Nutrition Metabolism and Cardiovascular Diseases最新文献

{"title":"Effect of Dietary Approaches to Stop Hypertension (DASH) diet on lipid profile in individuals with overweight/ obesity: A GRADE-assessed systematic review and meta-analysis of clinical trials","authors":"Paniz Zare ,&nbsp;Mohammad Vesal Bideshki ,&nbsp;Zahra Sohrabi ,&nbsp;Mehrdad Behzadi ,&nbsp;Mohsen Mohammadi Sartang","doi":"10.1016/j.numecd.2025.104057","DOIUrl":"10.1016/j.numecd.2025.104057","url":null,"abstract":"<div><h3>Background and aim</h3><div>Obesity is a major nutritional disease that increases the risk of developing serious health conditions like dyslipidemia. Plant-based diets, like DASH (dietary approaches to stop hypertension), can help lower the risk of dyslipidemia. However, evidence on the effect of DASH diet on lipid profile in populations with overweight/obesity is inconsistent. This meta-analysis of controlled trials investigated the effects of the DASH diet on lipid profile in individuals with overweight/obesity.</div></div><div><h3>Methods and results</h3><div>A search for relevant studies was conducted in databases like PubMed, Web of Science, and Scopus until January 2024. The calculation of weighted-mean differences (WMDs) and 95 % confidence intervals (CIs) was performed based on the random-effects model. Sensitivity, meta-regression and publication bias analyses were also conducted. 22 eligible studies with 26 arms and 3562 participants were included. DASH diet significantly reduced total cholesterol (TC) (WMD: 5.05 mg/dl, 95 % CI: 8.78, −1.31, p = 0.008), low-density lipoprotein cholesterol (LDL-C) (WMD: 5.33 mg/dl, 95 % CI: 8.54, −2.11, p = 0.001) and very low-density lipoprotein cholesterol (VLDL-C) (WMD: 3.26, 95 % CI: 6.19, -0.34, p = 0.029) levels. Greater reductions were observed in studies with durations ≤8 weeks. All of the included studies were classified as high quality except two, which were classified as moderate quality. LDL-C and VLDL-C were categorized as high-grade evidence, while others were categorized as moderate.</div></div><div><h3>Conclusions</h3><div>DASH diet could improve the lipid profile of individuals with overweight/obesity by decreasing TC, LDL-C and VLDL-C levels. However, it doesn't have significant effects on high-density lipoprotein cholesterol and triglyceride levels.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 9","pages":"Article 104057"},"PeriodicalIF":3.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a prediction model for gestational diabetes mellitus based on clinical characteristics and laboratory biomarkers among Chinese women.","authors":"Jinlang Lyu, Yuanzhou Peng, Li Yang, Tao Su, Qin Li, Yuelong Ji, Hui Wang, Shusheng Luo, Jue Liu, Hai-Jun Wang","doi":"10.1016/j.numecd.2025.104065","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104065","url":null,"abstract":"<p><strong>Background and aims: </strong>Early detection of gestational diabetes mellitus (GDM) is critical for maternal and child health. Although several prediction models exist, their complexity and reliance on less clinically accessible biomarkers have limited generalizability. This study aimed to develop and validate a clinically practical GDM prediction model.</p><p><strong>Methods and results: </strong>Based on a retrospective cohort containing 30 480 pregnant women from China (2014-2019), three prediction models (basic, full and optimal) were developed using logistic regression to select predictors. Predictive accuracy of prediction models was evaluated by the area under receiver operating characteristic curve (AUC). The nomogram was established to predict individual probability of GDM, with decision curve analysis (DCA) assessing clinical utility. A total of 8161 (26.8 %) women were diagnosed with GDM. The optimal model, incorporating nine clinical characteristics and biochemical indicators, had a good predictive effect for GDM with AUCs of 0.74 (95 % CI: 0.74-0.75) in the training cohort and 0.74 (0.73-0.76) in the validation cohort. The performance of the optimal model was significantly greater than the basic model (AUC of 0.62) and close to the full model (AUC of 0.75). The calibration curve showed that the established nomogram had good accuracy to predict individual probability of GDM. The DCA showed that the prediction model had a positive net benefit at threshold between 0.1 and 0.8.