Nutrition Metabolism and Cardiovascular Diseases最新文献

{"title":"Sugar-sweetened beverages, low/no-calorie beverages, fruit juices intake and risks of metabolic syndrome in adults: The SWEET project.","authors":"Novita D Naomi, Elske M Brouwer-Brolsma, Marion E C Buso, Sabita S Soedamah-Muthu, Christina Mavrogianni, Joanne A Harrold, Jason C G Halford, Anne Raben, Johanna M Geleijnse, Yannis Manios, Edith J M Feskens","doi":"10.1016/j.numecd.2024.09.014","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.09.014","url":null,"abstract":"<p><strong>Background and aims: </strong>Metabolic syndrome (MetS) is an important determinant of cardiometabolic disease development, with excessive sugar intake as one of the key modifiable risk factors. However, evidence on the association between sugar-sweetened beverages (SSB), their replacement by low/no caloric beverages (LNCB), and MetS development is still limited.</p><p><strong>Methods and results: </strong>Data from participants' of Lifelines (n = 58 220), NQPlus (n = 1094) and Feel4Diabetes (n = 342) were prospectively analysed. Dose-response associations were investigated using restricted cubic spline analyses (Lifelines). Cox proportional hazard regression analysis with robust variance was used to quantify associations between intakes of SSB, fruit juices (FJ) and LNCB and MetS incidence; data were pooled using random-effects models. Associations were adjusted for demographic, lifestyle and other dietary factors. In Lifelines, NQPlus, and Feel4Diabetes, 3853 (7 %), 47 (4 %), and 39 (11 %) participants developed MetS, respectively. Pooled analyses showed that each additional serving of SSB was associated with a 6 % higher risk of MetS (95%CI 1.02-1.10). A J-shaped association was observed for FJ and MetS, with a significant inverse association at moderate intake levels (IPR 0.89, 95 % CI 0.82-0.96). LNCB intake was not associated with MetS (IPR 1.59, 95%CI 0.74-2.43), but findings across studies were inconsistent (I² 94 %, p-value <0.01). Replacing SSB with FJ or LNCB did not show any associations with MetS incidence.</p><p><strong>Conclusion: </strong>SSB intake was adversely associated with MetS incidence. A J-shaped association was observed between FJ and MetS. For LNCB, results were inconsistent across studies and therefore findings must be interpreted cautiously.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-processed food, genetic risk, and the risk of cardiometabolic diseases and cardiometabolic multimorbidity: A prospective study","authors":"Jing Wang ,&nbsp;Tingting Chen ,&nbsp;Wenmin Zhu ,&nbsp;Ziwei Shi ,&nbsp;Xiaolong Yan ,&nbsp;Zhiqun Lei ,&nbsp;Qi Wang","doi":"10.1016/j.numecd.2024.09.011","DOIUrl":"10.1016/j.numecd.2024.09.011","url":null,"abstract":"<div><h3>Background and aims</h3><div>This study aims to evaluate the impact of ultra-processed food (UPF) on type 2 diabetes (T2D), cardiovascular disease (CVD), hypertension, and cardiometabolic multimorbidity (CMM), and to explore the role of genetic susceptibility in these associations.</div></div><div><h3>Methods and results</h3><div>90 631 participants from the UK Biobank were included (collected between 2006 and 2010). The outcomes assessed included T2D, CVD, hypertension and CMM. The Cox proportional hazards model was used to evaluate their associations and the potential modification by genetic risk, which was estimated using the polygenic risk score (PRS). Participants with high UPF consumption had a higher risk of T2D, CVD, and CMM, with the adjusted hazard ratio (HR) of 1.36 (95 % confidence interval [CI]: 1.15, 1.61), 1.13 (95%CI: 1.03, 1.23), and 1.14 (95%CI: 1.05, 1.24), respectively. Those with high UPF consumption and high PRS for T2D, CVD, and hypertension had the highest risk of T2D (HR: 4.01; 95%CI: 2.83, 5.69), CVD (HR: 2.18; 95%CI: 1.86, 2.56), and hypertension (HR: 1.79; 95%CI: 1.61, 1.99), respectively. In participants with one cardiometabolic disease (CMD), those with high UPF consumption and high PRS_T2D or PRS_CVD had the highest risk of developing CMM. A significant additive interaction was observed between PRS_T2D and UPF consumption on the risk of T2D.</div></div><div><h3>Conclusion</h3><div>Our study underscored the importance of identifying individuals with high UPF consumption for targeted dietary interventions to mitigate the risk of CMDs and CMM, particularly among those with a high genetic risk of CMDs.