Nutrition Metabolism and Cardiovascular Diseases最新文献

{"title":"Plasma adiponectin levels are associated with habitual dietary polyphenol intake in individuals at high cardiometabolic risk: a cross-sectional study.","authors":"Roberta Testa, Ersilia Nigro, Marta Mallardo, Dominic Salamone, Marilena Vitale, Paola Ciciola, Angela A Rivellese, Lutgarda Bozzetto, Giovanni Annuzzi, Aurora Daniele, Giuseppina Costabile","doi":"10.1016/j.numecd.2025.104164","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104164","url":null,"abstract":"<p><strong>Background and aim: </strong>Adiponectin, the most abundant adipokine secreted by adipose tissue, plays a key role in glucose and lipid metabolism while exhibiting anti-inflammatory properties. Its expression is influenced by age, sex, physical activity, and diet. While adherence to healthy dietary patterns like the Mediterranean and DASH diets has been linked to higher adiponectin levels, the specific impact of individual dietary components remains uncertain. In this cross-sectional study we investigated the relationship between plasma adiponectin levels, metabolic parameters, and habitual dietary composition in individuals at high cardiometabolic risk.</p><p><strong>Methods and results: </strong>Seventy-five overweight/obese participants from the Etherpaths European Project, with increased waist circumference and one additional metabolic syndrome component, were included in this cross-sectional study. Dietary intake was assessed using a 7-day food record, and plasma adiponectin levels were measured via ELISA. Correlations were analyzed at baseline, before any dietary intervention. Mean plasma adiponectin concentration was 10.2 ± 2.5 μg/mL. Adiponectin levels correlated inversely with diastolic blood pressure (r = -0.288, p = 0.015) and directly with HDL cholesterol (r = 0.268, p = 0.020). A significant positive association was observed with dietary fiber (r = 0.259, p = 0.028) and total polyphenol intake (r = 0.319, p = 0.006). Among polyphenols, phenolic acids (r = 0.308, p = 0.009), flavones (r = 0.270, p = 0.023), and tyrosols (r = 0.279, p = 0.018) showed the strongest associations. Adiponectin was significantly correlated with fruit and vegetable intake (r = 0.266, p = 0.021), but not with other food groups.</p><p><strong>Conclusion: </strong>A higher habitual intake of polyphenol-rich plant-based foods is associated with increased plasma adiponectin levels, which in turn correlate with a more favorable metabolic profile in individuals at high cardiometabolic risk.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104164"},"PeriodicalIF":3.3,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uric acid to high-density lipoprotein cholesterol ratio in association with adverse health outcomes in patients with chronic kidney disease.","authors":"Kaixin Lei, Sihan Hu, Yuxuan Zhang, Jiaao Wang, Jun Wang","doi":"10.1016/j.numecd.2025.104161","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104161","url":null,"abstract":"<p><strong>Background and aims: </strong>The ratio of uric acid to high-density lipoprotein cholesterol (UHR) has recently been identified as a new metabolic marker and has been shown to be associated with cardiovascular disease (CVD), chronic kidney disease (CKD), and diabetes. Nonetheless, the connection between UHR and negative health outcomes in CKD is still not well understood.</p><p><strong>Method and results: </strong>We analyzed data from the 1999-2018 National Health and Nutrition Examination Survey (NHANES), including 8071 individuals with chronic kidney disease (CKD). Wighted logistic regression models and weighted Cox proportional hazards models were employed to explore the association of UHR with health outcomes in CKD patients. A restricted cubic spline (RCS) regression model was applied to investigate potential nonlinear relationships. Additionally, subgroup analyses were conducted to examine potential interactions between UHR and other covariates. One unit increase in UHR was linked to a 4 % higher risk of cardiovascular disease (CVD), a 2 % increased risk of all-cause mortality, and a 3 % greater risk of CVD-related mortality (all P < 0.001). The RCS regression model demonstrated linear positive associations between UHR and these outcomes. The Kaplan-Meier curve revealed that individuals in the highest UHR quartile had significantly poorer outcomes in terms of both all-cause and CVD mortality. Subgroup analyses indicated that age, gender, and alcohol consumption might modulate the relationships between UHR and the three outcomes.