Nutrition Metabolism and Cardiovascular Diseases最新文献

{"title":"Comment on “Associations of the hs-CRP/HDL-C ratio with cardiovascular disease among US adults: Evidence from NHANES 2015–2018″","authors":"Wenlong Wang, Lina Wang, Jianguo Cui, Dong Wang","doi":"10.1016/j.numecd.2025.103978","DOIUrl":"10.1016/j.numecd.2025.103978","url":null,"abstract":"","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 6","pages":"Article 103978"},"PeriodicalIF":3.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of hypertension, obesity, and type 2 diabetes on lacunar stroke: A network Mendelian randomization study","authors":"Zhi-Ping Wu ,&nbsp;Wei Wei ,&nbsp;Shan Liu ,&nbsp;Meng-Die Hu ,&nbsp;Heng Zhao ,&nbsp;Xiao-Feng Li ,&nbsp;Xin Chen","doi":"10.1016/j.numecd.2025.103974","DOIUrl":"10.1016/j.numecd.2025.103974","url":null,"abstract":"<div><h3>Background and aims</h3><div>Previous studies have reported an association of lacunar stroke with hypertension, obesity, and type 2 diabetes (T2D). The aim of this study was to investigate whether the association was causal and whether body mass index mediated the effect of hypertension on lacunar stroke.</div></div><div><h3>Methods and results</h3><div>The independence and causal association of hypertension, obesity, and T2D with lacunar stroke were assessed by multivariate Mendelian randomization (MVMR) and network Mendelian randomization (NMR) with inverse variance weighting (IVW). The reliability of the results was increased by sensitivity analyses including MR-Egger, Cochrane's Q test, Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO), and leave-one-out. MVMR analysis found that genetically predicted hypertension had a 42 % higher lacunar stroke risk (OR: 1.42, 95 % CI: 1.29–1.56, <em>P</em> &lt; 0.001) when adjusted for obesity and T2D, genetically predicted T2D had a 9 % higher lacunar stroke risk (OR: 1.09, 95 % CI: 1.03–1.16, <em>P</em> &lt; 0.004) when adjusted for hypertension and obesity, and genetically predicted obesity had a 15 % lower lacunar stroke risk (OR: 0.85, 95 % CI: 0.77–0.93, <em>P</em> &lt; 0.001) when adjusted for hypertension and T2D. NMR found that 44 % of the association between hypertension and lacunar stroke risk was mediated by obesity.</div></div><div><h3>Conclusion</h3><div>This genetic association study found novel independent genetic associations between hypertension and T2D with high risk of lacunar stroke, whereas obesity attenuated the risk of lacunar stroke. The findings emphasize the importance of individualized lacunar stroke prevention strategies rather than uniform weight management optimize medical care in high-risk populations.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 6","pages":"Article 103974"},"PeriodicalIF":3.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sedentary lifestyle and physical inactivity: A mutual interplay with early and overt frailty","authors":"Francesca Battista ,&nbsp;Federica Duregon ,&nbsp;Marco Vecchiato ,&nbsp;Andrea Ermolao ,&nbsp;Daniel Neunhaeuserer","doi":"10.1016/j.numecd.2025.103971","DOIUrl":"10.1016/j.numecd.2025.103971","url":null,"abstract":"<div><h3>Aims</h3><div>In recent years medical science and research are increasingly directed towards a holistic approach that considers health as global well-being rather than solely as the absence of disease. In this framework, lifestyle interventions and, in particular, physical exercise, are of crucial importance in prevention and treatment. Therefore, the purpose of this study is to describe this mutual interplay between physical behaviours, sarcopenia, and frailty, as well as to illustrate the role of structured exercise training in aging and disease.</div></div><div><h3>Data synthesis</h3><div>Physical activity and exercise training are determinants of lifelong global wellness and healthy aging. On the contrary, sedentary behaviour and physical inactivity are strictly linked to frailty and pre-frailty, both in adults and the elderly, with or without chronic diseases. On the other hand, the presence of pathological conditions is associated with a more inactive and sedentary behaviour. The co-presence of these factors is characterized by a mutual causal exchange in which they are imbricated in a continuous mechanistic interplay that involves inflammation, sarcopenia, osteopenia, functional impairment and many other pathophysiological aspects that rapidly can lead to a status of frailty.