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"34 12","pages":"Pages 2799-2806"},"PeriodicalIF":3.3,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uric acid and risk of incident heart failure in individuals with cardiovascular disease","authors":"Na Li ,&nbsp;Yaqi Li ,&nbsp;Liufu Cui ,&nbsp;Rong Shu ,&nbsp;Jiaoyan Li ,&nbsp;Haicheng Song ,&nbsp;Jierui Wang ,&nbsp;Shuohua Chen ,&nbsp;Chenrui Zhu ,&nbsp;Maoxiang Zhao ,&nbsp;Xiang Gao ,&nbsp;Tong Liu ,&nbsp;Shouling Wu","doi":"10.1016/j.numecd.2024.09.012","DOIUrl":"10.1016/j.numecd.2024.09.012","url":null,"abstract":"<div><h3>Background and aims</h3><div>Uric acid has been positively associated with the risk of developing heart failure in the general population. Nevertheless, it remains unclear whether hyperuricemia is an independent risk factor for heart failure and further contributes to the risk of heart failure among the already at-risk cardiovascular disease (CVD) population. This study aimed to evaluate the association between uric acid and incident heart failure in individuals with established CVD.</div></div><div><h3>Methods and results</h3><div>Included were 18,438 adults with established CVD but free of heart failure at baseline, from the Kailuan Study. Incident heart failure cases were ascertained by medical records. Cause-specific Cox proportional hazards regression models were applied to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) of heart failure according to uric acid tertiles. Over a median follow-up of 6.1 years, we identified 1215 incident heart failure cases. Higher uric acid was associated with a higher risk of incident heart failure, with adjusted HR for the last vs. first tertile of 1.50 (95%CI:1.30–1.73). Higher uric acid concentrations were associated with an increased risk of heart failure in individuals with coronary heart disease, atrial fibrillation, and ischemic stroke, but not in those with hemorrhagic stroke. Moreover, the observed association between uric acid and heart failure risk was more pronounced in individuals diagnosed with heart failure with reduced ejection fraction subtype compared with heart failure with preserved ejection fraction.</div></div><div><h3>Conclusions</h3><div>In individuals with CVD, uric acid was positively associated with the risk of heart failure, in a dose-response manner.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"34 12","pages":"Pages 2763-2770"},"PeriodicalIF":3.3,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uric acid reference values for children and adolescents should be stratified by pubertal stage","authors":"Shurong Huang ,&nbsp;Qifa Hu ,&nbsp;Zhuoguang Li ,&nbsp;Yanyan Li ,&nbsp;Xiu Zhao ,&nbsp;Yue Shang ,&nbsp;Rongfei Zheng ,&nbsp;Qiru Su ,&nbsp;Jingfan Xiong ,&nbsp;Zhe Su","doi":"10.1016/j.numecd.2024.09.009","DOIUrl":"10.1016/j.numecd.2024.09.009","url":null,"abstract":"<div><h3>Background and aim</h3><div>To establish reference values for hyperuricemia (HUA) in children and adolescents.</div></div><div><h3>Methods and results</h3><div>The study enrolled 4807 students from “The Evaluation and Monitoring on School-based Nutrition and Growth in Shenzhen study.” Utilizing quantile regression, associations between age, body mass index (BMI), pubertal stage, and serum uric acid (SUA) were examined, alongside the relationship between SUA and cardiovascular disease (CVD) risk factors. Reference values for SUA were explored using receiver operating characteristic analysis, considering sex and pubertal stage. The prevalence of HUA was 34.3 % for boys and 29 % for girls (using the adult HUA diagnostic criteria: &gt;420 μmol/L for males, &gt;360 μmol/L for females), increasing with higher BMI, age, and pubertal stage. Pubertal stage had the largest influence on SUA in boys, while nutritional status was the most significant factor affecting SUA in girls. Adjusting for age and pubertal stage, higher SUA levels correlated with an increased risk of CVD risk factors. Proposed reference values included &gt;360 μmol/L for girls ages 6–17 years and prepubertal boys. For pubertal boys, reference values varied based on age: &gt;392 μmol/L for ages 9–11 in early-middle puberty, &gt;429 μmol/L for ages 12–14 in early-middle puberty, &gt;478 μmol/L for ages 12–14 in late puberty, and &gt;505 μmol/L for ages 15–17 in late puberty.</div></div><div><h3>Conclusions</h3><div>Stratifying HUA reference values by pubertal stage, particularly for boys, is crucial. Long-term follow-up of individuals with high SUA levels may aid in refining SUA reference values.