypertrophic cardiomyopathy: Mendelian randomization analysis 心血管风险因素与扩张型和肥厚型心肌病之间的关系：孟德尔随机分析

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-01-01 DOI: 10.1016/j.numecd.2024.09.022

Chenchao Zou , Huaxi Zou , Ying Jiang , Songqing Lai , Jichun Liu

{"title":"Association between cardiovascular risk factors and dilated and hypertrophic cardiomyopathy: Mendelian randomization analysis","authors":"Chenchao Zou , Huaxi Zou , Ying Jiang , Songqing Lai , Jichun Liu","doi":"10.1016/j.numecd.2024.09.022","DOIUrl":"10.1016/j.numecd.2024.09.022","url":null,"abstract":"<div><h3>Background and aim</h3><div>Dilated cardiomyopathy is a major cause of heart failure, and hypertrophic cardiomyopathy is a common cause of sudden cardiac death in young adults. Epidemiological studies reporting the association between these cardiomyopathies and common cardiovascular risk factors, including smoking, alcohol, and obesity, are limited, and the published studies are mostly observational, making them vulnerable to bias.</div></div><div><h3>Methods and results</h3><div>We performed a two-sample Mendelian randomization analysis to assess whether cardiovascular risk factors were causally associated with dilated and hypertrophic cardiomyopathies. Independent genetic variants associated with body mass index, smoking, and alcohol were selected as instrumental variables, with two sets of instrumental variables utilized for alcohol. Dilated cardiomyopathy data on 355,318 samples and hypertrophic cardiomyopathy data on 489,727 samples were obtained from a European population-based genome-wide association study (GWAS) meta-analysis. The large GWAS data sample size improved the statistical power. Our results showed significant associations between a genetic predisposition for smoking and the risk of dilated cardiomyopathy (odds ratio (OR) = 1.33; 95 % confidence level (CI): 1.07–1.67; p = 0.012) and between a genetic predisposition for obesity and the risk of dilated cardiomyopathy (OR = 1.62; 95 % CI, 1.30–2.02; p = 1.51 × 10<sup>−5</sup>). The results of the other associations were not significant.</div></div><div><h3>Conclusions</h3><div>This study suggests that smoking and obesity are causally associated with an increased risk of dilated cardiomyopathy.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 1","pages":"Article 103752"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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