Rundong Niu , Hao Wang , Gaokun Qiu , Pinpin Long , Kang Liu , Huiting Chen , Denghuan Hu , Yang Xiao , Yu Yuan , Wei Wang , Yufei Wang , Yuhui Lin , Tingting Mo , Zirui Zhang , Tingyue Diao , Yi Guo , Yuying Wen , Xulin Zhang , Sijie Chai , Ming Fu , Tangchun Wu
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引用次数: 0
Abstract
Background and aims
To explore the metabolomic profiles of different body shapes, their potential similarities and differences, and their associations with the risks of incident cardiovascular diseases.
Methods and results
Plasma metabolite, body mass index (BMI), and waist-to-height ratio (WHtR) data were available in 7471 Chinese adults. We categorized body shapes into four groups by combining BMI (low: <24 kg/m2, high: ≥24 kg/m2) with WHtR (low: <0.5, high: ≥0.5). We used linear regression and enrichment analysis to characterize metabolomic profiles and elastic-net regression to construct metabolite scores for body shapes. In nested case-control studies, we explored the associations of metabolite scores with the risks of coronary heart disease, acute coronary syndrome (ACS), and stroke, including 1621, 657, and 1289 case-control pairs, respectively. Compared with low BMI and low WHtR, four shared (e.g. arginine and proline metabolism) and eight specific (e.g. glutathione metabolism) metabolite sets were identified for the other three body shapes. Metabolite scores for low BMI and high WHtR, and high BMI and low WHtR were associated with increased and decreased risks of ACS, respectively [odd ratios (95 % confidence intervals): 1.28 (1.14, 1.45) and 0.81 (0.72, 0.91)]. The metabolite score for high BMI and high WHtR was associated with increased risks of ACS, total and ischemic stroke [odd ratios (95 % confidence intervals): 1.21 (1.07, 1.37), 1.10 (1.01, 1.21), and 1.15 (1.04, 1.28)].
Conclusions
This study unveiled metabolomic profiles of different body shapes, the underlying similarities and differences, and their associations with incident cardiovascular diseases.
期刊介绍:
Nutrition, Metabolism & Cardiovascular Diseases is a forum designed to focus on the powerful interplay between nutritional and metabolic alterations, and cardiovascular disorders. It aims to be a highly qualified tool to help refine strategies against the nutrition-related epidemics of metabolic and cardiovascular diseases. By presenting original clinical and experimental findings, it introduces readers and authors into a rapidly developing area of clinical and preventive medicine, including also vascular biology. Of particular concern are the origins, the mechanisms and the means to prevent and control diabetes, atherosclerosis, hypertension, and other nutrition-related diseases.