假设和数据驱动的年轻人疾病风险评分——德国DONALD队列研究分析

IF 3.3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Michaela Mark, Samuel Muli, Ines Perrar, Christina-Alexandra Conzen, Ute Nöthlings
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引用次数: 0

摘要

背景和目的:疾病风险评分(drs)可以识别有慢性疾病风险的个体,但对其在年轻成人人群中的潜在用途知之甚少。我们使用两种方法(假设和数据驱动)来描述年轻人的疾病风险概况。方法和结果:在多特蒙德营养与人体测量纵向设计(DONALD)队列研究中,我们对492名20-47岁的成人参与者应用了7个假设驱动的DRSs,并对12个连续代谢危险因素(n = 457)进行了聚类分析(分层,k-means)。我们使用年龄和性别校正线性回归和卡方检验比较drs。使用前向选择和年龄和性别调整的逻辑回归来检验每个得分成分的重要性。drs的纵向跟踪通过分蘖和聚类隶属度的一致性来评估。两类(1:“相对高风险”;2:“相对低风险”)。与聚类2相比,聚类1的参与者(41.1%)显示:所有假设驱动的drs的中位数更高,2型糖尿病的绝对风险更高(德国糖尿病风险评分),肝脏参数升高(脂肪肝指数,肝脂肪变性指数),更不利的心血管健康(Life's Simple 7),以及更高的绝对冠心病风险(Framingham风险评分-成人治疗小组III(女性))(P结论:drs的差异可以应用于相当年轻的成年人口。这些早期疾病风险特别受到人体测量标志物的影响,并且随着时间的推移相对稳定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hypothesis- and data-driven disease risk scores among young adults - An analysis in the German DONALD cohort study.

Background and aims: Disease risk scores (DRSs) can identify individuals at risk for chronic diseases, yet little is known about their potential use in young adult populations. We derived DRSs using two approaches (hypothesis- and data-driven) to describe subgroups of young adults regarding their disease risk profile.

Methods and results: In the DOrtmund Nutritional and Anthropometric Longitudinally Designed (DONALD) cohort study, we applied seven hypothesis-driven DRSs among 492 adult participants (20-47 years) and performed cluster analysis (hierarchical, k-means) with 12 continuous metabolic risk factors (n = 457). We compared the DRSs using age- and sex-adjusted linear regressions and chi-square tests. The importance of each score component was examined using forward selection and age- and sex-adjusted logistic regressions. Longitudinal tracking of DRSs was assessed via concordance in tertile and cluster membership. Two clusters (1: "comparably high-risk"; 2: "comparably low-risk") were identified. Participants in cluster 1 (41.1 %) compared to cluster 2 showed: higher median values in all hypothesis-driven DRSs, higher absolute type 2 diabetes risk (German Diabetes Risk Score), elevated liver parameters (Fatty Liver Index, Hepatic Steatosis Index), a more unfavourable cardiovascular health (Life's Simple 7), and higher absolute coronary heart disease risk (Framingham Risk Score - Adult Treatment Panel III (females)) (P < 0.05). Waist circumference and BMI were most important. The DRSs tracked considerably within a median follow-up of 4.9 years.

Conclusion: Differences in DRSs could be applied to a rather young adult population. These early disease risks are particularly shaped by anthropometric markers and are relatively stable over time.

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来源期刊
CiteScore
6.80
自引率
2.60%
发文量
332
审稿时长
57 days
期刊介绍: Nutrition, Metabolism & Cardiovascular Diseases is a forum designed to focus on the powerful interplay between nutritional and metabolic alterations, and cardiovascular disorders. It aims to be a highly qualified tool to help refine strategies against the nutrition-related epidemics of metabolic and cardiovascular diseases. By presenting original clinical and experimental findings, it introduces readers and authors into a rapidly developing area of clinical and preventive medicine, including also vascular biology. Of particular concern are the origins, the mechanisms and the means to prevent and control diabetes, atherosclerosis, hypertension, and other nutrition-related diseases.
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