Nutrition Metabolism and Cardiovascular Diseases最新文献_第8页

Trends and disability-attributable risk factors of type 2 diabetes mellitus in Southeast Asia (1990–2019): An in-depth 30-year analysis from the Global Burden of Disease study 东南亚 2 型糖尿病的趋势和致残风险因素（1990-2019 年）：全球疾病负担研究的 30 年深入分析。

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2024-09-30 DOI: 10.1016/j.numecd.2024.09.020

Annisa Salsabilla Dwi Nugrahani , Farizal Rizky Muharram , Hermina Novida , Julian Benedict Swannjo , Sony Wibisono , Citrawati Dyah Kencono Wungu

{"title":"Trends and disability-attributable risk factors of type 2 diabetes mellitus in Southeast Asia (1990–2019): An in-depth 30-year analysis from the Global Burden of Disease study","authors":"Annisa Salsabilla Dwi Nugrahani , Farizal Rizky Muharram , Hermina Novida , Julian Benedict Swannjo , Sony Wibisono , Citrawati Dyah Kencono Wungu","doi":"10.1016/j.numecd.2024.09.020","DOIUrl":"10.1016/j.numecd.2024.09.020","url":null,"abstract":"<div><h3>Background and aims</h3><div>To provide insight on targeted approach to mitigate diabetes burden, this research aims to analyze the trends of prevalence, mortality, and disability attributable to risk factors for type 2 diabetes mellitus (T2DM) from 1990 to 2019 in the Southeast Asia (SEA) region.</div></div><div><h3>Methods and results</h3><div>Age-standardized rates for prevalence (ASPR), mortality (ASMR), and disability-adjusted life years (DALYs) from 1990 to 2019 from the Global Burden of Disease Study were assessed. DALYs-related risk factors were estimated using multivariate regression analysis and estimated annual percentage change (EAPC) was calculated to quantify the temporal trends. Over 30 years, the SEA region experienced a 59.5 % rise in T2DM ASPR, 17.33 % in ASMR, and 26.97 % in DALYs. The T2DM DALYs rate per 100,000 population was 1002.91 (885.23–1132.40) in 1990 and 1273.42 (1103.92–1452.41) in 2019, increasing by 27 %. Cambodia and Indonesia had the highest worsening in three parameters, while most significant improvement in all parameters was observed in Singapore. The curvilinear association was demonstrated between ASMR and DALYs to Gross Domestic Product (GDP) per capita. Prominent risk factors affecting DALYs increase were high fasting plasma glucose (FPG) (p < 0.001), high body mass index (BMI) (p < 0.001), tobacco use (p = 0.012), and household pollution (p = 0.03). Men were more affected than women.</div></div><div><h3>Conclusion</h3><div>The burden of T2DM in the SEA region has increased significantly during the 30-year period. Policymakers should address high BMI, high FPG, smoking, and air pollution to regulate T2DM burden in SEA.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 1","pages":"Article 103750"},"PeriodicalIF":3.3,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adverse event reporting of combining SGLT2 inhibitor and GLP1 receptor agonist: A real-world study from FAERS 联合使用 SGLT2 抑制剂和 GLP1 受体激动剂的不良事件报告：来自 FAERS 的真实世界研究。

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2024-09-27 DOI: 10.1016/j.numecd.2024.09.028