</p><p><strong>Conclusion: </strong>UHR significantly positively correlates to CVD, all-cause mortality and CVD mortality in CKD population. Monitoring UHR at relatively low levels may protect long-term outcomes for CKD patients.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104161"},"PeriodicalIF":3.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediterranean Diet and athletic performance in elite and competitive athletes: a systematic review and meta-analysis.","authors":"Simona Fiorini, Monica Guglielmetti, Lenycia de Cassya Lopes Neri, Luca Correale, Anna Tagliabue, Cinzia Ferraris","doi":"10.1016/j.numecd.2025.104165","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104165","url":null,"abstract":"<p><strong>Aims: </strong>Mediterranean Diet (MedDiet) may represent the reference dietary pattern for athletes. Our aim was to study whether MedDiet could be associated with any changes in performance in adult athletes practicing different types of sport at various levels of competition.</p><p><strong>Data synthesis: </strong>A systematic literature review (PROSPERO n. CRD42023459039) was performed based on the PRISMA method. The search was conducted in PubMed/Medline, Scopus, Web of Science, and the Cochrane Library in October 2024. Competitive/elite healthy adult athletes performing at least 6 h/week. The risk of bias was assessed using the RoB 2.0 Cochrane tool for randomised-controlled trials, Robins-I tool for non-randomised studies and the Newcastle Ottawa Scale for the observational studies. A meta-analysis was conducted. 9 studies were included in this review (192 participants, mainly males), 5 of them had a cross-sectional design. The sample size ranged from 10 to 43 athletes performing different sports. 5 studies reported an impact of MedDiet on athletic performance; of these, 4 studies reported a positive effect. MedDiet adherence was positively related to anaerobic/aerobic power, explosive strength, and indirectly associated with body fat percentage. Reported adherence to MedDiet varied from low to high. The meta-analysis showed no MedDiet effect on the performance outcomes [SMD 0.00 (CI -0.26; 0.25)].</p><p><strong>Conclusions: </strong>The findings of this review suggest a general positive influence of the MedDiet on athletic performance, supporting its role as a beneficial dietary pattern for athletes. Quantitative analysis did not confirm these results, probably due to the few studies included, their heterogeneity and low-to-moderate quality.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104165"},"PeriodicalIF":3.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An acylcarnitine profile related to total dietary fibre intake, and its association with 24-hr blood pressure: The African-PREDICT study.","authors":"Michél Strauss-Kruger, Tertia van Zyl, Marlien Pieters, Adriaan Jacobs, Roan Louw, Catharina Mc Mels","doi":"10.1016/j.numecd.2025.104163","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104163","url":null,"abstract":"<p><strong>Background and aims: </strong>A fibre rich diet is linked to a healthier cardiometabolic profile and may promote fatty acid oxidation to lower acylcarnitine accumulation. This study aimed to determine whether total dietary fibre intake was related to cardiometabolic risk markers as well as acylcarnitine levels in apparently healthy adults, which concurrently may be related to blood pressure (BP).</p><p><strong>Methods and results: </strong>This study included 983 adults from the African-PREDICT study (aged 24 ± 3 years). Total fibre intake was determined using 24-hr dietary recalls, and 24-hr ambulatory BP was measured. Acylcarnitines were analysed in spot urine samples using liquid chromatography-tandem mass spectrometry-based metabolomics. Lower dietary fibre intake was related to a higher waist circumference (WC) and body mass index (BMI) as well as higher total cholesterol, low-density lipoprotein-cholesterol (LDL-C), triglycerides, Apo-lipoprotein-B, C-reactive protein (CRP), free carnitine, and short-chain acylcarnitine (C2-, C4- and C5-carnitine) levels (all p trend <0.05). Concurrently, all traditional cardiometabolic risk markers (WC, BMI, total cholesterol, LDL-C, triglycerides, Apo-B, and CRP) correlated positively with 24-hr BP. In multiple regression analyses, 24-hr SBP was associated with WC (β = 0.44; p < 0.001) and total energy intake (β = 0.096; p = 0.002), while 24-hr DBP was associated with WC (β = 0.283; p < 0.001), triglyceride levels (β = 0.085 p = 0.008), dietary fibre intake (β = -0.120; p < 0.001) and total energy intake (β = 0.128; p < 0.001). There was no relationship between acylcarnitine levels and 24-hr BP.