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"34 12","pages":"Pages 2757-2762"},"PeriodicalIF":3.3,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic dysfunction-associated steatotic liver disease, liver fibrosis and risk of cardiovascular disease: A prospective cohort study","authors":"Ji Woo Baek ,&nbsp;Yeun Soo Yang ,&nbsp;Keum Ji Jung ,&nbsp;Heejin Kimm ,&nbsp;So Young Kim ,&nbsp;Sunmi Lee ,&nbsp;Sun Ha Jee","doi":"10.1016/j.numecd.2024.09.001","DOIUrl":"10.1016/j.numecd.2024.09.001","url":null,"abstract":"<div><h3>Background and aims</h3><div>In patients with NAFLD, liver fibrosis increases liver-related complications, but there is controversy about the increase in CVD. Based on a prospective cohort study, this study investigated the risk of cardiovascular disease due to liver fibrosis in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).</div></div><div><h3>Methods and results</h3><div>This study analyzed KCPS-II prospective cohort that tracked 104,399 people who participated in health check-ups at 18 institutions nationwide from 2004 to 2013. If the fatty liver index was 30 or higher, it was defined as SLD, and participants were classified into No-SLD, MASLD, MetALD, ALD, and Cryptogenic SLD. Liver fibrosis was defined by the FIB-4 index, and the occurrence of cardiovascular disease according to SLD classification was analyzed using Cox proportional model regression analysis. Out study included a total of 6,942 participants (6.6%) had MASLD, 6,694 (6.4%) had MetALD, 4,751 (4.6%) had ALD, and 382 (0.3%) had Cryptogenic SLD. For the cases of FIB-4 index ≥1.3, the multivariable-adjusted HR (95% CI) of cardiovascular disease was 2.27 (1.87-2–76) in MASLD, 1.67 (1.30–2.10) in MetALD, and 2.56 (1.99–3.30) in ALD, but it was 0.78 (0.19–3.10) in Cryptogenic_SLD, which was not significant. The risk of cardiovascular disease according to the fibrosis stage classified by BARD also presented similar results.</div></div><div><h3>Conclusions</h3><div>This prospective cohort study of Korean patients with newly defined MASLD, MetALD, and ALD with FIB-4 ≥ 1.3 at high risk of developing cardiovascular disease.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"34 12","pages":"Pages 2623-2629"},"PeriodicalIF":3.3,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low triiodothyronine is associated with high risk of malnutrition and poor functional status in subacute stroke patients.","authors":"Olivia Di Vincenzo, Ermenegilda Pagano, Mariarosaria Cervone, Lucia Acampora, Monica Dentice, Chiara Francesca Gheri, Fabrizio Pasanisi, Luca Scalfi","doi":"10.1016/j.numecd.2024.09.008","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.09.008","url":null,"abstract":"<p><strong>Background and aims: </strong>Stroke patients may exhibit low thyroid hormone (TH) levels and disease-related malnutrition, both potentially affecting clinical status; their relationships remain unexplored. This study aimed to evaluate TH concentrations in subacute stroke patients and investigate the relationships between TH levels, nutritional risk, and functional status.</p><p><strong>Methods and results: </strong>Early subacute stroke patients admitted to a rehabilitation unit were assessed using various nutritional screening tools (Geriatric Nutritional Risk Index-GNRI, Prognostic Nutritional Index-PNI, and Controlling Nutritional Status-CONUT score) and with the Global Leadership Initiative on Malnutrition (GLIM) criteria. Thyroid-Stimulating Hormone (TSH), free Tetraiodothyronine-Thyroxine (fT4) and free Triiodothyronine (fT3) levels were determined. Functional and cognitive status was evaluated using different scales. Associations between altered THs and nutritional status were examined through univariate/multivariate analyses and ROC analyses. Among 264 patients (age 72.0 ± 10.5 yrs), significant correlations emerged between fT3 and nutritional risk and functional tests (mostly p < 0.001). The prevalence of high nutritional risk determined by GNRI, PNI and CONUT increased from higher to lower fT3 tertiles. Lower fT3 levels were observed in patients at high nutritional risk and with GLIM-based malnutrition. fT3 exhibited reasonable predictive power for high nutritional risk (particularly PNI: AUC 0.769, 95%CI 0.702-0.836, p < 0.001). Multivariate logistic regression identified nutritional risk (p < 0.001) and time from stroke onset as predictors of low fT3 values.</p><p><strong>Conclusion: </strong>Altered fT3 levels in early subacute stroke patients correlate with high nutritional risk and poor functional status. Low fT3 values upon admission for stroke rehabilitation may serve as a further parameter to be considered in patients at high nutritional risk.