高血压患者尿酸与高密度脂蛋白胆固醇比值与外周动脉疾病的关系：一项队列研究

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-03-27 DOI:10.1016/j.numecd.2025.104026

Congcong Yan , Zaohuang Zhen , Yumeng Shi , Peixu Zhao , Xiaoli Song , Qingling Peng , Xinyi Wang , Wei Zhou , Chao Yu , Tao Wang , Lingjuan Zhu , Huihui Bao , Jianhua Yu , Xiaoshu Cheng

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引用次数: 0

摘要

背景与目的：尿酸（UA）与高密度脂蛋白胆固醇（HDL-C）比值（UHR）是近年来研究提出的一种新的炎症和代谢指标。先前的研究已经证实，UHR与心血管死亡风险之间存在正相关。然而，UHR与外周动脉疾病（PAD）之间的关系尚不确定。方法和结果：该研究是一项前瞻性队列研究，包括来自中国高血压登记研究的6867名参与者，其中328名参与者在中位随访期48个月期间被确诊为PAD。采用多元logistic回归分析和平滑曲线拟合探讨男性和女性UHR与PAD的关系。在调整潜在混杂因素后，男性（HR: 1.27, 95% CI: 1.07-1.51）和女性（HR: 1.45, 95% CI: 1.19-1.77）的UHR与PAD呈正相关。亚组分析显示，UHR和PAD之间的关联在男性和女性亚组中保持稳定（相互作用的P值均为0.05）。结论：在中国男性和女性高血压人群中，UHR与新发PAD存在显著正相关。UHR升高预示着PAD的风险增加。

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Association between uric acid to high-density lipoprotein cholesterol ratio and peripheral arterial disease in hypertensive patients: A cohort study

Background and aims

Uric acid (UA) to high-density lipoprotein cholesterol (HDL-C) ratio (UHR) is a new indicator of inflammation and metabolism proposed by recent researches. Previous researches have confirmed a positive association between UHR and the risk of cardiovascular death. However, it is undetermined that the association between UHR and peripheral arterial disease (PAD).

Methods and results

The research is a prospective cohort study that included a total of 6,867 participants from the Chinese Hypertension Registry Study. 328 participants were identified with PAD during a median follow-up period of 48 months. Multiple logistic regression analysis and smooth curve fitting were applied to explore the association between UHR and PAD among men and women. After adjusting for potential confounders, UHR was positively associated with PAD both in men (HR: 1.27, 95 % CI: 1.07–1.51) and women (HR: 1.45, 95 % CI: 1.19–1.77). Subgroup analyses showed that the association between UHR and PAD remained stable across subgroups of men and women (all P for interaction >0.05).

Conclusions

There is a significant positive association between UHR and new-onset PAD in the Chinese hypertensive population both in men and women. An elevated UHR predicted increased risk of PAD.

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来源期刊

Nutrition Metabolism and Cardiovascular Diseases 医学-内分泌学与代谢

CiteScore

6.80

自引率

2.60%

发文量

332

审稿时长

57 days

期刊介绍： Nutrition, Metabolism & Cardiovascular Diseases is a forum designed to focus on the powerful interplay between nutritional and metabolic alterations, and cardiovascular disorders. It aims to be a highly qualified tool to help refine strategies against the nutrition-related epidemics of metabolic and cardiovascular diseases. By presenting original clinical and experimental findings, it introduces readers and authors into a rapidly developing area of clinical and preventive medicine, including also vascular biology. Of particular concern are the origins, the mechanisms and the means to prevent and control diabetes, atherosclerosis, hypertension, and other nutrition-related diseases.