Nutrition Metabolism and Cardiovascular Diseases最新文献

{"title":"The role of gut microbiota in obesity severity and metabolic risk in pediatric populations.","authors":"Thanyamas Burananat, Alisa Wilantho, Prapasri Kulalert, Sira Nanthapisal, Jutamat Tonglim, Warisara Deetienin, Pongsakorn Wangkumhang, Sissades Tongsima, Patcharapa Thaweekul","doi":"10.1016/j.numecd.2025.103970","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.103970","url":null,"abstract":"<p><strong>Background and aims: </strong>Childhood obesity is a considerable public health issue. Recent research has shown that alterations in gut microbiota can have an impact on developing obesity and other metabolic health problems in children. This study aimed to investigate whether the characteristics of gut microbiota in obese children and adolescents are associated with the severity of obesity and any metabolic complications.</p><p><strong>Methods and results: </strong>During May 2022 to May 2023, a total of 56 children and adolescents with obesity, aged 6-18 years, were recruited at Thammasat Hospital, situated in provincial Pathumthani in central Thailand. Participants were allocated into two groups, characterized by the severity of their obesity. Demographic data, body composition, along with resting energy expenditures were determined. Serum samples were collected for the metabolic profile and inflammatory markers. Fecal samples were obtained for gut microbiota analysis via 16S rRNA Illumina. The obese group exhibited notably greater relative abundance of Actinobacteriota in comparison to the severely obese group, along with a lower abundance of Bacteroidota. There were no statistically significant differences in the relative abundance of Firmicutes and the Firmicutes to Bacteroidota ratio between the two cohorts. Bacteroidota positively correlated with FMI, while Actinobacteriota showed a negative correlation with FMI.</p><p><strong>Conclusion: </strong>The data gathered from this study illustrated that children and adolescents with obesity and severe obesity in Thailand showed differences in the relative abundance of Actinobacteriota and Bacteroidota. Certain microbiome taxa showed correlations with various body and metabolic parameters.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"103970"},"PeriodicalIF":3.3,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between hemoglobin glycation index and adverse outcomes in critically ill patients with myocardial infarction: A retrospective cohort study.","authors":"Heshan Cao, Long Gui, Yuekang Hu, Jun Yang, Ping Hua, Songran Yang","doi":"10.1016/j.numecd.2025.103973","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.103973","url":null,"abstract":"<p><strong>Background and aim: </strong>The prognosis of critically ill patients with myocardial infarction (MI) is associated with metabolic disturbances. The hemoglobin glycation index (HGI), a marker of glycemic variability, has been linked to adverse outcomes in critically ill populations. This study aimed to explore the relationship between HGI and adverse outcomes in critically ill MI patients.</p><p><strong>Methods and results: </strong>This retrospective cohort study used data from the MIMIC-IV database, focusing on critically ill MI patients. Linear regression was applied to model the relationship between glucose and HbA1c, from which HGI values were calculated. Patients were grouped into quartiles based on HGI. Primary outcomes included 30-day, 180-day, and 365-day all-cause mortality. Kaplan-Meier survival analysis, logistic regression, Cox proportional hazards models, and restricted cubic spline (RCS) analysis were employed to assess the relationship between HGI and adverse outcomes. A total of 2480 patients were included. Lower HGI was associated with significantly increased risks of 30-day, 180-day, 365-day, and hospital all-cause mortality. RCS analysis revealed an inverse J-shaped relationship between HGI and mortality risk.</p><p><strong>Conclusions: </strong>Low HGI in critically ill MI patients is significantly associated with higher all-cause mortality, highlighting its potential as a prognostic marker for early risk stratification and management optimization.