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental caries and adolescent cardiometabolic health from the National Health and Nutrition Examination Survey (NHANES).","authors":"Kristal Wong, Srighana Nadella, Mel Mupparapu, Christine Sethna","doi":"10.1016/j.numecd.2024.09.006","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.09.006","url":null,"abstract":"<p><strong>Background and aims: </strong>To assess the association between dental caries and cardiometabolic risk in adolescents.</p><p><strong>Methods and results: </strong>The analysis included adolescents aged 13-17 years enrolled in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018 who completed an Oral Health Examination. Untreated caries was defined as having one or more decayed teeth. Caries experience was assessed by Decayed, Missing, Filled Teeth (DMFT) score. Primary cardiometabolic outcomes included elevated BP (defined as BP 120-129/<80 mmHg) and hypertensive BP (defined as BP ≥ 130/80 mmHg). Secondary cardiometabolic outcomes included obesity, dyslipidemia (defined as any abnormal lipid level), glucose intolerance (measured by HOMA-IR), and microalbuminuria (defined as urine albumin: creatinine ≥30 mg/mg). Adjusted linear and logistic models examined associations using complex survey design procedures. In the sample of 2861 adolescents, 25.6 % (1.3 %) had untreated caries. 55.4 % (1.3 %) had DMFT ≥1. In adjusted regression analyses, untreated caries status was not significantly associated with primary outcomes of elevated BP (OR = 1.04, 95 % CI 0.71, 1.52 p > 0.05), hypertensive BP (OR = 1.72, 95 % CI 0.71, 3.89 p > 0.05), nor secondary cardiometabolic outcomes. No statistically significant associations were found between DMFT score and primary outcomes of elevated BP (OR = 0.01, 95 % CI 0.34, 1.07 p > 0.05), hypertensive BP (OR = 0.91, 95 % CI 0.81, 1.08 p > 0.05), or secondary cardiometabolic outcomes.</p><p><strong>Conclusion: </strong>Although studies in other countries and in adults show associations between caries and cardiometabolic outcomes, this study did not find an association between caries and cardiometabolic markers.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basal and post-stress ceramide-based risk score CERT1 predicts all-cause mortality and nonfatal myocardial infarction in patients with suspected or established coronary artery disease undergoing stress myocardial perfusion scintigraphy.","authors":"Alessandro Mantovani, Agustin E Molinero, Stefano Bonapace, Gianluigi Lunardi, Matteo Salgarello, Riccardo Morandin, Francesca Moretta, Antonio Conti, Giulio Molon, Reijo Laaksonen, Christopher D Byrne, Giovanni Targher","doi":"10.1016/j.numecd.2024.09.005","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.09.005","url":null,"abstract":"<p><strong>Background and aim: </strong>We examined whether a plasma ceramide-based risk score (CERT1 score), a newly proposed tool for cardiovascular risk prediction, is associated with an increased risk of all-cause mortality and nonfatal myocardial infarction in patients with suspected or known coronary artery disease (CAD).</p><p><strong>Methods and results: </strong>We studied 167 ambulatory patients who consecutively underwent stress myocardial perfusion scintigraphy (MPS) for clinical reasons in 2017 (at baseline) and then followed for a median of 6 years (inter-quartile range: 4.7-6.6 years). For the calculation of the CERT1 score, both before and after stress MPS, we measured three specific plasma ceramide concentrations [Cer(d18:1/16:0), Cer(d18:1/18:0) and Cer(d18:1/24:1)] and their ratio to Cer(d18:1/24:0) using a targeted liquid chromatography-tandem mass spectrometry assay. The primary outcome of the study was a composite of all-cause mortality or nonfatal myocardial infarction. During a median of 6 years, a total of 50 events occurred (26 all-cause deaths and 24 nonfatal myocardial infarctions). There was a significant association between pre-stress CERT1 risk categories (high vs. low risk) at baseline and the risk of developing the primary composite outcome (unadjusted HR 1.78, 95% CI 1.02-3.14). This risk remained significant after adjustment for age, sex, smoking, diabetes, pre-existing CAD, left ventricular ejection fraction, and stress-induced inducible myocardial ischemia on MPS (adjusted HR 2.28, 95% CI 1.17-4.41, p = 0.015). Almost identical results were observed for post-stress CERT1 risk categories.</p><p><strong>Conclusions: </strong>Pre-stress and post-stress CERT1 high-risk categories at baseline were strongly associated with an increased long-term risk of all-cause mortality or nonfatal myocardial infarction in patients with suspected or established CAD.