</div></div><div><h3>Conclusion</h3><div>A sedentary lifestyle and physical inactivity critically affect alterations in body composition and loss in functional capacity, typically linked to aging and accelerated by chronic diseases. However, physical activity and exercise can counteract the onset of pre-frailty and frailty by conferring beneficial effects on the individual's overall well-being.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 6","pages":"Article 103971"},"PeriodicalIF":3.3,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal effects and mediating pathways of metabolic dysfunction-associated fatty liver disease on novel subtypes of adult-onset diabetes: A two-step Mendelian randomization study","authors":"Rongrong Li ,&nbsp;Ting Wang ,&nbsp;Hongping Luo,&nbsp;Yawei Fan,&nbsp;Yan Guan,&nbsp;Ye Tian","doi":"10.1016/j.numecd.2025.103976","DOIUrl":"10.1016/j.numecd.2025.103976","url":null,"abstract":"<div><h3>Background and aim</h3><div>Based on an in-depth understanding of diabetes heterogeneity, five novel subtypes of adult-onset diabetes have been identified. This study investigates the differential impact of metabolic dysfunction-associated fatty liver disease (MAFLD) on these subtypes using a Mendelian randomization (MR) approach, while also exploring modifiable mediating factors.</div></div><div><h3>Methods and results</h3><div>Genetic variants associated with MAFLD were selected at the genome-wide significance threshold (<em>P</em> &lt; 5 × 10⁻⁸), with 16 variants used to assess causal associations with the risk of severe autoimmune diabetes (SAID), mild obesity-related diabetes (MOD), severe insulin-resistant diabetes (SIRD), severe insulin-deficient diabetes (SIDD), and mild age-related diabetes (MARD). Two-step MR was used to estimate total, direct, and mediated effects, analyzing 55 potential mediators across five domains. The primary method used was inverse variance weighting (IVW) along with a series of sensitivity analyses to ensure robustness of the results. Genetically predicted MAFLD was significantly associated with increased risk of MARD (OR = 1.171, 95 % CI 1.091–1.256), SIDD (OR = 1.158, 95 % CI 1.056–1.270), and SIRD (OR = 1.267, 95 % CI 1.119–1.434), with suggestive evidence for SAID (OR = 1.161, 95 % CI 1.016–1.327), but no association with MOD. Among all subtypes, waist-to-hip ratio adjusted for BMI (WHRadjBMI) was a common mediator, with liver fat, alanine aminotransferase (ALT), gamma-glutamyl transferase, fasting insulin (FI), and BMI mediating at least three subtypes. Liver fat accounted for the largest proportion of mediation (43.63 %–73.09 %), followed by ALT (8.99 %–17.93 %) and FI (6.81 %–13.04 %).</div></div><div><h3>Conclusion</h3><div>This study underscores the causal relationship between MAFLD and specific diabetes subtypes, highlighting the importance of integrated management of liver lipid metabolism, abdominal obesity, and blood glucose regulation. These findings support personalized intervention strategies.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 6","pages":"Article 103976"},"PeriodicalIF":3.3,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Elevated concurrent carotid atherosclerosis rates in patients with metabolic dysfunction-associated fatty liver disease (MAFLD) compared to non-alcoholic fatty liver disease (NAFLD): A cross-sectional observational study","authors":"Saad Khan,&nbsp;Junaid Imran,&nbsp;Hiba Thasleem,&nbsp;Maryam Adnan,&nbsp;Fatima Sohail","doi":"10.1016/j.numecd.2025.103980","DOIUrl":"10.1016/j.numecd.2025.103980","url":null,"abstract":"<div><div>Recent studies suggest that metabolic dysfunction-associated fatty liver disease (MAFLD) poses a greater cardiovascular risk than non-alcoholic fatty liver disease (NAFLD), particularly in relation to carotid atherosclerosis. This letter discusses findings from Chung et al., highlighting an increased prevalence of carotid atherosclerosis in MAFLD patients. However, methodological limitations such as retrospective design, single-center scope, and lack of data on confounding factors raise concerns about causality and generalizability. Emerging evidence supports MAFLD’s stronger predictive value for cardiovascular disease compared to NAFLD, with studies indicating a significantly higher incidence of subclinical atherosclerosis and cardiovascular mortality. The inclusion of metabolic risk factors in MAFLD criteria enhances its clinical relevance. Future research should adopt prospective, multi-center designs with comprehensive lifestyle and medication data to validate findings and refine screening protocols. Recognizing MAFLD’s distinct cardiovascular implications may improve early intervention strategies and patient outcomes.