</p><p><strong>Conclusion: </strong>The nine-item optimal prediction model yielded high predictive accuracy, facilitating the identification of high-risk women, and the refinement of personalized diagnostic and treatment modalities.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104065"},"PeriodicalIF":3.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between nutritional status and heart failure with improved ejection fraction","authors":"Guanzhong Chen ,&nbsp;Chengchen Zhao ,&nbsp;Yu Jin ,&nbsp;Senmiao Chen ,&nbsp;Xushen Yang ,&nbsp;Chunna Jin ,&nbsp;Meixiang Xiang","doi":"10.1016/j.numecd.2025.104035","DOIUrl":"10.1016/j.numecd.2025.104035","url":null,"abstract":"<div><h3>Background and aims</h3><div>A proportion of patients with heart failure with reduced ejection fraction (HFrEF) may experience an improvement in ejection fraction, termed HFimpEF. Malnutrition is a common condition associated with adverse prognosis in HF patients. However, the association between nutritional status and HFimpEF remains unclear.</div></div><div><h3>Methods and results</h3><div>A total of 1057 hospitalized patients with HFrEF were retrospectively enrolled. Patients were grouped into HFimpEF (defined as follow-up EF&gt;40 % and ≥10 % absolute increase) or persistent HFrEF. Nutritional status was assessed by prognostic nutritional index (PNI), geriatric nutritional risk index (GNRI) and controlling nutritional status index (CONUT). Logistic regression and restricted cubic splines were conducted to assess the association between nutritional status and HFimpEF. Among 1057 patients (mean age 64.00 years, 72.94 % male), 418 (39.55 %) developed HFimpEF. After multivariate adjustment, a per-score increase of nutritional indices was associated with HFimpEF [PNI, OR (95 % CI): 1.03 (1.01–1.06); GNRI, OR (95 % CI): 1.02 (1.01–1.04); CONUT, OR (95 % CI): 0.89 (0.83–0.96)]. The restricted cubic splines revealed linear associations between nutritional indices and HFimpEF (P for non-linearity &gt;0.05). The addition of the CONUT score to the basic model had the most significant incremental effect on the prediction for HFimpEF [area under the curve = 0.698; continuous net reclassification improvement: 0.191 (0.068–0.313); integrated discrimination improvement: 0.009 (0.004–0.015)].</div></div><div><h3>Conclusion</h3><div>Malnutrition is associated with the development of HFimpEF. Assessment of nutritional status may provide incremental value for the prediction of HFimpEF.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 9","pages":"Article 104035"},"PeriodicalIF":3.3,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between neutrophil-lymphocyte ratio levels and mortality related to cardiovascular cause and all causes in coronary artery disease patients with low-density lipoprotein cholesterol below 1.4 mmol/L: A multicenter cohort study","authors":"Rengui Jiang ,&nbsp;Huangtao Ruan ,&nbsp;Weipeng Zhang ,&nbsp;Jinming Chen ,&nbsp;Yupeng Yang ,&nbsp;Shangyi Tang ,&nbsp;Yueting Wang ,&nbsp;Xianlin Ruan ,&nbsp;Jun Cao ,&nbsp;Hengqing Zhu ,&nbsp;Nianjin Xie ,&nbsp;Yong Liu ,&nbsp;Ning Tan","doi":"10.1016/j.numecd.2025.104058","DOIUrl":"10.1016/j.numecd.2025.104058","url":null,"abstract":"<div><h3>Background and aims</h3><div>Neutrophil-lymphocyte ratio (NLR) can reflect the residual risk of patients with coronary atherosclerotic disease (CAD). However, in CAD patients with low density lipoprotein cholesterol (LDL-C) less than 1.4 mmol/L, the relationship between NLR and poor prognosis remains unclear. The purpose of this research is to examine the relationship between NLR and mortality from cardiovascular causes as well as all causes in the study group.