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of early postnatal overnutrition on cardiac mitochondrial dysfunction in adult mice with ischemia/reperfusion.","authors":"Anatalia K G Vieira, Amélia F Bernardo, Fabiana A Neves, Vivian M Soares, Roberta M Guedes, Patrícia N Soares, Patrícia C Lisboa, Erika Cortez, Egberto G Moura, Bruna G da Silva, Erica P Garcia-Souza, Anibal S Moura","doi":"10.1016/j.numecd.2024.09.007","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.09.007","url":null,"abstract":"<p><strong>Background and aims: </strong>Nutritional imbalance at the beginning of life, a critical window period, leads to the development of obesity, overweight, dyslipidemia, diabetes, and cardiovascular disease in adulthood. In this study, the effects and associations of overnutrition during lactation on energy metabolism and oxidative stress in cardiomyocytes of adult male Swiss mice were examined.</p><p><strong>Methods and results: </strong>Animals were divided into two groups (control and overfed) subjected to baseline and ischemia/reperfusion conditions, forming four groups: control baseline (CBL), control ischemia/reperfusion (CIR), overfed baseline (OBL), and overfed ischemia/reperfusion (OIR). The hearts were analyzed for hemodynamics using the Langendorff technique, mitochondrial energy metabolism using the Oroboros apparatus, ATP production, oxidative stress, and SIRT1, pSTAT3 and STAT3 protein content by Western blotting. Hemodynamic abnormalities in the cardiovascular system were associated with mitochondrial dysfunction, as demonstrated by impaired carbohydrate and fatty acid oxidation capacity, decreased mitochondrial coupling in the OG, and reduced ATP production in the OIR group. Alteration in pSTAT3 and SIRT1 proteins expression in overfed mice reinforce energy metabolism impairment. Lipid and/or protein degradation is altered in the heart of OG, suggesting increased oxidative stress.</p><p><strong>Conclusion: </strong>Overnutrition during lactation associated with heart ischemia leads to molecular cardiac alterations in STAT3 and SIRT1 proteins, compromising energy metabolism via reduced mitochondrial oxidation capacity, ATP production and increased lipid peroxidation.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organisational initiatives to improve care in the prevention and management of cardiometabolic conditions: A scoping review","authors":"Hellena Hailu Habte-Asres ,&nbsp;Chuyou Hou ,&nbsp;Angus Forbes ,&nbsp;David C. Wheeler","doi":"10.1016/j.numecd.2024.09.004","DOIUrl":"10.1016/j.numecd.2024.09.004","url":null,"abstract":"<div><h3>Aim</h3><div>Cardiometabolic conditions such as cardiovascular disease, type 2 diabetes, and chronic kidney disease contribute to multimorbidity, posing a global health challenge. However, existing healthcare frameworks often struggle to adequately address the intricate needs of individuals living with these conditions. The review aims to map existing research on cardiometabolic care initiatives for the primary and secondary prevention of metabolic conditions.</div></div><div><h3>Data synthesis</h3><div>A scoping review was conducted following the methodology of the Joanna-Briggs-Institute. We searched Medline, Embase, and CINAHL. The review primarily sought studies comparing the effectiveness of cardiometabolic services/clinics in primary or secondary prevention of cardiometabolic conditions with standard care. The data from these studies were charted and summarised in tabular form, with a narrative synthesis.</div><div>The search identified 97 records across three databases, and 18 documents met inclusion criteria. Two studies addressed cardiometabolic care in primary prevention, while twelve focused on secondary prevention. Positive outcomes were observed in primary prevention, including reductions in waist circumference, body mass index, blood pressure, and cholesterol levels. For secondary prevention, the studies demonstrated positive metabolic outcomes, such as reductions in HbA1c, weight, blood pressure, and cholesterol levels. Additionally, data from the available studies reported improved adherence to diabetes care processes and the implementation of guideline-directed therapies.</div></div><div><h3>Conclusion</h3><div>This scoping review highlights the potential benefits of services such as cardiometabolic clinics for primary and secondary prevention in metabolic conditions. Future studies should use standardised outcome measures and include details on the structure, staffing and treatment intensity of clinics to aid their wider implementation.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"34 12","pages":"Pages 2630-2641"},"PeriodicalIF":3.3,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}