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"103973"},"PeriodicalIF":3.3,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of environmental pollution on metabolic health and the risk of non-communicable chronic metabolic diseases in humans.","authors":"Caterina Formichi, Sonia Caprio, Laura Nigi, Francesco Dotta","doi":"10.1016/j.numecd.2025.103975","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.103975","url":null,"abstract":"<p><strong>Aims: </strong>This review aims to provide a comprehensive overview to understand the role of pollution in the development of noncommunicable diseases (NCDs), with a focus on metabolic diseases.</p><p><strong>Data synthesis: </strong>In the context of NCDs, the incidence of metabolic diseases such as obesity and diabetes are increasing at an alarming rate. In addition to the well-known role of the so-called \"obesogenic\" environment, characterized by unhealthy diet and physical inactivity, great attention has been paid in recent years to the effects of pollution. Indeed, progressive urbanization has been associated with increased exposure to pollutants. The harmful effects of some pollutants on the endocrine system have been known for decades, but data on the metabolic impact of pollution are rather recent. Pollution in its various forms promotes a systemic inflammatory state, insulin resistance, and oxidative stress, which appear to be closely associated with increased risk of NCD, particularly obesity and diabetes.</p><p><strong>Conclusions: </strong>In conclusion, urbanization has so far had a predominantly negative impact on collective health, but a better understanding of the mechanisms linking pollution to metabolic health is crucial to implement preventive strategies, including careful urban planning to improve community health, understood not only as the absence of disease but also as psychological and social well-being, overcoming the risks associated with urbanization.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"103975"},"PeriodicalIF":3.3,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectories of activities of daily living/ instrumental activities of daily living and the risk of cardiovascular diseases.","authors":"Wenyang Han, Kangcheng Mao, Yiqun Li, Minglan Jiang, Xiao Ren, Xiaowei Zheng, Kaixin Zhang","doi":"10.1016/j.numecd.2025.103969","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.103969","url":null,"abstract":"<p><strong>Background and aim: </strong>Prior research has reported the association between activities of daily living (ADL)/instrumental activities of daily living (IADL) of cardiovascular disease (CVD). We aimed to identify distinctive ADL/IADL trajectories and evaluate their relationship of the risk of CVD.</p><p><strong>Methods and results: </strong>Our analysis included 7717 participants with four ADL/IADL assessments from the China Health and Retirement Longitudinal Study. Trajectories of ADL/IADL were identified by latent mixture modeling. Cox proportional hazards regression models were used to examine the association of ADL/IADL trajectories with CVD risk (stroke or cardiac events). Three distinct ADL/IADL trajectory groups were identified: maintaining a low ADL/IADL score throughout the follow-up (low-low trajectory); low starting ADL/IADL scores then increasing to mild scores (low-mild trajectory), and mild starting ADL/IADL scores then increasing (mild-increasing trajectory). During a median follow-up of 24 months (23 months-25months), a total of 519 respondents experienced CVD (including 143 stroke and 394 cardiac events). Individuals with low-mild and mild-increasing ADL trajectory were significantly associated with higher risk of CVD, with the corresponding hazard ratios were 1.50(1.24-1.81) and 2.02(1.44-2.84), respectively, compared to the individuals with low-low IADL trajectory. Similarly, individuals with low-mild and mild-increasing IADL trajectory were associated with 29 % (hazard ratios = 1.29, 95 % confidence intervals 1.06-1.58) and 59 % (hazard ratios = 1.59, 95 % confidence intervals 1.13-2.22) increased risk of CVD. Furthermore, Individuals with low-mild and mild-increasing ADL/IADL trajectory also had higher risks of stroke and cardiac events.