Chunyan Tian, Zheng Yang, Subei Zhao, Ping Zhang, Rong Li

{"title":"Adverse event reporting of combining SGLT2 inhibitor and GLP1 receptor agonist: A real-world study from FAERS","authors":"Chunyan Tian, Zheng Yang, Subei Zhao, Ping Zhang, Rong Li","doi":"10.1016/j.numecd.2024.09.028","DOIUrl":"10.1016/j.numecd.2024.09.028","url":null,"abstract":"<div><h3>Background and aims</h3><div>We evaluate whether the combination of sodium-glucose cotransporter-2 inhibitor(SGLT2i) and glucagon-like peptide-1 receptor agonist(GLP1RA) disproportionally increases the reporting of adverse events compared with SGLT2i or GLP1RA monotherapy in the FDA adverse event reporting system (FAERS).</div></div><div><h3>Methods and results</h3><div>Adverse events related to SGLT2i and GLP1RA were screened and selected, then data from the FAERS was underwent thorough disproportionality analysis. The proportional reporting ratio(PRR) of SGLT2i-related adverse events were compared between patients using SGLT2i alone and those using both SGLT2i and GLP1RA. Similarly, the PRR of GLP1RA-related adverse events were compared between patients using GLP1RA alone and those using both SGLT2i and GLP1RA. The results showed that the PRR of SGLT2i-related adverse events including diabetic ketoacidosis(DKA), ketosis, reproductive tract adverse events, urinary tract infection, and other adverse events, decreased in individuals using both SGLT2i and GLP1RA compared with those using SGLT2i alone, and the signal of fracture was not detected. Likewise, the PRR of GLP1RA-related adverse events including gastrointestinal adverse events, gallbladder and biliary tract disease, pancreatitis, and other adverse events, decreased in individuals using both SGLT2i and GLP1RA compared with those using GLP1RA alone, the PRR of hyperlipasaemia and hyperamylasaemia increased in the combination therapy and no signal of depression, suicidal and self-injurious behaviour was detected.</div></div><div><h3>Conclusion</h3><div>Adverse events reporting are not disproportionally higher among those using both SGLT-2i and GLP1RA compared with SGLT2i or GLP1RA monotherapy.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 1","pages":"Article 103758"},"PeriodicalIF":3.3,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison between Friedewald's and Sampson's formulas in the estimation of high levels of measured LDL-cholesterol in youth with obesity. 比较弗里德瓦尔德公式和桑普森公式对肥胖症青少年高水平低密度脂蛋白胆固醇测量值的估算。

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2024-09-26 DOI: 10.1016/j.numecd.2024.09.023

Procolo Di Bonito, Domenico Corica, Malgorzata Gabriela Wasniewska, Anna Di Sessa, Emanuele Miraglia Del Giudice, Maria Rosaria Licenziati, Nicola Improda, Giuliana Valerio

{"title":"Comparison between Friedewald's and Sampson's formulas in the estimation of high levels of measured LDL-cholesterol in youth with obesity.","authors":"Procolo Di Bonito, Domenico Corica, Malgorzata Gabriela Wasniewska, Anna Di Sessa, Emanuele Miraglia Del Giudice, Maria Rosaria Licenziati, Nicola Improda, Giuliana Valerio","doi":"10.1016/j.numecd.2024.09.023","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.09.023","url":null,"abstract":"<p><strong>Background and aim: </strong>To assess the performance of Friedewald's and Sampson's formulas in relation to high or borderline-high levels of measured LDL-Cholesterol (LDL-C) in youths with overweight/obesity (OW/OB).</p><p><strong>Methods and results: </strong>A cross-sectional study was performed in 1694 youths (age 5-17 years) with OW/OB observed in Italian centers of Messina (group 1) and Naples (group 2). LDL-C levels were both measured and calculated using Friedewald's (LDL-C<sub>F</sub>) and Sampson's (LDL-C<sub>S</sub>) formulas. The two groups were similar for sex, age, BMI, BMI Z-score, and measured LDL-C. Levels of LDL-C<sub>F</sub> and LDL-C<sub>S</sub> were higher in group 1 than group 2. In the overall sample, 9.9 % youths had measured LDL-C ≥130 mg/dL and 27.8 % ≥ 110 mg/dL, without differences between centers. The two formulas showed comparable high sensitivity and specificity in relation to levels of measured LDL-C ≥130 mg/dL or ≥110 mg/dL. However, LDL-C<sub>F</sub> showed a higher positive predictive value than LDL-C<sub>S</sub>.</p><p><strong>Conclusions: </strong>Both formulas estimate with high accuracy measured LDL-C levels in youths with OW/OB. Therefore, calculated LDL-C can be a useful tool for universal screening when direct LDL-C measurement is not available. The Friedewald's formula is more feasible in clinical practice for simplicity of calculation.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum uric acid and mortality in metabolic dysfunction-associated steatotic liver disease: Subgroup differences 代谢功能障碍相关脂肪性肝病患者的血清尿酸与死亡率：亚组差异。