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 6","pages":"Article 103980"},"PeriodicalIF":3.3,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: “Association between cardiovascular risk factors and dilated and hypertrophic cardiomyopathy: Mendelian randomization analysis.”","authors":"Sari Luthfiyah ,&nbsp;Wannarat Lawang ,&nbsp;Fathimath Shifaza","doi":"10.1016/j.numecd.2025.103977","DOIUrl":"10.1016/j.numecd.2025.103977","url":null,"abstract":"<div><div>This study investigates the causal relationships between cardiovascular risk factors, such as smoking, alcohol consumption, and obesity, and their association with dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM) through Mendelian randomization analysis. The results indicate that smoking and obesity are causally linked to an increased risk of DCM, while alcohol consumption and other examined factors did not show significant causal relationships. The study uses a robust Mendelian randomization methodology to minimize biases common in traditional observational research, although the dataset's limited genetic diversity (derived from individuals of European ancestry) and the potential for confounding remain as limitations. This research highlights the importance of smoking cessation and weight management in the prevention of DCM and provides valuable insights into the genetic and lifestyle determinants of cardiomyopathies.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 6","pages":"Article 103977"},"PeriodicalIF":3.3,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary special issue: “One Health”","authors":"Frida Leonetti","doi":"10.1016/j.numecd.2025.103979","DOIUrl":"10.1016/j.numecd.2025.103979","url":null,"abstract":"","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 6","pages":"Article 103979"},"PeriodicalIF":3.3,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between hemoglobin glycation index and adverse outcomes in critically ill patients with myocardial infarction: A retrospective cohort study","authors":"Heshan Cao ,&nbsp;Long Gui ,&nbsp;Yuekang Hu ,&nbsp;Jun Yang ,&nbsp;Ping Hua ,&nbsp;Songran Yang","doi":"10.1016/j.numecd.2025.103973","DOIUrl":"10.1016/j.numecd.2025.103973","url":null,"abstract":"<div><h3>Background and aim</h3><div>The prognosis of critically ill patients with myocardial infarction (MI) is associated with metabolic disturbances. The hemoglobin glycation index (HGI), a marker of glycemic variability, has been linked to adverse outcomes in critically ill populations. This study aimed to explore the relationship between HGI and adverse outcomes in critically ill MI patients.</div></div><div><h3>Methods and results</h3><div>This retrospective cohort study used data from the MIMIC-IV database, focusing on critically ill MI patients. Linear regression was applied to model the relationship between glucose and HbA1c, from which HGI values were calculated. Patients were grouped into quartiles based on HGI. Primary outcomes included 30-day, 180-day, and 365-day all-cause mortality. Kaplan-Meier survival analysis, logistic regression, Cox proportional hazards models, and restricted cubic spline (RCS) analysis were employed to assess the relationship between HGI and adverse outcomes. A total of 2480 patients were included. Lower HGI was associated with significantly increased risks of 30-day, 180-day, 365-day, and hospital all-cause mortality. RCS analysis revealed an inverse J-shaped relationship between HGI and mortality risk.</div></div><div><h3>Conclusions</h3><div>Low HGI in critically ill MI patients is significantly associated with higher all-cause mortality, highlighting its potential as a prognostic marker for early risk stratification and management optimization.