</p><p><strong>Conclusion: </strong>We demonstrate that participants consuming a higher fibre diet had a more favourable metabolic profile than those consuming a low fibre diet, which was ultimately associated with lower BP.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104163"},"PeriodicalIF":3.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining Risk: Integrating time-varying and culturally diverse approaches to obesity and cardiovascular health.","authors":"Riza Amalia, Ronal Surya Aditya, Basti Tetteng, Eva Meizara Puspita Dewi, Harwanti Noviandari, Rusnila, Alwita Susanti","doi":"10.1016/j.numecd.2025.104162","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104162","url":null,"abstract":"","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104162"},"PeriodicalIF":3.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal blood pressure during pregnancy and children's cardiometabolic function: A birth cohort study.","authors":"Hualong Zhen, Lu Chen, Xuemei Hao, Jingru Lu, Linlin Zhu, Yufan Guo, Shuangqin Yan, Fangbiao Tao, Kun Huang","doi":"10.1016/j.numecd.2025.104153","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104153","url":null,"abstract":"<p><strong>Background and aim: </strong>The evidence regarding the effect of the trajectory of blood pressure (BP) during pregnancy on children's cardiometabolic risk (CMR) was absence. The purpose of this study was to explore the relationship between maternal BP in the first, second, and third trimester of pregnancy and the trajectory of maternal BP during pregnancy and children's cardiometabolic function.</p><p><strong>Methods and results: </strong>2159 mother-child pairs with singleton live births from the Ma'anshan Birth Cohort were included in the study. Maternal BP was measured at antenatal checkups and children's cardiometabolic biomarkers were measured at 4-6 years. Then linear and generalized linear models were performed for analyses. We found that maternal BP in the 1st trimester of pregnancy mainly affected children's BP, while maternal BP in the 2nd and 3rd trimester affected children's total CMR, including glucose metabolism, lipid metabolism and BP. Maternal high BP trajectories were also associated with children's high CMR factors, especially in the systolic BP (SBP) trajectories. Similarly, maternal hypertensive disorders of pregnancy was associated with children's increased CMR.</p><p><strong>Conclusions: </strong>In our study, maternal high BP during pregnancy, especially in the 2nd and 3rd trimesters, might predict poor cardiometabolic health in offspring. And maternal SBP might have a greater effect on children's cardiometabolism than diastolic BP.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104153"},"PeriodicalIF":3.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty increases the risk of hospitalization for atrial fibrillation in older adults: a population-based cohort study.","authors":"Caterina Trevisan, Chiara Ceolin, Davide Liborio Vetrano, Mirko Petrovic, Gregory Y H Lip, Iain Buchan, Marina De Rui, Giuseppe Sergi, Stefania Maggi, Marianna Noale, Søren Påske Johnsen, Riccardo Proietti, Pia Cordsen, Gregory Lip, Deirdre Lane, Martin O'Flaherty, Carrol Gamble, Iain Buchan, Christodoulos Kypridemos, Brendan Collins, Donato Leo, Mirko Petrovic, Delphine De Smedt, Stefanie De Buyser, Cheima Amrouch, Davide Liborio Vetrano, Amaia Calderón-Larrañaga, Lu Dai, Stefania Maggi, Marianna Noale, D A N Gheorghe-Andrei, Anca Rodica Dan, Nicola Ferri, Alessandra Buja, Giuseppe Sergi, Vincenzo Stefano Rebba, Caterina Trevisan, Tatjana Potpara, Laura Vivani, Silvia Ananstasia, Alessandro Ferri, Gehad Shehata, Nadia Rosso, Marco Cicerone, Jacek Marczyk, Trudie Lobban, Georg Ruppe, Graziano Onder, Federica Censi, Robero Da Cas, Cecilia Damiano, Guendalina Graffigna, Caterina Bosio, Lorenzo Palamenghi, Serena Barello, Aldo Pietro Maggioni, Andrea Lorimer, Donata Lucci, Dipak Kalra, Nathan Lea, John Ainsworth, Charlotte Stockton-Powdrell, Alam Sanaullah, Francisco Marín, Vanessa Roldán, José Miguel Rivera-Caravaca, Mariya Tokmakova","doi":"10.1016/j.numecd.2025.104159","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104159","url":null,"abstract":"<p><strong>Background and aims: </strong>Atrial fibrillation (AF) is more common with increasing age and older adults have greater prevalence of frailty, multimorbidity and polypharmacy, which may impact clinical outcomes. The present study aims to investigate the relationship between frailty and the risk of hospitalization for AF in older adults, and second, the possible interaction of multimorbidity in this association.