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2024-09-21 DOI: 10.1016/j.numecd.2024.09.015

Wenya Chen , You Deng , Mengqi Li , Jiashuo Li , Ying Cao , Wen Xie

{"title":"Serum uric acid and mortality in metabolic dysfunction-associated steatotic liver disease: Subgroup differences","authors":"Wenya Chen , You Deng , Mengqi Li , Jiashuo Li , Ying Cao , Wen Xie","doi":"10.1016/j.numecd.2024.09.015","DOIUrl":"10.1016/j.numecd.2024.09.015","url":null,"abstract":"<div><h3>Background and aims</h3><div>This study aims to investigate the association between serum uric acid (SUA) and both the risk and long-term mortality of dysfunction-associated steatotic liver disease (MASLD), and to explore differences between the pure MASLD and metabolic and alcohol related/associated liver disease (MetALD) subgroups.</div></div><div><h3>Methods and results</h3><div>We included 11,675 participants from the Third National Health and Nutrition Examination Survey, with matched mortality data up to 2019. Logistic regression and Cox proportional hazards regression evaluated the relationship between SUA and both the risk and mortality of MASLD. Non-linear correlations and threshold effects were explored using restricted cubic splines and a two-piecewise Cox proportional hazards model. We found that SUA was positively associated with the risk of MASLD [odds ratio (OR): 1.19, 95 % confidence interval (CI) 1.12–1.27]. For pure MASLD, SUA showed a positive association with all-cause mortality [<4.7 mg/dL: hazard ratio (HR): 1.34, 95 % CI 1.04–1.73; ≥4.7 mg/dL: HR: 1.08, 95 % CI 1.02–1.15] and cardiovascular mortality (HR: 1.12, 95 % CI 1.02–1.22). For MetALD, there was an inverse J-shaped relationship (threshold: 6.6 mg/dL) between SUA and all-cause mortality. Below the threshold, SUA was negatively correlated with all-cause mortality (HR: 0.42, 95 % CI 0.19–0.93), but no association was found above it (HR: 0.81, 95 % CI 0.54–1.21). Additionally, no association was observed between SUA and cardiovascular mortality.</div></div><div><h3>Conclusions</h3><div>SUA serves as an independent predictor of the risk and all-cause mortality of MASLD. The relationship between SUA and both all-cause and cardiovascular mortality differs between the pure MASLD and MetALD subgroups.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"34 12","pages":"Pages 2771-2778"},"PeriodicalIF":3.3,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel metabolic indicators and the risk of cardiovascular disease in patients with hypertension: A primary-care cohort study. 新的代谢指标与高血压患者罹患心血管疾病的风险：一项初级保健队列研究。

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2024-09-21 DOI: 10.1016/j.numecd.2024.09.019

Deliang Lv, Zhen Liu, Xiaobing Wu, Fengzhu Xie, Qinggang Shang, Wei Xie, Ziyang Zhang, Zhiguang Zhao