</div></div><div><h3>Methods and results</h3><div>From the beginning of 2007 to the end of 2020, 2749 individuals with LDL-C under 1.4 mmol/L at baseline and CAD diagnosed via coronary angiography were part of this research. The selected population was divided into four groups according to the level of NLR, and Cox regression model was used mainly to evaluate the association between NLR and cardiovascular and all-cause mortality. After a follow-up of median 6 years, a total of 182 cardiovascular deaths and 460 all-cause deaths had occurred. The Cox regression analysis of fully adjusted model showed that an elevated NLR is connected to a higher risk of mortality from cardiovascular cause (HR: 2.18, 95 %CI: 1.38–3.43) and all causes (HR: 1.33, 95 %CI: 1.02–1.74) in the fourth quartile group. Subgroup analysis indicated that younger and middle-aged patients, as well as those with multivessel coronary artery disease, may have a heightened residual risk of inflammation.</div></div><div><h3>Conclusion</h3><div>NLR can be a useful risk factor indicator for cardiovascular and all-cause mortality in CAD patients with LDL-C levels below 1.4 mmol/L, and it also points to residual risk.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 9","pages":"Article 104058"},"PeriodicalIF":3.3,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary patterns of patients with acute coronary syndrome in the multi-ethnic New Zealand study of acute coronary syndromes (MENZACS)","authors":"Kathryn E. Bradbury ,&nbsp;Nikki J. Earle ,&nbsp;Anna Rolleston ,&nbsp;Christie Fyfe ,&nbsp;Corina Grey ,&nbsp;Erina Korohina ,&nbsp;Suneela Mehta ,&nbsp;Vicky Cameron ,&nbsp;Yeunhyang Choi ,&nbsp;Gerry Devlin ,&nbsp;Patrick A. Gladding ,&nbsp;Wil Harrison ,&nbsp;Kimiora Henare ,&nbsp;Andrew J. Kerr ,&nbsp;Greer Logue ,&nbsp;Thomas Lumley ,&nbsp;Vijaya Pera ,&nbsp;Anna P. Pilbrow ,&nbsp;Graeme Porter ,&nbsp;Ralph Stewart ,&nbsp;Clare Wall","doi":"10.1016/j.numecd.2025.104037","DOIUrl":"10.1016/j.numecd.2025.104037","url":null,"abstract":"<div><h3>Background and aims</h3><div>In Aotearoa-New Zealand (NZ) approximately 8000 people are admitted with a first-time acute coronary syndrome (ACS) annually. In this cross-sectional analysis, we describe the dietary patterns of patients who present with their first ACS and examine their associations with socio-demographic and clinical characteristics.</div></div><div><h3>Methods and results</h3><div>The Multi-Ethnic NZ study of Acute Coronary Syndromes (MENZACS) is a multi-centre, longitudinal cohort study of patients with first-time ACS. At study enrolment, patients (n = 1914) completed a validated short food frequency questionnaire asking about dietary intakes in the 12 months preceding their ACS. Three dietary patterns were identified using Principal Component Analysis. The Convenience pattern was characterised by high intakes of take-aways, and participants with higher scores were on average younger, more likely to be male, live in the most deprived areas, and current smokers (all p for trend&lt;0.001). The Harvest pattern was characterised by high intakes of vegetables and fruit, and participants with higher scores were on average older, less likely to be male, more likely to live in the least deprived areas, and have a history of hypertension, and less likely to be current smokers (all p for trend&lt;0.05). The Comfort pattern was characterised by high intakes of potatoes, biscuits, tea/coffee, meat, and jam, and participants with higher scores were on average older and more likely to be male (both p for trend&lt;0.05).</div></div><div><h3>Conclusion</h3><div>Three distinct dietary patterns were found in patients presenting with first-time ACS in NZ and these patterns were associated with various socio-demographic and clinical factors.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 9","pages":"Article 104037"},"PeriodicalIF":3.