</p><p><strong>Methods and results: </strong>Data from the Progetto Veneto Anziani (Pro.V.A.), an observational cohort study in north-eastern Italy, were utilised. The analyses included 2909 individuals aged ≥65 years without AF at baseline, assessed between 1995 and 1997, with follow-ups at 4.4 and 7 years. Frailty was defined according to Fried's criteria, and multimorbidity as the number of chronic diseases. AF-related hospitalizations and deaths were recorded up to December 31, 2018. Multi-adjusted mixed-effects Cox regressions were performed to test associations. Over the follow-up period, 318 (10.9 %) participants experienced AF-related hospitalizations. Compared to robust participants, the hazard ratio (HR) of hospitalizations due to AF was 1.42 (95 % Confidence Interval (95 %CI): 1.04-1.95) in pre-frail and 1.98 (95 %CI: 1.21-3.26) in frail individuals, even after adjusting for multimorbidity. The number of chronic diseases was only marginally and not significantly associated with AF-related hospitalizations (HR 1.07, 95 %CI: 0.99-1.15), but did not significantly interact with frailty in the association with AF-related hospitalizations.</p><p><strong>Conclusion: </strong>Older adults with frailty present with higher hazards of AF-related hospitalizations, irrespective of the presence of multimorbidity. Further studies are needed to evaluate whether reducing frailty may prevent AF development and improve health outcomes in older adults.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104159"},"PeriodicalIF":3.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-linear association between serum 25-hydroxyvitamin D levels and cardiovascular outcomes: Evidence from NHANES and mendelian randomization analysis.","authors":"Jingwei Li, Zhongyang Song, Yiming Hu, Jingnan Yan, Yanyun Shen, Yafeng Qi, Qian Xu, Lumei Zhang, Bing Zhao, Maofu Zhang, Zhiming Zhang","doi":"10.1016/j.numecd.2025.104155","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104155","url":null,"abstract":"<p><strong>Background and aims: </strong>The relationship between serum 25-hydroxyvitamin D (25(OH)D) and cardiovascular health is more complex than previously recognized. Observational studies link 25(OH)D deficiency to cardiovascular risk, while intervention trials show inconsistent results. This study evaluates the association between 25(OH)D levels and cardiovascular outcomes using both observational and genetic approaches, focusing on non-linear relationships and causality.</p><p><strong>Methods and results: </strong>We obtained data from the National Health and Nutrition Examination Survey (NHANES) 2021-2023, including 4792 adults aged ≥18 years with complete 25(OH)D measurements and cardiovascular assessments. Analysis across 25(OH)D quartiles (≤56.7, 56.8-78.1, 78.2-103.0, >103.0 nmol/L) showed distinct patterns. In fully adjusted models, the highest quartile had significantly elevated risks for coronary heart disease (CHD) (OR = 1.97, 95 % CI: 1.34-2.89, P < 0.001) and hypertension (OR = 1.48, 95 % CI: 1.28-1.71, P < 0.001) compared to the lowest quartile. Mendelian randomization analysis provided evidence of causal relationships with CHD (β = -0.465, SE = 0.137, P = 7.08 × 10^-4) and heart failure (β = -0.088, SE = 0.035, P = 0.011). Restricted cubic spline analyses revealed U-shaped associations, with optimal 25(OH)D levels (56.8-78.1 nmol/L) corresponding to lowest cardiovascular risk.</p><p><strong>Conclusion: </strong>Our findings reveal non-linear relationships between 25(OH)D and cardiovascular outcomes, with both observational and genetic evidence indicating causality for certain conditions. Results suggest that the optimal 25(OH)D range for cardiovascular health may be narrower than previously thought, highlighting the importance of maintaining balanced levels through personalized supplementation strategies.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104155"},"PeriodicalIF":3.