{"title":"Novel metabolic indicators and the risk of cardiovascular disease in patients with hypertension: A primary-care cohort study.","authors":"Deliang Lv, Zhen Liu, Xiaobing Wu, Fengzhu Xie, Qinggang Shang, Wei Xie, Ziyang Zhang, Zhiguang Zhao","doi":"10.1016/j.numecd.2024.09.019","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.09.019","url":null,"abstract":"<p><strong>Background and aims: </strong>Data are limited on whether several easily measured indices serve as effective tools for Cardiovascular disease (CVD) risk assessment in hypertensive patients. This study aimed to assess the associations of metabolic score for insulin resistance (METS-IR), lipid accumulation product (LAP), and visceral adiposity index (VAI) with CVD risk in hypertensive patients.</p><p><strong>Methods and results: </strong>Our data were drawn from the medical records of primary-care institutions in China. The present study included 306,680 individuals with hypertension attending primary healthcare centers. Cox regression analyses were applied to assess the associations of novel metabolic indicators with the risk of CVD. During a median follow-up of 1.98 years, 5820 participants developed CVD. When comparing with the lowest quartile of the indices, the highest quartile of METS-IR, LAP, and VAI was associated with 1.25-fold (95 % CI: 1.16-1.35), 1.15-fold (95 % CI: 1.05-1.25), and 1.19-fold (95 % CI: 1.10-1.28) risk of CVD after adjusting for potential confounders.</p><p><strong>Conclusion: </strong>This study provided additional evidence that novel metabolic indicators like METS-IR, LAP, and VAI were associated with the risk of CVD. These results suggest that proactive assessment of visceral adiposity and insulin resistance could be helpful for the effective clinical management of the hypertensive population.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-specific association of weight-adjusted waist index with mortality in stroke survivors: A national longitudinal cohort study. 体重调整后腰围指数与中风幸存者死亡率的性别特异性关联：一项全国纵向队列研究。

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2024-09-19 DOI: 10.1016/j.numecd.2024.09.013

Fei Liu, Jiarui Chen, Ying Yao, Reng Ren, Yue Yu, Yinghong Hu

{"title":"Sex-specific association of weight-adjusted waist index with mortality in stroke survivors: A national longitudinal cohort study.","authors":"Fei Liu, Jiarui Chen, Ying Yao, Reng Ren, Yue Yu, Yinghong Hu","doi":"10.1016/j.numecd.2024.09.013","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.09.013","url":null,"abstract":"<p><strong>Background and aims: </strong>The weight-adjusted waist index (WWI) is a novel indicator of obesity, and its association with mortality in stroke patients remains unknown. We aimed to explore these associations through a national longitudinal cohort study.</p><p><strong>Methods and results: </strong>We included stroke survivors from the National Health and Nutrition Examination Survey (NHANES) 1999-2018 who were followed up until December 31, 2019. The study outcomes were all-cause and cardiovascular disease (CVD) mortality in stroke patients. A total of 1427 stroke patients were enrolled, and after a median follow-up duration of 83 months, 624 stroke patients died, including 251 from CVD. Kaplan‒Meier survival analyses indicated that WWI was significantly associated with the probability of survival over time in stroke patients (log-rank tests, both p < 0.0001). After adjusting for confounders, WWI was significantly and positively associated with all-cause and CVD mortality after stroke. Restricted cubic spline analysis revealed that WWI was linearly associated with all-cause mortality and nonlinearly associated with CVD mortality. Stratified analyses suggested that sex significantly influenced the effect of WWI on all-cause mortality in stroke patients. Additional body mass index (BMI) adjustments did not significantly change the results.</p><p><strong>Conclusion: </strong>WWI was positively associated with all-cause and CVD mortality in stroke patients, independent of BMI. These effects were present only in men. These findings suggest that WWI is an independent prognostic factor in stroke patients and that maintaining appropriate WWI values can help improve the prognosis of stroke survivors.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing the lifestyle of patients with type 2 diabetes mellitus - Systematic review on the effects of combined diet-and-exercise interventions. 优化 2 型糖尿病患者的生活方式--饮食与运动相结合干预效果的系统回顾。

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2024-09-19 DOI: 10.1016/j.numecd.2024.09.016