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of hemoglobin-to-red blood cell distribution width ratio with all-cause and cardiovascular mortality among patients with hypertension","authors":"Xi Jiang,&nbsp;Qingsong Xiong,&nbsp;Lili Zou,&nbsp;Zhiyu Ling","doi":"10.1016/j.numecd.2025.104059","DOIUrl":"10.1016/j.numecd.2025.104059","url":null,"abstract":"<div><h3>Background and aims</h3><div>Hemoglobin-to-red blood cell distribution width ratio (HRR) is a novel marker indicating inflammation. However, the association between HRR and mortality among hypertensive populations remains unclear.</div></div><div><h3>Methods and results</h3><div>A total of 2,185 hypertensive participants were extracted from the National Health and Nutrition Examination Survey 2011–2018. Mortality data were obtained from the National Death Index (NDI). HRR values were calculated according to the given formula. Over a median follow-up period of 68.0 months, 273 (12.5 %) of the 2,185 participants died, with 77 (3.5 %) deaths attributed to cardiovascular diseases. Survival curve analyses revealed significant decreases in the survival rate for both all-cause and cardiovascular diseases in the lower HRR groups compared to the highest one (P &lt; 0.0001). After adjustment in the multifactorial Cox regression analyses and restricted cubic splines analyses, the lowest HRR quartile exhibited the highest risk of both all-cause and cardiovascular mortality. Time-dependent ROC analyses demonstrated that HRR possesses predictive ability for all-cause and cardiovascular mortality across different time periods, appearing superior to Hb and RDW. While stratified analyses revealed a similar trend among subgroups, the hazard ratio was notably higher in the female subgroup compared to the male subgroup.</div></div><div><h3>Conclusion</h3><div>Our findings indicate that lower HRR levels are significantly associated with higher risks of both all-cause and cardiovascular mortality among the hypertensive population, particularly among males. HRR could potentially serve as a straightforward and practical tool for identifying high-risk patients and guiding targeted interventions.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 9","pages":"Article 104059"},"PeriodicalIF":3.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution characteristics and screening reference values of NT-proBNP in high cardiovascular risk population","authors":"Pingfeng Feng ,&nbsp;Junlong Qin ,&nbsp;Zhixin Chai ,&nbsp;Dong Wei ,&nbsp;Yajie Zhang ,&nbsp;Peiyun Wang ,&nbsp;Minghai Zhao ,&nbsp;Bingbing He ,&nbsp;Zhongyi Ling ,&nbsp;Xin Li","doi":"10.1016/j.numecd.2025.104029","DOIUrl":"10.1016/j.numecd.2025.104029","url":null,"abstract":"<div><h3>Background and aim</h3><div>N-terminal pro B-type natriuretic peptide (NT-proBNP) is a key biomarker for assessing cardiac function and hemodynamic stress. However, clinical guidelines lack clear recommendations on its utility in populations at risk of heart failure (HF), including those with hypertension, diabetes, or dyslipidemia. This study aimed to characterize the distribution of NT-proBNP levels in HF-prone individuals and establish population-specific screening thresholds.</div></div><div><h3>Methods and results</h3><div>A cross-sectional analysis was conducted across three cohorts: 2421 patients with HF risk factors (hypertension, diabetes, or dyslipidemia), 625 patients with congestive HF, and 833 healthy controls. NT-proBNP levels were stratified by cardiovascular risk categories based on established guidelines. Receiver operating characteristic (ROC) curves were used to determine optimal screening thresholds. Key findings included.</div></div><div><h3>Conclusions</h3><div>NT-proBNP levels effectively mirror cardiovascular risk stratification in HF-susceptible populations. Adopting risk-stratified reference values (106.0–116.7 pg/mL vs. 124.6 pg/mL in healthy adults) may enhance early HF detection and personalized risk management.