</p><p><strong>Conclusion: </strong>Individuals with low-mild and mild-increasing ADL/IADL trajectory over time were associated with increased risk of incident CVD.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"103969"},"PeriodicalIF":3.3,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The time-averaged serum uric acid can better predict the prognosis of IgA nephropathy","authors":"Chenchen Qi ,&nbsp;Xudong Liu ,&nbsp;Jing Mao ,&nbsp;Sen Zhang ,&nbsp;Lan Ye ,&nbsp;Xuan Wang ,&nbsp;Jianan Peng ,&nbsp;Xiaoling Zhou","doi":"10.1016/j.numecd.2024.103800","DOIUrl":"10.1016/j.numecd.2024.103800","url":null,"abstract":"<div><h3>Background and aim</h3><div>To understand the clinical and pathological characteristics of patients with IgA nephropathy (IgAN) complicated by hyperuricemia, and to analyze the time-averaged SUA (TA-SUA) on the prognosis of IgAN.</div></div><div><h3>Methods and results</h3><div>A retrospective analysis of 718 IgAN patients with diagnosis confirmed by renal biopsy and follow-up of more than 1 year was performed. At least two serum uric acid (SUA) levels were measured at intervals of 0.5–1 year during follow-up. The TA-SUA was calculated according to the area under the curve during the follow-up period. The primary endpoint of the study was the doubling of creatinine or end-stage renal disease. Four groups (Q1-Q4) were divided according to TA-SUA quartile spacing from low to high, and the association of the TA-SUA with prognosis in IgAN patients was assessed using Kaplan-Meier survival analysis and Cox proportional hazards models.</div><div>This study included 718 patients with IgAN, of whom 181 (25.21 %) had hyperuricemia.Compared with the other three groups, the clinical and pathological characteristics of patients in the fourth quarter were more severe in both baseline SUA and TA-SUA groups. Multivariate results suggested that baseline SUA was not an independent risk factor for renal prognosis in IgAN patients after adjustment for clinical variables such as eGFR. High TA-SUA is an independent risk factor for renal prognosis in IgAN patients.</div></div><div><h3>Conclusions</h3><div>Hyperuricemia is common in IgA nephropathy.High TA-SUA in IgAN patients show more severe clinical features and pathological damage. TA-SUA is an independent risk factor for renal prognosis in IgA nephropathy patients.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 3","pages":"Article 103800"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The bone-heart axis in the pathogenesis of cardiovascular diseases: A narrative review","authors":"Anita Vergatti ,&nbsp;Veronica Abate ,&nbsp;Gabriella Iannuzzo ,&nbsp;Antonio Barbato ,&nbsp;Gianpaolo De Filippo ,&nbsp;Domenico Rendina","doi":"10.1016/j.numecd.2025.103872","DOIUrl":"10.1016/j.numecd.2025.103872","url":null,"abstract":"<div><div>Cardiovascular diseases (CVDs) cause about 30% of deaths worldwide, increasing social and economic burden in our societies. Although the treatment of the canonical cardiovascular risk factors has reduced the impact of CVDs on morbidity and mortality in the past few years, they continue to represent a major health problem. The definition of the biological properties of the bone-heart axis has led to new insights in the pathogenesis of CVDs; hence, the aim of this review is to try to elucidate the role of this axis on the susceptibility to CVDs. There is evidence that the bone interacts with extra-skeletal organs, including the cardiovascular system, through its endocrine functions. Clinical and experimental data strongly indicate that the interplay between the bone and the cardiovascular system represents a future tool for the prevention, diagnosis and treatment of CVDs. The identification of these non-canonical cardiovascular risk factors could prompt pharmacological research towards new target therapy aimed at precision medicine.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 3","pages":"Article 103872"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abdominal obesity: A lethal factor in elderly male osteoporosis patients – insights from NHANES","authors":"Ziyao Ding ,&nbsp;Xinzhe Qu ,&nbsp;Qirui Zhu ,&nbsp;Jinlong Tang ,&nbsp;Zhengya Zhu ,&nbsp;Changchang Chen ,&nbsp;Fuchao Chu ,&nbsp;Maji Sun ,&nbsp;Feng Yuan","doi":"10.1016/j.numecd.2024.103788","DOIUrl":"10.1016/j.numecd.2024.103788","url":null,"abstract":"<div><h3>Background and aim</h3><div>This study aims to investigate the relationship between A Body Shape Index (ABSI) Z-score and all-cause mortality among osteoporotic patients using data from the National Health and Nutrition Examination Survey (NHANES).