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 6","pages":"Article 103973"},"PeriodicalIF":3.3,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of gut microbiota in obesity severity and metabolic risk in pediatric populations","authors":"Thanyamas Burananat ,&nbsp;Alisa Wilantho ,&nbsp;Prapasri Kulalert ,&nbsp;Sira Nanthapisal ,&nbsp;Jutamat Tonglim ,&nbsp;Warisara Deetienin ,&nbsp;Pongsakorn Wangkumhang ,&nbsp;Sissades Tongsima ,&nbsp;Patcharapa Thaweekul","doi":"10.1016/j.numecd.2025.103970","DOIUrl":"10.1016/j.numecd.2025.103970","url":null,"abstract":"<div><h3>Background and aims</h3><div>Childhood obesity is a considerable public health issue. Recent research has shown that alterations in gut microbiota can have an impact on developing obesity and other metabolic health problems in children. This study aimed to investigate whether the characteristics of gut microbiota in obese children and adolescents are associated with the severity of obesity and any metabolic complications.</div></div><div><h3>Methods and results</h3><div>During May 2022 to May 2023, a total of 56 children and adolescents with obesity, aged 6–18 years, were recruited at Thammasat Hospital, situated in provincial Pathumthani in central Thailand. Participants were allocated into two groups, characterized by the severity of their obesity. Demographic data, body composition, along with resting energy expenditures were determined. Serum samples were collected for the metabolic profile and inflammatory markers. Fecal samples were obtained for gut microbiota analysis via 16S rRNA Illumina. The obese group exhibited notably greater relative abundance of <em>Actinobacteriota</em> in comparison to the severely obese group, along with a lower abundance of <em>Bacteroidota</em>. There were no statistically significant differences in the relative abundance of <em>Firmicutes</em> and the <em>Firmicutes</em> to <em>Bacteroidota</em> ratio between the two cohorts. <em>Bacteroidota</em> positively correlated with FMI, while <em>Actinobacteriota</em> showed a negative correlation with FMI.</div></div><div><h3>Conclusion</h3><div>The data gathered from this study illustrated that children and adolescents with obesity and severe obesity in Thailand showed differences in the relative abundance of <em>Actinobacteriota</em> and <em>Bacteroidota.</em> Certain microbiome taxa showed correlations with various body and metabolic parameters.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 6","pages":"Article 103970"},"PeriodicalIF":3.3,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of environmental pollution on metabolic health and the risk of non-communicable chronic metabolic diseases in humans","authors":"Caterina Formichi,&nbsp;Sonia Caprio,&nbsp;Laura Nigi,&nbsp;Francesco Dotta","doi":"10.1016/j.numecd.2025.103975","DOIUrl":"10.1016/j.numecd.2025.103975","url":null,"abstract":"<div><h3>Aims</h3><div>This review aims to provide a comprehensive overview to understand the role of pollution in the development of noncommunicable diseases (NCDs), with a focus on metabolic diseases.</div></div><div><h3>Data synthesis</h3><div>In the context of NCDs, the incidence of metabolic diseases such as obesity and diabetes are increasing at an alarming rate. In addition to the well-known role of the so-called “obesogenic” environment, characterized by unhealthy diet and physical inactivity, great attention has been paid in recent years to the effects of pollution. Indeed, progressive urbanization has been associated with increased exposure to pollutants. The harmful effects of some pollutants on the endocrine system have been known for decades, but data on the metabolic impact of pollution are rather recent. Pollution in its various forms promotes a systemic inflammatory state, insulin resistance, and oxidative stress, which appear to be closely associated with increased risk of NCD, particularly obesity and diabetes.</div></div><div><h3>Conclusions</h3><div>In conclusion, urbanization has so far had a predominantly negative impact on collective health, but a better understanding of the mechanisms linking pollution to metabolic health is crucial to implement preventive strategies, including careful urban planning to improve community health, understood not only as the absence of disease but also as psychological and social well-being, overcoming the risks associated with urbanization.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 6","pages":"Article 103975"},"PeriodicalIF":3.3,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}