Jessica Amerkamp, Süleyman Benli, Eduard Isenmann, Christian Brinkmann

{"title":"Optimizing the lifestyle of patients with type 2 diabetes mellitus - Systematic review on the effects of combined diet-and-exercise interventions.","authors":"Jessica Amerkamp, Süleyman Benli, Eduard Isenmann, Christian Brinkmann","doi":"10.1016/j.numecd.2024.09.016","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.09.016","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the effects of combined diet-and-exercise interventions in patients with type 2 diabetes mellitus (T2DM).</p><p><strong>Data synthesis: </strong>A systematic literature search was conducted on PubMed, Web of Science, SPORTDiscus and BISp Surf databases (latest update in June 2024). A total of 14706 records was identified. After screening procedures, 11 randomized controlled trials (n = 24 reports) were included. The included studies compared either the effects of a) a combined intervention versus a diet-only intervention or b) different combinations of diet and exercise. The overall quality of the included study reports was moderate (evaluated with the Risk of Bias 2 (RoB2) tool). Effects of adding exercise to a (calorie-restricted) diet were primarily reflected in increased physical fitness/performance. In far fewer cases, additional beneficial effects on glycemic control, number of subjects taking medication, body weight, body composition, or lipid profile were reported. Combined with regular exercise, an energy-restricted low-carbohydrate (LC) diet with either high-fat (HF) or high-protein (HP) contents showed superior effects compared with an energy-matched conventional (CONV) diet in terms of improvements in medication use (HF-LC versus CONV diet), lipids (HF-LC or HP-LC versus CONV diet) or wellbeing (HP-LC versus CONV diet) in some studies.</p><p><strong>Conclusions: </strong>Complementing a dietary intervention with regular exercise can have additional health benefits in T2DM, specifically improved physical fitness/performance. LC diets might be superior to other diets when combined with regular exercise. Other diet-and-exercise combinations than those analyzed in this review need to be investigated.</p><p><strong>Review registration number: </strong>CRD42023458830.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertension induced by peri-pubertal protein restriction depends on renin-angiotensin system dysfunction in adult male rats. 围青春期蛋白质限制诱发的高血压取决于成年雄性大鼠肾素-血管紧张素系统的功能障碍。

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2024-09-19 DOI: 10.1016/j.numecd.2024.09.003

Anna Rebeka Oliveira Ferreira, Maiara Vanusa Guedes Ribeiro, Maria Natalia Chimirri Peres, Gabriel Kian Guimarães Lopes, Lucas Paulo Jacinto Saavedra, Silvano Piovan, Leticia Ferreira Barbosa, Scarllet Rodrigues Raposo, Douglas Lopes Almeida, Ananda Malta, Jorge Juarez Vieira Teixeira, Paulo Cezar de Freitas Mathias, Kesia Palma-Rigo

{"title":"Hypertension induced by peri-pubertal protein restriction depends on renin-angiotensin system dysfunction in adult male rats.","authors":"Anna Rebeka Oliveira Ferreira, Maiara Vanusa Guedes Ribeiro, Maria Natalia Chimirri Peres, Gabriel Kian Guimarães Lopes, Lucas Paulo Jacinto Saavedra, Silvano Piovan, Leticia Ferreira Barbosa, Scarllet Rodrigues Raposo, Douglas Lopes Almeida, Ananda Malta, Jorge Juarez Vieira Teixeira, Paulo Cezar de Freitas Mathias, Kesia Palma-Rigo","doi":"10.1016/j.numecd.2024.09.003","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.09.003","url":null,"abstract":"<p><strong>Background and aims: </strong>Hypertension depends on renin-angiotensin system dysfunction; however, little is known about its implications in the outcomes of neurogenic hypertension induced by peri-pubertal insults. This study aimed to evaluate whether hypertension induced by a peri-pubertal low-protein diet is related to renin-angiotensin system dysfunction in adult male Wistar rats.</p><p><strong>Methods and results: </strong>Thirty-day-old male Wistar rats were fed a low-protein diet (4 % casein) for 30 days and subsequently fed a 20.5 % normal protein diet for a 60-day dietary recovery (LP group). Control animals (NP group) were fed a 20.5 % protein diet throughout their lives. Cardiovascular and renin-angiotensin system functions were evaluated on postnatal day 120 (6-24 animals per group). Statistical analyses were performed using the Student's t-test. Animals with LP show increased arterial blood pressure. The angiotensin 2 dose-response curve of LP animals showed an increase in the pressor response at a lower dose (50 ng/kg) and a reduction in the pressor response at a higher dose (400 ng/kg) compared with NP animals. Angiotensin 2 type 1 receptor mRNA levels were increased in the hearts of LP animals; however, angiotensin 2 type 2 receptor and MAS receptor mRNA levels were reduced. In the aorta, AT1 and AT2 mRNA levels were increased in LP animals, whereas MAS receptor mRNA levels were decreased in comparison to NP animals.</p><p><strong>Conclusion: </strong>The renin-angiotensin system is disrupted in hypertension induced by protein restriction exposure during peri-pubertal life.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visceral adiposity: A major mediator of the relationship between epicardial adiposity and cardiorespiratory fitness in adults. 内脏脂肪：成年人心外膜脂肪含量与心肺功能之间关系的主要调解因素。