</div></div><div><h3>Methods and results</h3><div>We analyzed NHANES data from 2005 to 2010, 2013 to 2014, and 2017 to 2018, focusing on individuals aged 50 and above with complete bone mineral density (BMD) data. The ABSI Z-score, calculated by adjusting waist circumference (WC) for height and weight, was used to independently assess abdominal fat beyond Body Mass Index (BMI). Mortality status was confirmed by linking NHANES data with the National Death Index (NDI), with follow-up until December 31, 2019. Weighted Cox proportional hazards models were employed for analysis, adjusting for age, gender, race, fracture history, anti-osteoporosis treatment history, diabetes, and cardiovascular disease (CVD). The study included 1596 participants. Higher ABSI Z-scores were significantly associated with increased all-cause mortality risk, especially among elderly male osteoporotic patients. This association remained robust after adjusting for multiple potential confounders.</div></div><div><h3>Conclusion</h3><div>The ABSI Z-score serves as a valuable non-invasive screening tool that effectively identifies osteoporotic patients at higher risk of mortality. These findings emphasize the importance of body management in health, supporting further research to explore the practical utility of ABSI Z-score in osteoporotic patients and how body management can enhance long-term survival rates.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 3","pages":"Article 103788"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating effect of physical activity on the relationship between high dietary live microbe intake and obesity among U.S adolescents, finding from NHANES 1999–2018","authors":"Jing-hong Liang ,&nbsp;Ying-qi Pu ,&nbsp;Xiu-zhi Yang,&nbsp;Jia-qi Chen,&nbsp;Zhuo-wen Wu,&nbsp;Mei-ling Liu,&nbsp;Nan Jiang,&nbsp;Shan Huang,&nbsp;Yu-shan Zhang,&nbsp;Li-xin Hu,&nbsp;Zheng-ge Jin,&nbsp;Wen-xin Ge,&nbsp;Xue-ya Pu,&nbsp;Shao-yi Huang,&nbsp;Ya-jun Chen","doi":"10.1016/j.numecd.2024.103786","DOIUrl":"10.1016/j.numecd.2024.103786","url":null,"abstract":"<div><h3>Background and aims</h3><div>The impact of dietary live microbe intake on adolescent obesity is still not fully understood. This study aims to investigate the potential relationship between dietary live microbe intake and obesity among U.S adolescents, and to explore the mediating role of physical activity (PA).</div></div><div><h3>Methods and results</h3><div>Data from NHANES (1999–2018) were analyzed, and dietary live microbe intake was categorized into low, medium, and high groups using a developed framework. Survey-weighted logistic regression and mediation analysis models were used to examine the association between live microbe intake and adolescent obesity, as well as the potential mediating effect of PA. Our study included 8443 participants aged 6–18, representing the noninstitutionalized U.S population of 184.5 million. We found that participants with a high dietary intake of live microbes had lower odds of developing obesity compared to those with the lowest exposure to live microbes (AOR = 0.900, 95 % CI: 0.812, 0.997). Additionally, our mediation analysis revealed a significant indirect effect of live microbes on obesity risk through PA (<em>P</em>-value &lt;0.001), with 39.4 % (95 % CI: 24.5 %, 86.5 %) of the effect mediated by PA.</div></div><div><h3>Conclusion</h3><div>Our study highlights the association between consuming a higher amount of live microbes in the diet and a decreased risk of obesity among U.S adolescents. It also suggests that PA may act as a mediator in this relationship. Therefore, it is crucial to emphasize the incorporation of both dietary interventions and PA in the development of prevention and therapy policies for managing adolescent obesity.