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 8","pages":"Article 104029"},"PeriodicalIF":3.3,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of intra-individual differences in estimated GFR by creatinine versus cystatin C with incident cardiovascular disease","authors":"Fan Zhang ,&nbsp;Yan Sun ,&nbsp;Yan Bai ,&nbsp;Wenlong Yu ,&nbsp;Mengchen Yin ,&nbsp;Yifei Zhong ,&nbsp;Yi Li","doi":"10.1016/j.numecd.2025.104034","DOIUrl":"10.1016/j.numecd.2025.104034","url":null,"abstract":"<div><h3>Background and aims</h3><div>This study investigates the association between intra-individual differences in estimated glomerular filtration rate based on serum creatinine (eGFR_scr) and cystatin C (ΔeGFR_cysc-scr) and incident CVD.</div></div><div><h3>Methods and results</h3><div>This study used data from the China Health and Retirement Longitudinal Study (CHARLS) from 2015 to 2020. ΔeGFR_cysc-scr were determined by subtracting eGFR_scr from eGFR_cysc. The outcome was the incidence of CVD, including heart diseases, and stroke, obtained through self-reports. Cox proportional hazard regression models were employed to examine the association between ΔeGFR_cysc-scr and CVD risks. Restricted cubic spline with three knots at the 10th, 50th, and 90th centiles was conducted to flexibly model the association. During this period, 1187 incident CVD events were documented. After adjusting for covariates, the risk of CVD was reduced by 13.2 % (Hazard ratio [HR] = 0.868; 95 % confidence interval [95 % CI]: 0.818–0.921) for every 15 mL/min/1.73 m² increase in baseline ΔeGFR_cysc-scr. Specifically, individuals in negative-ΔeGFR_cysc-scr group (&lt;-15 mL/min/1.73 m²) had a 33.6 % increased risk of CVD events (HR = 1.336; 95 % CI: 1.151–1.551), and positive-ΔeGFR_cysc-scr group (≥15 mL/min/1.73 m²) had a 34.5 % decrease risk of CVD events (HR = 0.655; 95 % CI: 0.541–0.794), compared with those in reference group (−15 to 15 mL/min/1.73 m²). These associations remained robust after adjusting for potential confounders or sensitivity analysis.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that intra-individual differences in eGFR estimates based on creatinine versus cystatin C are associated with CVD risk in the Chinese population. This highlights the potential value of using both markers for more accurate CVD risk stratification in clinical practice.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 9","pages":"Article 104034"},"PeriodicalIF":3.3,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of semaglutide on liver fat assessed by serial cardiac CT scans in patients with type 2 diabetes: Results from STOP trial","authors":"Ilana S. Golub,&nbsp;Venkat S. Manubolu,&nbsp;Jairo Aldana-Bitar,&nbsp;Suraj Dahal,&nbsp;Dhiran Verghese,&nbsp;Luay Alalawi,&nbsp;Srikanth Krishnan,&nbsp;Sina Kianoush,&nbsp;Travis Benzing,&nbsp;Keishi Ichikawa,&nbsp;April Kinninger,&nbsp;Hooman Fazlalizadeh,&nbsp;Leili Pourafkari,&nbsp;Khadije Ahmad,&nbsp;Shriraj Susarla,&nbsp;Czarina Mangaoang,&nbsp;Ahmed K. Ghanem,&nbsp;Denise Alison Javier,&nbsp;Sajad Hamal,&nbsp;Sion K. Roy,&nbsp;Matthew J. Budoff","doi":"10.1016/j.numecd.2025.104036","DOIUrl":"10.1016/j.numecd.2025.104036","url":null,"abstract":"<div><h3>Background and aim</h3><div>The prevalence of hepatic steatosis continues to increase worldwide. Hepatic steatosis is increasingly recognized as an independent risk factor for cardiovascular mortality. However, there are limited options for the treatment of fatty liver. In this study, we evaluated the effect of semaglutide on liver fat as measured by non-contrast cardiac CT scans.</div></div><div><h3>Methods and results</h3><div>STOP is a randomized controlled trial that evaluated the semaglutide treatment effect on coronary atherosclerosis progression (STOP) in type 2 diabetes. We utilized unenhanced cardiac CT scans to quantify liver fat based on the CT Hounsfield attenuation method. Of the 140 subjects who were originally randomized, a total of 114 individuals qualified for this study. 