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2024-09-19 DOI: 10.1016/j.numecd.2024.09.010

Dominic J Chartrand, Eric Larose, Paul Poirier, Patrick Mathieu, Natalie Alméras, Philippe Pibarot, Benoît Lamarche, Caroline Rhéaume, Isabelle Lemieux, Jean-Pierre Després, Marie-Eve Piché

{"title":"Visceral adiposity: A major mediator of the relationship between epicardial adiposity and cardiorespiratory fitness in adults.","authors":"Dominic J Chartrand, Eric Larose, Paul Poirier, Patrick Mathieu, Natalie Alméras, Philippe Pibarot, Benoît Lamarche, Caroline Rhéaume, Isabelle Lemieux, Jean-Pierre Després, Marie-Eve Piché","doi":"10.1016/j.numecd.2024.09.010","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.09.010","url":null,"abstract":"<p><strong>Background and aims: </strong>Epicardial adiposity has been positively associated with visceral adipose tissue (VAT). Few studies have examined the association between cardiorespiratory fitness (CRF) and epicardial adiposity. Furthermore, whether this relationship was independent of VAT remains unexplored. Our purpose was to investigate the contribution of VAT in the relationships between CRF, physical activity (PA) and epicardial adipose tissue (EAT) in asymptomatic women and men.</p><p><strong>Methods and results: </strong>We examined the associations between EAT and VAT measured by magnetic resonance imaging, CRF measured by cardiopulmonary exercise testing, and PA assessed using pedometers and a 3-day PA journal in 239 apparently healthy adults (43 % women). Participants were compared according to EAT tertiles and CRF level in both sexes. Participants with the highest EAT level presented more VAT (p < 0.001), lower CRF (p < 0.01), and a more deteriorated cardiometabolic health score (p < 0.01) than those with the lowest EAT level. CRF was negatively associated with EAT in both sexes (p < 0.01). No significant relationship was found with PA (p = NS). Stepwise multivariable regression analyses showed that VAT explained most of the variance in EAT in women and men. Mediation analyses confirmed that VAT was a mediator of the association between CRF and EAT in both sexes.</p><p><strong>Conclusion: </strong>In women and men, VAT appears as a major mediator of the association between CRF and EAT thereby suggesting that managing VAT by improving CRF could help in the prevention of cardiometabolic disorders related to excess EAT.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Population dietary-metabolic characteristics and mortality from major cardiovascular disease subtypes: the Seven Contries Study 60-year follow-up 人口膳食代谢特征与主要心血管疾病亚型的死亡率：七国研究 60 年随访。

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2024-09-19 DOI: 10.1016/j.numecd.2024.09.018

Alessandro Menotti , Paolo Emilio Puddu

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