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 3","pages":"Article 103786"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LP(a): The new marker of high cardiovascular risk","authors":"Maurizio Averna ,&nbsp;Angelo B. Cefalù","doi":"10.1016/j.numecd.2024.103845","DOIUrl":"10.1016/j.numecd.2024.103845","url":null,"abstract":"<div><div>The biological functions and role in human diseases of lipoprotein (a) discovered more than 60 years ago are still not fully understood. The high homology of apo(a) with plasminogen initially leads us to think of Lp(a) as a player in the coagulation system as pro-thrombotic factor. Over the years, a solid body of evidence from biology, epidemiology and from genetics and mendelian randomization has contributed to identify Lp(a) as a causal factor of atherosclerotic coronary heart disease, aortic calcific valve stenosis and ischaemic stroke. The active involvement of Lp(a) in atherogenesis and aortic calcific valve stenosis has been demonstrated by experimental data regarding the role of oxidized phospholipids, which are the cargo of Lp(a) and the presence of a Lp(a) receptor in valve interstitial cells. In secondary prevention, patients optimally treated for low density lipoprotein cholesterol (LDL-C) but with high Lp(a) levels show a residual cardiovascular risk. To date the LDL-C affecting drugs have a marginal effect on Lp(a). Statins produce a modest increase, monoclonal PCSK9i and Inclisiran a modest decrease not sufficient to reduce significantly the risk associated to Lp(a). Only lipoprotein apheresis and obicetrapib, a CETP novel inhibitor, reduce respectively by 75% and 40% Lp(a) levels. To obtain a lifetime risk reduction of 50% similar to that achieved by reducing LDL-C of about 40 mg/dl, Lp(a) should be reduced of about 100 mg/dl. The ongoing trials on drugs such as ASO, SiRnas, assembly inhibitors and maybe in the future the gene editing could obtain these results.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 3","pages":"Article 103845"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct metabolites in atherosclerosis based on metabolomics: A systematic review and meta-analysis primarily in Chinese population","authors":"Jinlin Tong ,&nbsp;Xu Han ,&nbsp;Yuanyuan Li ,&nbsp;Yuyao Wang ,&nbsp;Meijie Liu ,&nbsp;Hong Liu ,&nbsp;Jinghua Pan ,&nbsp;Lei Zhang ,&nbsp;Ying Liu ,&nbsp;Miao Jiang ,&nbsp;Hongyan Zhao","doi":"10.1016/j.numecd.2024.103789","DOIUrl":"10.1016/j.numecd.2024.103789","url":null,"abstract":"<div><h3>Aims</h3><div>Atherosclerosis is a life-threatening disease that develops when a plaque builds up inside an artery and progresses silently. Identifying the early pathological changes and the biomarkers of atherosclerosis deserves attention. We aimed to systematically study and integrate the various metabolites of atherosclerosis in the level of disease to provide more evidences to support early prevention and treatment of atherosclerosis.</div></div><div><h3>Data synthesis</h3><div>The protocol was registered with PROPSERO (CRD42023441845). We searched 14,985 records via EMBASE, PubMed, Web of Science, WanFang data, VIP data, and CNKI databases. The collected metabolites were for qualitative and quantitative meta-analysis. The I² statistic estimated heterogeneity, with over 50 % considered to adopt the random-effects model. A total of 49 articles were included in the meta-analysis. We finally integrated 83 and 16 metabolites presented more than two times in inclusion studies, respectively in blood (plasma and serum) and urine. Among them, the level of citric acid (SMD = −10.35 [95%CI -15.03, −5.67], p &lt; 0.001), lactic acid (SMD = 6.32 [95%CI 0.12, 12.52], p &lt; 0.001) and TMAO (SMD = 1.40 [95%CI 0.27, 2.53], p &lt; 0.001) had significant differences between atherosclerosis and controls. And we observed blood stasis syndrome of atherosclerosis patients present arterial ischemia and energy disorder obviously.</div></div><div><h3>Conclusions</h3><div>The study provides an in-depth understanding of the roles of metabolites on atherosclerosis progression and prediction primarily in Chinese population, which contributing to development of prevention and therapeutic potential in the future.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 3","pages":"Article 103789"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}