Setor K Kunutsor, Atanu Bhattacharjee, Sae Young Jae, Jari A Laukkanen
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引用次数: 0
Abstract
Background and aims: A Body Shape Index (ABSI) is a novel metric designed to more accurately reflect abdominal adiposity and visceral fat distribution - factors more strongly associated with cardiometabolic risk than body mass index (BMI) and waist circumference (WC). The association between ABSI and cardiometabolic multimorbidity (CMM) is unclear. This study aimed to assess the prospective association between ABSI and CMM risk, and to directly compare this association with those of other adiposity measures (BMI, WC, height, and weight) on CMM risk within the same population.
Methods and results: We analyzed data from 3408 participants (mean age: 63 years; 44.7 % male) who were free from hypertension, coronary heart disease, diabetes, and stroke at wave 4 of the English Longitudinal Study of Ageing. ABSI was calculated as WC/(BMI2/3height1/2). CMM was defined as the presence of at least two chronic conditions (hypertension, cardiovascular disease, diabetes, and stroke) at wave 10. Multivariable logistic regression models were used to estimate odds ratios (ORs) and 95 % confidence intervals (CIs). Over a 15-year follow-up period, 201 participants developed CMM. Spline analysis showed a U-shaped trend between ABSI and CMM risk. Compared with the middle tertile, the multivariable adjusted ORs (95 % CIs) for CMM were 1.57 (1.10-2.25) for the lowest tertile and .97 (.64-1.48) for the highest tertile. Increased levels of BMI, WC, height, and weight were each associated with an elevated CMM risk.
Conclusion: There was a U-shaped relationship between ABSI and CMM risk, with low ABSI being associated with an increased CMM risk.
期刊介绍：
Nutrition, Metabolism & Cardiovascular Diseases is a forum designed to focus on the powerful interplay between nutritional and metabolic alterations, and cardiovascular disorders. It aims to be a highly qualified tool to help refine strategies against the nutrition-related epidemics of metabolic and cardiovascular diseases. By presenting original clinical and experimental findings, it introduces readers and authors into a rapidly developing area of clinical and preventive medicine, including also vascular biology. Of particular concern are the origins, the mechanisms and the means to prevent and control diabetes, atherosclerosis, hypertension, and other nutrition-related diseases.
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