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma copeptin independently predicts cardiovascular events but not all-cause mortality in patients with type 2 diabetes: a prospective observational study.","authors":"Lee Ti Davidson, Simona I Chisalita, Emilia Gauffin, Jan Engvall, Carl J Östgren, Fredrik H Nyström","doi":"10.1016/j.numecd.2025.104158","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104158","url":null,"abstract":"<p><strong>Background and aim: </strong>Cardiovascular disease (CVD) is the major cause of death in patients with type 2 diabetes mellitus (T2DM), making it of interest to attain efficient methods for prognostic purposes. We aimed to prospectively investigate the association between plasma copeptin and cardiovascular disease (CVD) in individuals with type 2 diabetes mellitus (T2DM), adjusting for mean 24-h ambulatory blood pressure, left ventricular mass index, and traditional cardio-metabolic risk factors.</p><p><strong>Methods and results: </strong>A cohort of 523 patients with T2DM with complete data on copeptin, age, sex, body mass index (BMI), smoking, total cholesterol, eGFR, HbA1c, 24-h ambulatory systolic blood pressure (24-h SBP), and left ventricular mass index (LVMI) was derived from the Cardiovascular Risk Factors in Patients with Diabetes - a Prospective Study in Primary Care (CARDIPP) study. The incidence of major adverse cardiovascular events (MACE) and all-cause mortality were obtained from the Swedish Cause of Death Registry and the Inpatient Register. A Cox-proportional hazard analysis was conducted. Over 15 years, 120 patients had MACE, while 122 died of any cause. Patients with a copeptin level of ≥5.6 pmol/L exhibited a 2.05 hazard ratio (HR) for MACE (95 % CI 1.24-3.37, p < 0.005). However, after adjustment, no significant association with all-cause mortality (HR 1.30, 95 % CI 0.84-2.02, p = 0.238) was noted. These findings were independent of traditional cardio-metabolic risk factors, 24-h SBP, and LVMI.</p><p><strong>Conclusions: </strong>Elevated copeptin levels (≥5.6 pmol/L) in patients with T2DM were independently associated with an increased risk of MACE. Measuring plasma copeptin may help identify high-risk T2DM patients.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov: NCT01049737.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104158"},"PeriodicalIF":3.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of the uric acid to high-density cholesterol ratio (UHR) combined with atherogenic index of plasma (AIP) for abnormal bone mineral density in type 2 diabetes mellitus patients.","authors":"Qingxi Zhang, Xueting Zeng, Jingming Wang, Shishi Huang, Fei Hua, Xiaotong Zhou, Lu Chen, Ting Gong, Min Zhang","doi":"10.1016/j.numecd.2025.104156","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104156","url":null,"abstract":"<p><strong>Background and aims: </strong>Osteoporosis, characterized by systemic bone mass reduction and microstructural deterioration, is a growing clinical and economic burden. Type 2 diabetes mellitus (T2DM) has been increasingly linked to poor bone health, elevating the risk of osteoporosis and fragility fractures. The uric acid to high-density lipoprotein cholesterol ratio (UHR) and atherogenic index of plasma (AIP) have emerged as novel metabolic indicators, but their combined role in predicting abnormal bone mineral density (BMD) remains unexplored. This study aims to investigate the individual and combined contributions of UHR and AIP in predicting abnormal BMD in patients with T2DM.</p><p><strong>Methods and results: </strong>This retrospective study included 290 patients with T2DM, recruited from a single center between February 2016 and August 2018. Clinical data, including UHR, AIP, and BMD, were analyzed. Multivariable regression and receiver operating characteristic (ROC) analyses were performed to evaluate the associations between UHR, AIP, and abnormal BMD. Both UHR and AIP were independently associated with abnormal BMD, with stronger associations observed in females and individuals without a history of smoking or drinking. ROC analyses demonstrated modest predictive value for UHR (AUC = 0.5969) and AIP (AUC = 0.6224), with the combined metrics achieving an AUC of 0.6329.</p><p><strong>Conclusions: </strong>The study highlights that UHR and AIP are negatively associated with total BMD, which can serve as potential predictive markers for abnormal BMD in T2DM patients. A novel clinical prediction model integrating these markers may aid in the early assessment of abnormal BMD risk, facilitating timely preventive interventions.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104156"},"PeriodicalIF":3.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}