59 participants were in the semaglutide group and 55 were in the placebo group, and these subjects were followed for 12 months. The secondary outcome (liver fat attenuation) was quantified using non-contrast cardiac computed tomography (CT) images at both the baseline and 12-month follow-up time points. Multivariate regression models were then used to evaluate the change in liver fat content overtime.</div><div>One hundred and fourteen subjects were included in the study: 61 % male, mean age of 57.8 ± 8.1 years, and mean BMI of 32.0 ± 6.7. The average of three liver measures over 12 months showed an improvement in the semaglutide group of 1.4 ± 9.0 mean HU, versus a worsening in the placebo group of 1.9 ± 9.5 mean HU. The multivariable linear regression models (after adjusting for age, gender, BMI, hypertension, hyperlipidemia, past smoking and baseline liver attenuation) showed that average liver attenuation measures improved by 4.4 HU in the semaglutide group when compared to the placebo group (p = 0.002). This result demonstrated improvement in the liver fat content within the treatment group.</div></div><div><h3>Conclusion</h3><div>In type 2 diabetes patients with hepatic steatosis, treatment with semaglutide resulted in a significant improvement in fatty liver reduction when compared to placebo.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 9","pages":"Article 104036"},"PeriodicalIF":3.3,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic profiles of body shapes and their associations with the risks of incident cardiovascular diseases in Chinese adults","authors":"Rundong Niu ,&nbsp;Hao Wang ,&nbsp;Gaokun Qiu ,&nbsp;Pinpin Long ,&nbsp;Kang Liu ,&nbsp;Huiting Chen ,&nbsp;Denghuan Hu ,&nbsp;Yang Xiao ,&nbsp;Yu Yuan ,&nbsp;Wei Wang ,&nbsp;Yufei Wang ,&nbsp;Yuhui Lin ,&nbsp;Tingting Mo ,&nbsp;Zirui Zhang ,&nbsp;Tingyue Diao ,&nbsp;Yi Guo ,&nbsp;Yuying Wen ,&nbsp;Xulin Zhang ,&nbsp;Sijie Chai ,&nbsp;Ming Fu ,&nbsp;Tangchun Wu","doi":"10.1016/j.numecd.2025.104031","DOIUrl":"10.1016/j.numecd.2025.104031","url":null,"abstract":"<div><h3>Background and aims</h3><div>To explore the metabolomic profiles of different body shapes, their potential similarities and differences, and their associations with the risks of incident cardiovascular diseases.</div></div><div><h3>Methods and results</h3><div>Plasma metabolite, body mass index (BMI), and waist-to-height ratio (WHtR) data were available in 7471 Chinese adults. We categorized body shapes into four groups by combining BMI (low: &lt;24 kg/m², high: ≥24 kg/m²) with WHtR (low: &lt;0.5, high: ≥0.5). We used linear regression and enrichment analysis to characterize metabolomic profiles and elastic-net regression to construct metabolite scores for body shapes. In nested case-control studies, we explored the associations of metabolite scores with the risks of coronary heart disease, acute coronary syndrome (ACS), and stroke, including 1621, 657, and 1289 case-control pairs, respectively. Compared with low BMI and low WHtR, four shared (e.g. arginine and proline metabolism) and eight specific (e.g. glutathione metabolism) metabolite sets were identified for the other three body shapes. Metabolite scores for low BMI and high WHtR, and high BMI and low WHtR were associated with increased and decreased risks of ACS, respectively [odd ratios (95 % confidence intervals): 1.28 (1.14, 1.45) and 0.81 (0.72, 0.91)]. The metabolite score for high BMI and high WHtR was associated with increased risks of ACS, total and ischemic stroke [odd ratios (95 % confidence intervals): 1.21 (1.07, 1.37), 1.10 (1.01, 1.21), and 1.15 (1.04, 1.28)].</div></div><div><h3>Conclusions</h3><div>This study unveiled metabolomic profiles of different body shapes, the underlying similarities and differences, and their associations with incident cardiovascular diseases.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 9","pages":"Article 104031"},"PeriodicalIF":3.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}